{"id":"https://openalex.org/W3204525294","doi":"https://doi.org/10.1371/journal.pcbi.1009422","title":"Heterodimer-heterotetramer formation mediates enhanced sensor activity in a biophysical model for BMP signaling","display_name":"Heterodimer-heterotetramer formation mediates enhanced sensor activity in a biophysical model for BMP signaling","publication_year":2021,"publication_date":"2021-09-30","ids":{"openalex":"https://openalex.org/W3204525294","doi":"https://doi.org/10.1371/journal.pcbi.1009422","mag":"3204525294","pmid":"https://pubmed.ncbi.nlm.nih.gov/34591841"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1009422","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009422","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009422&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009422&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044114280","display_name":"Md. Shahriar Karim","orcid":"https://orcid.org/0000-0001-8039-2742"},"institutions":[{"id":"https://openalex.org/I157386601","display_name":"North South University","ror":"https://ror.org/05wdbfp45","country_code":"BD","type":"education","lineage":["https://openalex.org/I157386601"]},{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["BD","US"],"is_corresponding":false,"raw_author_name":"Md. Shahriar Karim","raw_affiliation_strings":["Agricultural and Biological Engineering, Purdue University, West Lafayette, Indiana, United States of America","Department of Electrical and Computer Engineering, North South University, Dhaka, Bangladesh"],"raw_orcid":"https://orcid.org/0000-0001-8039-2742","affiliations":[{"raw_affiliation_string":"Agricultural and Biological Engineering, Purdue University, West Lafayette, Indiana, United States of America","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, North South University, Dhaka, Bangladesh","institution_ids":["https://openalex.org/I157386601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069606235","display_name":"Aasakiran Madamanchi","orcid":"https://orcid.org/0000-0003-1047-6646"},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aasakiran Madamanchi","raw_affiliation_strings":["Polytechnic Institute, Purdue University, West Lafayette, Indiana, United States of America","Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-1047-6646","affiliations":[{"raw_affiliation_string":"Polytechnic Institute, Purdue University, West Lafayette, Indiana, United States of America","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, United States of America","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027518953","display_name":"James A. Dutko","orcid":"https://orcid.org/0000-0001-9835-7531"},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James A. Dutko","raw_affiliation_strings":["University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-9835-7531","affiliations":[{"raw_affiliation_string":"University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072410833","display_name":"Mary C. Mullins","orcid":"https://orcid.org/0000-0002-9979-1564"},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary C. Mullins","raw_affiliation_strings":["University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-9979-1564","affiliations":[{"raw_affiliation_string":"University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024376067","display_name":"David M. Umulis","orcid":"https://orcid.org/0000-0003-1913-2284"},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David M. Umulis","raw_affiliation_strings":["Agricultural and Biological Engineering, Purdue University, West Lafayette, Indiana, United States of America","Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-1913-2284","affiliations":[{"raw_affiliation_string":"Agricultural and Biological Engineering, Purdue University, West Lafayette, Indiana, United States of America","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, United States of America","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5024376067"],"corresponding_institution_ids":["https://openalex.org/I219193219"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.8141,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.71441876,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"17","issue":"9","first_page":"e1009422","last_page":"e1009422"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9918000102043152,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heterotetramer","display_name":"Heterotetramer","score":0.9428079724311829},{"id":"https://openalex.org/keywords/homomeric","display_name":"Homomeric","score":0.6897602677345276},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.611361563205719},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.48994582891464233},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4800325930118561},{"id":"https://openalex.org/keywords/tetramer","display_name":"Tetramer","score":0.4610077738761902},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.4550912380218506},{"id":"https://openalex.org/keywords/ligand","display_name":"Ligand (biochemistry)","score":0.45360761880874634},{"id":"https://openalex.org/keywords/bone-morphogenetic-protein","display_name":"Bone morphogenetic protein","score":0.43019434809684753},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.4285939633846283},{"id":"https://openalex.org/keywords/ephrin","display_name":"Ephrin","score":0.41962751746177673},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.35603025555610657},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.31546923518180847},{"id":"https://openalex.org/keywords/protein-subunit","display_name":"Protein subunit","score":0.1361982226371765}],"concepts":[{"id":"https://openalex.org/C2780126713","wikidata":"https://www.wikidata.org/wiki/Q3408232","display_name":"Heterotetramer","level":4,"score":0.9428079724311829},{"id":"https://openalex.org/C2776104367","wikidata":"https://www.wikidata.org/wiki/Q5891451","display_name":"Homomeric","level":4,"score":0.6897602677345276},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.611361563205719},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48994582891464233},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4800325930118561},{"id":"https://openalex.org/C2778886173","wikidata":"https://www.wikidata.org/wiki/Q53832","display_name":"Tetramer","level":3,"score":0.4610077738761902},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4550912380218506},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.45360761880874634},{"id":"https://openalex.org/C31507581","wikidata":"https://www.wikidata.org/wiki/Q425383","display_name":"Bone morphogenetic protein","level":3,"score":0.43019434809684753},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4285939633846283},{"id":"https://openalex.org/C170286479","wikidata":"https://www.wikidata.org/wiki/Q24787399","display_name":"Ephrin","level":3,"score":0.41962751746177673},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.35603025555610657},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31546923518180847},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.1361982226371765},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019485","descriptor_name":"Bone Morphogenetic Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019485","descriptor_name":"Bone Morphogenetic Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019485","descriptor_name":"Bone Morphogenetic Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019485","descriptor_name":"Bone Morphogenetic Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019485","descriptor_name":"Bone Morphogenetic Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019485","descriptor_name":"Bone Morphogenetic Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052004","descriptor_name":"Bone Morphogenetic Protein Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052004","descriptor_name":"Bone Morphogenetic Protein Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052004","descriptor_name":"Bone Morphogenetic Protein Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055592","descriptor_name":"Biophysical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055592","descriptor_name":"Biophysical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055592","descriptor_name":"Biophysical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1009422","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009422","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009422&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:34591841","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34591841","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:fa9f6624e9504963a9768fc815f313a3","is_oa":true,"landing_page_url":"https://doaj.org/article/fa9f6624e9504963a9768fc815f313a3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 17, Iss 9, p e1009422 (2021)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8509922","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8509922","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1009422","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009422","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009422&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/14","display_name":"Life below water","score":0.4399999976158142}],"awards":[{"id":"https://openalex.org/G1623030905","display_name":null,"funder_award_id":"R01-GM056326","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7488454608","display_name":null,"funder_award_id":"R01GM132501","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8288036582","display_name":null,"funder_award_id":"NIH R01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3204525294.pdf","grobid_xml":"https://content.openalex.org/works/W3204525294.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1574498833","https://openalex.org/W1581965207","https://openalex.org/W1756591279","https://openalex.org/W1965681992","https://openalex.org/W1968512837","https://openalex.org/W1971807163","https://openalex.org/W1972509609","https://openalex.org/W1981220126","https://openalex.org/W1982169021","https://openalex.org/W1982882987","https://openalex.org/W1984568074","https://openalex.org/W1997259342","https://openalex.org/W2005640477","https://openalex.org/W2012794478","https://openalex.org/W2030125648","https://openalex.org/W2049860667","https://openalex.org/W2051465511","https://openalex.org/W2052069159","https://openalex.org/W2053009960","https://openalex.org/W2053201547","https://openalex.org/W2071251725","https://openalex.org/W2075802272","https://openalex.org/W2085991000","https://openalex.org/W2097240335","https://openalex.org/W2103997264","https://openalex.org/W2110126772","https://openalex.org/W2113150782","https://openalex.org/W2117054621","https://openalex.org/W2119373499","https://openalex.org/W2121759639","https://openalex.org/W2128584428","https://openalex.org/W2153336711","https://openalex.org/W2155539632","https://openalex.org/W2156124926","https://openalex.org/W2158512948","https://openalex.org/W2169427725","https://openalex.org/W2171453760","https://openalex.org/W2325657998","https://openalex.org/W2621998816","https://openalex.org/W2743660457","https://openalex.org/W2752405730","https://openalex.org/W3064293923","https://openalex.org/W3139699141","https://openalex.org/W3158303107","https://openalex.org/W6674527150"],"related_works":["https://openalex.org/W1979240150","https://openalex.org/W2503901518","https://openalex.org/W4400615637","https://openalex.org/W2312807137","https://openalex.org/W3011999150","https://openalex.org/W2033078860","https://openalex.org/W2181639278","https://openalex.org/W2981558981","https://openalex.org/W2141188038","https://openalex.org/W4230637843"],"abstract_inverted_index":{"Numerous":[0],"stages":[1],"of":[2,10,12,17,29,69,86,108,157,163,177,186,205,219,226],"organismal":[3],"development":[4],"rely":[5],"on":[6,132,213],"the":[7,18,35,58,100,155,178,184,214,217],"cellular":[8],"interpretation":[9,221],"gradients":[11,28],"secreted":[13],"morphogens":[14],"including":[15,173],"members":[16],"Bone":[19],"Morphogenetic":[20],"Protein":[21],"(BMP)":[22],"family":[23],"through":[24,80],"transmembrane":[25],"receptors.":[26,97],"Early":[27],"BMPs":[30],"drive":[31],"dorsal/ventral":[32],"patterning":[33,236],"throughout":[34],"animal":[36],"kingdom":[37],"in":[38,45,64,66,222,235,240],"both":[39],"vertebrates":[40],"and":[41,49,72,93,103,138,165,168,197,210],"invertebrates.":[42],"Growing":[43],"evidence":[44],"Drosophila,":[46],"zebrafish,":[47],"murine":[48],"other":[50,117,170],"systems":[51,65],"suggests":[52],"that":[53,142],"BMP":[54,60,70,91,110,119,128,192],"ligand":[55,166],"heterodimers":[56,73,78],"are":[57,74],"primary":[59],"signaling":[61,188,234],"ligand,":[62],"even":[63],"which":[67],"mixtures":[68],"homodimers":[71],"present.":[75],"Signaling":[76],"by":[77],"occurs":[79],"a":[81,124,145,202,223,229,241],"hetero-tetrameric":[82],"receptor":[83,164],"complex":[84,193,199],"comprising":[85],"two":[87,94],"distinct":[88],"type":[89,95],"one":[90],"receptors":[92],"II":[96],"To":[98],"understand":[99],"system":[101],"dynamics":[102],"determine":[104],"whether":[105],"kinetic":[106,125],"assembly":[107,194],"heterodimer-heterotetramer":[109,148,187],"complexes":[111,159],"is":[112,150],"favored,":[113],"as":[114],"compared":[115],"to":[116,144],"plausible":[118],"ligand-receptor":[120],"configurations,":[121],"we":[122],"developed":[123],"model":[126],"for":[127,135,232],"tetramer":[129],"formation":[130,149,156,200],"based":[131],"current":[133],"measurements":[134],"binding":[136],"rates":[137],"affinities.":[139],"We":[140],"find":[141],"contrary":[143],"common":[146],"hypothesis,":[147],"not":[151],"kinetically":[152],"favored":[153],"over":[154,201],"homodimer-tetramer":[158],"under":[160],"physiological":[161],"conditions":[162],"concentrations":[167],"therefore":[169],"mechanisms,":[171],"potentially":[172],"differential":[174],"kinase":[175],"activities":[176],"formed":[179],"heterotetramer":[180],"complexes,":[181],"must":[182],"be":[183],"cause":[185],"primacy.":[189],"Further,":[190],"although":[191],"favors":[195],"homodimer":[196],"homomeric":[198],"wide":[203],"range":[204,218],"parameters,":[206],"ignoring":[207],"these":[208],"signals":[209],"instead":[211],"relying":[212],"heterodimer":[215,233],"improves":[216],"morphogen":[220],"broad":[224],"set":[225],"conditions,":[227],"suggesting":[228],"performance":[230],"advantage":[231],"multiple":[237],"cell":[238],"types":[239],"gradient.":[242]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
