{"id":"https://openalex.org/W4282914796","doi":"https://doi.org/10.1371/journal.pcbi.1009409","title":"Pre- and postsynaptically expressed spike-timing-dependent plasticity contribute differentially to neuronal learning","display_name":"Pre- and postsynaptically expressed spike-timing-dependent plasticity contribute differentially to neuronal learning","publication_year":2022,"publication_date":"2022-06-14","ids":{"openalex":"https://openalex.org/W4282914796","doi":"https://doi.org/10.1371/journal.pcbi.1009409","pmid":"https://pubmed.ncbi.nlm.nih.gov/35700188"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1009409","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009409","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1009409","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029473346","display_name":"Beatriz Eymi Pimentel Mizusaki","orcid":"https://orcid.org/0000-0001-6351-8980"},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]},{"id":"https://openalex.org/I2800293973","display_name":"Montreal General Hospital","ror":"https://ror.org/04gbhgc79","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800293973","https://openalex.org/I2801766832"]},{"id":"https://openalex.org/I2801766832","display_name":"McGill University Health Centre","ror":"https://ror.org/04cpxjv19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801766832"]},{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["BR","CA","GB"],"is_corresponding":false,"raw_author_name":"Beatriz Eymi Pimentel Mizusaki","raw_affiliation_strings":["Centre for Research in Neuroscience, Brain Repair and Integrative Neuroscience Programme, Departments of Medicine, Neurology and Neurosurgery, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada","Computational Neuroscience Unit, Department of Computer Science, SCEEM, Faculty of Engineering, University of Bristol, Bristol, United Kingdom","Instituto de F\u00edsica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil"],"affiliations":[{"raw_affiliation_string":"Centre for Research in Neuroscience, Brain Repair and Integrative Neuroscience Programme, Departments of Medicine, Neurology and Neurosurgery, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I2801766832","https://openalex.org/I2800293973"]},{"raw_affiliation_string":"Computational Neuroscience Unit, Department of Computer Science, SCEEM, Faculty of Engineering, University of Bristol, Bristol, United Kingdom","institution_ids":["https://openalex.org/I36234482"]},{"raw_affiliation_string":"Instituto de F\u00edsica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil","institution_ids":["https://openalex.org/I130442723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077025313","display_name":"Sally Li","orcid":"https://orcid.org/0000-0001-6115-0924"},"institutions":[{"id":"https://openalex.org/I2800293973","display_name":"Montreal General Hospital","ror":"https://ror.org/04gbhgc79","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800293973","https://openalex.org/I2801766832"]},{"id":"https://openalex.org/I2801766832","display_name":"McGill University Health Centre","ror":"https://ror.org/04cpxjv19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801766832"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sally Si Ying Li","raw_affiliation_strings":["Centre for Research in Neuroscience, Brain Repair and Integrative Neuroscience Programme, Departments of Medicine, Neurology and Neurosurgery, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada"],"affiliations":[{"raw_affiliation_string":"Centre for Research in Neuroscience, Brain Repair and Integrative Neuroscience Programme, Departments of Medicine, Neurology and Neurosurgery, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I2801766832","https://openalex.org/I2800293973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039460327","display_name":"Rui Ponte Costa","orcid":"https://orcid.org/0000-0003-2595-2027"},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["CH","GB"],"is_corresponding":false,"raw_author_name":"Rui Ponte Costa","raw_affiliation_strings":["Centre for Neural Circuits and Behaviour, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom","Computational Neuroscience Unit, Department of Computer Science, SCEEM, Faculty of Engineering, University of Bristol, Bristol, United Kingdom","Department of Physiology, University of Bern, Bern, Switzerland"],"affiliations":[{"raw_affiliation_string":"Centre for Neural Circuits and Behaviour, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Computational Neuroscience Unit, Department of Computer Science, SCEEM, Faculty of Engineering, University of Bristol, Bristol, United Kingdom","institution_ids":["https://openalex.org/I36234482"]},{"raw_affiliation_string":"Department of Physiology, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051239989","display_name":"P. Jesper Sj\u00f6str\u00f6m","orcid":"https://orcid.org/0000-0001-7085-2223"},"institutions":[{"id":"https://openalex.org/I2800293973","display_name":"Montreal General Hospital","ror":"https://ror.org/04gbhgc79","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800293973","https://openalex.org/I2801766832"]},{"id":"https://openalex.org/I2801766832","display_name":"McGill University Health Centre","ror":"https://ror.org/04cpxjv19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801766832"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Per Jesper Sj\u00f6str\u00f6m","raw_affiliation_strings":["Centre for Research in Neuroscience, Brain Repair and Integrative Neuroscience Programme, Departments of Medicine, Neurology and Neurosurgery, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada"],"affiliations":[{"raw_affiliation_string":"Centre for Research in Neuroscience, Brain Repair and Integrative Neuroscience Programme, Departments of Medicine, Neurology and Neurosurgery, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I2801766832","https://openalex.org/I2800293973"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5051239989"],"corresponding_institution_ids":["https://openalex.org/I2800293973","https://openalex.org/I2801766832"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.9235,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.72739692,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"18","issue":"6","first_page":"e1009409","last_page":"e1009409"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10502","display_name":"Advanced Memory and Neural Computing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10502","display_name":"Advanced Memory and Neural Computing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/postsynaptic-potential","display_name":"Postsynaptic potential","score":0.800787091255188},{"id":"https://openalex.org/keywords/nonsynaptic-plasticity","display_name":"Nonsynaptic plasticity","score":0.7625957131385803},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.7572671175003052},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"Synaptic plasticity","score":0.740465521812439},{"id":"https://openalex.org/keywords/metaplasticity","display_name":"Metaplasticity","score":0.6824342012405396},{"id":"https://openalex.org/keywords/spike-timing-dependent-plasticity","display_name":"Spike-timing-dependent plasticity","score":0.6461565494537354},{"id":"https://openalex.org/keywords/synaptic-scaling","display_name":"Synaptic scaling","score":0.5748835802078247},{"id":"https://openalex.org/keywords/plasticity","display_name":"Plasticity","score":0.5722514986991882},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5505051612854004},{"id":"https://openalex.org/keywords/homosynaptic-plasticity","display_name":"Homosynaptic plasticity","score":0.5180578231811523},{"id":"https://openalex.org/keywords/post-tetanic-potentiation","display_name":"Post-tetanic potentiation","score":0.5178237557411194},{"id":"https://openalex.org/keywords/synapse","display_name":"Synapse","score":0.5058236122131348},{"id":"https://openalex.org/keywords/neuroplasticity","display_name":"Neuroplasticity","score":0.49935197830200195},{"id":"https://openalex.org/keywords/inhibitory-postsynaptic-potential","display_name":"Inhibitory postsynaptic potential","score":0.4572368264198303},{"id":"https://openalex.org/keywords/synaptic-augmentation","display_name":"Synaptic augmentation","score":0.42462587356567383},{"id":"https://openalex.org/keywords/homeostatic-plasticity","display_name":"Homeostatic plasticity","score":0.4130079746246338},{"id":"https://openalex.org/keywords/excitatory-postsynaptic-potential","display_name":"Excitatory postsynaptic potential","score":0.33378374576568604},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.1272566020488739},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.07554349303245544},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.05905374884605408}],"concepts":[{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.800787091255188},{"id":"https://openalex.org/C26410512","wikidata":"https://www.wikidata.org/wiki/Q3906363","display_name":"Nonsynaptic plasticity","level":5,"score":0.7625957131385803},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7572671175003052},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.740465521812439},{"id":"https://openalex.org/C194973443","wikidata":"https://www.wikidata.org/wiki/Q1420291","display_name":"Metaplasticity","level":4,"score":0.6824342012405396},{"id":"https://openalex.org/C159919123","wikidata":"https://www.wikidata.org/wiki/Q7577157","display_name":"Spike-timing-dependent plasticity","level":4,"score":0.6461565494537354},{"id":"https://openalex.org/C117718741","wikidata":"https://www.wikidata.org/wiki/Q7662041","display_name":"Synaptic scaling","level":5,"score":0.5748835802078247},{"id":"https://openalex.org/C79186407","wikidata":"https://www.wikidata.org/wiki/Q472074","display_name":"Plasticity","level":2,"score":0.5722514986991882},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5505051612854004},{"id":"https://openalex.org/C83119035","wikidata":"https://www.wikidata.org/wiki/Q17030659","display_name":"Homosynaptic plasticity","level":5,"score":0.5180578231811523},{"id":"https://openalex.org/C118232355","wikidata":"https://www.wikidata.org/wiki/Q7233588","display_name":"Post-tetanic potentiation","level":4,"score":0.5178237557411194},{"id":"https://openalex.org/C127445978","wikidata":"https://www.wikidata.org/wiki/Q187181","display_name":"Synapse","level":2,"score":0.5058236122131348},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.49935197830200195},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.4572368264198303},{"id":"https://openalex.org/C95293801","wikidata":"https://www.wikidata.org/wiki/Q7662035","display_name":"Synaptic augmentation","level":4,"score":0.42462587356567383},{"id":"https://openalex.org/C5687787","wikidata":"https://www.wikidata.org/wiki/Q5889850","display_name":"Homeostatic plasticity","level":5,"score":0.4130079746246338},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.33378374576568604},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1272566020488739},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07554349303245544},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.05905374884605408},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007858","descriptor_name":"Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007858","descriptor_name":"Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007858","descriptor_name":"Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1009409","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009409","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:35700188","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35700188","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:215f0e3a5e7b48969c7c0bfa625d7fea","is_oa":true,"landing_page_url":"https://doaj.org/article/215f0e3a5e7b48969c7c0bfa625d7fea","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 6, p e1009409 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9236267","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9236267","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1009409","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009409","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1044646533","display_name":null,"funder_award_id":"202183/2015-7","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G1250202696","display_name":null,"funder_award_id":"288936","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G1448343398","display_name":null,"funder_award_id":"28331","funder_id":"https://openalex.org/F4320319952","funder_display_name":"Canada Foundation for Innovation"},{"id":"https://openalex.org/G1527931292","display_name":null,"funder_award_id":"04730","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G1788170961","display_name":null,"funder_award_id":"DG 418546-2","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G1959167151","display_name":null,"funder_award_id":"2017-04730","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G2165548363","display_name":null,"funder_award_id":"Canada","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G2939866019","display_name":null,"funder_award_id":"F500385/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G361948359","display_name":null,"funder_award_id":"EPSRC EP","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G4839469465","display_name":null,"funder_award_id":"126137","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G5310261134","display_name":null,"funder_award_id":"EP/F500385/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G6096513441","display_name":null,"funder_award_id":"NIA 288936","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G6678054109","display_name":null,"funder_award_id":"418546-2","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G6839946225","display_name":null,"funder_award_id":"SFRH/BD/60301/2009","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G6856557226","display_name":null,"funder_award_id":"NSERC DG","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G7316528640","display_name":"LSI Doctoral Training Centres - Neuroinformatics and computational neuroscience","funder_award_id":"BB/F529254/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G7622900505","display_name":null,"funder_award_id":"156223","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G7879865761","display_name":null,"funder_award_id":"2017-507818","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G7914070021","display_name":null,"funder_award_id":"507818","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G8021926335","display_name":null,"funder_award_id":"254033","funder_id":"https://openalex.org/F4320334618","funder_display_name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9"},{"id":"https://openalex.org/G8323284177","display_name":null,"funder_award_id":"CB Sr 254033","funder_id":"https://openalex.org/F4320334618","funder_display_name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9"},{"id":"https://openalex.org/G8349401747","display_name":null,"funder_award_id":"DG 2017-04730","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G8688769077","display_name":null,"funder_award_id":"DAS 2017-507818","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"}],"funders":[{"id":"https://openalex.org/F4320319952","display_name":"Canada Foundation for Innovation","ror":"https://ror.org/000az4664"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"},{"id":"https://openalex.org/F4320334618","display_name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","ror":"https://ror.org/02eqrsj93"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"},{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":71,"referenced_works":["https://openalex.org/W78755966","https://openalex.org/W1147225692","https://openalex.org/W1486852018","https://openalex.org/W1489333352","https://openalex.org/W1547526327","https://openalex.org/W1733248925","https://openalex.org/W1875306972","https://openalex.org/W1921182138","https://openalex.org/W1970053578","https://openalex.org/W1975412204","https://openalex.org/W1976738367","https://openalex.org/W1993868308","https://openalex.org/W1996589480","https://openalex.org/W1997208576","https://openalex.org/W2001860569","https://openalex.org/W2009782005","https://openalex.org/W2010655017","https://openalex.org/W2022995207","https://openalex.org/W2026161211","https://openalex.org/W2031543773","https://openalex.org/W2050066016","https://openalex.org/W2056038034","https://openalex.org/W2059010387","https://openalex.org/W2061897041","https://openalex.org/W2065188087","https://openalex.org/W2065546903","https://openalex.org/W2080177800","https://openalex.org/W2082000963","https://openalex.org/W2082878385","https://openalex.org/W2083252150","https://openalex.org/W2084008684","https://openalex.org/W2084845865","https://openalex.org/W2085966567","https://openalex.org/W2097574751","https://openalex.org/W2101310282","https://openalex.org/W2102365206","https://openalex.org/W2103594871","https://openalex.org/W2110240734","https://openalex.org/W2112927743","https://openalex.org/W2118064450","https://openalex.org/W2120431135","https://openalex.org/W2122925692","https://openalex.org/W2125614519","https://openalex.org/W2127388521","https://openalex.org/W2128378732","https://openalex.org/W2128949090","https://openalex.org/W2133083344","https://openalex.org/W2137645899","https://openalex.org/W2138913040","https://openalex.org/W2144205676","https://openalex.org/W2146732533","https://openalex.org/W2153564253","https://openalex.org/W2160361560","https://openalex.org/W2162019295","https://openalex.org/W2162222153","https://openalex.org/W2163982115","https://openalex.org/W2164874302","https://openalex.org/W2165196764","https://openalex.org/W2290470375","https://openalex.org/W2291586862","https://openalex.org/W2620137608","https://openalex.org/W2757787969","https://openalex.org/W2761921473","https://openalex.org/W2887242076","https://openalex.org/W2950806340","https://openalex.org/W3013281916","https://openalex.org/W3135825807","https://openalex.org/W4210360421","https://openalex.org/W4247763225","https://openalex.org/W4251731575","https://openalex.org/W6684165403"],"related_works":["https://openalex.org/W1986719288","https://openalex.org/W2203294387","https://openalex.org/W2401732305","https://openalex.org/W2348453215","https://openalex.org/W1599215781","https://openalex.org/W2075289911","https://openalex.org/W2040128952","https://openalex.org/W2007490344","https://openalex.org/W1526145606","https://openalex.org/W2911877659"],"abstract_inverted_index":{"A":[0],"plethora":[1],"of":[2,21,35,49,69,84,110,122,125,127,135,157,201,214,252,263],"experimental":[3],"studies":[4],"have":[5,113],"shown":[6],"that":[7,45,144,208,282],"long-term":[8,72,85,128,136],"synaptic":[9,53,60,73,129,265],"plasticity":[10,50,74,86,141,241,266,287],"can":[11],"be":[12],"expressed":[13,147,286],"pre-":[14,150,283],"or":[15,151,153],"postsynaptically":[16,285],"depending":[17],"on":[18,107],"a":[19,88,114,133,155,167,178,199,250,274],"range":[20],"factors":[22],"such":[23,143],"as":[24,77,87],"developmental":[25],"stage,":[26],"synapse":[27],"type,":[28],"and":[29,63,166,173,195,226,284],"activity":[30,253],"patterns.":[31],"The":[32,82],"functional":[33,120],"consequences":[34],"this":[36,108],"diversity":[37,124],"are":[38,288],"not":[39,289],"clear,":[40],"although":[41],"it":[42,145],"is":[43,75],"understood":[44],"whereas":[46],"postsynaptic":[47,115,217,233,245,275],"expression":[48,57,126,218,231],"predominantly":[51],"affects":[52],"response":[54,61,237],"amplitude,":[55],"presynaptic":[56,100,209,240],"alters":[58],"both":[59,158,230],"amplitude":[62,92],"short-term":[64],"dynamics.":[65],"In":[66],"most":[67],"models":[68,165],"neuronal":[70],"learning,":[71,215],"implemented":[76],"changes":[78,210,234],"in":[79,91,154,177,186,196,277],"connective":[80],"weights.":[81],"consideration":[83],"fixed":[89],"change":[90],"corresponds":[93],"more":[94,138,220],"closely":[95],"to":[96,99],"post-":[97],"than":[98],"expression,":[101],"which":[102],"means":[103],"theoretical":[104],"outcomes":[105,176],"based":[106],"choice":[109,262],"implementation":[111],"may":[112,271],"bias.":[116],"To":[117],"explore":[118],"the":[119,123,175,187,197,212,236,259],"implications":[121],"plasticity,":[130,137],"we":[131],"adapted":[132],"model":[134],"specifically":[139],"spike-timing-dependent":[140],"(STDP),":[142],"was":[146,219],"either":[148],"independently":[149],"postsynaptically,":[152],"mixture":[156],"ways.":[159],"We":[160,206,280],"compared":[161],"pair-based":[162],"standard":[163],"STDP":[164,171],"biologically":[168],"tuned":[169],"triplet":[170],"model,":[172],"investigated":[174],"minimal":[179],"setting,":[180],"using":[181],"two":[182],"different":[183,193],"learning":[184],"schemes:":[185],"first,":[188],"inputs":[189,202],"were":[190,203],"triggered":[191],"at":[192,222],"latencies,":[194],"second":[198],"subset":[200],"temporally":[204],"correlated.":[205],"found":[207],"adjusted":[211],"speed":[213],"while":[216,239],"efficient":[221],"regulating":[223],"spike":[224],"timing":[225],"frequency.":[227],"When":[228],"combining":[229],"loci,":[232],"amplified":[235],"range,":[238],"allowed":[242],"control":[243],"over":[244],"firing":[246],"rates,":[247],"potentially":[248],"providing":[249],"form":[251],"homeostasis.":[254],"Our":[255],"findings":[256],"highlight":[257],"how":[258],"seemingly":[260],"innocuous":[261],"implementing":[264],"by":[267],"single":[268],"weight":[269],"modification":[270],"unwittingly":[272],"introduce":[273],"bias":[276],"modelling":[278],"outcomes.":[279],"conclude":[281],"interchangeable,":[290],"but":[291],"enable":[292],"complimentary":[293],"functions.":[294]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}