{"id":"https://openalex.org/W4281919216","doi":"https://doi.org/10.1371/journal.pcbi.1009398","title":"A musculoskeletal finite element model of rat knee joint for evaluating cartilage biomechanics during gait","display_name":"A musculoskeletal finite element model of rat knee joint for evaluating cartilage biomechanics during gait","publication_year":2022,"publication_date":"2022-06-03","ids":{"openalex":"https://openalex.org/W4281919216","doi":"https://doi.org/10.1371/journal.pcbi.1009398","pmid":"https://pubmed.ncbi.nlm.nih.gov/35657996"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1009398","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009398","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009398&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009398&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071634037","display_name":"Gustavo A. Orozco","orcid":"https://orcid.org/0000-0002-1054-7937"},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]},{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["FI","SE"],"is_corresponding":true,"raw_author_name":"Gustavo A. Orozco","raw_affiliation_strings":["Department of Applied Physics, University of Eastern Finland, Kuopio, Finland","Department of Biomedical Engineering, Lund University, Lund, Sweden"],"raw_orcid":"https://orcid.org/0000-0002-1054-7937","affiliations":[{"raw_affiliation_string":"Department of Applied Physics, University of Eastern Finland, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059292038","display_name":"Kalle Karjalainen","orcid":"https://orcid.org/0000-0003-3508-2088"},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Kalle Karjalainen","raw_affiliation_strings":["Department of Applied Physics, University of Eastern Finland, Kuopio, Finland"],"raw_orcid":"https://orcid.org/0000-0003-3508-2088","affiliations":[{"raw_affiliation_string":"Department of Applied Physics, University of Eastern Finland, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013903559","display_name":"Eng Kuan Moo","orcid":"https://orcid.org/0000-0001-6363-6063"},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]},{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["CA","FI"],"is_corresponding":false,"raw_author_name":"Eng Kuan Moo","raw_affiliation_strings":["Department of Applied Physics, University of Eastern Finland, Kuopio, Finland","Faculty of Kinesiology, Human Performance Laboratory, University of Calgary, Calgary, Alberta, Canada"],"raw_orcid":"https://orcid.org/0000-0001-6363-6063","affiliations":[{"raw_affiliation_string":"Department of Applied Physics, University of Eastern Finland, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]},{"raw_affiliation_string":"Faculty of Kinesiology, Human Performance Laboratory, University of Calgary, Calgary, Alberta, Canada","institution_ids":["https://openalex.org/I168635309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011229826","display_name":"Lauri Stenroth","orcid":"https://orcid.org/0000-0002-7705-9188"},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["DK","FI"],"is_corresponding":false,"raw_author_name":"Lauri Stenroth","raw_affiliation_strings":["Department of Applied Physics, University of Eastern Finland, Kuopio, Finland","Department of Biomedical Sciences, University of Copenhagen, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-7705-9188","affiliations":[{"raw_affiliation_string":"Department of Applied Physics, University of Eastern Finland, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]},{"raw_affiliation_string":"Department of Biomedical Sciences, University of Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082454261","display_name":"Petri Tanska","orcid":"https://orcid.org/0000-0002-9684-6902"},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Petri Tanska","raw_affiliation_strings":["Department of Applied Physics, University of Eastern Finland, Kuopio, Finland"],"raw_orcid":"https://orcid.org/0000-0002-9684-6902","affiliations":[{"raw_affiliation_string":"Department of Applied Physics, University of Eastern Finland, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005863834","display_name":"Jaqueline Lourdes Rios","orcid":"https://orcid.org/0000-0002-3679-2869"},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]},{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["CA","NL"],"is_corresponding":false,"raw_author_name":"Jaqueline Lourdes Rios","raw_affiliation_strings":["Faculty of Kinesiology, Human Performance Laboratory, University of Calgary, Calgary, Alberta, Canada","Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht, Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-3679-2869","affiliations":[{"raw_affiliation_string":"Faculty of Kinesiology, Human Performance Laboratory, University of Calgary, Calgary, Alberta, Canada","institution_ids":["https://openalex.org/I168635309"]},{"raw_affiliation_string":"Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht, Netherlands","institution_ids":["https://openalex.org/I193662353","https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085183156","display_name":"Teemu V. Tuomainen","orcid":"https://orcid.org/0000-0002-8115-9296"},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Teemu V. Tuomainen","raw_affiliation_strings":["Department of Applied Physics, University of Eastern Finland, Kuopio, Finland"],"raw_orcid":"https://orcid.org/0000-0002-8115-9296","affiliations":[{"raw_affiliation_string":"Department of Applied Physics, University of Eastern Finland, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048540578","display_name":"Mikko J. Nissi","orcid":"https://orcid.org/0000-0002-5678-0689"},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Mikko J. Nissi","raw_affiliation_strings":["Department of Applied Physics, University of Eastern Finland, Kuopio, Finland"],"raw_orcid":"https://orcid.org/0000-0002-5678-0689","affiliations":[{"raw_affiliation_string":"Department of Applied Physics, University of Eastern Finland, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074735538","display_name":"Hanna Isaksson","orcid":"https://orcid.org/0000-0002-9690-8907"},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Hanna Isaksson","raw_affiliation_strings":["Department of Biomedical Engineering, Lund University, Lund, Sweden"],"raw_orcid":"https://orcid.org/0000-0002-9690-8907","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069322953","display_name":"Walter Herzog","orcid":"https://orcid.org/0000-0002-5341-0033"},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Walter Herzog","raw_affiliation_strings":["Faculty of Kinesiology, Human Performance Laboratory, University of Calgary, Calgary, Alberta, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Kinesiology, Human Performance Laboratory, University of Calgary, Calgary, Alberta, Canada","institution_ids":["https://openalex.org/I168635309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022590395","display_name":"Rami K. Korhonen","orcid":"https://orcid.org/0000-0002-3486-7855"},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Rami K. Korhonen","raw_affiliation_strings":["Department of Applied Physics, University of Eastern Finland, Kuopio, Finland"],"raw_orcid":"https://orcid.org/0000-0002-3486-7855","affiliations":[{"raw_affiliation_string":"Department of Applied Physics, University of Eastern Finland, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5071634037"],"corresponding_institution_ids":["https://openalex.org/I175532246","https://openalex.org/I187531555"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2276,"currency":"EUR","value_usd":2454},"fwci":1.9935,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.86881997,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"18","issue":"6","first_page":"e1009398","last_page":"e1009398"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11018","display_name":"Lower Extremity Biomechanics and Pathologies","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10442","display_name":"Knee injuries and reconstruction techniques","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biomechanics","display_name":"Biomechanics","score":0.7486836910247803},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"Osteoarthritis","score":0.7226141691207886},{"id":"https://openalex.org/keywords/gait","display_name":"Gait","score":0.6873489022254944},{"id":"https://openalex.org/keywords/knee-joint","display_name":"Knee Joint","score":0.6574460864067078},{"id":"https://openalex.org/keywords/poromechanics","display_name":"Poromechanics","score":0.6547073721885681},{"id":"https://openalex.org/keywords/cartilage","display_name":"Cartilage","score":0.6203992962837219},{"id":"https://openalex.org/keywords/gait-cycle","display_name":"Gait cycle","score":0.6001208424568176},{"id":"https://openalex.org/keywords/gait-analysis","display_name":"Gait analysis","score":0.48171764612197876},{"id":"https://openalex.org/keywords/hindlimb","display_name":"Hindlimb","score":0.4623817801475525},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.45126935839653015},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.44673654437065125},{"id":"https://openalex.org/keywords/joint","display_name":"Joint (building)","score":0.43394118547439575},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.4196077883243561},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.3241440951824188},{"id":"https://openalex.org/keywords/physical-medicine-and-rehabilitation","display_name":"Physical medicine and rehabilitation","score":0.307417094707489},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.19817763566970825},{"id":"https://openalex.org/keywords/kinematics","display_name":"Kinematics","score":0.17409056425094604},{"id":"https://openalex.org/keywords/structural-engineering","display_name":"Structural engineering","score":0.16746023297309875},{"id":"https://openalex.org/keywords/surgery","display_name":"Surgery","score":0.12085896730422974},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.12043598294258118},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.07765871286392212}],"concepts":[{"id":"https://openalex.org/C170700871","wikidata":"https://www.wikidata.org/wiki/Q193378","display_name":"Biomechanics","level":2,"score":0.7486836910247803},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.7226141691207886},{"id":"https://openalex.org/C151800584","wikidata":"https://www.wikidata.org/wiki/Q2370000","display_name":"Gait","level":2,"score":0.6873489022254944},{"id":"https://openalex.org/C2908736133","wikidata":"https://www.wikidata.org/wiki/Q37425","display_name":"Knee Joint","level":2,"score":0.6574460864067078},{"id":"https://openalex.org/C181965411","wikidata":"https://www.wikidata.org/wiki/Q2314330","display_name":"Poromechanics","level":4,"score":0.6547073721885681},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.6203992962837219},{"id":"https://openalex.org/C2985215115","wikidata":"https://www.wikidata.org/wiki/Q22305006","display_name":"Gait cycle","level":3,"score":0.6001208424568176},{"id":"https://openalex.org/C173906292","wikidata":"https://www.wikidata.org/wiki/Q1493441","display_name":"Gait analysis","level":3,"score":0.48171764612197876},{"id":"https://openalex.org/C51738704","wikidata":"https://www.wikidata.org/wiki/Q5766112","display_name":"Hindlimb","level":2,"score":0.4623817801475525},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.45126935839653015},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44673654437065125},{"id":"https://openalex.org/C18555067","wikidata":"https://www.wikidata.org/wiki/Q8375051","display_name":"Joint (building)","level":2,"score":0.43394118547439575},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4196077883243561},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3241440951824188},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.307417094707489},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19817763566970825},{"id":"https://openalex.org/C39920418","wikidata":"https://www.wikidata.org/wiki/Q11476","display_name":"Kinematics","level":2,"score":0.17409056425094604},{"id":"https://openalex.org/C66938386","wikidata":"https://www.wikidata.org/wiki/Q633538","display_name":"Structural engineering","level":1,"score":0.16746023297309875},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.12085896730422974},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.12043598294258118},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.07765871286392212},{"id":"https://openalex.org/C6648577","wikidata":"https://www.wikidata.org/wiki/Q622669","display_name":"Porosity","level":2,"score":0.0},{"id":"https://openalex.org/C74650414","wikidata":"https://www.wikidata.org/wiki/Q11397","display_name":"Classical mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C105569014","wikidata":"https://www.wikidata.org/wiki/Q3271208","display_name":"Porous medium","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002356","descriptor_name":"Cartilage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002356","descriptor_name":"Cartilage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002356","descriptor_name":"Cartilage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005684","descriptor_name":"Gait","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005684","descriptor_name":"Gait","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005684","descriptor_name":"Gait","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007719","descriptor_name":"Knee Joint","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007719","descriptor_name":"Knee Joint","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007719","descriptor_name":"Knee Joint","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020342","descriptor_name":"Finite Element Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020342","descriptor_name":"Finite Element Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020342","descriptor_name":"Finite Element Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1009398","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009398","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009398&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:35657996","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35657996","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:9166403","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9166403","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:13d4218103bd42c6a50bb01165b0ccd4","is_oa":true,"landing_page_url":"https://doaj.org/article/13d4218103bd42c6a50bb01165b0ccd4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 6, p e1009398 (2022)","raw_type":"article"},{"id":"pmh:oai:lup.lub.lu.se:95a9cad1-45a9-415f-a990-a1435504cf03","is_oa":false,"landing_page_url":"https://lup.lub.lu.se/record/95a9cad1-45a9-415f-a990-a1435504cf03","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1553-7358","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/bda8efca-076d-43ef-bf40-2e196ae6d21f","is_oa":true,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/bda8efca-076d-43ef-bf40-2e196ae6d21f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Orozco , G A , Karjalainen , K , Moo , E K , Stenroth , L , Tanska , P , Rios , J L , Tuomainen , T V , Nissi , M J , Isaksson , H , Herzog , W & Korhonen , R K 2022 , ' A musculoskeletal finite element model of rat knee joint for evaluating cartilage biomechanics during gait ' , PLOS Computational Biology , vol. 18 , no. 6 , e1009398 , pp. 1-23 . https://doi.org/10.1371/journal.pcbi.1009398","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1009398","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009398","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009398&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.46000000834465027,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G1803075340","display_name":null,"funder_award_id":"191044","funder_id":"https://openalex.org/F4320321726","funder_display_name":"Suomen Kulttuurirahasto"},{"id":"https://openalex.org/G1803817292","display_name":null,"funder_award_id":"328920","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G2383916810","display_name":null,"funder_award_id":"191044; 200059","funder_id":"https://openalex.org/F4320321726","funder_display_name":"Suomen Kulttuurirahasto"},{"id":"https://openalex.org/G2432854586","display_name":null,"funder_award_id":"334773","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G2853405523","display_name":"Development and validation of template-based modeling to predict patient specific progression of knee osteoarthritis, and possibilities in economic and societal benefits","funder_award_id":"324994","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G384915824","display_name":"Biomedical Engineering and Medical Physics","funder_award_id":"713645","funder_id":"https://openalex.org/F4320338337","funder_display_name":"H2020 Marie Sk\u0142odowska-Curie Actions"},{"id":"https://openalex.org/G4760263881","display_name":null,"funder_award_id":"9088-00006B","funder_id":"https://openalex.org/F4320313796","funder_display_name":"Innovationsfonden"},{"id":"https://openalex.org/G4877644328","display_name":null,"funder_award_id":"00953","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G603458735","display_name":null,"funder_award_id":"#324529","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G630568159","display_name":null,"funder_award_id":"#285909","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G7031944916","display_name":"Role of age-related loss of muscle function in knee osteoarthritis","funder_award_id":"332915","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G7192791369","display_name":null,"funder_award_id":"200059","funder_id":"https://openalex.org/F4320321726","funder_display_name":"Suomen Kulttuurirahasto"},{"id":"https://openalex.org/G8931634832","display_name":"A novel tool for personalized and socio-economically optimal treatment planning for patients with osteoarthritis","funder_award_id":"2019-00953","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"}],"funders":[{"id":"https://openalex.org/F4320310055","display_name":"It\u00e4-Suomen Yliopisto","ror":"https://ror.org/00cyydd11"},{"id":"https://openalex.org/F4320311810","display_name":"Maud Kuistilan Muistos\u00e4\u00e4ti\u00f6","ror":"https://ror.org/05xs6nw18"},{"id":"https://openalex.org/F4320313796","display_name":"Innovationsfonden","ror":"https://ror.org/00daj4111"},{"id":"https://openalex.org/F4320321108","display_name":"Academy of Finland","ror":"https://ror.org/05k73zm37"},{"id":"https://openalex.org/F4320321726","display_name":"Suomen Kulttuurirahasto","ror":"https://ror.org/027xav248"},{"id":"https://openalex.org/F4320321806","display_name":"Lunds Universitet","ror":"https://ror.org/012a77v79"},{"id":"https://openalex.org/F4320322337","display_name":"Killam Trusts","ror":"https://ror.org/021cbtn85"},{"id":"https://openalex.org/F4320322456","display_name":"P\u00e4ivikki ja Sakari Sohlbergin S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/03bj5da63"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"},{"id":"https://openalex.org/F4320323760","display_name":"Sigrid Jus\u00e9liuksen S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/00ckakm23"},{"id":"https://openalex.org/F4320329810","display_name":"Saastamoisen s\u00e4\u00e4ti\u00f6","ror":"https://ror.org/03f0nw643"},{"id":"https://openalex.org/F4320331813","display_name":"Maire Lisko Foundation","ror":null},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320338337","display_name":"H2020 Marie Sk\u0142odowska-Curie Actions","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4281919216.pdf","grobid_xml":"https://content.openalex.org/works/W4281919216.grobid-xml"},"referenced_works_count":88,"referenced_works":["https://openalex.org/W35361850","https://openalex.org/W205941132","https://openalex.org/W770081596","https://openalex.org/W1485697373","https://openalex.org/W1661953964","https://openalex.org/W1962014213","https://openalex.org/W1972995937","https://openalex.org/W1975890825","https://openalex.org/W1979296380","https://openalex.org/W1980768104","https://openalex.org/W1982270184","https://openalex.org/W1986835919","https://openalex.org/W1991993108","https://openalex.org/W1999158053","https://openalex.org/W2000658986","https://openalex.org/W2002251686","https://openalex.org/W2002642565","https://openalex.org/W2003328208","https://openalex.org/W2004485411","https://openalex.org/W2010676740","https://openalex.org/W2018225094","https://openalex.org/W2022508393","https://openalex.org/W2022730012","https://openalex.org/W2026616100","https://openalex.org/W2034522296","https://openalex.org/W2043121079","https://openalex.org/W2045092981","https://openalex.org/W2045942656","https://openalex.org/W2051342344","https://openalex.org/W2059167678","https://openalex.org/W2082510662","https://openalex.org/W2083299205","https://openalex.org/W2084579679","https://openalex.org/W2091921078","https://openalex.org/W2098013710","https://openalex.org/W2103610860","https://openalex.org/W2105204667","https://openalex.org/W2108268894","https://openalex.org/W2112924835","https://openalex.org/W2123123614","https://openalex.org/W2129355235","https://openalex.org/W2134509372","https://openalex.org/W2137332670","https://openalex.org/W2139041287","https://openalex.org/W2144768887","https://openalex.org/W2151101874","https://openalex.org/W2153152769","https://openalex.org/W2158729807","https://openalex.org/W2167037356","https://openalex.org/W2284548609","https://openalex.org/W2295761641","https://openalex.org/W2298981934","https://openalex.org/W2320885348","https://openalex.org/W2372306910","https://openalex.org/W2379070273","https://openalex.org/W2395070024","https://openalex.org/W2398508378","https://openalex.org/W2428266841","https://openalex.org/W2558753149","https://openalex.org/W2565699065","https://openalex.org/W2573875118","https://openalex.org/W2609680256","https://openalex.org/W2729074126","https://openalex.org/W2765380943","https://openalex.org/W2788400190","https://openalex.org/W2799756319","https://openalex.org/W2801488115","https://openalex.org/W2805774367","https://openalex.org/W2896072682","https://openalex.org/W2900876443","https://openalex.org/W2908856150","https://openalex.org/W2911572729","https://openalex.org/W2920165127","https://openalex.org/W2949027991","https://openalex.org/W2949917634","https://openalex.org/W2967394183","https://openalex.org/W2972997186","https://openalex.org/W2988095053","https://openalex.org/W2992674319","https://openalex.org/W2993658583","https://openalex.org/W3013200586","https://openalex.org/W3041958896","https://openalex.org/W3090668929","https://openalex.org/W3093057760","https://openalex.org/W3122827122","https://openalex.org/W3154541293","https://openalex.org/W3174762330","https://openalex.org/W4205492949"],"related_works":["https://openalex.org/W4402463764","https://openalex.org/W4317183107","https://openalex.org/W4378804466","https://openalex.org/W2549172904","https://openalex.org/W2147467411","https://openalex.org/W4312975234","https://openalex.org/W2390631805","https://openalex.org/W1983573550","https://openalex.org/W2134815295","https://openalex.org/W76152581"],"abstract_inverted_index":{"Abnormal":[0],"loading":[1,40,88],"of":[2,17,57,98,107,115,125,175,196,218,226,239,242,247],"the":[3,15,84,90,99,108,123,132,152,163,169,173,176,180,187,193,199,216,222,240],"knee":[4,60,73,134,228],"due":[5],"to":[6,12,14,34,62,235],"injuries":[7],"or":[8,250],"obesity":[9],"is":[10],"thought":[11],"contribute":[13],"development":[16],"osteoarthritis":[18],"(OA).":[19],"Small":[20],"animal":[21,43],"models":[22,33,44],"have":[23,45],"been":[24,47],"used":[25,234],"for":[26,136],"studying":[27],"OA":[28,243],"progression":[29,241],"mechanisms.":[30],"However,":[31],"numerical":[32,120],"study":[35],"cartilage":[36,64,110],"responses":[37,66,139],"under":[38],"dynamic":[39],"in":[41,89,131,162,179],"preclinical":[42],"not":[46],"developed.":[48],"Here":[49],"we":[50,184],"present":[51],"a":[52,58,68,79,95,211,245],"musculoskeletal":[53,96],"finite":[54],"element":[55],"model":[56,97],"rat":[59,72,100,109,133,227],"joint":[61,74,91,135,229,248],"evaluate":[63,236],"biomechanical":[65],"during":[67,192],"gait":[69,177,219],"cycle.":[70],"The":[71,102],"geometries":[75],"were":[76,92,111,159],"obtained":[77],"from":[78,94,113],"3-D":[80],"MRI":[81],"dataset":[82],"and":[83,128,146,155,224,231],"boundary":[85],"conditions":[86],"regarding":[87],"extracted":[93],"hindlimb.":[101],"fibril-reinforced":[103],"poroelastic":[104],"(FRPE)":[105],"properties":[106],"derived":[112],"data":[114],"mechanical":[116],"indentation":[117],"tests.":[118],"Our":[119],"results":[121],"showed":[122,168],"relevance":[124],"simulating":[126],"anatomical":[127],"locomotion":[129],"characteristics":[130],"estimating":[137],"tissue":[138],"such":[140],"as":[141,210,244],"contact":[142,153],"pressures,":[143],"stresses,":[144],"strains,":[145],"fluid":[147],"pressures.":[148],"We":[149,204],"found":[150,185],"that":[151,186,206],"pressure":[154],"maximum":[156,188],"principal":[157,189],"strain":[158],"virtually":[160],"constant":[161],"medial":[164],"compartment":[165],"whereas":[166],"they":[167],"highest":[170],"values":[171,201],"at":[172,202],"beginning":[174],"cycle":[178],"lateral":[181],"compartment.":[182],"Furthermore,":[183],"stress":[190],"increased":[191],"stance":[194],"phase":[195],"gait,":[197],"with":[198],"greatest":[200],"midstance.":[203],"anticipate":[205],"our":[207],"approach":[208],"serves":[209],"first":[212],"step":[213],"towards":[214],"investigating":[215],"effects":[217],"abnormalities":[220],"on":[221],"adaptation":[223],"degeneration":[225],"tissues":[230],"could":[232],"be":[233],"biomechanically-driven":[237],"mechanisms":[238],"consequence":[246],"injury":[249],"obesity.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":7}],"updated_date":"2026-08-11T07:18:39.950985","created_date":"2025-10-10T00:00:00"}