{"id":"https://openalex.org/W4221110725","doi":"https://doi.org/10.1371/journal.pcbi.1009389","title":"Analysing pneumococcal invasiveness using Bayesian models of pathogen progression rates","display_name":"Analysing pneumococcal invasiveness using Bayesian models of pathogen progression rates","publication_year":2022,"publication_date":"2022-02-17","ids":{"openalex":"https://openalex.org/W4221110725","doi":"https://doi.org/10.1371/journal.pcbi.1009389","pmid":"https://pubmed.ncbi.nlm.nih.gov/35176026"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1009389","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009389","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009389&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009389&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002225868","display_name":"Alessandra L\u00f8chen","orcid":"https://orcid.org/0000-0002-8068-1293"},"institutions":[{"id":"https://openalex.org/I4210120729","display_name":"St Mary's Hospital","ror":"https://ror.org/02jv2qv86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210120729","https://openalex.org/I4210127145"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alessandra L\u00f8chen","raw_affiliation_strings":["Department of Infectious Disease Epidemiology, School of Public Health, St. Mary's Campus, Imperial College London, London, United Kingdom","MRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, School of Public Health, White City Campus, Imperial College London, London, United Kingdom","Department of Infectious Disease Epidemiology, School of Public Health, St. Mary\u2019s Campus, Imperial College London, London, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Department of Infectious Disease Epidemiology, School of Public Health, St. Mary's Campus, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I47508984","https://openalex.org/I4210120729"]},{"raw_affiliation_string":"MRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, School of Public Health, White City Campus, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Infectious Disease Epidemiology, School of Public Health, St. Mary\u2019s Campus, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043581494","display_name":"James E. Truscott","orcid":"https://orcid.org/0000-0002-2555-7636"},"institutions":[{"id":"https://openalex.org/I4210120729","display_name":"St Mary's Hospital","ror":"https://ror.org/02jv2qv86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210120729","https://openalex.org/I4210127145"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James E. Truscott","raw_affiliation_strings":["Department of Infectious Disease Epidemiology, School of Public Health, St. Mary's Campus, Imperial College London, London, United Kingdom","Department of Infectious Disease Epidemiology, School of Public Health, St. Mary\u2019s Campus, Imperial College London, London, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Department of Infectious Disease Epidemiology, School of Public Health, St. Mary's Campus, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I47508984","https://openalex.org/I4210120729"]},{"raw_affiliation_string":"Department of Infectious Disease Epidemiology, School of Public Health, St. Mary\u2019s Campus, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029973916","display_name":"Nicholas J. Croucher","orcid":"https://orcid.org/0000-0001-6303-8768"},"institutions":[{"id":"https://openalex.org/I4210120729","display_name":"St Mary's Hospital","ror":"https://ror.org/02jv2qv86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210120729","https://openalex.org/I4210127145"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Nicholas J. Croucher","raw_affiliation_strings":["Department of Infectious Disease Epidemiology, School of Public Health, St. Mary's Campus, Imperial College London, London, United Kingdom","MRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, School of Public Health, White City Campus, Imperial College London, London, United Kingdom","Department of Infectious Disease Epidemiology, School of Public Health, St. Mary\u2019s Campus, Imperial College London, London, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Department of Infectious Disease Epidemiology, School of Public Health, St. Mary's Campus, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I47508984","https://openalex.org/I4210120729"]},{"raw_affiliation_string":"MRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, School of Public Health, White City Campus, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Infectious Disease Epidemiology, School of Public Health, St. Mary\u2019s Campus, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5029973916"],"corresponding_institution_ids":["https://openalex.org/I4210120729","https://openalex.org/I47508984"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":6.3873,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.97543394,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"18","issue":"2","first_page":"e1009389","last_page":"e1009389"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.9861999750137329,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6466502547264099},{"id":"https://openalex.org/keywords/bayes-theorem","display_name":"Bayes' theorem","score":0.49904513359069824},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.48315638303756714},{"id":"https://openalex.org/keywords/streptococcus-pneumoniae","display_name":"Streptococcus pneumoniae","score":0.4786832928657532},{"id":"https://openalex.org/keywords/serotype","display_name":"Serotype","score":0.44403380155563354},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.42956656217575073},{"id":"https://openalex.org/keywords/pneumococcal-infections","display_name":"Pneumococcal infections","score":0.42254722118377686},{"id":"https://openalex.org/keywords/bayesian-probability","display_name":"Bayesian probability","score":0.2968907356262207},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2509009540081024},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.250565767288208},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.24155232310295105},{"id":"https://openalex.org/keywords/microbiology","display_name":"Microbiology","score":0.21444612741470337},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.17577049136161804}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6466502547264099},{"id":"https://openalex.org/C207201462","wikidata":"https://www.wikidata.org/wiki/Q182505","display_name":"Bayes' theorem","level":3,"score":0.49904513359069824},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.48315638303756714},{"id":"https://openalex.org/C2781253189","wikidata":"https://www.wikidata.org/wiki/Q221179","display_name":"Streptococcus pneumoniae","level":3,"score":0.4786832928657532},{"id":"https://openalex.org/C10389963","wikidata":"https://www.wikidata.org/wiki/Q848328","display_name":"Serotype","level":2,"score":0.44403380155563354},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.42956656217575073},{"id":"https://openalex.org/C2776152631","wikidata":"https://www.wikidata.org/wiki/Q4366062","display_name":"Pneumococcal infections","level":4,"score":0.42254722118377686},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.2968907356262207},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2509009540081024},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.250565767288208},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24155232310295105},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.21444612741470337},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17577049136161804},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002353","descriptor_name":"Carrier State","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D002353","descriptor_name":"Carrier State","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D002353","descriptor_name":"Carrier State","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D002353","descriptor_name":"Carrier State","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011008","descriptor_name":"Pneumococcal Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D011008","descriptor_name":"Pneumococcal Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D011008","descriptor_name":"Pneumococcal Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D011008","descriptor_name":"Pneumococcal Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D011008","descriptor_name":"Pneumococcal Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D011008","descriptor_name":"Pneumococcal Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D011008","descriptor_name":"Pneumococcal Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D011008","descriptor_name":"Pneumococcal Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D013296","descriptor_name":"Streptococcus pneumoniae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013296","descriptor_name":"Streptococcus pneumoniae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013296","descriptor_name":"Streptococcus pneumoniae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013296","descriptor_name":"Streptococcus pneumoniae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D022242","descriptor_name":"Pneumococcal Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022242","descriptor_name":"Pneumococcal Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022242","descriptor_name":"Pneumococcal Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022242","descriptor_name":"Pneumococcal Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065288","descriptor_name":"Serogroup","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065288","descriptor_name":"Serogroup","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065288","descriptor_name":"Serogroup","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065288","descriptor_name":"Serogroup","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1009389","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009389","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009389&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:35176026","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35176026","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1009389","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1009389","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:b48356135503418bbe8569b21e408a02","is_oa":true,"landing_page_url":"https://doaj.org/article/b48356135503418bbe8569b21e408a02","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 2, p e1009389 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8901055","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8901055","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1009389","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009389","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009389&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7400000095367432}],"awards":[{"id":"https://openalex.org/G1019185187","display_name":null,"funder_award_id":"Society","funder_id":"https://openalex.org/F4320307874","funder_display_name":"Wellcome"},{"id":"https://openalex.org/G1905922291","display_name":null,"funder_award_id":"104169/Z/14/A","funder_id":"https://openalex.org/F4320320006","funder_display_name":"Royal Society"},{"id":"https://openalex.org/G2366809377","display_name":null,"funder_award_id":"104169/Z/14/A","funder_id":"https://openalex.org/F4320307874","funder_display_name":"Wellcome"},{"id":"https://openalex.org/G2626217064","display_name":null,"funder_award_id":"Fellowship","funder_id":"https://openalex.org/F4320307874","funder_display_name":"Wellcome"},{"id":"https://openalex.org/G2674840903","display_name":null,"funder_award_id":"Fellowship","funder_id":"https://openalex.org/F4320320006","funder_display_name":"Royal Society"},{"id":"https://openalex.org/G2740751069","display_name":"MRC Centre for Global Infectious Disease Analysis","funder_award_id":"MR/R015600/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G6520098237","display_name":null,"funder_award_id":"MR/R015600/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G6764088995","display_name":null,"funder_award_id":"MR/T016434/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G8146979789","display_name":null,"funder_award_id":"104169","funder_id":"https://openalex.org/F4320307874","funder_display_name":"Wellcome"},{"id":"https://openalex.org/G8620367992","display_name":"Integrating genomic surveillance and ecological modelling to maximise pneumococcal vaccine efficacy","funder_award_id":"MR/T016434/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320307773","display_name":"GlaxoSmithKline","ror":"https://ror.org/01xsqw823"},{"id":"https://openalex.org/F4320307874","display_name":"Wellcome","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320006","display_name":"Royal Society","ror":"https://ror.org/03wnrjx87"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4221110725.pdf","grobid_xml":"https://content.openalex.org/works/W4221110725.grobid-xml"},"referenced_works_count":100,"referenced_works":["https://openalex.org/W1919385003","https://openalex.org/W1954112402","https://openalex.org/W1972265710","https://openalex.org/W1980348076","https://openalex.org/W1982276718","https://openalex.org/W1987330843","https://openalex.org/W1990113961","https://openalex.org/W1991241797","https://openalex.org/W1992756742","https://openalex.org/W2000499723","https://openalex.org/W2001167483","https://openalex.org/W2002459863","https://openalex.org/W2007622735","https://openalex.org/W2011152742","https://openalex.org/W2012457803","https://openalex.org/W2029274790","https://openalex.org/W2032866129","https://openalex.org/W2057948774","https://openalex.org/W2077184748","https://openalex.org/W2077370019","https://openalex.org/W2077927362","https://openalex.org/W2087083322","https://openalex.org/W2093931806","https://openalex.org/W2101218683","https://openalex.org/W2102257617","https://openalex.org/W2102449781","https://openalex.org/W2102924550","https://openalex.org/W2105008621","https://openalex.org/W2108855502","https://openalex.org/W2114698211","https://openalex.org/W2116281719","https://openalex.org/W2119458127","https://openalex.org/W2121861720","https://openalex.org/W2123990722","https://openalex.org/W2126338526","https://openalex.org/W2126890688","https://openalex.org/W2130492588","https://openalex.org/W2132049801","https://openalex.org/W2135610044","https://openalex.org/W2135891608","https://openalex.org/W2136127443","https://openalex.org/W2147768434","https://openalex.org/W2150107853","https://openalex.org/W2150562212","https://openalex.org/W2154300732","https://openalex.org/W2155641525","https://openalex.org/W2155988679","https://openalex.org/W2156326100","https://openalex.org/W2156871304","https://openalex.org/W2157583453","https://openalex.org/W2158004575","https://openalex.org/W2160040448","https://openalex.org/W2166348867","https://openalex.org/W2167840853","https://openalex.org/W2203714058","https://openalex.org/W2282225105","https://openalex.org/W2307886479","https://openalex.org/W2345616528","https://openalex.org/W2430882255","https://openalex.org/W2432197333","https://openalex.org/W2520501427","https://openalex.org/W2559766601","https://openalex.org/W2584449073","https://openalex.org/W2588622272","https://openalex.org/W2591806215","https://openalex.org/W2740693121","https://openalex.org/W2748398359","https://openalex.org/W2763692854","https://openalex.org/W2766009727","https://openalex.org/W2767152246","https://openalex.org/W2784744055","https://openalex.org/W2804135104","https://openalex.org/W2808668519","https://openalex.org/W2810449130","https://openalex.org/W2886508921","https://openalex.org/W2890697983","https://openalex.org/W2909509146","https://openalex.org/W2912278099","https://openalex.org/W2937635380","https://openalex.org/W2949236085","https://openalex.org/W2950216222","https://openalex.org/W2950614621","https://openalex.org/W2951188778","https://openalex.org/W2952549240","https://openalex.org/W2952568525","https://openalex.org/W2972653216","https://openalex.org/W2990427812","https://openalex.org/W3003540327","https://openalex.org/W3008266717","https://openalex.org/W3028254348","https://openalex.org/W3045505453","https://openalex.org/W3096128412","https://openalex.org/W3118572295","https://openalex.org/W3123421154","https://openalex.org/W3147813568","https://openalex.org/W3154953303","https://openalex.org/W3182741347","https://openalex.org/W4234749634","https://openalex.org/W4245581120","https://openalex.org/W4298346378"],"related_works":["https://openalex.org/W2363900734","https://openalex.org/W1954256027","https://openalex.org/W2159916672","https://openalex.org/W1972720851","https://openalex.org/W2160667747","https://openalex.org/W1555141257","https://openalex.org/W3201224243","https://openalex.org/W1513923140","https://openalex.org/W2109370421","https://openalex.org/W2033126492"],"abstract_inverted_index":{"The":[0,75,91,156,192],"disease":[1,55],"burden":[2],"attributable":[3],"to":[4,21,100,169,202,204],"opportunistic":[5,218],"pathogens":[6,40,219],"depends":[7],"on":[8,78],"their":[9],"prevalence":[10],"in":[11,26,70,103,171,190,206,211],"asymptomatic":[12],"colonisation":[13],"and":[14,57,174,187,230],"the":[15,34,95,112,129,153,207,224],"rate":[16,97],"at":[17],"which":[18,172],"they":[19],"progress":[20],"cause":[22],"symptomatic":[23],"disease.":[24],"Increases":[25],"infections":[27],"caused":[28],"by":[29],"commensals":[30],"can":[31,41,235],"result":[32],"from":[33,54,85,98,115],"emergence":[35],"of":[36,51,87,93,117,152,196,209,217,226],"\"hyperinvasive\"":[37],"strains.":[38],"Such":[39],"be":[42,147],"identified":[43,137],"through":[44,162],"quantifying":[45,223],"progression":[46,96],"rates":[47],"using":[48],"matched":[49],"samples":[50],"typed":[52],"microbes":[53],"cases":[56,104],"healthy":[58],"carriers.":[59],"This":[60,136],"study":[61],"describes":[62],"Bayesian":[63,130],"models":[64,76,131],"for":[65,159,179,185,222],"analysing":[66],"such":[67],"datasets,":[68],"implemented":[69],"an":[71],"RStan":[72],"package":[73,157],"(https://github.com/nickjcroucher/progressionEstimation).":[74],"converged":[77],"stable":[79],"fits":[80],"that":[81,145,234],"accurately":[82],"reproduced":[83],"observations":[84],"meta-analyses":[86,233],"Streptococcus":[88],"pneumoniae":[89,143,181],"datasets.":[90],"estimates":[92],"invasiveness,":[94],"carriage":[99],"invasive":[101,239],"disease,":[102],"per":[105,107],"carrier":[106],"year":[108],"correlated":[109],"strongly":[110],"with":[111,165],"dimensionless":[113],"values":[114],"meta-analysis":[116],"odds":[118],"ratios":[119],"when":[120],"sample":[121,127],"sizes":[122],"were":[123,177],"large.":[124],"At":[125],"smaller":[126],"sizes,":[128],"produced":[132],"more":[133],"informative":[134],"estimates.":[135],"historically":[138],"rare":[139],"but":[140],"high-risk":[141],"S.":[142,180],"serotypes":[144],"could":[146],"problematic":[148],"following":[149],"vaccine-associated":[150],"disruption":[151],"bacterial":[154],"population.":[155],"allows":[158],"hypothesis":[160],"testing":[161],"model":[163],"comparisons":[164],"Bayes":[166],"factors.":[167],"Application":[168],"datasets":[170],"strain":[173],"serotype":[175],"information":[176],"available":[178],"found":[182],"significant":[183],"evidence":[184],"within-strain":[186],"within-serotype":[188],"variation":[189],"invasiveness.":[191],"heterogeneous":[193],"geographical":[194],"distribution":[195],"these":[197],"genotypes":[198],"is":[199,220],"therefore":[200],"likely":[201],"contribute":[203],"differences":[205],"impact":[208],"vaccination":[210],"between":[212],"locations.":[213],"Hence":[214],"genomic":[215],"surveillance":[216],"crucial":[221],"effectiveness":[225],"public":[227],"health":[228],"interventions,":[229],"enabling":[231],"ongoing":[232],"identify":[236],"new,":[237],"highly":[238],"variants.":[240]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
