{"id":"https://openalex.org/W3198138308","doi":"https://doi.org/10.1371/journal.pcbi.1009357","title":"Multiscale model of defective interfering particle replication for influenza A virus infection in animal cell culture","display_name":"Multiscale model of defective interfering particle replication for influenza A virus infection in animal cell culture","publication_year":2021,"publication_date":"2021-09-07","ids":{"openalex":"https://openalex.org/W3198138308","doi":"https://doi.org/10.1371/journal.pcbi.1009357","mag":"3198138308","pmid":"https://pubmed.ncbi.nlm.nih.gov/34491996"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1009357","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009357","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1009357","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014926983","display_name":"Daniel R\u00fcdiger","orcid":"https://orcid.org/0000-0002-7817-1884"},"institutions":[{"id":"https://openalex.org/I4210127568","display_name":"Max Planck Institute for Dynamics of Complex Technical Systems","ror":"https://ror.org/030h7k016","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210127568"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Daniel R\u00fcdiger","raw_affiliation_strings":["Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany"],"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany","institution_ids":["https://openalex.org/I4210127568"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043945449","display_name":"Lars Pelz","orcid":"https://orcid.org/0000-0001-7848-2298"},"institutions":[{"id":"https://openalex.org/I4210127568","display_name":"Max Planck Institute for Dynamics of Complex Technical Systems","ror":"https://ror.org/030h7k016","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210127568"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lars Pelz","raw_affiliation_strings":["Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany"],"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany","institution_ids":["https://openalex.org/I4210127568"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010921351","display_name":"Marc D. Hein","orcid":"https://orcid.org/0000-0001-6466-2132"},"institutions":[{"id":"https://openalex.org/I95793202","display_name":"Otto-von-Guericke University Magdeburg","ror":"https://ror.org/00ggpsq73","country_code":"DE","type":"education","lineage":["https://openalex.org/I95793202"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marc D. Hein","raw_affiliation_strings":["Chair of Bioprocess Engineering, Institute of Process Engineering, Faculty of Process & Systems Engineering, Otto-von-Guericke University, Magdeburg, Germany"],"affiliations":[{"raw_affiliation_string":"Chair of Bioprocess Engineering, Institute of Process Engineering, Faculty of Process & Systems Engineering, Otto-von-Guericke University, Magdeburg, Germany","institution_ids":["https://openalex.org/I95793202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016107448","display_name":"Sascha Young Kupke","orcid":"https://orcid.org/0000-0003-3943-9718"},"institutions":[{"id":"https://openalex.org/I4210127568","display_name":"Max Planck Institute for Dynamics of Complex Technical Systems","ror":"https://ror.org/030h7k016","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210127568"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Sascha Y. Kupke","raw_affiliation_strings":["Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany"],"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany","institution_ids":["https://openalex.org/I4210127568"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082695733","display_name":"Udo Reichl","orcid":"https://orcid.org/0000-0001-6538-1332"},"institutions":[{"id":"https://openalex.org/I4210127568","display_name":"Max Planck Institute for Dynamics of Complex Technical Systems","ror":"https://ror.org/030h7k016","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210127568"]},{"id":"https://openalex.org/I95793202","display_name":"Otto-von-Guericke University Magdeburg","ror":"https://ror.org/00ggpsq73","country_code":"DE","type":"education","lineage":["https://openalex.org/I95793202"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Udo Reichl","raw_affiliation_strings":["Chair of Bioprocess Engineering, Institute of Process Engineering, Faculty of Process & Systems Engineering, Otto-von-Guericke University, Magdeburg, Germany","Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany"],"affiliations":[{"raw_affiliation_string":"Chair of Bioprocess Engineering, Institute of Process Engineering, Faculty of Process & Systems Engineering, Otto-von-Guericke University, Magdeburg, Germany","institution_ids":["https://openalex.org/I95793202"]},{"raw_affiliation_string":"Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany","institution_ids":["https://openalex.org/I4210127568"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5014926983","https://openalex.org/A5016107448"],"corresponding_institution_ids":["https://openalex.org/I4210127568"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.7155,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.73661334,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"17","issue":"9","first_page":"e1009357","last_page":"e1009357"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10976","display_name":"Viral gastroenteritis research and epidemiology","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10976","display_name":"Viral gastroenteritis research and epidemiology","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/viral-replication","display_name":"Viral replication","score":0.744555652141571},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.7008990049362183},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6605714559555054},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.5997806787490845},{"id":"https://openalex.org/keywords/influenza-a-virus","display_name":"Influenza A virus","score":0.5522640347480774},{"id":"https://openalex.org/keywords/cell-culture","display_name":"Cell culture","score":0.5122589468955994},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.4760693907737732},{"id":"https://openalex.org/keywords/viral-interference","display_name":"Viral Interference","score":0.44633209705352783},{"id":"https://openalex.org/keywords/viral-entry","display_name":"Viral entry","score":0.44229748845100403},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.43502259254455566},{"id":"https://openalex.org/keywords/intracellular","display_name":"Intracellular","score":0.4312819540500641},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.14115694165229797}],"concepts":[{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.744555652141571},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.7008990049362183},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6605714559555054},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5997806787490845},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.5522640347480774},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5122589468955994},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4760693907737732},{"id":"https://openalex.org/C2909928835","wikidata":"https://www.wikidata.org/wiki/Q70684351","display_name":"Viral Interference","level":4,"score":0.44633209705352783},{"id":"https://openalex.org/C58475186","wikidata":"https://www.wikidata.org/wiki/Q4118894","display_name":"Viral entry","level":4,"score":0.44229748845100403},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43502259254455566},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4312819540500641},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14115694165229797},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003673","descriptor_name":"Defective Viruses","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003673","descriptor_name":"Defective Viruses","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003673","descriptor_name":"Defective Viruses","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003673","descriptor_name":"Defective Viruses","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003673","descriptor_name":"Defective Viruses","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D003673","descriptor_name":"Defective Viruses","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D003673","descriptor_name":"Defective Viruses","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D003673","descriptor_name":"Defective Viruses","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D003673","descriptor_name":"Defective Viruses","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003673","descriptor_name":"Defective Viruses","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003673","descriptor_name":"Defective Viruses","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003673","descriptor_name":"Defective Viruses","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009976","descriptor_name":"Orthomyxoviridae Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D009976","descriptor_name":"Orthomyxoviridae Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D009976","descriptor_name":"Orthomyxoviridae Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D009976","descriptor_name":"Orthomyxoviridae Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061985","descriptor_name":"Madin Darby Canine Kidney Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061985","descriptor_name":"Madin Darby Canine Kidney Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061985","descriptor_name":"Madin Darby Canine Kidney Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061985","descriptor_name":"Madin Darby Canine Kidney Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1009357","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009357","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:34491996","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34491996","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:966bf3bc5b8e4f32b7114a566f90a7d9","is_oa":true,"landing_page_url":"https://doaj.org/article/966bf3bc5b8e4f32b7114a566f90a7d9","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 17, Iss 9, p e1009357 (2021)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:7340426","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8448327","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:8448327","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8448327","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1009357","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009357","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G7501912343","display_name":null,"funder_award_id":"DARPA INTERCEPT W911NF-17-2-0012","funder_id":"https://openalex.org/F4320332180","funder_display_name":"Defense Advanced Research Projects Agency"}],"funders":[{"id":"https://openalex.org/F4320332180","display_name":"Defense Advanced Research Projects Agency","ror":"https://ror.org/02caytj08"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":71,"referenced_works":["https://openalex.org/W181611061","https://openalex.org/W781343893","https://openalex.org/W863957672","https://openalex.org/W1941892174","https://openalex.org/W1975470618","https://openalex.org/W1978386381","https://openalex.org/W1996903617","https://openalex.org/W2003235235","https://openalex.org/W2003969287","https://openalex.org/W2026020811","https://openalex.org/W2031837694","https://openalex.org/W2035105077","https://openalex.org/W2041801099","https://openalex.org/W2044889656","https://openalex.org/W2047321451","https://openalex.org/W2048726798","https://openalex.org/W2058837218","https://openalex.org/W2071657440","https://openalex.org/W2077528494","https://openalex.org/W2083130194","https://openalex.org/W2086162889","https://openalex.org/W2086666408","https://openalex.org/W2088678118","https://openalex.org/W2089903552","https://openalex.org/W2096119005","https://openalex.org/W2097375195","https://openalex.org/W2098803005","https://openalex.org/W2099533162","https://openalex.org/W2109977701","https://openalex.org/W2112036188","https://openalex.org/W2112688502","https://openalex.org/W2115343689","https://openalex.org/W2117386204","https://openalex.org/W2117949217","https://openalex.org/W2141506775","https://openalex.org/W2142635246","https://openalex.org/W2143250568","https://openalex.org/W2144576389","https://openalex.org/W2148114753","https://openalex.org/W2157510603","https://openalex.org/W2173211537","https://openalex.org/W2173356783","https://openalex.org/W2336372057","https://openalex.org/W2342422368","https://openalex.org/W2414881902","https://openalex.org/W2554587931","https://openalex.org/W2619552848","https://openalex.org/W2732268064","https://openalex.org/W2775505123","https://openalex.org/W2808408400","https://openalex.org/W2901514971","https://openalex.org/W2909386475","https://openalex.org/W2916067797","https://openalex.org/W2920781917","https://openalex.org/W2942874686","https://openalex.org/W2948601199","https://openalex.org/W2965216793","https://openalex.org/W2981186273","https://openalex.org/W2990504506","https://openalex.org/W3000377092","https://openalex.org/W3093414068","https://openalex.org/W3100821484","https://openalex.org/W3109132986","https://openalex.org/W3129046948","https://openalex.org/W3135503078","https://openalex.org/W3158189707","https://openalex.org/W3182203540","https://openalex.org/W3200553375","https://openalex.org/W3204810204","https://openalex.org/W4225723704","https://openalex.org/W4253992562"],"related_works":["https://openalex.org/W1996999543","https://openalex.org/W2059794436","https://openalex.org/W2518258943","https://openalex.org/W2065684697","https://openalex.org/W4286495801","https://openalex.org/W2911957497","https://openalex.org/W4377011168","https://openalex.org/W2915093830","https://openalex.org/W1974962646","https://openalex.org/W3136026187"],"abstract_inverted_index":{"Cell":[0],"culture-derived":[1],"defective":[2,206],"interfering":[3,207],"particles":[4],"(DIPs)":[5],"are":[6],"considered":[7],"for":[8,54,65,103,169,227,279,292],"antiviral":[9],"therapy":[10],"due":[11],"to":[12,15,107,211,251],"their":[13,31,44],"ability":[14],"inhibit":[16],"influenza":[17],"A":[18],"virus":[19,47,109,125],"(IAV)":[20],"production.":[21],"DIPs":[22,106,239,272],"contain":[23],"a":[24,52,93,156,173,224,263],"large":[25],"internal":[26,220],"deletion":[27],"in":[28,51,111],"one":[29],"of":[30,82,95,101,139,160,176,238,249,255,266,284],"eight":[32],"viral":[33,57,142,199,229],"RNAs":[34],"(vRNAs)":[35],"rendering":[36],"them":[37],"replication-incompetent.":[38],"However,":[39],"they":[40],"can":[41,185],"propagate":[42],"alongside":[43],"homologous":[45],"standard":[46],"(STV)":[48],"during":[49,273],"infection":[50],"competition":[53],"cellular":[55],"and":[56,62,84,105,136,141,162,191,204,223,271,282],"resources.":[58],"So":[59],"far,":[60],"experimental":[61],"modeling":[63],"studies":[64],"IAV":[66],"have":[67],"focused":[68],"on":[69,150],"either":[70],"the":[71,74,80,151,196,216,236,253,258,267,280],"intracellular":[72,137],"or":[73],"cell":[75,128],"population":[76],"level":[77],"when":[78],"investigating":[79],"interaction":[81],"STVs":[83,104,250,270],"DIPs.":[85],"To":[86],"examine":[87],"these":[88],"levels":[89,138,214],"simultaneously,":[90],"we":[91,123,154],"conducted":[92],"series":[94],"experiments":[96],"using":[97,132,144],"highly":[98],"different":[99,213],"multiplicities":[100],"infections":[102],"characterize":[108],"replication":[110],"Madin-Darby":[112],"Canine":[113],"Kidney":[114],"suspension":[115],"cells.":[116],"At":[117],"several":[118],"time":[119],"points":[120],"post":[121],"infection,":[122],"quantified":[124],"titers,":[126],"viable":[127],"concentration,":[129],"virus-induced":[130,193],"apoptosis":[131],"imaging":[133],"flow":[134],"cytometry,":[135],"vRNA":[140],"mRNA":[143],"real-time":[145],"reverse":[146],"transcription":[147],"qPCR.":[148],"Based":[149],"obtained":[152],"data,":[153],"developed":[155],"mathematical":[157],"multiscale":[158],"model":[159,232,259],"STV":[161,188],"DIP":[163,183,290],"co-infection":[164,274],"that":[165,180,235,248],"describes":[166],"dynamics":[167],"closely":[168],"all":[170],"scenarios":[171],"with":[172],"single":[174],"set":[175],"parameters.":[177],"We":[178],"show":[179],"applying":[181],"high":[182],"concentrations":[184],"shut":[186],"down":[187],"propagation":[189],"completely":[190],"prevent":[192,252],"apoptosis.":[194],"Interestingly,":[195],"three":[197],"observed":[198],"mRNAs":[200],"(full-length":[201],"segment":[202,208],"1":[203],"5,":[205],"1)":[209],"accumulated":[210],"vastly":[212],"suggesting":[215],"interplay":[217],"between":[218,269],"an":[219,276],"regulation":[221],"mechanism":[222],"growth":[225],"advantage":[226],"shorter":[228],"RNAs.":[230],"Furthermore,":[231],"simulations":[233],"predict":[234],"concentration":[237],"should":[240],"be":[241],"at":[242],"least":[243],"10000":[244],"times":[245],"higher":[246],"than":[247],"spread":[254],"IAV.":[256],"Ultimately,":[257],"presented":[260],"here":[261],"supports":[262],"comprehensive":[264],"understanding":[265],"interactions":[268],"providing":[275],"ideal":[277],"platform":[278],"prediction":[281],"optimization":[283],"vaccine":[285],"manufacturing":[286],"as":[287,289],"well":[288],"production":[291],"therapeutic":[293],"use.":[294]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}
