{"id":"https://openalex.org/W3197398866","doi":"https://doi.org/10.1371/journal.pcbi.1009331","title":"Computational modeling of blood component transport related to coronary artery thrombosis in Kawasaki disease","display_name":"Computational modeling of blood component transport related to coronary artery thrombosis in Kawasaki disease","publication_year":2021,"publication_date":"2021-09-07","ids":{"openalex":"https://openalex.org/W3197398866","doi":"https://doi.org/10.1371/journal.pcbi.1009331","mag":"3197398866","pmid":"https://pubmed.ncbi.nlm.nih.gov/34491991"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1009331","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009331","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009331&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009331&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090383833","display_name":"Noelia Grande Guti\u00e9rrez","orcid":"https://orcid.org/0000-0002-7827-4752"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Noelia Grande Guti\u00e9rrez","raw_affiliation_strings":["Department of Mechanical Engineering, Stanford University, Stanford, California, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-7827-4752","affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, Stanford University, Stanford, California, United States of America","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000234159","display_name":"Mark Alber","orcid":"https://orcid.org/0000-0002-7153-1138"},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Alber","raw_affiliation_strings":["Department of Mathematics and Interdisciplinary Center for Quantitative Modeling in Biology, University of California, Riverside, Riverside, California, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-7153-1138","affiliations":[{"raw_affiliation_string":"Department of Mathematics and Interdisciplinary Center for Quantitative Modeling in Biology, University of California, Riverside, Riverside, California, United States of America","institution_ids":["https://openalex.org/I103635307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089502168","display_name":"Andrew M. Kahn","orcid":"https://orcid.org/0000-0002-6677-4215"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew M. Kahn","raw_affiliation_strings":["Department of Medicine, University of California, San Diego, San Diego, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California, San Diego, San Diego, California, United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065297743","display_name":"Jane C. Burns","orcid":"https://orcid.org/0000-0001-5679-1217"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jane C. Burns","raw_affiliation_strings":["Department of Pediatrics, University of California, San Diego, San Diego, California, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-5679-1217","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California, San Diego, San Diego, California, United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102765187","display_name":"Mathew Mathew","orcid":"https://orcid.org/0000-0002-8485-6361"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]},{"id":"https://openalex.org/I4210141030","display_name":"SickKids Foundation","ror":"https://ror.org/04374qe70","country_code":"CA","type":"funder","lineage":["https://openalex.org/I4210141030"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mathew Mathew","raw_affiliation_strings":["The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":"https://orcid.org/0000-0002-8485-6361","affiliations":[{"raw_affiliation_string":"The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2801317318","https://openalex.org/I4210141030"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027489789","display_name":"Brian W. McCrindle","orcid":"https://orcid.org/0000-0001-6485-6551"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]},{"id":"https://openalex.org/I4210141030","display_name":"SickKids Foundation","ror":"https://ror.org/04374qe70","country_code":"CA","type":"funder","lineage":["https://openalex.org/I4210141030"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Brian W. McCrindle","raw_affiliation_strings":["The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":"https://orcid.org/0000-0001-6485-6551","affiliations":[{"raw_affiliation_string":"The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2801317318","https://openalex.org/I4210141030"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087790536","display_name":"Alison L. Marsden","orcid":"https://orcid.org/0000-0003-1902-171X"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alison L. Marsden","raw_affiliation_strings":["Department of Pediatrics, Bioengineering and Institute for Computational and Mathematical Engineering, Stanford University, Stanford, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Bioengineering and Institute for Computational and Mathematical Engineering, Stanford University, Stanford, California, United States of America","institution_ids":["https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5087790536"],"corresponding_institution_ids":["https://openalex.org/I97018004"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":4.4169,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.95379694,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"17","issue":"9","first_page":"e1009331","last_page":"e1009331"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11892","display_name":"Kawasaki Disease and Coronary Complications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11892","display_name":"Kawasaki Disease and Coronary Complications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12230","display_name":"Cardiovascular Issues in Pregnancy","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kawasaki-disease","display_name":"Kawasaki disease","score":0.9069615602493286},{"id":"https://openalex.org/keywords/thrombosis","display_name":"Thrombosis","score":0.6557772159576416},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.6478656530380249},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"Coronary artery disease","score":0.5602230429649353},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5098804235458374},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.5021567344665527},{"id":"https://openalex.org/keywords/artery","display_name":"Artery","score":0.36287063360214233}],"concepts":[{"id":"https://openalex.org/C2781423770","wikidata":"https://www.wikidata.org/wiki/Q265936","display_name":"Kawasaki disease","level":3,"score":0.9069615602493286},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.6557772159576416},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6478656530380249},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.5602230429649353},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5098804235458374},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5021567344665527},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.36287063360214233}],"mesh":[{"descriptor_ui":"D000244","descriptor_name":"Adenosine Diphosphate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000244","descriptor_name":"Adenosine Diphosphate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000244","descriptor_name":"Adenosine Diphosphate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009080","descriptor_name":"Mucocutaneous Lymph Node Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009080","descriptor_name":"Mucocutaneous Lymph Node Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009080","descriptor_name":"Mucocutaneous Lymph Node Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009080","descriptor_name":"Mucocutaneous Lymph Node Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009080","descriptor_name":"Mucocutaneous Lymph Node Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009080","descriptor_name":"Mucocutaneous Lymph Node Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D010974","descriptor_name":"Platelet Aggregation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010974","descriptor_name":"Platelet Aggregation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010974","descriptor_name":"Platelet Aggregation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015539","descriptor_name":"Platelet Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015539","descriptor_name":"Platelet Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015539","descriptor_name":"Platelet Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1009331","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009331","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009331&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:34491991","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34491991","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:533ba75e53ac4e98b8c71b3b43537203","is_oa":true,"landing_page_url":"https://doaj.org/article/533ba75e53ac4e98b8c71b3b43537203","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 17, Iss 9, p e1009331 (2021)","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt3v0481dk","is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/3v0481dk","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS Computational Biology, vol 17, iss 9","raw_type":"article"},{"id":"pmh:oai:europepmc.org:7340474","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8448376","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:8448376","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8448376","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1009331","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009331","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009331&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8100000023841858,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G7823922472","display_name":null,"funder_award_id":"UO1 HL116330","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8101135009","display_name":null,"funder_award_id":"16PRE31090024","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3197398866.pdf"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W1701189641","https://openalex.org/W1857886162","https://openalex.org/W1964509762","https://openalex.org/W1967734296","https://openalex.org/W1984085475","https://openalex.org/W1984730857","https://openalex.org/W1987394367","https://openalex.org/W1993441527","https://openalex.org/W1998762602","https://openalex.org/W2001314317","https://openalex.org/W2001395014","https://openalex.org/W2006059744","https://openalex.org/W2007077437","https://openalex.org/W2007206486","https://openalex.org/W2011338555","https://openalex.org/W2019308962","https://openalex.org/W2041815335","https://openalex.org/W2046417991","https://openalex.org/W2060939612","https://openalex.org/W2065880897","https://openalex.org/W2072721782","https://openalex.org/W2073707438","https://openalex.org/W2083884362","https://openalex.org/W2084076985","https://openalex.org/W2085984758","https://openalex.org/W2096955972","https://openalex.org/W2101558308","https://openalex.org/W2103413070","https://openalex.org/W2104366157","https://openalex.org/W2104849069","https://openalex.org/W2108156759","https://openalex.org/W2111679581","https://openalex.org/W2113351822","https://openalex.org/W2119286443","https://openalex.org/W2127946991","https://openalex.org/W2128602721","https://openalex.org/W2129447163","https://openalex.org/W2133370274","https://openalex.org/W2154520046","https://openalex.org/W2155570053","https://openalex.org/W2265447718","https://openalex.org/W2301461111","https://openalex.org/W2311257432","https://openalex.org/W2328847125","https://openalex.org/W2387521711","https://openalex.org/W2511826598","https://openalex.org/W2526478306","https://openalex.org/W2528381731","https://openalex.org/W2548021374","https://openalex.org/W2560585316","https://openalex.org/W2573635522","https://openalex.org/W2587197733","https://openalex.org/W2604027935","https://openalex.org/W2756290699","https://openalex.org/W2769324061","https://openalex.org/W2781479171","https://openalex.org/W2800027574","https://openalex.org/W2805657234","https://openalex.org/W2807587701","https://openalex.org/W2912219160","https://openalex.org/W2968554553","https://openalex.org/W3017838347","https://openalex.org/W3081271885","https://openalex.org/W3134613945"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W3183948672","https://openalex.org/W3173606202","https://openalex.org/W3110381201","https://openalex.org/W2948807893","https://openalex.org/W2778153218","https://openalex.org/W2758277628","https://openalex.org/W1531601525","https://openalex.org/W2364784099","https://openalex.org/W3011943744"],"abstract_inverted_index":{"Coronary":[0],"artery":[1,43,150],"thrombosis":[2,205,283],"is":[3,120,263],"the":[4,29,51,97,135,173,177,194,209,221,229,238,266],"major":[5],"risk":[6,23,190],"associated":[7,47,213],"with":[8,17,48,89,148,157,203,214],"Kawasaki":[9],"disease":[10],"(KD).":[11],"Long-term":[12],"management":[13],"of":[14,31,54,85,99,109,118,125,131,137,166,169,176,182,197,220,232,240,251,259],"KD":[15,41],"patients":[16],"persistent":[18],"aneurysms":[19,151],"requires":[20],"a":[21,65,83,90,123,141,233,257,270],"thrombotic":[22],"assessment":[24],"and":[25,79,102,113,128,145,172,199,218],"clinical":[26],"decisions":[27],"regarding":[28],"administration":[30],"anticoagulation":[32],"therapy.":[33],"Computational":[34],"fluid":[35],"dynamics":[36],"has":[37],"demonstrated":[38],"that":[39,248],"abnormal":[40],"coronary":[42,143,149],"hemodynamics":[44],"can":[45],"be":[46],"thrombosis.":[49,159,192],"However,":[50],"underlying":[52],"mechanisms":[53],"clot":[55],"formation":[56],"are":[57,206],"not":[58],"yet":[59],"fully":[60],"understood.":[61],"Here":[62],"we":[63],"present":[64],"new":[66],"model":[67,184],"incorporating":[68],"data":[69],"from":[70],"patient-specific":[71],"simulated":[72],"velocity":[73],"fields":[74],"to":[75,95,269],"track":[76],"platelet":[77,104,215],"activation":[78,117,219],"accumulation.":[80],"We":[81,133],"use":[82],"system":[84],"Reaction-Advection-Diffusion":[86],"equations":[87],"solved":[88],"stabilized":[91],"finite":[92],"element":[93],"method":[94],"describe":[96],"evolution":[98],"non-activated":[100],"platelets":[101,119,139,171],"activated":[103,138,170],"concentrations":[105,108],"[AP],":[106],"local":[107,129,260],"adenosine":[110],"diphosphate":[111],"(ADP)":[112,217],"poly-phosphate":[114],"(PolyP).":[115,225],"The":[116],"modeled":[121],"as":[122,256],"function":[124],"shear-rate":[126],"exposure":[127],"concentration":[130,168,195],"agonists.":[132],"compared":[134],"distribution":[136],"in":[140,201,237,249,273],"healthy":[142],"case":[144],"six":[146],"cases":[147,202],"caused":[152],"by":[153],"KD,":[154],"including":[155],"three":[156],"confirmed":[158,204],"Results":[160],"show":[161,247],"spatial":[162],"correlation":[163],"between":[164],"regions":[165,187,250],"higher":[167,207],"reported":[174,210],"location":[175],"clot,":[178],"suggesting":[179],"predictive":[180],"capabilities":[181],"this":[183],"towards":[185],"identifying":[186],"at":[188],"high":[189],"for":[191,282,286],"Also,":[193],"levels":[196],"ADP":[198],"PolyP":[200],"than":[208],"critical":[211],"values":[212],"aggregation":[216],"intrinsic":[222],"coagulation":[223,234],"pathway":[224,235],"These":[226],"findings":[227],"suggest":[228],"potential":[230],"initiation":[231],"even":[236],"absence":[239],"an":[241],"extrinsic":[242],"factor.":[243],"Finally,":[244],"computational":[245],"simulations":[246],"flow":[252],"stagnation,":[253],"biochemical":[254],"activation,":[255],"result":[258],"agonist":[261],"concentration,":[262],"dominant.":[264],"Identifying":[265],"leading":[267],"factors":[268],"pro-coagulant":[271],"environment":[272],"each":[274,287],"case-mechanical":[275],"or":[276],"biochemical-could":[277],"help":[278],"define":[279],"improved":[280],"strategies":[281],"prevention":[284],"tailored":[285],"patient.":[288]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":7}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}
