{"id":"https://openalex.org/W3195840525","doi":"https://doi.org/10.1371/journal.pcbi.1009328","title":"Targeted modulation of protein liquid\u2013liquid phase separation by evolution of amino-acid sequence","display_name":"Targeted modulation of protein liquid\u2013liquid phase separation by evolution of amino-acid sequence","publication_year":2021,"publication_date":"2021-08-24","ids":{"openalex":"https://openalex.org/W3195840525","doi":"https://doi.org/10.1371/journal.pcbi.1009328","mag":"3195840525","pmid":"https://pubmed.ncbi.nlm.nih.gov/34428231"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1009328","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009328","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1009328","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074315542","display_name":"Simon M Lichtinger","orcid":"https://orcid.org/0000-0002-0643-6724"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Simon M. Lichtinger","raw_affiliation_strings":["Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-0643-6724","affiliations":[{"raw_affiliation_string":"Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006864005","display_name":"Adiran Garaizar","orcid":"https://orcid.org/0000-0002-9320-2984"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Adiran Garaizar","raw_affiliation_strings":["Department of Physics, Cavendish Laboratory, Maxwell Centre, University of Cambridge, Cambridge, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-9320-2984","affiliations":[{"raw_affiliation_string":"Department of Physics, Cavendish Laboratory, Maxwell Centre, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071393850","display_name":"Rosana Collepardo\u2010Guevara","orcid":"https://orcid.org/0000-0003-1781-7351"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Rosana Collepardo-Guevara","raw_affiliation_strings":["Department of Genetics, University of Cambridge, Cambridge, United Kingdom","Department of Physics, Cavendish Laboratory, Maxwell Centre, University of Cambridge, Cambridge, United Kingdom","Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0003-1781-7351","affiliations":[{"raw_affiliation_string":"Department of Genetics, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Department of Physics, Cavendish Laboratory, Maxwell Centre, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027924966","display_name":"Aleks Reinhardt","orcid":null},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Aleks Reinhardt","raw_affiliation_strings":["Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-9393-3429","affiliations":[{"raw_affiliation_string":"Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5027924966","https://openalex.org/A5071393850"],"corresponding_institution_ids":["https://openalex.org/I241749"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.1167,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.88199163,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"17","issue":"8","first_page":"e1009328","last_page":"e1009328"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9957000017166138,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.5022497177124023},{"id":"https://openalex.org/keywords/modulation","display_name":"Modulation (music)","score":0.48663005232810974},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.46643948554992676},{"id":"https://openalex.org/keywords/amino-acid","display_name":"Amino acid","score":0.42570340633392334},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4005061686038971},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3893592357635498},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.32953011989593506},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.3038368821144104},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.17910894751548767},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.12439072132110596}],"concepts":[{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.5022497177124023},{"id":"https://openalex.org/C123079801","wikidata":"https://www.wikidata.org/wiki/Q750240","display_name":"Modulation (music)","level":2,"score":0.48663005232810974},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.46643948554992676},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.42570340633392334},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4005061686038971},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3893592357635498},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32953011989593506},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3038368821144104},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.17910894751548767},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12439072132110596},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059625","descriptor_name":"Liquid-Liquid Extraction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059625","descriptor_name":"Liquid-Liquid Extraction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059625","descriptor_name":"Liquid-Liquid Extraction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059625","descriptor_name":"Liquid-Liquid Extraction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1009328","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009328","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:34428231","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34428231","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1009328","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1009328","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:8451791b5c80476b8177c2c6cc4e33b7","is_oa":true,"landing_page_url":"https://doaj.org/article/8451791b5c80476b8177c2c6cc4e33b7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 17, Iss 8, p e1009328 (2021)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8415608","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8415608","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1009328","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009328","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2071862857","display_name":null,"funder_award_id":"EP/N509620","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G2465893628","display_name":"Peta-5: A National Facility for Petascale Data Intensive Computation and Analytics","funder_award_id":"EP/P020259/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G2867726338","display_name":null,"funder_award_id":"EP/N509620/","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G3129715815","display_name":"DTP 2016-2017 University of Cambridge","funder_award_id":"EP/N509620/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G5258663329","display_name":null,"funder_award_id":"EP/P020259/","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G5368029276","display_name":null,"funder_award_id":"EP/P020259/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G6162173305","display_name":null,"funder_award_id":"grant EP/N509620/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G8815423876","display_name":"Towards Realistic Modelling of Nucleosome Organization Inside Functional Chromatin Domains","funder_award_id":"803326","funder_id":"https://openalex.org/F4320338335","funder_display_name":"H2020 European Research Council"}],"funders":[{"id":"https://openalex.org/F4320322572","display_name":"Studienstiftung des Deutschen Volkes","ror":"https://ror.org/05xwwfy96"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320334632","display_name":"Science and Technology Facilities Council","ror":"https://ror.org/057g20z61"},{"id":"https://openalex.org/F4320338335","display_name":"H2020 European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":123,"referenced_works":["https://openalex.org/W155626891","https://openalex.org/W157468466","https://openalex.org/W1505352099","https://openalex.org/W1541691514","https://openalex.org/W1800445960","https://openalex.org/W1854281301","https://openalex.org/W1895367194","https://openalex.org/W1912455695","https://openalex.org/W1963555269","https://openalex.org/W1970022221","https://openalex.org/W1970294718","https://openalex.org/W1975003836","https://openalex.org/W1976660940","https://openalex.org/W1976677255","https://openalex.org/W1988635099","https://openalex.org/W1999390565","https://openalex.org/W2011513747","https://openalex.org/W2020252677","https://openalex.org/W2022637272","https://openalex.org/W2025138408","https://openalex.org/W2026226960","https://openalex.org/W2030661492","https://openalex.org/W2042655455","https://openalex.org/W2043308634","https://openalex.org/W2044821164","https://openalex.org/W2053978056","https://openalex.org/W2054352933","https://openalex.org/W2058047116","https://openalex.org/W2079336704","https://openalex.org/W2083309296","https://openalex.org/W2085978470","https://openalex.org/W2092188627","https://openalex.org/W2101206889","https://openalex.org/W2105755207","https://openalex.org/W2111796925","https://openalex.org/W2118076674","https://openalex.org/W2120156669","https://openalex.org/W2128451145","https://openalex.org/W2139066576","https://openalex.org/W2150860983","https://openalex.org/W2163599324","https://openalex.org/W2164357985","https://openalex.org/W2168639701","https://openalex.org/W2236156346","https://openalex.org/W2314659927","https://openalex.org/W2345490732","https://openalex.org/W2461977200","https://openalex.org/W2466864989","https://openalex.org/W2467565876","https://openalex.org/W2526054337","https://openalex.org/W2547162692","https://openalex.org/W2553996574","https://openalex.org/W2603000633","https://openalex.org/W2611048578","https://openalex.org/W2619239407","https://openalex.org/W2694038906","https://openalex.org/W2722642526","https://openalex.org/W2740507605","https://openalex.org/W2742396220","https://openalex.org/W2755486970","https://openalex.org/W2756821926","https://openalex.org/W2764210034","https://openalex.org/W2766423371","https://openalex.org/W2784384705","https://openalex.org/W2791184926","https://openalex.org/W2792129356","https://openalex.org/W2792238679","https://openalex.org/W2792436658","https://openalex.org/W2794654572","https://openalex.org/W2810866092","https://openalex.org/W2887994055","https://openalex.org/W2889287833","https://openalex.org/W2902106157","https://openalex.org/W2920659730","https://openalex.org/W2921365922","https://openalex.org/W2941604165","https://openalex.org/W2943435541","https://openalex.org/W2949615111","https://openalex.org/W2950315093","https://openalex.org/W2951283121","https://openalex.org/W2951339840","https://openalex.org/W2969279439","https://openalex.org/W2969788883","https://openalex.org/W2971594646","https://openalex.org/W2977849281","https://openalex.org/W2980597982","https://openalex.org/W2980646921","https://openalex.org/W2982135975","https://openalex.org/W2998532901","https://openalex.org/W3002736232","https://openalex.org/W3005177895","https://openalex.org/W3009501790","https://openalex.org/W3011387478","https://openalex.org/W3018725402","https://openalex.org/W3022557047","https://openalex.org/W3024423177","https://openalex.org/W3025909849","https://openalex.org/W3031487353","https://openalex.org/W3035864988","https://openalex.org/W3035871125","https://openalex.org/W3039888907","https://openalex.org/W3041271009","https://openalex.org/W3087360621","https://openalex.org/W3092646203","https://openalex.org/W3101362013","https://openalex.org/W3101707265","https://openalex.org/W3101848056","https://openalex.org/W3102696908","https://openalex.org/W3102972469","https://openalex.org/W3108187028","https://openalex.org/W3109040218","https://openalex.org/W3110645309","https://openalex.org/W3112091782","https://openalex.org/W3120901452","https://openalex.org/W3123608039","https://openalex.org/W3126320701","https://openalex.org/W3131479422","https://openalex.org/W3132315222","https://openalex.org/W3132347536","https://openalex.org/W3132553925","https://openalex.org/W3158151541","https://openalex.org/W4200346882","https://openalex.org/W4220921879"],"related_works":["https://openalex.org/W2193237397","https://openalex.org/W2084679820","https://openalex.org/W2391644650","https://openalex.org/W2387003094","https://openalex.org/W2150659537","https://openalex.org/W1476194286","https://openalex.org/W2040329887","https://openalex.org/W1993048108","https://openalex.org/W1587346125","https://openalex.org/W2016342626"],"abstract_inverted_index":{"Rationally":[0],"and":[1,68,111,121,132,181],"efficiently":[2],"modifying":[3],"the":[4,58,79,85,97,100,136,157,161,165,170,185,193,205,208,211,229],"amino-acid":[5,59,139,187,196],"sequence":[6],"of":[7,61,84,103,115,129,138,160,167,195,207,215,225,232],"proteins":[8],"to":[9,13,30,50,56,75,99,198,204],"control":[10],"their":[11,73],"ability":[12],"undergo":[14,122],"liquid-liquid":[15],"phase":[16,226],"separation":[17,227],"(LLPS)":[18],"on":[19,184],"demand":[20],"is":[21,144,201],"not":[22],"only":[23],"highly":[24],"desirable,":[25],"but":[26],"can":[27],"also":[28],"help":[29],"elucidate":[31],"which":[32,217],"protein":[33,54,65],"features":[34],"are":[35],"important":[36],"for":[37,222],"LLPS.":[38],"Here,":[39],"we":[40,133,190],"propose":[41],"a":[42,47,51,90],"computational":[43],"method":[44],"that":[45,117,135,174,192],"couples":[46],"genetic":[48],"algorithm":[49,98],"sequence-dependent":[52],"coarse-grained":[53],"model":[55],"evolve":[57],"sequences":[60,87,140,197],"phase-separating":[62,101],"intrinsically":[63],"disordered":[64],"regions":[66,116],"(IDRs),":[67],"purposely":[69],"enhance":[70,175],"or":[71,213],"inhibit":[72],"capacity":[74],"phase-separate.":[76],"We":[77,95],"validate":[78],"predicted":[80],"critical":[81],"solution":[82],"temperatures":[83],"mutated":[86],"with":[88],"ABSINTH,":[89],"more":[91],"accurate":[92],"all-atom":[93],"model.":[94],"apply":[96],"IDRs":[102],"three":[104,148],"naturally":[105],"occurring":[106],"proteins,":[107],"namely":[108],"FUS,":[109],"hnRNPA1":[110],"LAF1,":[112],"as":[113,178],"prototypes":[114],"exist":[118],"in":[119,146,156,169],"cells":[120],"homotypic":[123],"LLPS":[124,143,176,200],"driven":[125,145],"by":[126,153],"different":[127],"types":[128],"intermolecular":[130],"interaction,":[131],"find":[134],"evolution":[137,194],"towards":[141],"enhanced":[142],"these":[147],"cases,":[149],"among":[150],"other":[151],"factors,":[152],"an":[154],"increase":[155],"average":[158],"size":[159],"amino":[162],"acids.":[163],"However,":[164],"direction":[166],"change":[168],"molecular":[171],"driving":[172],"forces":[173],"(such":[177],"hydrophobicity,":[179],"aromaticity":[180],"charge)":[182],"depends":[183],"initial":[186],"sequence.":[188],"Finally,":[189],"show":[191],"modulate":[199],"strongly":[202],"coupled":[203],"make-up":[206],"medium":[209],"(e.g.":[210],"presence":[212],"absence":[214],"RNA),":[216],"may":[218],"have":[219],"significant":[220],"implications":[221],"our":[223],"understanding":[224],"within":[228],"many-component":[230],"mixtures":[231],"biological":[233],"systems.":[234]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":4}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}