{"id":"https://openalex.org/W4225328348","doi":"https://doi.org/10.1371/journal.pcbi.1009312","title":"Application of modular response analysis to medium- to large-size biological systems","display_name":"Application of modular response analysis to medium- to large-size biological systems","publication_year":2022,"publication_date":"2022-04-20","ids":{"openalex":"https://openalex.org/W4225328348","doi":"https://doi.org/10.1371/journal.pcbi.1009312","pmid":"https://pubmed.ncbi.nlm.nih.gov/35442961"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1009312","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009312","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1009312","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052787373","display_name":"Meriem Mekedem","orcid":"https://orcid.org/0000-0002-8561-310X"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210140335","display_name":"Institut de Recherche en Canc\u00e9rologie de Montpellier","ror":"https://ror.org/03capj968","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210140335","https://openalex.org/I4210141925","https://openalex.org/I4387154388"]},{"id":"https://openalex.org/I4387154388","display_name":"Institut Regional du Cancer de Montpellier","ror":"https://ror.org/02693j602","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210141925","https://openalex.org/I4387154388"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Meriem Mekedem","raw_affiliation_strings":["Institut de Recherche en Canc\u00e9rologie de Montpellier, Inserm U1194, Montpellier, France","Institut r\u00e9gional du Cancer Montpellier, Montpellier, France","Universit\u00e9 de Montpellier, Montpellier, France"],"affiliations":[{"raw_affiliation_string":"Institut de Recherche en Canc\u00e9rologie de Montpellier, Inserm U1194, Montpellier, France","institution_ids":["https://openalex.org/I4210140335","https://openalex.org/I154526488"]},{"raw_affiliation_string":"Institut r\u00e9gional du Cancer Montpellier, Montpellier, France","institution_ids":["https://openalex.org/I4210140335","https://openalex.org/I4387154388"]},{"raw_affiliation_string":"Universit\u00e9 de Montpellier, Montpellier, France","institution_ids":["https://openalex.org/I19894307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013413507","display_name":"Patrice Ravel","orcid":"https://orcid.org/0000-0002-5752-7343"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210140335","display_name":"Institut de Recherche en Canc\u00e9rologie de Montpellier","ror":"https://ror.org/03capj968","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210140335","https://openalex.org/I4210141925","https://openalex.org/I4387154388"]},{"id":"https://openalex.org/I4387154388","display_name":"Institut Regional du Cancer de Montpellier","ror":"https://ror.org/02693j602","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210141925","https://openalex.org/I4387154388"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Patrice Ravel","raw_affiliation_strings":["Facult\u00e9 de Pharmacie, Universit\u00e9 de Montpellier, Montpellier, France","Institut de Recherche en Canc\u00e9rologie de Montpellier, Inserm U1194, Montpellier, France","Institut r\u00e9gional du Cancer Montpellier, Montpellier, France","Universit\u00e9 de Montpellier, Montpellier, France"],"affiliations":[{"raw_affiliation_string":"Facult\u00e9 de Pharmacie, Universit\u00e9 de Montpellier, Montpellier, France","institution_ids":["https://openalex.org/I19894307"]},{"raw_affiliation_string":"Institut de Recherche en Canc\u00e9rologie de Montpellier, Inserm U1194, Montpellier, France","institution_ids":["https://openalex.org/I4210140335","https://openalex.org/I154526488"]},{"raw_affiliation_string":"Institut r\u00e9gional du Cancer Montpellier, Montpellier, France","institution_ids":["https://openalex.org/I4210140335","https://openalex.org/I4387154388"]},{"raw_affiliation_string":"Universit\u00e9 de Montpellier, Montpellier, France","institution_ids":["https://openalex.org/I19894307"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029758467","display_name":"Jacques Colinge","orcid":"https://orcid.org/0000-0003-2466-4824"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210140335","display_name":"Institut de Recherche en Canc\u00e9rologie de Montpellier","ror":"https://ror.org/03capj968","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210140335","https://openalex.org/I4210141925","https://openalex.org/I4387154388"]},{"id":"https://openalex.org/I4387154388","display_name":"Institut Regional du Cancer de Montpellier","ror":"https://ror.org/02693j602","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210141925","https://openalex.org/I4387154388"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Jacques Colinge","raw_affiliation_strings":["Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Montpellier, Montpellier, France","Institut de Recherche en Canc\u00e9rologie de Montpellier, Inserm U1194, Montpellier, France","Institut r\u00e9gional du Cancer Montpellier, Montpellier, France","Universit\u00e9 de Montpellier, Montpellier, France"],"affiliations":[{"raw_affiliation_string":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Montpellier, Montpellier, France","institution_ids":["https://openalex.org/I19894307"]},{"raw_affiliation_string":"Institut de Recherche en Canc\u00e9rologie de Montpellier, Inserm U1194, Montpellier, France","institution_ids":["https://openalex.org/I4210140335","https://openalex.org/I154526488"]},{"raw_affiliation_string":"Institut r\u00e9gional du Cancer Montpellier, Montpellier, France","institution_ids":["https://openalex.org/I4210140335","https://openalex.org/I4387154388"]},{"raw_affiliation_string":"Universit\u00e9 de Montpellier, Montpellier, France","institution_ids":["https://openalex.org/I19894307"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5029758467"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210140335","https://openalex.org/I4387154388"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2391,"currency":"EUR","value_usd":2578},"fwci":0.4332,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.57735203,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"18","issue":"4","first_page":"e1009312","last_page":"e1009312"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/modular-design","display_name":"Modular design","score":0.6955054998397827},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6849013566970825},{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.5698442459106445},{"id":"https://openalex.org/keywords/heuristic","display_name":"Heuristic","score":0.5449139475822449},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.5445717573165894},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5239448547363281},{"id":"https://openalex.org/keywords/cas9","display_name":"Cas9","score":0.5211946368217468},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.5198398232460022},{"id":"https://openalex.org/keywords/crispr","display_name":"CRISPR","score":0.5161769986152649},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.5098758935928345},{"id":"https://openalex.org/keywords/a-priori-and-a-posteriori","display_name":"A priori and a posteriori","score":0.47184017300605774},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.46699845790863037},{"id":"https://openalex.org/keywords/network-analysis","display_name":"Network analysis","score":0.46344876289367676},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4118683934211731},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2963874936103821},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.28269699215888977},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2663941979408264},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1390906274318695},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.13724932074546814}],"concepts":[{"id":"https://openalex.org/C101468663","wikidata":"https://www.wikidata.org/wiki/Q1620158","display_name":"Modular design","level":2,"score":0.6955054998397827},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6849013566970825},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.5698442459106445},{"id":"https://openalex.org/C173801870","wikidata":"https://www.wikidata.org/wiki/Q201413","display_name":"Heuristic","level":2,"score":0.5449139475822449},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.5445717573165894},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5239448547363281},{"id":"https://openalex.org/C132455925","wikidata":"https://www.wikidata.org/wiki/Q16965677","display_name":"Cas9","level":4,"score":0.5211946368217468},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.5198398232460022},{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.5161769986152649},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.5098758935928345},{"id":"https://openalex.org/C75553542","wikidata":"https://www.wikidata.org/wiki/Q178161","display_name":"A priori and a posteriori","level":2,"score":0.47184017300605774},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.46699845790863037},{"id":"https://openalex.org/C32946077","wikidata":"https://www.wikidata.org/wiki/Q618079","display_name":"Network analysis","level":2,"score":0.46344876289367676},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4118683934211731},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2963874936103821},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.28269699215888977},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2663941979408264},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1390906274318695},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.13724932074546814},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072669","descriptor_name":"Gene Editing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000072669","descriptor_name":"Gene Editing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000072669","descriptor_name":"Gene Editing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1009312","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009312","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:35442961","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35442961","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:HAL:hal-04130157v1","is_oa":true,"landing_page_url":"https://hal.science/hal-04130157","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, 2022, 18 (4), pp.e1009312. ⟨10.1371/journal.pcbi.1009312⟩","raw_type":"Journal articles"},{"id":"pmh:oai:RePEc:plo:pcbi00:1009312","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1009312","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:039642338f284a4f883cb8fe6cb83a0b","is_oa":true,"landing_page_url":"https://doaj.org/article/039642338f284a4f883cb8fe6cb83a0b","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 4, p e1009312 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9060349","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9060349","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1009312","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009312","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5,"display_name":"Partnerships for the goals","id":"https://metadata.un.org/sdg/17"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1988263223","https://openalex.org/W1989119979","https://openalex.org/W1992452843","https://openalex.org/W1999895438","https://openalex.org/W2003787610","https://openalex.org/W2015538881","https://openalex.org/W2034827925","https://openalex.org/W2044525257","https://openalex.org/W2057545775","https://openalex.org/W2078149659","https://openalex.org/W2082463698","https://openalex.org/W2097698606","https://openalex.org/W2115108153","https://openalex.org/W2121695897","https://openalex.org/W2123060905","https://openalex.org/W2128962304","https://openalex.org/W2136760727","https://openalex.org/W2139439234","https://openalex.org/W2156716434","https://openalex.org/W2161868542","https://openalex.org/W2163296115","https://openalex.org/W2170272380","https://openalex.org/W2485369312","https://openalex.org/W2493614923","https://openalex.org/W2612467560","https://openalex.org/W2616561032","https://openalex.org/W2626108736","https://openalex.org/W2793399117","https://openalex.org/W2900205062","https://openalex.org/W2954218722","https://openalex.org/W3015964336","https://openalex.org/W3099289621","https://openalex.org/W3148252621","https://openalex.org/W3202201721","https://openalex.org/W4238492599","https://openalex.org/W4312258136"],"related_works":["https://openalex.org/W2158714033","https://openalex.org/W78967844","https://openalex.org/W2949927938","https://openalex.org/W3213185671","https://openalex.org/W4210989272","https://openalex.org/W4206945140","https://openalex.org/W4386628104","https://openalex.org/W2029387041","https://openalex.org/W2130939068","https://openalex.org/W249159571"],"abstract_inverted_index":{"The":[0],"development":[1],"of":[2,40,45,125,134],"high-throughput":[3],"genomic":[4],"technologies":[5],"associated":[6],"with":[7,107],"recent":[8],"genetic":[9],"perturbation":[10,31],"techniques":[11],"such":[12,77],"as":[13],"short":[14],"hairpin":[15],"RNA":[16],"(shRNA),":[17],"gene":[18,21,55],"trapping,":[19],"or":[20],"editing":[22],"(CRISPR/Cas9)":[23],"has":[24,84],"made":[25],"it":[26],"possible":[27],"to":[28,52,87,154],"obtain":[29],"large":[30,105,156],"data":[32,35],"sets.":[33],"These":[34],"sets":[36],"are":[37],"invaluable":[38],"sources":[39],"information":[41],"regarding":[42],"the":[43,132],"function":[44],"genes,":[46],"and":[47],"they":[48],"offer":[49],"unique":[50],"opportunities":[51],"reverse":[53],"engineer":[54],"regulatory":[56],"networks":[57],"in":[58,150],"specific":[59],"cell":[60],"types.":[61],"Modular":[62],"response":[63],"analysis":[64],"(MRA)":[65],"is":[66,73],"a":[67,135,142,147],"well-accepted":[68],"mathematical":[69],"modeling":[70],"method":[71],"that":[72,99,116,138],"precisely":[74],"aimed":[75],"at":[76],"network":[78,110],"inference":[79],"tasks,":[80],"but":[81],"its":[82],"use":[83],"been":[85],"limited":[86],"rather":[88],"small":[89],"biological":[90],"systems":[91,106],"so":[92],"far.":[93],"In":[94,112],"this":[95],"study,":[96],"we":[97,114],"show":[98,115],"MRA":[100,117,151],"can":[101],"be":[102],"employed":[103],"on":[104],"almost":[108],"1,000":[109],"components.":[111],"particular,":[113],"performance":[118],"surpasses":[119],"general-purpose":[120],"mutual":[121],"information-based":[122],"algorithms.":[123],"Part":[124],"these":[126],"competitive":[127],"results":[128],"was":[129],"obtained":[130],"by":[131],"application":[133],"novel":[136],"heuristic":[137],"pruned":[139],"MRA-inferred":[140],"interactions":[141],"posteriori.":[143],"We":[144],"also":[145],"exploited":[146],"block":[148],"structure":[149],"linear":[152],"algebra":[153],"parallelize":[155],"system":[157],"resolutions.":[158]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}