{"id":"https://openalex.org/W3196186574","doi":"https://doi.org/10.1371/journal.pcbi.1009289","title":"Estimating the conditional probability of developing human papilloma virus related oropharyngeal cancer by combining machine learning and inverse Bayesian modelling","display_name":"Estimating the conditional probability of developing human papilloma virus related oropharyngeal cancer by combining machine learning and inverse Bayesian modelling","publication_year":2021,"publication_date":"2021-08-20","ids":{"openalex":"https://openalex.org/W3196186574","doi":"https://doi.org/10.1371/journal.pcbi.1009289","mag":"3196186574","pmid":"https://pubmed.ncbi.nlm.nih.gov/34415913"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1009289","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009289","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009289&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009289&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031790108","display_name":"Prerna Tewari","orcid":"https://orcid.org/0000-0001-7111-875X"},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]},{"id":"https://openalex.org/I4210089527","display_name":"Coombe Women & Infants University Hospital","ror":"https://ror.org/00bx71042","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210089527"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"Prerna Tewari","raw_affiliation_strings":["Department Histopathology and Morbid Anatomy, Trinity College Dublin, Dublin, Ireland","Molecular Pathology Research, Coombe Women & Infants University Hospital, Dublin, Ireland"],"raw_orcid":"https://orcid.org/0000-0001-7111-875X","affiliations":[{"raw_affiliation_string":"Department Histopathology and Morbid Anatomy, Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]},{"raw_affiliation_string":"Molecular Pathology Research, Coombe Women & Infants University Hospital, Dublin, Ireland","institution_ids":["https://openalex.org/I4210089527"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090165940","display_name":"Eugene Kashdan","orcid":"https://orcid.org/0000-0002-8137-4981"},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Eugene Kashdan","raw_affiliation_strings":["School of Medicine, University College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027926967","display_name":"Cathal Walsh","orcid":"https://orcid.org/0000-0001-6599-9562"},"institutions":[{"id":"https://openalex.org/I230495080","display_name":"University of Limerick","ror":"https://ror.org/00a0n9e72","country_code":"IE","type":"education","lineage":["https://openalex.org/I230495080"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Cathal Walsh","raw_affiliation_strings":["Department Mathematics and Statistics, University of Limerick, Limerick, Ireland"],"raw_orcid":"https://orcid.org/0000-0001-6599-9562","affiliations":[{"raw_affiliation_string":"Department Mathematics and Statistics, University of Limerick, Limerick, Ireland","institution_ids":["https://openalex.org/I230495080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001707582","display_name":"Cara Martin","orcid":"https://orcid.org/0000-0001-8411-8564"},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]},{"id":"https://openalex.org/I4210089527","display_name":"Coombe Women & Infants University Hospital","ror":"https://ror.org/00bx71042","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210089527"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Cara M. Martin","raw_affiliation_strings":["Department Histopathology and Morbid Anatomy, Trinity College Dublin, Dublin, Ireland","Molecular Pathology Research, Coombe Women & Infants University Hospital, Dublin, Ireland"],"raw_orcid":"https://orcid.org/0000-0001-8411-8564","affiliations":[{"raw_affiliation_string":"Department Histopathology and Morbid Anatomy, Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]},{"raw_affiliation_string":"Molecular Pathology Research, Coombe Women & Infants University Hospital, Dublin, Ireland","institution_ids":["https://openalex.org/I4210089527"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072332476","display_name":"Andrew Parnell","orcid":"https://orcid.org/0000-0001-7956-7939"},"institutions":[{"id":"https://openalex.org/I157286207","display_name":"National University of Ireland, Maynooth","ror":"https://ror.org/048nfjm95","country_code":"IE","type":"education","lineage":["https://openalex.org/I157286207"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Andrew C. Parnell","raw_affiliation_strings":["Hamilton Institute, Insight Centre for Data Analytics, Maynooth University, Kildare, Ireland"],"raw_orcid":"https://orcid.org/0000-0001-7956-7939","affiliations":[{"raw_affiliation_string":"Hamilton Institute, Insight Centre for Data Analytics, Maynooth University, Kildare, Ireland","institution_ids":["https://openalex.org/I157286207"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043621658","display_name":"John O\u2019Leary","orcid":"https://orcid.org/0000-0001-7311-9326"},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]},{"id":"https://openalex.org/I4210089527","display_name":"Coombe Women & Infants University Hospital","ror":"https://ror.org/00bx71042","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210089527"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"John J. O\u2019Leary","raw_affiliation_strings":["Department Histopathology and Morbid Anatomy, Trinity College Dublin, Dublin, Ireland","Molecular Pathology Research, Coombe Women & Infants University Hospital, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Histopathology and Morbid Anatomy, Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]},{"raw_affiliation_string":"Molecular Pathology Research, Coombe Women & Infants University Hospital, Dublin, Ireland","institution_ids":["https://openalex.org/I4210089527"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5031790108"],"corresponding_institution_ids":["https://openalex.org/I205274468","https://openalex.org/I4210089527"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.632,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.84277509,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"17","issue":"8","first_page":"e1009289","last_page":"e1009289"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.992900013923645,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.992900013923645,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9510999917984009,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bayesian-probability","display_name":"Bayesian probability","score":0.6324169635772705},{"id":"https://openalex.org/keywords/human-papilloma-virus","display_name":"Human papilloma virus","score":0.520294725894928},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4275626838207245},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.42610377073287964},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.42081063985824585},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.32095080614089966},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3206322491168976},{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"Cervical cancer","score":0.3030668795108795},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.16532132029533386},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.059247612953186035}],"concepts":[{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.6324169635772705},{"id":"https://openalex.org/C2994539378","wikidata":"https://www.wikidata.org/wiki/Q184627","display_name":"Human papilloma virus","level":4,"score":0.520294725894928},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4275626838207245},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.42610377073287964},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.42081063985824585},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.32095080614089966},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3206322491168976},{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.3030668795108795},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16532132029533386},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.059247612953186035}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009959","descriptor_name":"Oropharyngeal Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D009959","descriptor_name":"Oropharyngeal Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D009959","descriptor_name":"Oropharyngeal Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D009959","descriptor_name":"Oropharyngeal Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D009959","descriptor_name":"Oropharyngeal Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D009959","descriptor_name":"Oropharyngeal Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018426","descriptor_name":"SEER Program","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018426","descriptor_name":"SEER Program","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018426","descriptor_name":"SEER Program","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052685","descriptor_name":"Alphapapillomavirus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D052685","descriptor_name":"Alphapapillomavirus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D052685","descriptor_name":"Alphapapillomavirus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1009289","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009289","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009289&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:34415913","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34415913","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:http://www.rian.ie/198881/","is_oa":false,"landing_page_url":"http://hdl.handle.net/10344/10608","pdf_url":null,"source":{"id":"https://openalex.org/S4306400033","display_name":"Arrow@dit (Dublin Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I115570527","host_organization_name":"Dublin Institute of Technology","host_organization_lineage":["https://openalex.org/I115570527"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"PLoS Computational Biology;17(8), e1009289","raw_type":"Journal article"},{"id":"pmh:oai:doaj.org/article:a354830f3e9c4c39ae136edeed152edc","is_oa":true,"landing_page_url":"https://doaj.org/article/a354830f3e9c4c39ae136edeed152edc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 17, Iss 8, p e1009289 (2021)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/19814356","is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Estimating_the_conditional_probability_of_developing_human_papilloma_virus_related_oropharyngeal_cancer_by_combining_machine_learning_and_inverse_bayesian_modelling/19814356","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:8409636","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8409636","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1009289","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009289","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009289&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8100000023841858,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G2545334760","display_name":null,"funder_award_id":"12/RC/2289 P2","funder_id":"https://openalex.org/F4320320847","funder_display_name":"Science Foundation Ireland"},{"id":"https://openalex.org/G3695527833","display_name":null,"funder_award_id":"12/RC/2289_P2","funder_id":"https://openalex.org/F4320320847","funder_display_name":"Science Foundation Ireland"},{"id":"https://openalex.org/G4718266304","display_name":null,"funder_award_id":"ICE-2015-1037","funder_id":"https://openalex.org/F4320312041","funder_display_name":"Health Research Board"},{"id":"https://openalex.org/G5098725405","display_name":null,"funder_award_id":"12/RC/","funder_id":"https://openalex.org/F4320320847","funder_display_name":"Science Foundation Ireland"},{"id":"https://openalex.org/G7354596360","display_name":null,"funder_award_id":"17/CDA/4695","funder_id":"https://openalex.org/F4320320847","funder_display_name":"Science Foundation Ireland"}],"funders":[{"id":"https://openalex.org/F4320312041","display_name":"Health Research Board","ror":"https://ror.org/003hb2249"},{"id":"https://openalex.org/F4320320847","display_name":"Science Foundation Ireland","ror":"https://ror.org/0271asj38"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3196186574.pdf","grobid_xml":"https://content.openalex.org/works/W3196186574.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W147186041","https://openalex.org/W1582622987","https://openalex.org/W1979135699","https://openalex.org/W1983187600","https://openalex.org/W1987350137","https://openalex.org/W1998253083","https://openalex.org/W2026996973","https://openalex.org/W2072466513","https://openalex.org/W2083564544","https://openalex.org/W2083796093","https://openalex.org/W2126292488","https://openalex.org/W2129363191","https://openalex.org/W2129870884","https://openalex.org/W2131255017","https://openalex.org/W2132239791","https://openalex.org/W2132639608","https://openalex.org/W2149166037","https://openalex.org/W2150799358","https://openalex.org/W2151269016","https://openalex.org/W2154131697","https://openalex.org/W2260007524","https://openalex.org/W2269417520","https://openalex.org/W2406213538","https://openalex.org/W2472485111","https://openalex.org/W2487037907","https://openalex.org/W2495364486","https://openalex.org/W2502245586","https://openalex.org/W2514361797","https://openalex.org/W2594409922","https://openalex.org/W2626724458","https://openalex.org/W2758767377","https://openalex.org/W2778988196","https://openalex.org/W2794355471","https://openalex.org/W2889646458","https://openalex.org/W2906249136","https://openalex.org/W2985532529","https://openalex.org/W2999147538","https://openalex.org/W3003249044","https://openalex.org/W3099006712"],"related_works":["https://openalex.org/W4386948194","https://openalex.org/W2920813532","https://openalex.org/W4213135093","https://openalex.org/W2911638444","https://openalex.org/W2374713766","https://openalex.org/W2347821325","https://openalex.org/W3028701127","https://openalex.org/W2344082821","https://openalex.org/W2412243172","https://openalex.org/W3202688321"],"abstract_inverted_index":{"The":[0,77,158,212,260],"epidemic":[1],"increase":[2],"in":[3,17,39,51,75,112,204,250],"the":[4,40,52,68,142,168,175,192,201,205,235,282],"incidence":[5,41],"of":[6,43,67,71,108,123,144,218,267,272,285,289],"Human":[7],"Papilloma":[8],"Virus":[9],"(HPV)":[10],"related":[11,90,117],"Oropharyngeal":[12],"Squamous":[13],"Cell":[14],"Carcinomas":[15],"(OPSCCs)":[16],"several":[18],"countries":[19],"worldwide":[20],"represents":[21,264],"a":[22,37,129,135,238,265,268,278],"significant":[23],"public":[24],"health":[25],"concern.":[26],"Although":[27],"gender":[28],"neutral":[29],"HPV":[30,73,89,116,150,189,224,248,273,295],"vaccination":[31],"programmes":[32],"are":[33,58],"expected":[34],"to":[35,63,105,120,166,208,257],"cause":[36],"reduction":[38],"rates":[42],"OPSCCs,":[44],"these":[45,109],"effects":[46],"will":[47],"not":[48,60],"be":[49,94],"evident":[50],"foreseeable":[53],"future.":[54],"Secondary":[55],"prevention":[56,125],"strategies":[57],"currently":[59],"feasible":[61],"due":[62],"an":[64,145,148,222,246,286,293],"incomplete":[65],"understanding":[66],"natural":[69,82,269],"history":[70,83,270],"oral":[72,149,223,247,294],"infections":[74],"OPSCCs.":[76],"key":[78],"parameters":[79,111],"that":[80],"govern":[81],"models":[84,101],"remain":[85],"largely":[86],"ill-defined":[87,110],"for":[88,242,280],"OPSCCs":[91,244,275],"and":[92,154,178,186,191,195,233,254,276],"cannot":[93],"easily":[95],"inferred":[96],"from":[97,174],"experimental":[98],"data.":[99],"Mathematical":[100],"have":[102],"been":[103],"used":[104],"estimate":[106],"some":[107],"cervical":[113],"cancer,":[114],"another":[115],"cancer":[118,124,182],"leading":[119],"successful":[121],"implementation":[122],"strategies.":[126],"We":[127,171],"outline":[128],"\"double-Bayesian\"":[130],"mathematical":[131],"modelling":[132],"approach,":[133],"whereby,":[134],"Bayesian":[136,262],"machine":[137],"learning":[138],"model":[139,159,213,236,263,271],"first":[140],"estimates":[141],"probability":[143,169,241,284],"individual":[146],"having":[147],"infection,":[151],"given":[152,245],"OPSCC":[153,216,291],"other":[155,258],"covariate":[156],"information.":[157],"is":[160],"then":[161],"inverted":[162],"using":[163],"Bayes'":[164],"theorem":[165],"reverse":[167],"relationship.":[170],"use":[172],"data":[173],"Surveillance,":[176],"Epidemiology,":[177],"End":[179],"Results":[180],"(SEER)":[181],"registry,":[183],"SEER":[184],"Head":[185],"Neck":[187],"with":[188],"Database":[190],"National":[193],"Health":[194],"Nutrition":[196],"Examination":[197],"Surveys":[198],"(NHANES),":[199],"representing":[200],"adult":[202],"population":[203],"United":[206],"States":[207],"derive":[209],"our":[210],"model.":[211],"contains":[214],"8,106":[215],"patients":[217],"which":[219],"73.0%":[220],"had":[221],"infection.":[225,296],"When":[226],"stratified":[227],"by":[228],"age,":[229],"sex,":[230],"marital":[231],"status":[232],"race/ethnicity,":[234],"estimated":[237],"higher":[239],"conditional":[240,283],"developing":[243,290],"infection":[249],"non-Hispanic":[251],"White":[252],"males":[253],"females":[255],"compared":[256],"races/ethnicities.":[259],"proposed":[261],"proof-of-concept":[266],"driven":[274],"outlines":[277],"strategy":[279],"estimating":[281],"individual's":[287],"risk":[288],"following":[292]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}