{"id":"https://openalex.org/W3196385085","doi":"https://doi.org/10.1371/journal.pcbi.1009250","title":"IUSMMT: Survival mediation analysis of gene expression with multiple DNA methylation exposures and its application to cancers of TCGA","display_name":"IUSMMT: Survival mediation analysis of gene expression with multiple DNA methylation exposures and its application to cancers of TCGA","publication_year":2021,"publication_date":"2021-08-31","ids":{"openalex":"https://openalex.org/W3196385085","doi":"https://doi.org/10.1371/journal.pcbi.1009250","mag":"3196385085","pmid":"https://pubmed.ncbi.nlm.nih.gov/34464378"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1009250","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009250","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1009250","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069015108","display_name":"Zhonghe Shao","orcid":null},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhonghe Shao","raw_affiliation_strings":["Department of Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu, China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100427963","display_name":"Ting Wang","orcid":"https://orcid.org/0000-0002-6800-242X"},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ting Wang","raw_affiliation_strings":["Department of Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu, China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100437684","display_name":"Meng Zhang","orcid":"https://orcid.org/0000-0001-5841-4079"},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meng Zhang","raw_affiliation_strings":["Department of Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu, China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103027624","display_name":"Zhou Jiang","orcid":"https://orcid.org/0000-0002-4776-429X"},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhou Jiang","raw_affiliation_strings":["Department of Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu, China"],"raw_orcid":"https://orcid.org/0000-0002-4776-429X","affiliations":[{"raw_affiliation_string":"Department of Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu, China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059375168","display_name":"Shuiping Huang","orcid":null},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shuiping Huang","raw_affiliation_strings":["Center for Medical Statistics and Data Analysis, Xuzhou Medical University, Xuzhou, Jiangsu, China","Department of Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu, China","Key Laboratory of Human Genetics and Environmental Medicine, Xuzhou Medical University, Xuzhou, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Medical Statistics and Data Analysis, Xuzhou Medical University, Xuzhou, Jiangsu, China","institution_ids":["https://openalex.org/I177388780"]},{"raw_affiliation_string":"Department of Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu, China","institution_ids":["https://openalex.org/I177388780"]},{"raw_affiliation_string":"Key Laboratory of Human Genetics and Environmental Medicine, Xuzhou Medical University, Xuzhou, Jiangsu, China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010438328","display_name":"Ping Zeng","orcid":"https://orcid.org/0000-0003-2710-3440"},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ping Zeng","raw_affiliation_strings":["Center for Medical Statistics and Data Analysis, Xuzhou Medical University, Xuzhou, Jiangsu, China","Department of Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu, China","Key Laboratory of Human Genetics and Environmental Medicine, Xuzhou Medical University, Xuzhou, Jiangsu, China"],"raw_orcid":"https://orcid.org/0000-0003-2710-3440","affiliations":[{"raw_affiliation_string":"Center for Medical Statistics and Data Analysis, Xuzhou Medical University, Xuzhou, Jiangsu, China","institution_ids":["https://openalex.org/I177388780"]},{"raw_affiliation_string":"Department of Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu, China","institution_ids":["https://openalex.org/I177388780"]},{"raw_affiliation_string":"Key Laboratory of Human Genetics and Environmental Medicine, Xuzhou Medical University, Xuzhou, Jiangsu, China","institution_ids":["https://openalex.org/I177388780"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5010438328","https://openalex.org/A5059375168"],"corresponding_institution_ids":["https://openalex.org/I177388780"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.9772,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.74692683,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"17","issue":"8","first_page":"e1009250","last_page":"e1009250"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mediation","display_name":"Mediation","score":0.6622697710990906},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.6550487875938416},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5867348909378052},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4874253571033478},{"id":"https://openalex.org/keywords/methylation","display_name":"Methylation","score":0.46247851848602295},{"id":"https://openalex.org/keywords/cpg-site","display_name":"CpG site","score":0.4451582729816437},{"id":"https://openalex.org/keywords/survival-analysis","display_name":"Survival analysis","score":0.4248139262199402},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.40638887882232666},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.3819851875305176},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.3711889386177063},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3376564383506775},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.327267587184906},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.3269497752189636},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.2786591649055481},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.22643250226974487}],"concepts":[{"id":"https://openalex.org/C179420905","wikidata":"https://www.wikidata.org/wiki/Q223871","display_name":"Mediation","level":2,"score":0.6622697710990906},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6550487875938416},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5867348909378052},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4874253571033478},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.46247851848602295},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.4451582729816437},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.4248139262199402},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.40638887882232666},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3819851875305176},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3711889386177063},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3376564383506775},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.327267587184906},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3269497752189636},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2786591649055481},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22643250226974487},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000081983","descriptor_name":"Mediation Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000081983","descriptor_name":"Mediation Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000081983","descriptor_name":"Mediation Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000081983","descriptor_name":"Mediation Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005821","descriptor_name":"Genetic Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005821","descriptor_name":"Genetic Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005821","descriptor_name":"Genetic Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005821","descriptor_name":"Genetic Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D063990","descriptor_name":"Gene Ontology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063990","descriptor_name":"Gene Ontology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063990","descriptor_name":"Gene Ontology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063990","descriptor_name":"Gene Ontology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1009250","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009250","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:34464378","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34464378","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:3bf421620a1e4c44be8da50c319f7cc1","is_oa":true,"landing_page_url":"https://doaj.org/article/3bf421620a1e4c44be8da50c319f7cc1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 17, Iss 8, p e1009250 (2021)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8437300","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8437300","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1009250","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009250","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6899999976158142,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G1009987021","display_name":null,"funder_award_id":"BK20181472","funder_id":"https://openalex.org/F4320322769","funder_display_name":"Natural Science Foundation of Jiangsu Province"},{"id":"https://openalex.org/G1492908170","display_name":null,"funder_award_id":"2014LY112","funder_id":"https://openalex.org/F4320322769","funder_display_name":"Natural Science Foundation of Jiangsu Province"},{"id":"https://openalex.org/G1677096536","display_name":null,"funder_award_id":"2014LY112","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1845217550","display_name":null,"funder_award_id":"18YJC910002","funder_id":"https://openalex.org/F4320321106","funder_display_name":"Ministry of Education of the People's Republic of China"},{"id":"https://openalex.org/G1895920423","display_name":null,"funder_award_id":"2018M630607","funder_id":"https://openalex.org/F4320311212","funder_display_name":"National Bureau of Statistics of China"},{"id":"https://openalex.org/G2075957598","display_name":null,"funder_award_id":"81402765","funder_id":"https://openalex.org/F4320311212","funder_display_name":"National Bureau of Statistics of China"},{"id":"https://openalex.org/G3592081163","display_name":null,"funder_award_id":"BK20181472","funder_id":"https://openalex.org/F4320321106","funder_display_name":"Ministry of Education of the People's Republic of China"},{"id":"https://openalex.org/G3729922176","display_name":null,"funder_award_id":"81402765","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4430663139","display_name":null,"funder_award_id":"81402765","funder_id":"https://openalex.org/F4320322769","funder_display_name":"Natural Science Foundation of Jiangsu Province"},{"id":"https://openalex.org/G560192598","display_name":null,"funder_award_id":"2018M630607, 2019T120465","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"},{"id":"https://openalex.org/G567964774","display_name":null,"funder_award_id":"BK20181472","funder_id":"https://openalex.org/F4320311212","funder_display_name":"National Bureau of Statistics of China"},{"id":"https://openalex.org/G5816857061","display_name":null,"funder_award_id":"2018M630607","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5845036985","display_name":null,"funder_award_id":"WSN-087","funder_id":"https://openalex.org/F4320327794","funder_display_name":"Qinglan Project of Jiangsu Province of China"},{"id":"https://openalex.org/G6267223338","display_name":null,"funder_award_id":"2018M630607","funder_id":"https://openalex.org/F4320322769","funder_display_name":"Natural Science Foundation of Jiangsu Province"},{"id":"https://openalex.org/G6782915653","display_name":null,"funder_award_id":"TD202008","funder_id":"https://openalex.org/F4320322769","funder_display_name":"Natural Science Foundation of Jiangsu Province"},{"id":"https://openalex.org/G6976118666","display_name":null,"funder_award_id":"BK20181472","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7084516657","display_name":null,"funder_award_id":"2014LY112","funder_id":"https://openalex.org/F4320321106","funder_display_name":"Ministry of Education of the People's Republic of China"},{"id":"https://openalex.org/G7531050838","display_name":null,"funder_award_id":"81402765","funder_id":"https://openalex.org/F4320321106","funder_display_name":"Ministry of Education of the People's Republic of China"},{"id":"https://openalex.org/G7895891260","display_name":null,"funder_award_id":"2014LY112","funder_id":"https://openalex.org/F4320311212","funder_display_name":"National Bureau of Statistics of China"},{"id":"https://openalex.org/G8021595845","display_name":null,"funder_award_id":"2018M630607","funder_id":"https://openalex.org/F4320321106","funder_display_name":"Ministry of Education of the People's Republic of China"},{"id":"https://openalex.org/G8164692623","display_name":null,"funder_award_id":"18YJC910002","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8193475218","display_name":null,"funder_award_id":"18YJC910002","funder_id":"https://openalex.org/F4320322769","funder_display_name":"Natural Science Foundation of Jiangsu Province"},{"id":"https://openalex.org/G8378159790","display_name":null,"funder_award_id":"TD202008","funder_id":"https://openalex.org/F4320327501","funder_display_name":"Xuzhou Medical University"},{"id":"https://openalex.org/G8392474469","display_name":null,"funder_award_id":"18YJC910002","funder_id":"https://openalex.org/F4320311212","funder_display_name":"National Bureau of Statistics of China"},{"id":"https://openalex.org/G839331110","display_name":null,"funder_award_id":"TD202008","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320311212","display_name":"National Bureau of Statistics of China","ror":"https://ror.org/008zm7t63"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321106","display_name":"Ministry of Education of the People's Republic of China","ror":"https://ror.org/01mv9t934"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"},{"id":"https://openalex.org/F4320321605","display_name":"Government of Jiangsu Province","ror":"https://ror.org/004svx814"},{"id":"https://openalex.org/F4320322769","display_name":"Natural Science Foundation of Jiangsu Province","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320327501","display_name":"Xuzhou Medical University","ror":"https://ror.org/04fe7hy80"},{"id":"https://openalex.org/F4320327794","display_name":"Qinglan Project of Jiangsu Province of China","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":153,"referenced_works":["https://openalex.org/W1107917109","https://openalex.org/W1200752817","https://openalex.org/W1496983321","https://openalex.org/W1504303645","https://openalex.org/W1533942137","https://openalex.org/W1535600844","https://openalex.org/W1560239518","https://openalex.org/W1570622790","https://openalex.org/W1574244515","https://openalex.org/W1640894779","https://openalex.org/W1924458325","https://openalex.org/W1929501557","https://openalex.org/W1964712168","https://openalex.org/W1964895626","https://openalex.org/W1966714873","https://openalex.org/W1971383683","https://openalex.org/W1971440513","https://openalex.org/W1973285887","https://openalex.org/W1975528145","https://openalex.org/W1976765441","https://openalex.org/W1976876708","https://openalex.org/W1978335181","https://openalex.org/W1978819645","https://openalex.org/W1982538126","https://openalex.org/W1985420066","https://openalex.org/W1989360964","https://openalex.org/W1990528070","https://openalex.org/W1992980220","https://openalex.org/W1997866877","https://openalex.org/W2001528153","https://openalex.org/W2001820152","https://openalex.org/W2003569144","https://openalex.org/W2006208922","https://openalex.org/W2009660843","https://openalex.org/W2010143351","https://openalex.org/W2025388636","https://openalex.org/W2030678916","https://openalex.org/W2031288274","https://openalex.org/W2033207105","https://openalex.org/W2036982851","https://openalex.org/W2038700261","https://openalex.org/W2038933398","https://openalex.org/W2041953582","https://openalex.org/W2046284411","https://openalex.org/W2046387526","https://openalex.org/W2051001991","https://openalex.org/W2051138734","https://openalex.org/W2054044968","https://openalex.org/W2054523001","https://openalex.org/W2056040742","https://openalex.org/W2056621649","https://openalex.org/W2057138378","https://openalex.org/W2064273032","https://openalex.org/W2065311047","https://openalex.org/W2068463156","https://openalex.org/W2072301590","https://openalex.org/W2081043824","https://openalex.org/W2081769927","https://openalex.org/W2087936498","https://openalex.org/W2090808827","https://openalex.org/W2091001933","https://openalex.org/W2091841926","https://openalex.org/W2093012377","https://openalex.org/W2099343472","https://openalex.org/W2105381419","https://openalex.org/W2113155233","https://openalex.org/W2114584570","https://openalex.org/W2116615980","https://openalex.org/W2118069309","https://openalex.org/W2121500952","https://openalex.org/W2122617678","https://openalex.org/W2125905177","https://openalex.org/W2127230573","https://openalex.org/W2130523009","https://openalex.org/W2134087142","https://openalex.org/W2136916987","https://openalex.org/W2138848739","https://openalex.org/W2139077902","https://openalex.org/W2152656267","https://openalex.org/W2155460954","https://openalex.org/W2155706733","https://openalex.org/W2157367015","https://openalex.org/W2163953557","https://openalex.org/W2164143816","https://openalex.org/W2170546016","https://openalex.org/W2170918883","https://openalex.org/W2171304795","https://openalex.org/W2193561325","https://openalex.org/W2297701691","https://openalex.org/W2300795841","https://openalex.org/W2413008724","https://openalex.org/W2460516726","https://openalex.org/W2474105078","https://openalex.org/W2529024004","https://openalex.org/W2587862832","https://openalex.org/W2595709335","https://openalex.org/W2603566939","https://openalex.org/W2614199773","https://openalex.org/W2618142594","https://openalex.org/W2749874071","https://openalex.org/W2761275051","https://openalex.org/W2766173132","https://openalex.org/W2795164082","https://openalex.org/W2795989238","https://openalex.org/W2796153844","https://openalex.org/W2800839876","https://openalex.org/W2804646658","https://openalex.org/W2883982812","https://openalex.org/W2890965399","https://openalex.org/W2896468934","https://openalex.org/W2896921363","https://openalex.org/W2898317262","https://openalex.org/W2901972846","https://openalex.org/W2913283787","https://openalex.org/W2939805937","https://openalex.org/W2941351579","https://openalex.org/W2944117578","https://openalex.org/W2949748124","https://openalex.org/W2964679279","https://openalex.org/W2970322015","https://openalex.org/W2975325624","https://openalex.org/W2977483297","https://openalex.org/W2986860507","https://openalex.org/W2990439639","https://openalex.org/W2994306405","https://openalex.org/W2995898384","https://openalex.org/W3000247917","https://openalex.org/W3016916364","https://openalex.org/W3024032044","https://openalex.org/W3027286012","https://openalex.org/W3038026221","https://openalex.org/W3039314589","https://openalex.org/W3040877387","https://openalex.org/W3046260387","https://openalex.org/W3080780919","https://openalex.org/W3088375236","https://openalex.org/W3098536600","https://openalex.org/W3103154150","https://openalex.org/W3108283336","https://openalex.org/W3110952580","https://openalex.org/W3121505931","https://openalex.org/W3124408455","https://openalex.org/W3129102191","https://openalex.org/W3129523955","https://openalex.org/W3166723582","https://openalex.org/W3179112797","https://openalex.org/W4212838134","https://openalex.org/W4229766664","https://openalex.org/W4235432393","https://openalex.org/W4243871924","https://openalex.org/W4287938879","https://openalex.org/W4292811746","https://openalex.org/W6780558648"],"related_works":["https://openalex.org/W2902329290","https://openalex.org/W2169344098","https://openalex.org/W2139872319","https://openalex.org/W2052355316","https://openalex.org/W2046964473","https://openalex.org/W2107880877","https://openalex.org/W2151182744","https://openalex.org/W2921336251","https://openalex.org/W2944524138","https://openalex.org/W2024490794"],"abstract_inverted_index":{"Effective":[0],"and":[1,36,87,114,138,158,164],"powerful":[2,139],"survival":[3,38,47,126,142],"mediation":[4,20,49,57,118,143],"models":[5],"are":[6],"currently":[7],"lacking.":[8],"To":[9],"partly":[10],"fill":[11],"such":[12],"knowledge":[13],"gap,":[14],"we":[15,71],"particularly":[16],"focus":[17],"on":[18],"the":[19,34,41,54,73,101,125,152],"analysis":[21],"that":[22,91,98],"includes":[23],"multiple":[24,89],"DNA":[25,120,156],"methylations":[26],"acting":[27],"as":[28,33,40,108],"exposures,":[29],"one":[30,37],"gene":[31,159],"expression":[32,160],"mediator":[35],"time":[39],"outcome.":[42],"We":[43,80,95],"proposed":[44],"IUSMMT":[45,76,82,134],"(intersection-union":[46],"mixture-adjusted":[48],"test)":[50],"to":[51,83,124],"effectively":[52],"examine":[53],"existence":[55],"of":[56,75,100,128,131,155],"effect":[58],"by":[59],"fitting":[60],"an":[61,136],"empirical":[62],"three-component":[63],"mixture":[64],"null":[65],"distribution.":[66],"With":[67],"extensive":[68],"simulation":[69],"studies,":[70],"demonstrated":[72],"advantage":[74],"over":[77],"existing":[78],"methods.":[79],"applied":[81],"ten":[84],"TCGA":[85],"cancers":[86],"identified":[88,102],"genes":[90,106],"exhibited":[92,115],"mediating":[93],"effects.":[94],"further":[96],"revealed":[97],"most":[99],"regions,":[103],"in":[104,161],"which":[105],"behaved":[107],"active":[109],"mediators,":[110],"were":[111],"cancer":[112,162],"type-specific":[113],"a":[116],"full":[117],"from":[119],"methylation":[121,157],"CpG":[122],"sites":[123],"risk":[127],"various":[129],"types":[130],"cancers.":[132],"Overall,":[133],"represents":[135],"effective":[137],"alternative":[140],"for":[141,169],"analysis;":[144],"our":[145],"results":[146],"also":[147],"provide":[148],"new":[149],"insights":[150],"into":[151],"functional":[153],"role":[154],"progression/prognosis":[163],"demonstrate":[165],"potential":[166],"therapeutic":[167],"targets":[168],"future":[170],"clinical":[171],"practice.":[172]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":8}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}