{"id":"https://openalex.org/W3184900817","doi":"https://doi.org/10.1371/journal.pcbi.1009239","title":"Modeling NaV1.1/SCN1A sodium channel mutations in a microcircuit with realistic ion concentration dynamics suggests differential GABAergic mechanisms leading to hyperexcitability in epilepsy and hemiplegic migraine","display_name":"Modeling NaV1.1/SCN1A sodium channel mutations in a microcircuit with realistic ion concentration dynamics suggests differential GABAergic mechanisms leading to hyperexcitability in epilepsy and hemiplegic migraine","publication_year":2021,"publication_date":"2021-07-27","ids":{"openalex":"https://openalex.org/W3184900817","doi":"https://doi.org/10.1371/journal.pcbi.1009239","mag":"3184900817","pmid":"https://pubmed.ncbi.nlm.nih.gov/34314446"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1009239","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009239","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009239&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009239&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021766849","display_name":"Louisiane Lemaire","orcid":"https://orcid.org/0000-0002-9260-2521"},"institutions":[{"id":"https://openalex.org/I201841394","display_name":"Universit\u00e9 C\u00f4te d'Azur","ror":"https://ror.org/019tgvf94","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394"]},{"id":"https://openalex.org/I4210106545","display_name":"Centre Inria d'Universit\u00e9 C\u00f4te d'Azur","ror":"https://ror.org/01nzkaw91","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1326498283","https://openalex.org/I201841394","https://openalex.org/I4210106545"]},{"id":"https://openalex.org/I4210126779","display_name":"Observatoire de la C\u00f4te d\u2019Azur","ror":"https://ror.org/039fj2469","country_code":"FR","type":"facility","lineage":["https://openalex.org/I201841394","https://openalex.org/I4210126779"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Louisiane Lemaire","raw_affiliation_strings":["Inria Sophia Antipolis M\u00e9diterran\u00e9e Research Centre, MathNeuro Team, Valbonne-Sophia Antipolis, France","Universit\u00e9 C\u00f4te d'Azur, Nice, France"],"raw_orcid":"https://orcid.org/0000-0002-9260-2521","affiliations":[{"raw_affiliation_string":"Inria Sophia Antipolis M\u00e9diterran\u00e9e Research Centre, MathNeuro Team, Valbonne-Sophia Antipolis, France","institution_ids":["https://openalex.org/I4210106545"]},{"raw_affiliation_string":"Universit\u00e9 C\u00f4te d'Azur, Nice, France","institution_ids":["https://openalex.org/I4210126779","https://openalex.org/I201841394"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077245992","display_name":"Mathieu Desroches","orcid":"https://orcid.org/0000-0002-9325-4207"},"institutions":[{"id":"https://openalex.org/I201841394","display_name":"Universit\u00e9 C\u00f4te d'Azur","ror":"https://ror.org/019tgvf94","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394"]},{"id":"https://openalex.org/I4210106545","display_name":"Centre Inria d'Universit\u00e9 C\u00f4te d'Azur","ror":"https://ror.org/01nzkaw91","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1326498283","https://openalex.org/I201841394","https://openalex.org/I4210106545"]},{"id":"https://openalex.org/I4210126779","display_name":"Observatoire de la C\u00f4te d\u2019Azur","ror":"https://ror.org/039fj2469","country_code":"FR","type":"facility","lineage":["https://openalex.org/I201841394","https://openalex.org/I4210126779"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mathieu Desroches","raw_affiliation_strings":["Inria Sophia Antipolis M\u00e9diterran\u00e9e Research Centre, MathNeuro Team, Valbonne-Sophia Antipolis, France","Universit\u00e9 C\u00f4te d'Azur, Nice, France"],"raw_orcid":"https://orcid.org/0000-0002-9325-4207","affiliations":[{"raw_affiliation_string":"Inria Sophia Antipolis M\u00e9diterran\u00e9e Research Centre, MathNeuro Team, Valbonne-Sophia Antipolis, France","institution_ids":["https://openalex.org/I4210106545"]},{"raw_affiliation_string":"Universit\u00e9 C\u00f4te d'Azur, Nice, France","institution_ids":["https://openalex.org/I4210126779","https://openalex.org/I201841394"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016275776","display_name":"Martin Krupa","orcid":"https://orcid.org/0000-0001-9330-4705"},"institutions":[{"id":"https://openalex.org/I201841394","display_name":"Universit\u00e9 C\u00f4te d'Azur","ror":"https://ror.org/019tgvf94","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394"]},{"id":"https://openalex.org/I4210106545","display_name":"Centre Inria d'Universit\u00e9 C\u00f4te d'Azur","ror":"https://ror.org/01nzkaw91","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1326498283","https://openalex.org/I201841394","https://openalex.org/I4210106545"]},{"id":"https://openalex.org/I4210112930","display_name":"Laboratoire Jean-Alexandre Dieudonn\u00e9","ror":"https://ror.org/0274zdr66","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I201841394","https://openalex.org/I4210112930","https://openalex.org/I4210141950"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Martin Krupa","raw_affiliation_strings":["Inria Sophia Antipolis M\u00e9diterran\u00e9e Research Centre, MathNeuro Team, Valbonne-Sophia Antipolis, France","Universit\u00e9 C\u00f4te d'Azur, Laboratoire Jean-Alexandre Dieudonn\u00e9, Nice, France"],"raw_orcid":"https://orcid.org/0000-0001-9330-4705","affiliations":[{"raw_affiliation_string":"Inria Sophia Antipolis M\u00e9diterran\u00e9e Research Centre, MathNeuro Team, Valbonne-Sophia Antipolis, France","institution_ids":["https://openalex.org/I4210106545"]},{"raw_affiliation_string":"Universit\u00e9 C\u00f4te d'Azur, Laboratoire Jean-Alexandre Dieudonn\u00e9, Nice, France","institution_ids":["https://openalex.org/I4210112930","https://openalex.org/I201841394"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036572967","display_name":"Lara Pizzamiglio","orcid":"https://orcid.org/0000-0003-4723-8510"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I201841394","display_name":"Universit\u00e9 C\u00f4te d'Azur","ror":"https://ror.org/019tgvf94","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394"]},{"id":"https://openalex.org/I4210160500","display_name":"Institut de Pharmacologie Mol\u00e9culaire et Cellulaire","ror":"https://ror.org/05k4ema52","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I201841394","https://openalex.org/I4210096427","https://openalex.org/I4210160500"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Lara Pizzamiglio","raw_affiliation_strings":["CNRS UMR7275, Institute of Molecular and Cellular Pharmacology (IPMC), Valbonne-Sophia Antipolis, France","Universit\u00e9 C\u00f4te d'Azur, Institute of Molecular and Cellular Pharmacology (IPMC), Valbonne-Sophia Antipolis, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS UMR7275, Institute of Molecular and Cellular Pharmacology (IPMC), Valbonne-Sophia Antipolis, France","institution_ids":["https://openalex.org/I4210160500","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Universit\u00e9 C\u00f4te d'Azur, Institute of Molecular and Cellular Pharmacology (IPMC), Valbonne-Sophia Antipolis, France","institution_ids":["https://openalex.org/I4210160500","https://openalex.org/I201841394"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027657686","display_name":"Paolo Scalmani","orcid":"https://orcid.org/0000-0002-3992-0926"},"institutions":[{"id":"https://openalex.org/I4210164485","display_name":"Fondazione IRCCS Istituto Neurologico Carlo Besta","ror":"https://ror.org/05rbx8m02","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210164485"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paolo Scalmani","raw_affiliation_strings":["U.O. VII Clinical and Experimental Epileptology, Foundation IRCCS Neurological Institute Carlo Besta, Milan, Italy"],"raw_orcid":"https://orcid.org/0000-0002-3992-0926","affiliations":[{"raw_affiliation_string":"U.O. VII Clinical and Experimental Epileptology, Foundation IRCCS Neurological Institute Carlo Besta, Milan, Italy","institution_ids":["https://openalex.org/I4210164485"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047472731","display_name":"Massimo Mantegazza","orcid":"https://orcid.org/0000-0002-1070-7929"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I201841394","display_name":"Universit\u00e9 C\u00f4te d'Azur","ror":"https://ror.org/019tgvf94","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394"]},{"id":"https://openalex.org/I4210160500","display_name":"Institut de Pharmacologie Mol\u00e9culaire et Cellulaire","ror":"https://ror.org/05k4ema52","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I201841394","https://openalex.org/I4210096427","https://openalex.org/I4210160500"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Massimo Mantegazza","raw_affiliation_strings":["CNRS UMR7275, Institute of Molecular and Cellular Pharmacology (IPMC), Valbonne-Sophia Antipolis, France","Inserm, Valbonne-Sophia Antipolis, France","Universit\u00e9 C\u00f4te d'Azur, Institute of Molecular and Cellular Pharmacology (IPMC), Valbonne-Sophia Antipolis, France"],"raw_orcid":"https://orcid.org/0000-0002-1070-7929","affiliations":[{"raw_affiliation_string":"CNRS UMR7275, Institute of Molecular and Cellular Pharmacology (IPMC), Valbonne-Sophia Antipolis, France","institution_ids":["https://openalex.org/I4210160500","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Inserm, Valbonne-Sophia Antipolis, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Universit\u00e9 C\u00f4te d'Azur, Institute of Molecular and Cellular Pharmacology (IPMC), Valbonne-Sophia Antipolis, France","institution_ids":["https://openalex.org/I4210160500","https://openalex.org/I201841394"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5021766849","https://openalex.org/A5047472731"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I201841394","https://openalex.org/I4210106545","https://openalex.org/I4210126779","https://openalex.org/I4210160500"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2191,"currency":"EUR","value_usd":2362},"fwci":3.8949,"has_fulltext":true,"cited_by_count":49,"citation_normalized_percentile":{"value":0.94445533,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"17","issue":"7","first_page":"e1009239","last_page":"e1009239"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sodium-channel","display_name":"Sodium channel","score":0.7364354133605957},{"id":"https://openalex.org/keywords/depolarization","display_name":"Depolarization","score":0.7281374335289001},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.7022555470466614},{"id":"https://openalex.org/keywords/gabaergic","display_name":"GABAergic","score":0.6843843460083008},{"id":"https://openalex.org/keywords/epilepsy","display_name":"Epilepsy","score":0.6332405805587769},{"id":"https://openalex.org/keywords/familial-hemiplegic-migraine","display_name":"Familial hemiplegic migraine","score":0.622498095035553},{"id":"https://openalex.org/keywords/interneuron","display_name":"Interneuron","score":0.47255605459213257},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.45020735263824463},{"id":"https://openalex.org/keywords/potassium-channel","display_name":"Potassium channel","score":0.44757041335105896},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.40961259603500366},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2897469997406006},{"id":"https://openalex.org/keywords/sodium","display_name":"Sodium","score":0.17223626375198364},{"id":"https://openalex.org/keywords/migraine-with-aura","display_name":"Migraine with aura","score":0.1488470733165741},{"id":"https://openalex.org/keywords/migraine","display_name":"Migraine","score":0.14493206143379211},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.1429067850112915},{"id":"https://openalex.org/keywords/inhibitory-postsynaptic-potential","display_name":"Inhibitory postsynaptic potential","score":0.1374591886997223},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.11126750707626343}],"concepts":[{"id":"https://openalex.org/C50952357","wikidata":"https://www.wikidata.org/wiki/Q424960","display_name":"Sodium channel","level":3,"score":0.7364354133605957},{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.7281374335289001},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7022555470466614},{"id":"https://openalex.org/C2779177108","wikidata":"https://www.wikidata.org/wiki/Q18356742","display_name":"GABAergic","level":3,"score":0.6843843460083008},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.6332405805587769},{"id":"https://openalex.org/C2778042195","wikidata":"https://www.wikidata.org/wiki/Q3312899","display_name":"Familial hemiplegic migraine","level":5,"score":0.622498095035553},{"id":"https://openalex.org/C2779296341","wikidata":"https://www.wikidata.org/wiki/Q1500732","display_name":"Interneuron","level":3,"score":0.47255605459213257},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45020735263824463},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.44757041335105896},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.40961259603500366},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2897469997406006},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.17223626375198364},{"id":"https://openalex.org/C2776497919","wikidata":"https://www.wikidata.org/wiki/Q739481","display_name":"Migraine with aura","level":4,"score":0.1488470733165741},{"id":"https://openalex.org/C2778541695","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Migraine","level":2,"score":0.14493206143379211},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1429067850112915},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.1374591886997223},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11126750707626343},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2777350023","wikidata":"https://www.wikidata.org/wiki/Q1154226","display_name":"Aura","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000073658","descriptor_name":"Loss of Function Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000073658","descriptor_name":"Loss of Function Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000073658","descriptor_name":"Loss of Function Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000073659","descriptor_name":"Gain of Function Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000073659","descriptor_name":"Gain of Function Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000073659","descriptor_name":"Gain of Function Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007395","descriptor_name":"Interneurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007395","descriptor_name":"Interneurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007395","descriptor_name":"Interneurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013003","descriptor_name":"Somatosensory Cortex","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013003","descriptor_name":"Somatosensory Cortex","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013003","descriptor_name":"Somatosensory Cortex","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013181","descriptor_name":"Cortical Spreading Depression","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013181","descriptor_name":"Cortical Spreading Depression","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013181","descriptor_name":"Cortical Spreading Depression","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055641","descriptor_name":"Mathematical Concepts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055641","descriptor_name":"Mathematical Concepts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055641","descriptor_name":"Mathematical Concepts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059330","descriptor_name":"GABAergic Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D059330","descriptor_name":"GABAergic Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D059330","descriptor_name":"GABAergic Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D062547","descriptor_name":"Voltage-Gated Sodium Channel beta-1 Subunit","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D062547","descriptor_name":"Voltage-Gated Sodium Channel beta-1 Subunit","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D062547","descriptor_name":"Voltage-Gated Sodium Channel beta-1 Subunit","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D062547","descriptor_name":"Voltage-Gated Sodium Channel beta-1 Subunit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D062547","descriptor_name":"Voltage-Gated Sodium Channel beta-1 Subunit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D062547","descriptor_name":"Voltage-Gated Sodium Channel beta-1 Subunit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D062547","descriptor_name":"Voltage-Gated Sodium Channel beta-1 Subunit","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D062547","descriptor_name":"Voltage-Gated Sodium Channel beta-1 Subunit","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D062547","descriptor_name":"Voltage-Gated Sodium Channel beta-1 Subunit","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D062550","descriptor_name":"NAV1.1 Voltage-Gated Sodium Channel","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D062550","descriptor_name":"NAV1.1 Voltage-Gated Sodium Channel","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D062550","descriptor_name":"NAV1.1 Voltage-Gated Sodium Channel","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D062550","descriptor_name":"NAV1.1 Voltage-Gated Sodium Channel","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D062550","descriptor_name":"NAV1.1 Voltage-Gated Sodium Channel","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D062550","descriptor_name":"NAV1.1 Voltage-Gated Sodium Channel","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D062550","descriptor_name":"NAV1.1 Voltage-Gated Sodium Channel","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D062550","descriptor_name":"NAV1.1 Voltage-Gated Sodium Channel","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D062550","descriptor_name":"NAV1.1 Voltage-Gated Sodium Channel","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1009239","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009239","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009239&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:34314446","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34314446","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:HAL:hal-03191275v2","is_oa":true,"landing_page_url":"https://inria.hal.science/hal-03191275","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, 2021, 17 (7), pp.e1009239. ⟨10.1371/journal.pcbi.1009239⟩","raw_type":"Journal articles"},{"id":"pmh:oai:doaj.org/article:b538d9200f734f90a078c46f6bac4bb7","is_oa":true,"landing_page_url":"https://doaj.org/article/b538d9200f734f90a078c46f6bac4bb7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 17, Iss 7, p e1009239 (2021)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8345895","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8345895","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1009239","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009239","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009239&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.46000000834465027,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G1627634760","display_name":null,"funder_award_id":"ANR-11-LABX-0015-01","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G2689869783","display_name":"Idex UCA JEDI","funder_award_id":"ANR-15-IDEX-0001","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G3549817427","display_name":"Canaux ioniques d'int\u00e9r\u00eat th\u00e9rapeutique","funder_award_id":"ANR-11-LABX-0015","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G5348977864","display_name":null,"funder_award_id":"ANR-15-IDEX-01","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G8800819381","display_name":null,"funder_award_id":"-15-IDEX-01","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3184900817.pdf","grobid_xml":"https://content.openalex.org/works/W3184900817.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W578891880","https://openalex.org/W1500569882","https://openalex.org/W1501360999","https://openalex.org/W1576838367","https://openalex.org/W1590117132","https://openalex.org/W1820068830","https://openalex.org/W1836848727","https://openalex.org/W1841463848","https://openalex.org/W1963788090","https://openalex.org/W1964533239","https://openalex.org/W1973004621","https://openalex.org/W1980176764","https://openalex.org/W1984390450","https://openalex.org/W1988507461","https://openalex.org/W1990394276","https://openalex.org/W1998998851","https://openalex.org/W2001216459","https://openalex.org/W2003102260","https://openalex.org/W2031637767","https://openalex.org/W2039304943","https://openalex.org/W2055448024","https://openalex.org/W2056326370","https://openalex.org/W2062958718","https://openalex.org/W2063829584","https://openalex.org/W2064108635","https://openalex.org/W2066048083","https://openalex.org/W2069107563","https://openalex.org/W2072231967","https://openalex.org/W2075183260","https://openalex.org/W2082047564","https://openalex.org/W2085957678","https://openalex.org/W2088553721","https://openalex.org/W2093998927","https://openalex.org/W2096181241","https://openalex.org/W2105003565","https://openalex.org/W2105423985","https://openalex.org/W2106495485","https://openalex.org/W2114962415","https://openalex.org/W2122708962","https://openalex.org/W2128519053","https://openalex.org/W2129032286","https://openalex.org/W2131797361","https://openalex.org/W2133100820","https://openalex.org/W2133125918","https://openalex.org/W2144759791","https://openalex.org/W2149405816","https://openalex.org/W2154423365","https://openalex.org/W2157702138","https://openalex.org/W2167970717","https://openalex.org/W2416630006","https://openalex.org/W2430451014","https://openalex.org/W2471954838","https://openalex.org/W2481556052","https://openalex.org/W2503929286","https://openalex.org/W2520514017","https://openalex.org/W2613761605","https://openalex.org/W2615262201","https://openalex.org/W2767441342","https://openalex.org/W2807765515","https://openalex.org/W2851508674","https://openalex.org/W2885328146","https://openalex.org/W2887582341","https://openalex.org/W2919532134","https://openalex.org/W2936800100","https://openalex.org/W2952995021","https://openalex.org/W2985579279","https://openalex.org/W2992454104","https://openalex.org/W2998729088","https://openalex.org/W2999332292","https://openalex.org/W3000439708","https://openalex.org/W3009404535","https://openalex.org/W3011685602","https://openalex.org/W3137528429","https://openalex.org/W4232066994","https://openalex.org/W4235527302","https://openalex.org/W4287555321"],"related_works":["https://openalex.org/W2099952757","https://openalex.org/W139322991","https://openalex.org/W2911633778","https://openalex.org/W3022974827","https://openalex.org/W2890527931","https://openalex.org/W1987707352","https://openalex.org/W2899704640","https://openalex.org/W3178230853","https://openalex.org/W3143021766","https://openalex.org/W4289541880"],"abstract_inverted_index":{"Loss":[0,194],"of":[1,4,18,22,56,74,84,147,149,166,175,191,195,213,231,238,245,264,278,291],"function":[2,23,150,196],"mutations":[3,24,104,116,132,152,233],"SCN1A,":[5],"the":[6,10,72,107,112,119,123,134,144,163,172,178,200,229,239,243,259,266,269,289,297],"gene":[7],"coding":[8],"for":[9,281],"voltage-gated":[11,167],"sodium":[12,109,120],"channel":[13],"NaV1.1,":[14],"cause":[15,25],"different":[16,276],"types":[17],"epilepsy,":[19],"whereas":[20],"gain":[21,148,174],"sporadic":[26],"and":[27,87,114,130,177,234,268,283],"familial":[28],"hemiplegic":[29],"migraine":[30,60,260,282],"type":[31],"3":[32],"(FHM-3).":[33],"However,":[34],"it":[35],"is":[36,153,185],"not":[37,186,295],"clear":[38],"yet":[39],"how":[40],"these":[41,75,249],"opposite":[42],"effects":[43,250],"can":[44,251],"induce":[45],"paroxysmal":[46],"pathological":[47,76,300],"activities":[48],"involving":[49],"neuronal":[50],"networks'":[51],"hyperexcitability":[52,280],"that":[53,288],"are":[54],"specific":[55],"epilepsy":[57],"(seizures)":[58],"or":[59],"(cortical":[61],"spreading":[62],"depolarization,":[63],"CSD).":[64],"To":[65],"better":[66],"understand":[67],"differential":[68],"mechanisms":[69,277],"leading":[70],"to":[71,207,223,253],"initiation":[73],"activities,":[77],"we":[78,93,126],"used":[79],"a":[80],"two-neuron":[81],"conductance-based":[82],"model":[83],"interconnected":[85],"GABAergic":[86,204,240,267],"pyramidal":[88,254,270],"glutamatergic":[89],"neurons,":[90],"in":[91,98,111,122,228,242,258],"which":[92,184],"incorporated":[94],"ionic":[95],"concentration":[96],"dynamics":[97],"both":[99,128,265],"neurons.":[100],"We":[101],"modeled":[102],"FHM-3":[103,129,151,232],"by":[105,117,171,189],"increasing":[106],"persistent":[108],"current":[110],"interneuron":[113],"epileptogenic":[115,131,197,246,284],"decreasing":[118],"conductance":[121],"interneuron.":[124],"Therefore,":[125],"studied":[127],"within":[133],"same":[135],"framework,":[136],"modifying":[137],"only":[138,188,298],"two":[139],"parameters.":[140],"In":[141],"our":[142,273],"model,":[143],"key":[145],"effect":[146],"ion":[154],"fluxes":[155],"modification":[156],"at":[157],"each":[158],"action":[159],"potential":[160],"(in":[161],"particular":[162],"larger":[164],"activation":[165],"potassium":[168,182,226],"channels":[169],"induced":[170],"NaV1.1":[173,285],"function),":[176],"resulting":[179],"CSD-triggering":[180],"extracellular":[181],"accumulation,":[183],"caused":[187],"modifications":[190,212,290],"firing":[192,214,292],"frequency.":[193],"mutations,":[198,286],"on":[199],"other":[201],"hand,":[202],"increase":[203],"neurons'":[205],"susceptibility":[206],"depolarization":[208,236,262],"block,":[209],"without":[210],"major":[211],"frequency":[215,293],"before":[216],"it.":[217],"Our":[218],"modeling":[219],"results":[220],"connect":[221],"qualitatively":[222],"experimental":[224],"data:":[225],"accumulation":[227],"case":[230,244],"facilitated":[235],"block":[237,263],"neuron":[241,255],"mutations.":[247],"Both":[248],"lead":[252],"hyperexcitability,":[256],"inducing":[257],"condition":[261],"neuron.":[271],"Overall,":[272],"findings":[274],"suggest":[275],"network":[279],"implying":[287],"may":[294],"be":[296],"relevant":[299],"mechanism.":[301]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":2}],"updated_date":"2026-06-22T08:00:12.763002","created_date":"2025-10-10T00:00:00"}