{"id":"https://openalex.org/W3183732732","doi":"https://doi.org/10.1371/journal.pcbi.1009235","title":"Theta-gamma coupling emerges from spatially heterogeneous cholinergic neuromodulation","display_name":"Theta-gamma coupling emerges from spatially heterogeneous cholinergic neuromodulation","publication_year":2021,"publication_date":"2021-07-30","ids":{"openalex":"https://openalex.org/W3183732732","doi":"https://doi.org/10.1371/journal.pcbi.1009235","mag":"3183732732","pmid":"https://pubmed.ncbi.nlm.nih.gov/34329297"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1009235","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009235","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009235&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009235&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000845071","display_name":"Yihao Yang","orcid":"https://orcid.org/0000-0002-9229-0054"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210111179","display_name":"Michigan United","ror":"https://ror.org/0291ys696","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210111179"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yihao Yang","raw_affiliation_strings":["Department of Physics, University of Michigan, Ann Arbor, Michigan, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, University of Michigan, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210111179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052843707","display_name":"Howard J. Gritton","orcid":"https://orcid.org/0000-0003-3194-3258"},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard Gritton","raw_affiliation_strings":["Department of Comparative Biosciences and Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-3194-3258","affiliations":[{"raw_affiliation_string":"Department of Comparative Biosciences and Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013793527","display_name":"Martin Sarter","orcid":"https://orcid.org/0000-0003-0441-9936"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210111179","display_name":"Michigan United","ror":"https://ror.org/0291ys696","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210111179"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin Sarter","raw_affiliation_strings":["Department of Psychology and Neuroscience Program, University of Michigan, Ann Arbor, Michigan, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology and Neuroscience Program, University of Michigan, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210111179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061970781","display_name":"Sara J. Aton","orcid":"https://orcid.org/0000-0002-2921-0509"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210111179","display_name":"Michigan United","ror":"https://ror.org/0291ys696","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210111179"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara J. Aton","raw_affiliation_strings":["Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-2921-0509","affiliations":[{"raw_affiliation_string":"Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210111179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000878033","display_name":"Victoria Booth","orcid":"https://orcid.org/0000-0003-2586-8001"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210111179","display_name":"Michigan United","ror":"https://ror.org/0291ys696","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210111179"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Victoria Booth","raw_affiliation_strings":["Departments of Mathematics and Anesthesiology, University of Michigan, Ann Arbor, Michigan, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-2586-8001","affiliations":[{"raw_affiliation_string":"Departments of Mathematics and Anesthesiology, University of Michigan, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210111179"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009654819","display_name":"Micha\u0142 \u017bochowski","orcid":"https://orcid.org/0000-0002-1722-986X"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210111179","display_name":"Michigan United","ror":"https://ror.org/0291ys696","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210111179"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michal Zochowski","raw_affiliation_strings":["Department of Physics and Biophysics Program, University of Michigan, Ann Arbor, Michigan, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-1722-986X","affiliations":[{"raw_affiliation_string":"Department of Physics and Biophysics Program, University of Michigan, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210111179"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5000878033","https://openalex.org/A5009654819"],"corresponding_institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210111179"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.987,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.86099351,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"17","issue":"7","first_page":"e1009235","last_page":"e1009235"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.8223527669906616},{"id":"https://openalex.org/keywords/neuromodulation","display_name":"Neuromodulation","score":0.6958326101303101},{"id":"https://openalex.org/keywords/excitatory-postsynaptic-potential","display_name":"Excitatory postsynaptic potential","score":0.6893558502197266},{"id":"https://openalex.org/keywords/cholinergic","display_name":"Cholinergic","score":0.633931577205658},{"id":"https://openalex.org/keywords/inhibitory-postsynaptic-potential","display_name":"Inhibitory postsynaptic potential","score":0.6130130290985107},{"id":"https://openalex.org/keywords/acetylcholine","display_name":"Acetylcholine","score":0.5792019367218018},{"id":"https://openalex.org/keywords/coupling","display_name":"Coupling (piping)","score":0.5203577876091003},{"id":"https://openalex.org/keywords/forebrain","display_name":"Forebrain","score":0.43825453519821167},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.41651201248168945},{"id":"https://openalex.org/keywords/stimulation","display_name":"Stimulation","score":0.4145326614379883},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3732491731643677},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"Central nervous system","score":0.1293029487133026}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.8223527669906616},{"id":"https://openalex.org/C2780375056","wikidata":"https://www.wikidata.org/wiki/Q905905","display_name":"Neuromodulation","level":3,"score":0.6958326101303101},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.6893558502197266},{"id":"https://openalex.org/C22885893","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic","level":2,"score":0.633931577205658},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.6130130290985107},{"id":"https://openalex.org/C2775910092","wikidata":"https://www.wikidata.org/wiki/Q180623","display_name":"Acetylcholine","level":2,"score":0.5792019367218018},{"id":"https://openalex.org/C131584629","wikidata":"https://www.wikidata.org/wiki/Q4308705","display_name":"Coupling (piping)","level":2,"score":0.5203577876091003},{"id":"https://openalex.org/C2779715522","wikidata":"https://www.wikidata.org/wiki/Q507027","display_name":"Forebrain","level":3,"score":0.43825453519821167},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.41651201248168945},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.4145326614379883},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3732491731643677},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.1293029487133026},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007858","descriptor_name":"Learning","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007858","descriptor_name":"Learning","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007858","descriptor_name":"Learning","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007858","descriptor_name":"Learning","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007858","descriptor_name":"Learning","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007858","descriptor_name":"Learning","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011950","descriptor_name":"Receptors, Cholinergic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011950","descriptor_name":"Receptors, Cholinergic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011950","descriptor_name":"Receptors, Cholinergic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011950","descriptor_name":"Receptors, Cholinergic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011950","descriptor_name":"Receptors, Cholinergic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011950","descriptor_name":"Receptors, Cholinergic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013826","descriptor_name":"Theta Rhythm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013826","descriptor_name":"Theta Rhythm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013826","descriptor_name":"Theta Rhythm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013826","descriptor_name":"Theta Rhythm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013826","descriptor_name":"Theta Rhythm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013826","descriptor_name":"Theta Rhythm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016548","descriptor_name":"Prosencephalon","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016548","descriptor_name":"Prosencephalon","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016548","descriptor_name":"Prosencephalon","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016548","descriptor_name":"Prosencephalon","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016548","descriptor_name":"Prosencephalon","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016548","descriptor_name":"Prosencephalon","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018678","descriptor_name":"Cholinergic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018678","descriptor_name":"Cholinergic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018678","descriptor_name":"Cholinergic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059329","descriptor_name":"Cholinergic Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059329","descriptor_name":"Cholinergic Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059329","descriptor_name":"Cholinergic Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059329","descriptor_name":"Cholinergic Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D059329","descriptor_name":"Cholinergic Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D059329","descriptor_name":"Cholinergic Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D065818","descriptor_name":"Gamma Rhythm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D065818","descriptor_name":"Gamma Rhythm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D065818","descriptor_name":"Gamma Rhythm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D065818","descriptor_name":"Gamma Rhythm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D065818","descriptor_name":"Gamma Rhythm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D065818","descriptor_name":"Gamma Rhythm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1009235","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009235","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009235&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:34329297","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34329297","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:8357148","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8357148","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:4234b9b80a7c465081980f2e87aacbd7","is_oa":true,"landing_page_url":"https://doaj.org/article/4234b9b80a7c465081980f2e87aacbd7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 17, Iss 7, p e1009235 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1009235","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009235","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009235&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.49000000953674316,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G198739881","display_name":"EAGER: Identifying network dynamics promoting memory consolidation during sleep","funder_award_id":"1749430","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G2452623952","display_name":null,"funder_award_id":"R01NS118440","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G2457059051","display_name":null,"funder_award_id":"P50NS123067","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G2461801747","display_name":null,"funder_award_id":"PO50NS091856","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G330719072","display_name":null,"funder_award_id":"P50NS091856","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3549444432","display_name":null,"funder_award_id":"RF1 NS118440","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3644146415","display_name":null,"funder_award_id":"DP2 MH104119","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G4099333414","display_name":null,"funder_award_id":"R01 NS 104776","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4225804950","display_name":null,"funder_award_id":"T32-HD007109","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G4339186819","display_name":null,"funder_award_id":"R01 EB018297","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G4749096249","display_name":null,"funder_award_id":"R01DA045063","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3183732732.pdf","grobid_xml":"https://content.openalex.org/works/W3183732732.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W37795517","https://openalex.org/W121915106","https://openalex.org/W1500840952","https://openalex.org/W1519137707","https://openalex.org/W1856463674","https://openalex.org/W1972854589","https://openalex.org/W1975221291","https://openalex.org/W1976437022","https://openalex.org/W1977177901","https://openalex.org/W1978389345","https://openalex.org/W1982695759","https://openalex.org/W1998240840","https://openalex.org/W2019159182","https://openalex.org/W2020832630","https://openalex.org/W2029374903","https://openalex.org/W2031131997","https://openalex.org/W2034596982","https://openalex.org/W2043101183","https://openalex.org/W2046700922","https://openalex.org/W2056336718","https://openalex.org/W2057397555","https://openalex.org/W2067463771","https://openalex.org/W2073248815","https://openalex.org/W2078304769","https://openalex.org/W2080019475","https://openalex.org/W2086053557","https://openalex.org/W2089178801","https://openalex.org/W2089473508","https://openalex.org/W2090265061","https://openalex.org/W2099457853","https://openalex.org/W2101060374","https://openalex.org/W2101491694","https://openalex.org/W2101636354","https://openalex.org/W2108393070","https://openalex.org/W2108662618","https://openalex.org/W2110802967","https://openalex.org/W2112575160","https://openalex.org/W2114802515","https://openalex.org/W2118615399","https://openalex.org/W2121895272","https://openalex.org/W2125737923","https://openalex.org/W2126879375","https://openalex.org/W2129452432","https://openalex.org/W2133125918","https://openalex.org/W2153492891","https://openalex.org/W2153647051","https://openalex.org/W2162870648","https://openalex.org/W2167792419","https://openalex.org/W2170814877","https://openalex.org/W2171523413","https://openalex.org/W2283703766","https://openalex.org/W2337039197","https://openalex.org/W2588195201","https://openalex.org/W2588278731","https://openalex.org/W2777639606","https://openalex.org/W2791552377","https://openalex.org/W2878370351","https://openalex.org/W2888363576","https://openalex.org/W2894963129","https://openalex.org/W2925616628","https://openalex.org/W2982191444","https://openalex.org/W3002595038","https://openalex.org/W3015834540","https://openalex.org/W3090462036"],"related_works":["https://openalex.org/W327925360","https://openalex.org/W2406564231","https://openalex.org/W4400956346","https://openalex.org/W2318544508","https://openalex.org/W147820899","https://openalex.org/W2416561763","https://openalex.org/W2419003037","https://openalex.org/W2284904446","https://openalex.org/W4206532927","https://openalex.org/W21362761"],"abstract_inverted_index":{"Theta":[0],"and":[1,4,15,44,57,106],"gamma":[2,71,146],"rhythms":[3],"their":[5],"cross-frequency":[6],"coupling":[7],"play":[8],"critical":[9],"roles":[10],"in":[11,47,117,172],"perception,":[12],"attention,":[13],"learning,":[14],"memory.":[16],"Available":[17],"data":[18],"suggest":[19],"that":[20,38,63,112],"forebrain":[21],"acetylcholine":[22],"(ACh)":[23],"signaling":[24,40,171,190],"promotes":[25],"theta-gamma":[26,136,177],"coupling,":[27],"although":[28],"the":[29,50,82,91,140,160,173,192],"mechanism":[30],"has":[31],"not":[32],"been":[33],"identified.":[34],"Recent":[35],"evidence":[36],"suggests":[37],"cholinergic":[39,66],"is":[41],"both":[42],"temporally":[43],"spatially":[45,55,64,168],"constrained,":[46],"contrast":[48],"to":[49,162],"traditional":[51],"notion":[52],"of":[53,84,93,142,175,197],"slow,":[54],"homogeneous,":[56],"diffuse":[58],"neuromodulation.":[59],"Here,":[60],"we":[61,80,110],"find":[62],"constrained":[65],"stimulation":[67],"can":[68],"generate":[69],"theta-modulated":[70],"rhythms.":[72],"Using":[73],"biophysically-based":[74],"excitatory-inhibitory":[75],"(E-I)":[76],"neural":[77,87],"network":[78,120],"models,":[79],"simulate":[81],"effects":[83],"ACh":[85,118,130,170,189],"on":[86],"excitability":[88],"by":[89,187],"varying":[90],"conductance":[92],"a":[94,164],"muscarinic":[95],"receptor-regulated":[96],"K+":[97],"current.":[98],"In":[99],"E-I":[100],"networks":[101],"with":[102,128],"local":[103],"excitatory":[104],"connectivity":[105],"global":[107],"inhibitory":[108],"connectivity,":[109],"demonstrate":[111],"theta-gamma-coupled":[113],"firing":[114,124],"patterns":[115],"emerge":[116],"modulated":[119],"regions.":[121,144],"Stable":[122],"gamma-modulated":[123],"arises":[125],"within":[126],"regions":[127],"high":[129],"signaling,":[131],"while":[132],"theta":[133,155],"or":[134],"mixed":[135],"activity":[137,147],"occurs":[138],"at":[139,154],"peripheries":[141],"these":[143],"High":[145],"also":[148,181],"alternates":[149],"between":[150],"different":[151],"high-ACh":[152],"regions,":[153],"frequency.":[156],"Our":[157,179],"results":[158],"are":[159],"first":[161],"indicate":[163],"causal":[165],"role":[166],"for":[167],"heterogenous":[169],"emergence":[174],"localized":[176],"rhythmicity.":[178],"findings":[180],"provide":[182],"novel":[183],"insights":[184],"into":[185],"mechanisms":[186],"which":[188],"supports":[191],"brain":[193],"region-specific":[194],"attentional":[195],"processing":[196],"sensory":[198],"information.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":2}],"updated_date":"2026-08-12T21:12:35.861297","created_date":"2025-10-10T00:00:00"}
