{"id":"https://openalex.org/W3189222101","doi":"https://doi.org/10.1371/journal.pcbi.1009233","title":"A computational method for identifying an optimal combination of existing drugs to repair the action potentials of SQT1 ventricular myocytes","display_name":"A computational method for identifying an optimal combination of existing drugs to repair the action potentials of SQT1 ventricular myocytes","publication_year":2021,"publication_date":"2021-08-12","ids":{"openalex":"https://openalex.org/W3189222101","doi":"https://doi.org/10.1371/journal.pcbi.1009233","mag":"3189222101","pmid":"https://pubmed.ncbi.nlm.nih.gov/34383746"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1009233","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009233","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009233&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009233&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040424903","display_name":"Karoline Horgmo J\u00e6ger","orcid":"https://orcid.org/0000-0003-4234-9094"},"institutions":[{"id":"https://openalex.org/I2799829267","display_name":"Simula Research Laboratory","ror":"https://ror.org/00vn06n10","country_code":"NO","type":"facility","lineage":["https://openalex.org/I2799829267"]}],"countries":["NO"],"is_corresponding":true,"raw_author_name":"Karoline Horgmo J\u00e6ger","raw_affiliation_strings":["Simula Research Laboratory, Oslo, Norway"],"raw_orcid":"https://orcid.org/0000-0003-4234-9094","affiliations":[{"raw_affiliation_string":"Simula Research Laboratory, Oslo, Norway","institution_ids":["https://openalex.org/I2799829267"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033213039","display_name":"Andrew G. Edwards","orcid":"https://orcid.org/0000-0001-7421-5977"},"institutions":[{"id":"https://openalex.org/I2799829267","display_name":"Simula Research Laboratory","ror":"https://ror.org/00vn06n10","country_code":"NO","type":"facility","lineage":["https://openalex.org/I2799829267"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["NO","US"],"is_corresponding":false,"raw_author_name":"Andrew G. Edwards","raw_affiliation_strings":["Department of Pharmacology, University of California, Davis, California United States of America","Simula Research Laboratory, Oslo, Norway"],"raw_orcid":"https://orcid.org/0000-0001-7421-5977","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of California, Davis, California United States of America","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Simula Research Laboratory, Oslo, Norway","institution_ids":["https://openalex.org/I2799829267"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088846739","display_name":"Wayne R. Giles","orcid":"https://orcid.org/0000-0002-8077-5935"},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]},{"id":"https://openalex.org/I2799829267","display_name":"Simula Research Laboratory","ror":"https://ror.org/00vn06n10","country_code":"NO","type":"facility","lineage":["https://openalex.org/I2799829267"]}],"countries":["CA","NO"],"is_corresponding":false,"raw_author_name":"Wayne R. Giles","raw_affiliation_strings":["Department of Physiology and Pharmacology, Faculty of Medicine, University of Calgary, Calgary, Canada","Simula Research Laboratory, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, Faculty of Medicine, University of Calgary, Calgary, Canada","institution_ids":["https://openalex.org/I168635309"]},{"raw_affiliation_string":"Simula Research Laboratory, Oslo, Norway","institution_ids":["https://openalex.org/I2799829267"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016700859","display_name":"Aslak Tveito","orcid":"https://orcid.org/0000-0003-2362-146X"},"institutions":[{"id":"https://openalex.org/I2799829267","display_name":"Simula Research Laboratory","ror":"https://ror.org/00vn06n10","country_code":"NO","type":"facility","lineage":["https://openalex.org/I2799829267"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Aslak Tveito","raw_affiliation_strings":["Simula Research Laboratory, Oslo, Norway"],"raw_orcid":"https://orcid.org/0000-0003-2362-146X","affiliations":[{"raw_affiliation_string":"Simula Research Laboratory, Oslo, Norway","institution_ids":["https://openalex.org/I2799829267"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5040424903"],"corresponding_institution_ids":["https://openalex.org/I2799829267"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.5426,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.90832626,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"17","issue":"8","first_page":"e1009233","last_page":"e1009233"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.9739000201225281,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mutant","display_name":"Mutant","score":0.6075271964073181},{"id":"https://openalex.org/keywords/ion-channel","display_name":"Ion channel","score":0.564924418926239},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.5060452818870544},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.5051198601722717},{"id":"https://openalex.org/keywords/transmembrane-protein","display_name":"Transmembrane protein","score":0.4920746684074402},{"id":"https://openalex.org/keywords/drug-action","display_name":"Drug action","score":0.4792780578136444},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4592594504356384},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.4232969284057617},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.40503454208374023},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.38982754945755005},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.37345442175865173},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.3712365925312042},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.35952335596084595},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.23439675569534302},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.10994058847427368}],"concepts":[{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6075271964073181},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.564924418926239},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5060452818870544},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5051198601722717},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.4920746684074402},{"id":"https://openalex.org/C86380466","wikidata":"https://www.wikidata.org/wiki/Q5308872","display_name":"Drug action","level":3,"score":0.4792780578136444},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4592594504356384},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4232969284057617},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.40503454208374023},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38982754945755005},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.37345442175865173},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3712365925312042},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.35952335596084595},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23439675569534302},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10994058847427368},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000072237","descriptor_name":"ERG1 Potassium Channel","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000072237","descriptor_name":"ERG1 Potassium Channel","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000072237","descriptor_name":"ERG1 Potassium Channel","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000072237","descriptor_name":"ERG1 Potassium Channel","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000072237","descriptor_name":"ERG1 Potassium Channel","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000072237","descriptor_name":"ERG1 Potassium Channel","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000072237","descriptor_name":"ERG1 Potassium Channel","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000072237","descriptor_name":"ERG1 Potassium Channel","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000072237","descriptor_name":"ERG1 Potassium Channel","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000889","descriptor_name":"Anti-Arrhythmia Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000889","descriptor_name":"Anti-Arrhythmia Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000889","descriptor_name":"Anti-Arrhythmia Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":false},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":false},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":false},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006330","descriptor_name":"Heart Defects, Congenital","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006330","descriptor_name":"Heart Defects, Congenital","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006330","descriptor_name":"Heart Defects, Congenital","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006330","descriptor_name":"Heart Defects, Congenital","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006330","descriptor_name":"Heart Defects, Congenital","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006330","descriptor_name":"Heart Defects, Congenital","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006330","descriptor_name":"Heart Defects, Congenital","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006330","descriptor_name":"Heart Defects, Congenital","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006330","descriptor_name":"Heart Defects, Congenital","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1009233","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009233","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009233&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:34383746","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34383746","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1009233","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1009233","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:6bfa1b88237b4a23a733a16602288d87","is_oa":true,"landing_page_url":"https://doaj.org/article/6bfa1b88237b4a23a733a16602288d87","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 17, Iss 8, p e1009233 (2021)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8360568","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8360568","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1009233","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009233","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009233&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G8302378389","display_name":null,"funder_award_id":"309871/E50","funder_id":"https://openalex.org/F4320323299","funder_display_name":"Norges Forskningsr\u00e5d"}],"funders":[{"id":"https://openalex.org/F4320323299","display_name":"Norges Forskningsr\u00e5d","ror":"https://ror.org/00epmv149"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3189222101.pdf","grobid_xml":"https://content.openalex.org/works/W3189222101.grobid-xml"},"referenced_works_count":95,"referenced_works":["https://openalex.org/W169709354","https://openalex.org/W595896130","https://openalex.org/W1502330209","https://openalex.org/W1517242685","https://openalex.org/W1583128097","https://openalex.org/W1809798419","https://openalex.org/W1912682098","https://openalex.org/W1967867484","https://openalex.org/W1969060286","https://openalex.org/W1971343049","https://openalex.org/W1976683973","https://openalex.org/W1978141597","https://openalex.org/W1980647259","https://openalex.org/W1982140992","https://openalex.org/W1985718987","https://openalex.org/W1992100955","https://openalex.org/W1996138247","https://openalex.org/W2000146797","https://openalex.org/W2003251032","https://openalex.org/W2007048322","https://openalex.org/W2009539616","https://openalex.org/W2020905073","https://openalex.org/W2030308282","https://openalex.org/W2032472801","https://openalex.org/W2034943103","https://openalex.org/W2038657224","https://openalex.org/W2039978986","https://openalex.org/W2045548568","https://openalex.org/W2047563311","https://openalex.org/W2056968647","https://openalex.org/W2058240154","https://openalex.org/W2061451182","https://openalex.org/W2073921281","https://openalex.org/W2081864503","https://openalex.org/W2084985537","https://openalex.org/W2098624213","https://openalex.org/W2099823887","https://openalex.org/W2100078256","https://openalex.org/W2102516854","https://openalex.org/W2115765852","https://openalex.org/W2119327737","https://openalex.org/W2121483408","https://openalex.org/W2124929662","https://openalex.org/W2131750503","https://openalex.org/W2137618884","https://openalex.org/W2148764498","https://openalex.org/W2151757076","https://openalex.org/W2161052908","https://openalex.org/W2166550586","https://openalex.org/W2176172672","https://openalex.org/W2219201578","https://openalex.org/W2225891147","https://openalex.org/W2273267066","https://openalex.org/W2281504005","https://openalex.org/W2289337326","https://openalex.org/W2318517467","https://openalex.org/W2328454508","https://openalex.org/W2339788706","https://openalex.org/W2345853117","https://openalex.org/W2383092858","https://openalex.org/W2512710853","https://openalex.org/W2580314938","https://openalex.org/W2738319041","https://openalex.org/W2738562479","https://openalex.org/W2749687630","https://openalex.org/W2762983659","https://openalex.org/W2763945434","https://openalex.org/W2794179796","https://openalex.org/W2894963980","https://openalex.org/W2902064929","https://openalex.org/W2904689287","https://openalex.org/W2911352784","https://openalex.org/W2927849102","https://openalex.org/W2947507329","https://openalex.org/W2951315938","https://openalex.org/W2952336269","https://openalex.org/W2956154393","https://openalex.org/W3006379757","https://openalex.org/W3007670977","https://openalex.org/W3008738184","https://openalex.org/W3016939841","https://openalex.org/W3026299230","https://openalex.org/W3028089343","https://openalex.org/W3037222822","https://openalex.org/W3040786754","https://openalex.org/W3043243506","https://openalex.org/W3048728735","https://openalex.org/W3096416176","https://openalex.org/W3097429727","https://openalex.org/W3106188448","https://openalex.org/W3118295897","https://openalex.org/W3132825319","https://openalex.org/W4237523220","https://openalex.org/W6659820584","https://openalex.org/W6677665380"],"related_works":["https://openalex.org/W2480711475","https://openalex.org/W2061997414","https://openalex.org/W1587522533","https://openalex.org/W2153190755","https://openalex.org/W2803627340","https://openalex.org/W2121182182","https://openalex.org/W2005600404","https://openalex.org/W2256537570","https://openalex.org/W2051476546","https://openalex.org/W2062873043"],"abstract_inverted_index":{"Mutations":[0],"are":[1,118,194,213],"known":[2,62],"to":[3,102,151,164],"cause":[4],"perturbations":[5],"in":[6,24,44,225],"essential":[7,236],"functional":[8],"features":[9],"of":[10,28,34,48,82,89,92,132,141,168,175,202,231,238,277,290,298],"integral":[11],"membrane":[12],"proteins,":[13],"including":[14],"ion":[15,29,40,97,278],"channels.":[16],"Even":[17],"restricted":[18],"or":[19],"point":[20],"mutations":[21],"can":[22,42,59,67,107,221],"result":[23,43,60],"substantially":[25],"changed":[26,46],"properties":[27,47,249],"currents.":[30],"The":[31],"additive":[32],"effect":[33,201],"these":[35],"alterations":[36],"for":[37,76,180,216,260,286],"a":[38,73],"specific":[39],"channel":[41],"significantly":[45],"the":[49,65,87,109,115,130,133,137,142,157,166,173,181,189,200,206,214,226,229,232,239,271,275,282,287,296,299],"action":[50],"potential":[51,135],"(AP).":[52],"Both":[53],"AP":[54,57,111,230,283],"shortening":[55],"and":[56,64,136,265],"prolongation":[58],"from":[61,252],"mutations,":[63],"consequences":[66],"be":[68],"life-threatening.":[69],"Here,":[70],"we":[71,122,171,255],"present":[72],"computational":[74,218],"method":[75],"identifying":[77],"new":[78],"drugs":[79,94,204],"utilizing":[80],"combinations":[81,105,259],"existing":[83,93],"drugs.":[84],"Based":[85],"on":[86,95,205],"knowledge":[88],"theoretical":[90],"effects":[91],"individual":[96],"currents,":[98],"our":[99,217],"aim":[100],"is":[101,284,295],"compute":[103,123,256],"optimal":[104,178,223,257,300],"that":[106,114,129,198,228,280],"'repair'":[108],"mutant":[110,143,233],"waveforms":[112,131],"so":[113,294],"baseline":[116],"AP-properties":[117],"restored.":[119],"More":[120],"specifically,":[121],"optimal,":[124],"combined,":[125],"drug":[126,158,179,258],"concentrations":[127],"such":[128],"transmembrane":[134],"cytosolic":[138],"calcium":[139],"concentration":[140],"cardiomyocytes":[144],"(CMs)":[145],"becomes":[146],"as":[147,149],"similar":[148],"possible":[150],"their":[152],"wild":[153,240],"type":[154,185,241],"counterparts":[155],"after":[156],"has":[159],"been":[160],"applied.":[161],"In":[162],"order":[163],"demonstrate":[165],"utility":[167],"this":[169],"method,":[170],"address":[172],"question":[174],"computing":[176],"an":[177],"short":[182],"QT":[183],"syndrome":[184],"1":[186],"(SQT1).":[187],"For":[188],"SQT1":[190,272],"mutation":[191],"N588K,":[192],"there":[193],"available":[195],"data":[196],"sets":[197],"describe":[199],"various":[203],"mutated":[207],"K+":[208],"channel.":[209],"These":[210],"published":[211],"findings":[212],"basis":[215],"analysis":[219],"which":[220],"identify":[222],"compounds":[224],"sense":[227],"CMs":[234,264,269],"resembles":[235],"biomarkers":[237],"CMs.":[242],"Using":[243],"recently":[244],"developed":[245],"insights":[246],"regarding":[247],"electrophysiological":[248],"among":[250],"myocytes":[251,291],"different":[253,285],"species,":[254],"hiPSC-CMs,":[261],"rabbit":[262],"ventricular":[263,268],"adult":[266],"human":[267],"with":[270],"mutation.":[273],"Since":[274],"'composition'":[276],"channels":[279],"form":[281],"three":[288],"types":[289],"under":[292],"consideration,":[293],"composition":[297],"drug.":[301]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}