{"id":"https://openalex.org/W4220799572","doi":"https://doi.org/10.1371/journal.pcbi.1009223","title":"Bayesian calibration, process modeling and uncertainty quantification in biotechnology","display_name":"Bayesian calibration, process modeling and uncertainty quantification in biotechnology","publication_year":2022,"publication_date":"2022-03-07","ids":{"openalex":"https://openalex.org/W4220799572","doi":"https://doi.org/10.1371/journal.pcbi.1009223","pmid":"https://pubmed.ncbi.nlm.nih.gov/35255090"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1009223","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009223","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009223&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009223&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075431427","display_name":"Laura M. Helleckes","orcid":"https://orcid.org/0000-0001-7825-7998"},"institutions":[{"id":"https://openalex.org/I171892758","display_name":"Forschungszentrum J\u00fclich","ror":"https://ror.org/02nv7yv05","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Laura Marie Helleckes","raw_affiliation_strings":["Institute of Bio- and Geosciences, IBG-1: Biotechnology, Forschungszentrum J\u00fclich GmbH, J\u00fclich, Germany","Institute of Biotechnology, RWTH Aachen University, Aachen, Germany"],"raw_orcid":"https://orcid.org/0000-0001-7825-7998","affiliations":[{"raw_affiliation_string":"Institute of Bio- and Geosciences, IBG-1: Biotechnology, Forschungszentrum J\u00fclich GmbH, J\u00fclich, Germany","institution_ids":["https://openalex.org/I171892758"]},{"raw_affiliation_string":"Institute of Biotechnology, RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088060174","display_name":"Michael Osthege","orcid":"https://orcid.org/0000-0002-2734-7624"},"institutions":[{"id":"https://openalex.org/I171892758","display_name":"Forschungszentrum J\u00fclich","ror":"https://ror.org/02nv7yv05","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Osthege","raw_affiliation_strings":["Institute of Bio- and Geosciences, IBG-1: Biotechnology, Forschungszentrum J\u00fclich GmbH, J\u00fclich, Germany","Institute of Biotechnology, RWTH Aachen University, Aachen, Germany"],"raw_orcid":"https://orcid.org/0000-0002-2734-7624","affiliations":[{"raw_affiliation_string":"Institute of Bio- and Geosciences, IBG-1: Biotechnology, Forschungszentrum J\u00fclich GmbH, J\u00fclich, Germany","institution_ids":["https://openalex.org/I171892758"]},{"raw_affiliation_string":"Institute of Biotechnology, RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018520418","display_name":"Wolfgang Wiechert","orcid":"https://orcid.org/0000-0001-8501-0694"},"institutions":[{"id":"https://openalex.org/I171892758","display_name":"Forschungszentrum J\u00fclich","ror":"https://ror.org/02nv7yv05","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolfgang Wiechert","raw_affiliation_strings":["Computational Systems Biotechnology (AVT.CSB), RWTH Aachen University, Aachen, Germany","Institute of Bio- and Geosciences, IBG-1: Biotechnology, Forschungszentrum J\u00fclich GmbH, J\u00fclich, Germany"],"raw_orcid":"https://orcid.org/0000-0001-8501-0694","affiliations":[{"raw_affiliation_string":"Computational Systems Biotechnology (AVT.CSB), RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]},{"raw_affiliation_string":"Institute of Bio- and Geosciences, IBG-1: Biotechnology, Forschungszentrum J\u00fclich GmbH, J\u00fclich, Germany","institution_ids":["https://openalex.org/I171892758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070703265","display_name":"Eric von Lieres","orcid":"https://orcid.org/0000-0002-0309-8408"},"institutions":[{"id":"https://openalex.org/I171892758","display_name":"Forschungszentrum J\u00fclich","ror":"https://ror.org/02nv7yv05","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Eric von Lieres","raw_affiliation_strings":["Institute of Bio- and Geosciences, IBG-1: Biotechnology, Forschungszentrum J\u00fclich GmbH, J\u00fclich, Germany"],"raw_orcid":"https://orcid.org/0000-0002-0309-8408","affiliations":[{"raw_affiliation_string":"Institute of Bio- and Geosciences, IBG-1: Biotechnology, Forschungszentrum J\u00fclich GmbH, J\u00fclich, Germany","institution_ids":["https://openalex.org/I171892758"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046653316","display_name":"Marco Oldiges","orcid":"https://orcid.org/0000-0003-0704-5597"},"institutions":[{"id":"https://openalex.org/I171892758","display_name":"Forschungszentrum J\u00fclich","ror":"https://ror.org/02nv7yv05","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Marco Oldiges","raw_affiliation_strings":["Institute of Bio- and Geosciences, IBG-1: Biotechnology, Forschungszentrum J\u00fclich GmbH, J\u00fclich, Germany","Institute of Biotechnology, RWTH Aachen University, Aachen, Germany"],"raw_orcid":"https://orcid.org/0000-0003-0704-5597","affiliations":[{"raw_affiliation_string":"Institute of Bio- and Geosciences, IBG-1: Biotechnology, Forschungszentrum J\u00fclich GmbH, J\u00fclich, Germany","institution_ids":["https://openalex.org/I171892758"]},{"raw_affiliation_string":"Institute of Biotechnology, RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5046653316"],"corresponding_institution_ids":["https://openalex.org/I171892758","https://openalex.org/I887968799"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.1658,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.88050924,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"18","issue":"3","first_page":"e1009223","last_page":"e1009223"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9818000197410583,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6958014965057373},{"id":"https://openalex.org/keywords/calibration","display_name":"Calibration","score":0.6272060871124268},{"id":"https://openalex.org/keywords/uncertainty-quantification","display_name":"Uncertainty quantification","score":0.6100905537605286},{"id":"https://openalex.org/keywords/python","display_name":"Python (programming language)","score":0.5618161559104919},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5550598502159119},{"id":"https://openalex.org/keywords/experimental-data","display_name":"Experimental data","score":0.5204153656959534},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.5137813687324524},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.5021495819091797},{"id":"https://openalex.org/keywords/design-of-experiments","display_name":"Design of experiments","score":0.48741963505744934},{"id":"https://openalex.org/keywords/univariate","display_name":"Univariate","score":0.47808337211608887},{"id":"https://openalex.org/keywords/workflow","display_name":"Workflow","score":0.4743058681488037},{"id":"https://openalex.org/keywords/bayesian-probability","display_name":"Bayesian probability","score":0.43562859296798706},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.36920201778411865},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.15673789381980896},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.14827311038970947},{"id":"https://openalex.org/keywords/multivariate-statistics","display_name":"Multivariate statistics","score":0.12985175848007202}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6958014965057373},{"id":"https://openalex.org/C165838908","wikidata":"https://www.wikidata.org/wiki/Q736777","display_name":"Calibration","level":2,"score":0.6272060871124268},{"id":"https://openalex.org/C32230216","wikidata":"https://www.wikidata.org/wiki/Q7882499","display_name":"Uncertainty quantification","level":2,"score":0.6100905537605286},{"id":"https://openalex.org/C519991488","wikidata":"https://www.wikidata.org/wiki/Q28865","display_name":"Python (programming language)","level":2,"score":0.5618161559104919},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5550598502159119},{"id":"https://openalex.org/C55037315","wikidata":"https://www.wikidata.org/wiki/Q5421151","display_name":"Experimental data","level":2,"score":0.5204153656959534},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.5137813687324524},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.5021495819091797},{"id":"https://openalex.org/C34559072","wikidata":"https://www.wikidata.org/wiki/Q2334061","display_name":"Design of experiments","level":2,"score":0.48741963505744934},{"id":"https://openalex.org/C199163554","wikidata":"https://www.wikidata.org/wiki/Q1681619","display_name":"Univariate","level":3,"score":0.47808337211608887},{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.4743058681488037},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.43562859296798706},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.36920201778411865},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.15673789381980896},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.14827311038970947},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.12985175848007202},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000078332","descriptor_name":"Data Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000078332","descriptor_name":"Data Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000078332","descriptor_name":"Data Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000078332","descriptor_name":"Data Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001709","descriptor_name":"Biotechnology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001709","descriptor_name":"Biotechnology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001709","descriptor_name":"Biotechnology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001709","descriptor_name":"Biotechnology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002138","descriptor_name":"Calibration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002138","descriptor_name":"Calibration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002138","descriptor_name":"Calibration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002138","descriptor_name":"Calibration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035501","descriptor_name":"Uncertainty","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035501","descriptor_name":"Uncertainty","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035501","descriptor_name":"Uncertainty","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035501","descriptor_name":"Uncertainty","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1009223","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009223","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009223&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:35255090","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35255090","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1009223","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1009223","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:9e32fa9cf4154fb1823287398eab7b12","is_oa":true,"landing_page_url":"https://doaj.org/article/9e32fa9cf4154fb1823287398eab7b12","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 3, p e1009223 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8939798","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8939798","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1009223","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009223","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009223&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/12","score":0.5,"display_name":"Responsible consumption and production"}],"awards":[{"id":"https://openalex.org/G6362432573","display_name":null,"funder_award_id":"031B0463A","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"}],"funders":[{"id":"https://openalex.org/F4320310693","display_name":"Deutsches Krebsforschungszentrum","ror":"https://ror.org/04cdgtt98"},{"id":"https://openalex.org/F4320320876","display_name":"Helmholtz-Gemeinschaft","ror":"https://ror.org/0281dp749"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4220799572.pdf","grobid_xml":"https://content.openalex.org/works/W4220799572.grobid-xml"},"referenced_works_count":74,"referenced_works":["https://openalex.org/W565446105","https://openalex.org/W568856612","https://openalex.org/W1669146697","https://openalex.org/W1853291804","https://openalex.org/W1897231799","https://openalex.org/W1967485420","https://openalex.org/W2011301426","https://openalex.org/W2027873737","https://openalex.org/W2056760934","https://openalex.org/W2063397409","https://openalex.org/W2069260705","https://openalex.org/W2079828141","https://openalex.org/W2087579091","https://openalex.org/W2094344799","https://openalex.org/W2102653059","https://openalex.org/W2106943551","https://openalex.org/W2119357336","https://openalex.org/W2129728285","https://openalex.org/W2132071446","https://openalex.org/W2132071585","https://openalex.org/W2144661611","https://openalex.org/W2144683622","https://openalex.org/W2146755591","https://openalex.org/W2166751342","https://openalex.org/W2172237924","https://openalex.org/W2179083909","https://openalex.org/W2215848943","https://openalex.org/W2217402295","https://openalex.org/W2342249984","https://openalex.org/W2408017125","https://openalex.org/W2417863416","https://openalex.org/W2569195183","https://openalex.org/W2577537660","https://openalex.org/W2614283331","https://openalex.org/W2749069611","https://openalex.org/W2765845615","https://openalex.org/W2776707578","https://openalex.org/W2778259892","https://openalex.org/W2804004722","https://openalex.org/W2886347104","https://openalex.org/W2897058899","https://openalex.org/W2897613819","https://openalex.org/W2910719176","https://openalex.org/W2921051283","https://openalex.org/W2962727772","https://openalex.org/W2963977107","https://openalex.org/W3003257820","https://openalex.org/W3014365047","https://openalex.org/W3024659207","https://openalex.org/W3035965352","https://openalex.org/W3086784814","https://openalex.org/W3099878876","https://openalex.org/W3102014803","https://openalex.org/W3103145119","https://openalex.org/W3112100299","https://openalex.org/W3128782210","https://openalex.org/W3142344196","https://openalex.org/W3174451819","https://openalex.org/W3196266556","https://openalex.org/W3209273247","https://openalex.org/W4214648962","https://openalex.org/W4220799572","https://openalex.org/W4220894006","https://openalex.org/W4240193798","https://openalex.org/W4240292118","https://openalex.org/W4386373863","https://openalex.org/W6760353796","https://openalex.org/W6780234213","https://openalex.org/W6893870551","https://openalex.org/W6912626055","https://openalex.org/W6912858111","https://openalex.org/W6930962431","https://openalex.org/W6968573939","https://openalex.org/W6969259846"],"related_works":["https://openalex.org/W3033927325","https://openalex.org/W2116312697","https://openalex.org/W2362353273","https://openalex.org/W2973566697","https://openalex.org/W4316276477","https://openalex.org/W4383108770","https://openalex.org/W4320010348","https://openalex.org/W3009997745","https://openalex.org/W3184080862","https://openalex.org/W2020256641"],"abstract_inverted_index":{"High-throughput":[0],"experimentation":[1],"has":[2],"revolutionized":[3],"data-driven":[4],"experimental":[5,43,71],"sciences":[6],"and":[7,33,48,60,164,173,183,224,247,299,308],"opened":[8],"the":[9,12,19,28,31,35,42,54,95,98,115,146,192,205,216,263,303,306],"door":[10],"to":[11,37,87,105,131,191,204,231,253,279],"application":[13],"of":[14,21,30,67,100,171,181,195,207,276,283,305],"machine":[15,153],"learning":[16,154],"techniques.":[17],"Nevertheless,":[18],"quality":[20,29],"any":[22],"data":[23,32,249],"analysis":[24,250],"strongly":[25],"depends":[26],"on":[27],"specifically":[34],"degree":[36],"which":[38,227],"random":[39],"effects":[40],"in":[41,70,74,118,198,219,257],"data-generating":[44],"process":[45,184,289],"are":[46,128,292],"quantified":[47],"accounted":[49],"for.":[50],"Accordingly":[51],"calibration,":[52,78],"i.e.":[53],"quantitative":[55,89,106],"association":[56],"between":[57],"observed":[58,255],"quantities":[59],"measurement":[61,120,126,194],"responses,":[62],"is":[63,102,188],"a":[64,119,140,161,199,269],"core":[65],"element":[66],"many":[68,143,169],"workflows":[69,256],"sciences.":[72,259],"Particularly":[73],"life":[75,258],"sciences,":[76],"univariate":[77],"often":[79],"involving":[80],"non-linear":[81],"saturation":[82],"effects,":[83],"must":[84],"be":[85],"performed":[86],"extract":[88],"information":[90],"from":[91],"measured":[92],"data.":[93],"At":[94],"same":[96,147],"time,":[97],"estimation":[99,298],"uncertainty":[101,233],"inseparably":[103],"connected":[104],"experimentation.":[107],"Adequate":[108],"calibration":[109,137,177,237,266],"models":[110,267],"that":[111,167],"describe":[112,280],"not":[113],"only":[114],"input/output":[116],"relationship":[117],"system":[121],"but":[122],"also":[123],"its":[124,132],"inherent":[125],"noise":[127],"required.":[129],"Due":[130],"mathematical":[133],"nature,":[134],"statistically":[135],"robust":[136],"modeling":[138,178],"remains":[139],"challenge":[141],"for":[142,152,179,235],"practitioners,":[144],"at":[145],"time":[148],"being":[149],"extremely":[150],"beneficial":[151],"applications.":[155],"In":[156],"this":[157],"work,":[158],"we":[159,228,261],"present":[160],"bottom-up":[162],"conceptual":[163,217],"computational":[165,309],"approach":[166],"solves":[168],"problems":[170],"understanding":[172],"implementing":[174],"non-linear,":[175],"empirical":[176],"quantification":[180,206,234],"analytes":[182],"modeling.":[185],"The":[186],"methodology":[187],"first":[189],"applied":[190],"optical":[193],"biomass":[196],"concentrations":[197],"high-throughput":[200],"cultivation":[201],"system,":[202],"then":[203],"glucose":[208],"by":[209,294],"an":[210],"automated":[211],"enzymatic":[212],"assay.":[213],"We":[214],"implemented":[215],"framework":[218],"two":[220],"Python":[221],"packages,":[222],"calibr8":[223],"murefi,":[225],"with":[226,268],"demonstrate":[229],"how":[230],"make":[232],"various":[236],"tasks":[238],"more":[239,245],"accessible.":[240],"Our":[241],"software":[242],"packages":[243],"enable":[244],"reproducible":[246],"automatable":[248],"routines":[251],"compared":[252],"commonly":[254],"Subsequently,":[260],"combine":[262],"previously":[264],"established":[265],"hierarchical":[270],"Monod-like":[271],"ordinary":[272],"differential":[273],"equation":[274],"model":[275,290],"microbial":[277],"growth":[278],"multiple":[281],"replicates":[282],"Corynebacterium":[284],"glutamicum":[285],"batch":[286],"cultures.":[287],"Key":[288],"parameters":[291],"learned":[293],"both":[295],"maximum":[296],"likelihood":[297],"Bayesian":[300],"inference,":[301],"highlighting":[302],"flexibility":[304],"statistical":[307],"framework.":[310]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6}],"updated_date":"2026-05-31T08:46:17.908082","created_date":"2025-10-10T00:00:00"}