{"id":"https://openalex.org/W3091988491","doi":"https://doi.org/10.1371/journal.pcbi.1009189","title":"Rational design of complex phenotype via network models","display_name":"Rational design of complex phenotype via network models","publication_year":2021,"publication_date":"2021-07-29","ids":{"openalex":"https://openalex.org/W3091988491","doi":"https://doi.org/10.1371/journal.pcbi.1009189","mag":"3091988491","pmid":"https://pubmed.ncbi.nlm.nih.gov/34324484"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1009189","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009189","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["arxiv","crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1009189","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051475216","display_name":"Marcio Gameiro","orcid":"https://orcid.org/0000-0003-2168-0757"},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4210131883","display_name":"Brazilian Society of Computational and Applied Mathematics","ror":"https://ror.org/03kcw4w74","country_code":"BR","type":"other","lineage":["https://openalex.org/I4210131883"]}],"countries":["BR","US"],"is_corresponding":true,"raw_author_name":"Marcio Gameiro","raw_affiliation_strings":["Department of Mathematics, Rutgers, The State University of New Jersey, Piscataway, New Jersey, United States of America","Instituto de Ci\u00eancias Matem\u00e1ticas e de Computa\u00e7\u00e3o, Universidade de S\u00e3o Paulo, S\u00e3o Carlos, S\u00e3o Paulo, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-2168-0757","affiliations":[{"raw_affiliation_string":"Department of Mathematics, Rutgers, The State University of New Jersey, Piscataway, New Jersey, United States of America","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Instituto de Ci\u00eancias Matem\u00e1ticas e de Computa\u00e7\u00e3o, Universidade de S\u00e3o Paulo, S\u00e3o Carlos, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I4210131883","https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070531641","display_name":"Tom\u00e1\u0161 Gedeon","orcid":"https://orcid.org/0000-0001-5555-6741"},"institutions":[{"id":"https://openalex.org/I23732399","display_name":"Montana State University","ror":"https://ror.org/02w0trx84","country_code":"US","type":"education","lineage":["https://openalex.org/I23732399","https://openalex.org/I4210126032"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tom\u00e1\u0161 Gedeon","raw_affiliation_strings":["Department of Mathematical Sciences, Montana State University, Bozeman, Montana, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-5555-6741","affiliations":[{"raw_affiliation_string":"Department of Mathematical Sciences, Montana State University, Bozeman, Montana, United States of America","institution_ids":["https://openalex.org/I23732399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030270091","display_name":"Shane Kepley","orcid":"https://orcid.org/0000-0001-6447-9418"},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shane Kepley","raw_affiliation_strings":["Department of Mathematics, Rutgers, The State University of New Jersey, Piscataway, New Jersey, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-6447-9418","affiliations":[{"raw_affiliation_string":"Department of Mathematics, Rutgers, The State University of New Jersey, Piscataway, New Jersey, United States of America","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049298090","display_name":"Konstantin Mischaikow","orcid":"https://orcid.org/0000-0003-2876-4558"},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Konstantin Mischaikow","raw_affiliation_strings":["Department of Mathematics, Rutgers, The State University of New Jersey, Piscataway, New Jersey, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, Rutgers, The State University of New Jersey, Piscataway, New Jersey, United States of America","institution_ids":["https://openalex.org/I102322142"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5051475216"],"corresponding_institution_ids":["https://openalex.org/I102322142","https://openalex.org/I17974374","https://openalex.org/I4210131883"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.8958,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.71915935,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"17","issue":"7","first_page":"e1009189","last_page":"e1009189"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11975","display_name":"Evolutionary Algorithms and Applications","score":0.9869999885559082,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9758999943733215,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.8436250686645508},{"id":"https://openalex.org/keywords/bistability","display_name":"Bistability","score":0.737644374370575},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6569106578826904},{"id":"https://openalex.org/keywords/a-priori-and-a-posteriori","display_name":"A priori and a posteriori","score":0.5282441973686218},{"id":"https://openalex.org/keywords/ordinary-differential-equation","display_name":"Ordinary differential equation","score":0.47589123249053955},{"id":"https://openalex.org/keywords/network-analysis","display_name":"Network analysis","score":0.4274032711982727},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.3476971387863159},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.34651756286621094},{"id":"https://openalex.org/keywords/differential-equation","display_name":"Differential equation","score":0.2223798930644989},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.22064027190208435},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.13110443949699402},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.09786516427993774}],"concepts":[{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.8436250686645508},{"id":"https://openalex.org/C97292510","wikidata":"https://www.wikidata.org/wiki/Q2304620","display_name":"Bistability","level":2,"score":0.737644374370575},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6569106578826904},{"id":"https://openalex.org/C75553542","wikidata":"https://www.wikidata.org/wiki/Q178161","display_name":"A priori and a posteriori","level":2,"score":0.5282441973686218},{"id":"https://openalex.org/C51544822","wikidata":"https://www.wikidata.org/wiki/Q465274","display_name":"Ordinary differential equation","level":3,"score":0.47589123249053955},{"id":"https://openalex.org/C32946077","wikidata":"https://www.wikidata.org/wiki/Q618079","display_name":"Network analysis","level":2,"score":0.4274032711982727},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.3476971387863159},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.34651756286621094},{"id":"https://openalex.org/C78045399","wikidata":"https://www.wikidata.org/wiki/Q11214","display_name":"Differential equation","level":2,"score":0.2223798930644989},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.22064027190208435},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13110443949699402},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.09786516427993774},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058615","descriptor_name":"Synthetic Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058615","descriptor_name":"Synthetic Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058615","descriptor_name":"Synthetic Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1009189","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009189","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:34324484","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34324484","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:arXiv.org:2010.03803","is_oa":true,"landing_page_url":"http://arxiv.org/abs/2010.03803","pdf_url":"https://arxiv.org/pdf/2010.03803","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:doaj.org/article:4e3fa112aaf9476398ffc49fdda9e05f","is_oa":true,"landing_page_url":"https://doaj.org/article/4e3fa112aaf9476398ffc49fdda9e05f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 17, Iss 7, p e1009189 (2021)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8354484","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8354484","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1009189","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009189","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1799101986","display_name":null,"funder_award_id":"DMS-1839294 and HDR TRIPODS award CCF-1934924","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G2405702604","display_name":null,"funder_award_id":"2019/06249-7","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G295657101","display_name":null,"funder_award_id":"2019/","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G3064008058","display_name":null,"funder_award_id":"309073/2019-7","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G3622826299","display_name":null,"funder_award_id":"FA8750-17-C-0054","funder_id":"https://openalex.org/F4320332180","funder_display_name":"Defense Advanced Research Projects Agency"},{"id":"https://openalex.org/G4111821730","display_name":"Tripods+X:Res: Collaborative Research: Identification of Gene Regulatory Network Function from Data","funder_award_id":"1839294","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4535464598","display_name":null,"funder_award_id":"R01 GM126555","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4713059963","display_name":null,"funder_award_id":"FA8750","funder_id":"https://openalex.org/F4320332180","funder_display_name":"Defense Advanced Research Projects Agency"},{"id":"https://openalex.org/G4873432650","display_name":null,"funder_award_id":"DMS-1839294","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4939759924","display_name":null,"funder_award_id":"R01 GM126555","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5049875059","display_name":null,"funder_award_id":"5R01GM126555","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5270150132","display_name":null,"funder_award_id":"HR0011-16-2-0033","funder_id":"https://openalex.org/F4320332180","funder_display_name":"Defense Advanced Research Projects Agency"},{"id":"https://openalex.org/G5337114324","display_name":null,"funder_award_id":"CCF-1934924","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6094672901","display_name":null,"funder_award_id":"DMS-1839299","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6517621824","display_name":null,"funder_award_id":"309073/2019-7","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G7133055043","display_name":"HDR TRIPODS: Data Science Principles of the Human-Machine Convergence","funder_award_id":"1934924","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7398947381","display_name":null,"funder_award_id":"2019/06249-7","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G8033913750","display_name":null,"funder_award_id":"5R01GM126555-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G869520669","display_name":"Tripods+X:Res: Collaborative Research: Identification of Gene Regulatory Network Function from Data","funder_award_id":"1839299","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306164","display_name":"Simons Foundation","ror":"https://ror.org/01cmst727"},{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332180","display_name":"Defense Advanced Research Projects Agency","ror":"https://ror.org/02caytj08"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1560787783","https://openalex.org/W1866328638","https://openalex.org/W1977624796","https://openalex.org/W1999679140","https://openalex.org/W2014425442","https://openalex.org/W2018435536","https://openalex.org/W2027789855","https://openalex.org/W2028617788","https://openalex.org/W2031369606","https://openalex.org/W2056313562","https://openalex.org/W2097894461","https://openalex.org/W2124614690","https://openalex.org/W2134759932","https://openalex.org/W2169959828","https://openalex.org/W2171280873","https://openalex.org/W2290756165","https://openalex.org/W2314752401","https://openalex.org/W2513283730","https://openalex.org/W2606865284","https://openalex.org/W2751997290","https://openalex.org/W2786631874","https://openalex.org/W2794402253","https://openalex.org/W2801926645","https://openalex.org/W2892163263","https://openalex.org/W2949148219","https://openalex.org/W3006469388","https://openalex.org/W3012725541","https://openalex.org/W3033750364","https://openalex.org/W3091988491","https://openalex.org/W3099697088","https://openalex.org/W3207943564","https://openalex.org/W4252405764","https://openalex.org/W4288020263","https://openalex.org/W6638938885","https://openalex.org/W6698751441"],"related_works":["https://openalex.org/W4224217224","https://openalex.org/W1964519618","https://openalex.org/W3118640947","https://openalex.org/W4388308731","https://openalex.org/W1969697984","https://openalex.org/W3048730783","https://openalex.org/W1992416820","https://openalex.org/W3094197880","https://openalex.org/W2183786486","https://openalex.org/W2042875514"],"abstract_inverted_index":{"We":[0,51,96],"demonstrate":[1,86,114],"a":[2,32,42,115,120],"modeling":[3],"and":[4,40,53,90,113],"computational":[5,125],"framework":[6],"that":[7],"allows":[8],"for":[9,18,34,44],"rapid":[10],"screening":[11],"of":[12,14,30,36,46,108,123],"thousands":[13],"potential":[15],"network":[16],"designs":[17],"particular":[19],"dynamic":[20,77],"behavior.":[21],"To":[22],"illustrate":[23],"this":[24],"capability":[25],"we":[26,85],"consider":[27],"the":[28,81,124],"problem":[29],"hysteresis,":[31],"prerequisite":[33],"construction":[35,45],"robust":[37],"bistable":[38],"switches":[39],"hence":[41],"cornerstone":[43],"more":[47,101],"complex":[48],"synthetic":[49],"circuits.":[50],"evaluate":[52],"rank":[54],"most":[55],"three":[56],"node":[57],"networks":[58],"according":[59],"to":[60,63,73,100],"their":[61],"ability":[62],"robustly":[64],"exhibit":[65],"hysteresis":[66],"where":[67],"robustness":[68,89],"is":[69],"measured":[70],"with":[71],"respect":[72],"parameters":[74],"over":[75],"multiple":[76],"phenotypes.":[78],"Focusing":[79],"on":[80,105],"highest":[82],"ranked":[83],"networks,":[84],"how":[87],"additional":[88],"design":[91],"constraints":[92],"can":[93],"be":[94],"applied.":[95],"compare":[97],"our":[98],"results":[99],"traditional":[102],"methods":[103],"based":[104],"specific":[106],"parameterization":[107],"ordinary":[109],"differential":[110],"equation":[111],"models":[112],"strong":[116],"qualitative":[117],"match":[118],"at":[119],"small":[121],"fraction":[122],"cost.":[126]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-06-24T13:16:06.693445","created_date":"2025-10-10T00:00:00"}