{"id":"https://openalex.org/W4220899762","doi":"https://doi.org/10.1371/journal.pcbi.1009156","title":"Computational modelling of cell motility modes emerging from cell-matrix adhesion dynamics","display_name":"Computational modelling of cell motility modes emerging from cell-matrix adhesion dynamics","publication_year":2022,"publication_date":"2022-02-14","ids":{"openalex":"https://openalex.org/W4220899762","doi":"https://doi.org/10.1371/journal.pcbi.1009156","pmid":"https://pubmed.ncbi.nlm.nih.gov/35157694"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1009156","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009156","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1009156","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041001759","display_name":"Leonie van Steijn","orcid":"https://orcid.org/0000-0002-3282-5571"},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Leonie van Steijn","raw_affiliation_strings":["Mathematical Institute, Leiden University, Leiden, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-3282-5571","affiliations":[{"raw_affiliation_string":"Mathematical Institute, Leiden University, Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054334001","display_name":"Inge M. N. Wortel","orcid":"https://orcid.org/0000-0003-3362-5229"},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Inge M. N. Wortel","raw_affiliation_strings":["Data Science, Institute for Computing and Information Sciences, Radboud University, Nijmegen, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0003-3362-5229","affiliations":[{"raw_affiliation_string":"Data Science, Institute for Computing and Information Sciences, Radboud University, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I145872427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053210310","display_name":"Cl\u00e9ment Sire","orcid":"https://orcid.org/0000-0003-4089-4013"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555"]},{"id":"https://openalex.org/I17866349","display_name":"Universit\u00e9 F\u00e9d\u00e9rale de Toulouse Midi-Pyr\u00e9n\u00e9es","ror":"https://ror.org/004raaa70","country_code":"FR","type":"education","lineage":["https://openalex.org/I17866349"]},{"id":"https://openalex.org/I4210109170","display_name":"Laboratoire de Physique Th\u00e9orique","ror":"https://ror.org/01w0hda30","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I4210098836","https://openalex.org/I4210109170","https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Cl\u00e9ment Sire","raw_affiliation_strings":["Laboratoire de Physique Th\u00e9orique, Centre National de la Recherche Scientifique (CNRS) & Universit\u00e9 de Toulouse-Paul Sabatier, Toulouse, France","Laboratoire de Physique Th\u00e9orique, Centre National de la Recherche Scientifique (CNRS) & Universit\u00e9 de Toulouse\u2014Paul Sabatier, Toulouse, France"],"raw_orcid":"https://orcid.org/0000-0003-4089-4013","affiliations":[{"raw_affiliation_string":"Laboratoire de Physique Th\u00e9orique, Centre National de la Recherche Scientifique (CNRS) & Universit\u00e9 de Toulouse-Paul Sabatier, Toulouse, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I134560555"]},{"raw_affiliation_string":"Laboratoire de Physique Th\u00e9orique, Centre National de la Recherche Scientifique (CNRS) & Universit\u00e9 de Toulouse\u2014Paul Sabatier, Toulouse, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I134560555","https://openalex.org/I17866349","https://openalex.org/I4210109170"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042010611","display_name":"Lo\u0131\u0308c Dupr\u00e9","orcid":"https://orcid.org/0000-0002-7278-6503"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I17866349","display_name":"Universit\u00e9 F\u00e9d\u00e9rale de Toulouse Midi-Pyr\u00e9n\u00e9es","ror":"https://ror.org/004raaa70","country_code":"FR","type":"education","lineage":["https://openalex.org/I17866349"]},{"id":"https://openalex.org/I4210142115","display_name":"Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases","ror":"https://ror.org/03hgkg910","country_code":"AT","type":"facility","lineage":["https://openalex.org/I2799334681","https://openalex.org/I4210142115"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT","FR"],"is_corresponding":false,"raw_author_name":"Lo\u00efc Dupr\u00e9","raw_affiliation_strings":["Department of Dermatology, Medical University of Vienna, Vienna, Austria","Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria","Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy), INSERM, CNRS, Universit\u00e9 de Toulouse, Toulouse, France"],"raw_orcid":"https://orcid.org/0000-0002-7278-6503","affiliations":[{"raw_affiliation_string":"Department of Dermatology, Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria","institution_ids":["https://openalex.org/I4210142115"]},{"raw_affiliation_string":"Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy), INSERM, CNRS, Universit\u00e9 de Toulouse, Toulouse, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I17866349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087901292","display_name":"Guy Th\u00e9raulaz","orcid":"https://orcid.org/0000-0002-3062-4215"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555"]},{"id":"https://openalex.org/I17866349","display_name":"Universit\u00e9 F\u00e9d\u00e9rale de Toulouse Midi-Pyr\u00e9n\u00e9es","ror":"https://ror.org/004raaa70","country_code":"FR","type":"education","lineage":["https://openalex.org/I17866349"]},{"id":"https://openalex.org/I4210098684","display_name":"Centre de Recherches sur la Cognition Animale","ror":"https://ror.org/0111s2360","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210098684","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4405266242","display_name":"Centre de Biologie Int\u00e9grative de Toulouse","ror":"https://ror.org/01f4pb571","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4405258862","https://openalex.org/I4405266242"]},{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["FR","IN"],"is_corresponding":false,"raw_author_name":"Guy Theraulaz","raw_affiliation_strings":["Centre de Recherches sur la Cognition Animale (CRCA), Centre de Biologie Int\u00e9grative (CBI), Centre National de la Recherche Scientifique (CNRS) & Universit\u00e9 de Toulouse-Paul Sabatier, Toulouse, France","Centre for Ecological Sciences, Indian Institute of Science, Bengaluru, India","Centre de Recherches sur la Cognition Animale (CRCA), Centre de Biologie Int\u00e9grative (CBI), Centre National de la Recherche Scientifique (CNRS) & Universit\u00e9 de Toulouse\u2014Paul Sabatier, Toulouse, France"],"raw_orcid":"https://orcid.org/0000-0002-3062-4215","affiliations":[{"raw_affiliation_string":"Centre de Recherches sur la Cognition Animale (CRCA), Centre de Biologie Int\u00e9grative (CBI), Centre National de la Recherche Scientifique (CNRS) & Universit\u00e9 de Toulouse-Paul Sabatier, Toulouse, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I134560555","https://openalex.org/I4210098684","https://openalex.org/I4405266242"]},{"raw_affiliation_string":"Centre for Ecological Sciences, Indian Institute of Science, Bengaluru, India","institution_ids":["https://openalex.org/I59270414"]},{"raw_affiliation_string":"Centre de Recherches sur la Cognition Animale (CRCA), Centre de Biologie Int\u00e9grative (CBI), Centre National de la Recherche Scientifique (CNRS) & Universit\u00e9 de Toulouse\u2014Paul Sabatier, Toulouse, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I134560555","https://openalex.org/I17866349","https://openalex.org/I4210098684","https://openalex.org/I4405266242"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049980767","display_name":"Roeland M. H. Merks","orcid":"https://orcid.org/0000-0002-6152-687X"},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Roeland M. H. Merks","raw_affiliation_strings":["Institute of Biology Leiden, Leiden University, Leiden, The Netherlands","Mathematical Institute, Leiden University, Leiden, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-6152-687X","affiliations":[{"raw_affiliation_string":"Institute of Biology Leiden, Leiden University, Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]},{"raw_affiliation_string":"Mathematical Institute, Leiden University, Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5049980767"],"corresponding_institution_ids":["https://openalex.org/I121797337"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":3.5534,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.94093639,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"18","issue":"2","first_page":"e1009156","last_page":"e1009156"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.9939000010490417,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13187","display_name":"Diffusion and Search Dynamics","score":0.9912999868392944,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/motility","display_name":"Motility","score":0.6912934184074402},{"id":"https://openalex.org/keywords/dynamics","display_name":"Dynamics (music)","score":0.6487432718276978},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"Cell adhesion","score":0.5796318650245667},{"id":"https://openalex.org/keywords/adhesion","display_name":"Adhesion","score":0.46708106994628906},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.441620796918869},{"id":"https://openalex.org/keywords/matrix","display_name":"Matrix (chemical analysis)","score":0.4246990382671356},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.41323965787887573},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"Extracellular matrix","score":0.41136765480041504},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.395177960395813},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.3443833589553833},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.32906192541122437},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.32426905632019043},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.31309974193573},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.24065816402435303},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.07697266340255737}],"concepts":[{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.6912934184074402},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.6487432718276978},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.5796318650245667},{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.46708106994628906},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.441620796918869},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.4246990382671356},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.41323965787887573},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.41136765480041504},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.395177960395813},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3443833589553833},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.32906192541122437},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32426905632019043},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.31309974193573},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.24065816402435303},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07697266340255737},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D021982","descriptor_name":"Cell-Matrix Junctions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D021982","descriptor_name":"Cell-Matrix Junctions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D021982","descriptor_name":"Cell-Matrix Junctions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pcbi.1009156","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009156","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:35157694","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35157694","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:eprints.iisc.ac.in:71579","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4377196309","display_name":"NOT FOUND REPOSITORY (Indian Institute of Science Bangalore)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I59270414","host_organization_name":"Indian Institute of Science Bangalore","host_organization_lineage":["https://openalex.org/I59270414"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-03648631v1","is_oa":false,"landing_page_url":"https://hal.science/hal-03648631","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, 2022, 18 (2), pp.e1009156. ⟨10.1371/journal.pcbi.1009156⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:RePEc:plo:pcbi00:1009156","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1009156","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:d287ed4aded643598f220f86d6e0e51e","is_oa":true,"landing_page_url":"https://doaj.org/article/d287ed4aded643598f220f86d6e0e51e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 2, p e1009156 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8880896","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8880896","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:repository.ubn.ru.nl:2066/247531","is_oa":false,"landing_page_url":"https://repository.ubn.ru.nl/handle/2066/247531","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Plos Computational Biology, 18, 2, pp. 1-28","raw_type":"Article / Letter to editor"},{"id":"pmh:ru:oai:repository.ubn.ru.nl:2066/247531","is_oa":true,"landing_page_url":"http://hdl.handle.net/2066/247531","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Plos Computational Biology, 18, 1 - 28","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1009156","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009156","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7300000190734863,"display_name":"Life below water","id":"https://metadata.un.org/sdg/14"}],"awards":[{"id":"https://openalex.org/G4238935856","display_name":"Mathematics-based strategies for repairing tumour blood vessels","funder_award_id":"865.17.004","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G6226754758","display_name":null,"funder_award_id":"ENW-VICI 865.17.004","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G746711610","display_name":null,"funder_award_id":"NWO/ENW\u2010VICI 865.17.004","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"}],"funders":[{"id":"https://openalex.org/F4320310071","display_name":"Indian Institute of Science","ror":"https://ror.org/04dese585"},{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W636958302","https://openalex.org/W1564175926","https://openalex.org/W1656531078","https://openalex.org/W1816275442","https://openalex.org/W1973400757","https://openalex.org/W1973957973","https://openalex.org/W1982024084","https://openalex.org/W1988642695","https://openalex.org/W1993312924","https://openalex.org/W1996326412","https://openalex.org/W1996764730","https://openalex.org/W2002731589","https://openalex.org/W2007876874","https://openalex.org/W2007988618","https://openalex.org/W2019558320","https://openalex.org/W2020644315","https://openalex.org/W2030549554","https://openalex.org/W2037170319","https://openalex.org/W2037866119","https://openalex.org/W2038601596","https://openalex.org/W2038857997","https://openalex.org/W2041040218","https://openalex.org/W2042478946","https://openalex.org/W2047510979","https://openalex.org/W2053097306","https://openalex.org/W2053324351","https://openalex.org/W2060661444","https://openalex.org/W2062478481","https://openalex.org/W2062515939","https://openalex.org/W2064657497","https://openalex.org/W2073281753","https://openalex.org/W2075114093","https://openalex.org/W2080132440","https://openalex.org/W2087261938","https://openalex.org/W2097685445","https://openalex.org/W2098518658","https://openalex.org/W2099158550","https://openalex.org/W2100345558","https://openalex.org/W2111719518","https://openalex.org/W2128863573","https://openalex.org/W2136949471","https://openalex.org/W2149747650","https://openalex.org/W2159325467","https://openalex.org/W2160648230","https://openalex.org/W2164244652","https://openalex.org/W2166927847","https://openalex.org/W2167552306","https://openalex.org/W2172016564","https://openalex.org/W2261563054","https://openalex.org/W2370196678","https://openalex.org/W2411957021","https://openalex.org/W2554991854","https://openalex.org/W2584556639","https://openalex.org/W2681130294","https://openalex.org/W2738160504","https://openalex.org/W2738851605","https://openalex.org/W2781887816","https://openalex.org/W2798084266","https://openalex.org/W2952427366","https://openalex.org/W2965555992","https://openalex.org/W2995369486","https://openalex.org/W3041639619","https://openalex.org/W3044083314","https://openalex.org/W3080101006","https://openalex.org/W3146965333","https://openalex.org/W3160630995","https://openalex.org/W3170703302","https://openalex.org/W3186424135","https://openalex.org/W6929490307"],"related_works":["https://openalex.org/W4361262202","https://openalex.org/W4361244275","https://openalex.org/W4361244281","https://openalex.org/W4361244280","https://openalex.org/W4361262221","https://openalex.org/W4361262226","https://openalex.org/W4361244157","https://openalex.org/W2392388241","https://openalex.org/W1965866142","https://openalex.org/W1988655739"],"abstract_inverted_index":{"Lymphocytes":[0],"have":[1],"been":[2],"described":[3],"to":[4,39,59,79,93,102,275],"perform":[5,112],"different":[6,188],"motility":[7,50,76,86,131,255],"patterns":[8,51],"such":[9,24],"as":[10,25,239],"Brownian":[11,34],"random":[12,15,115,213],"walks,":[13,16],"persistent":[14,114,217,254],"and":[17,84,146,172,176,191,199,206],"L\u00e9vy":[18,36],"walks.":[19],"Depending":[20],"on":[21,67,106,122,282],"the":[22,28,44,60,68,80,94,103,107,123,127,143,162,203,210,233,249,260,277,295],"conditions,":[23],"confinement":[26],"or":[27,35,82,90,96,117],"distribution":[29,235],"of":[30,48,142,164,178,227,236,279,292,297],"target":[31],"cells,":[32],"either":[33,72,111],"walks":[37,214],"lead":[38],"more":[40,253],"efficient":[41],"interaction":[42],"with":[43,87,99,215],"targets.":[45],"The":[46,286],"diversity":[47],"these":[49],"may":[52],"be":[53],"explained":[54],"by":[55],"an":[56,195,272],"adaptive":[57],"response":[58],"surrounding":[61],"extracellular":[62],"matrix":[63],"(ECM).":[64],"Indeed,":[65],"depending":[66,121],"ECM":[69,124,128,280],"composition,":[70],"lymphocytes":[71,110],"display":[73],"a":[74,113,118,154,224,240,263,289],"floating":[75],"without":[77],"attaching":[78],"ECM,":[81,95],"sliding":[83],"stepping":[85],"respectively":[88],"continuous":[89],"discontinuous":[91],"attachment":[92,101,197],"pivoting":[97,225],"behaviour":[98],"sustained":[100],"ECM.":[104],"Moreover,":[105],"long":[108],"term,":[109],"walk":[116],"Brownian-like":[119],"movement":[120],"composition.":[125],"How":[126],"affects":[129],"cell":[130,151,181,244],"is":[132],"still":[133],"incompletely":[134],"understood.":[135],"Here,":[136],"we":[137,270],"integrate":[138],"essential":[139],"mechanistic":[140],"details":[141],"lymphocyte-matrix":[144],"adhesions":[145,179,237,247],"lymphocyte":[147,185,189,298],"intrinsic":[148],"cytoskeletal":[149],"induced":[150],"propulsion":[152,182],"into":[153],"Cellular":[155],"Potts":[156],"model":[157,211,287],"(CPM).":[158],"We":[159],"show":[160],"that":[161],"combination":[163],"de":[165],"novo":[166],"cell-matrix":[167,283],"adhesion":[168,170,174,201,231,266,284],"formation,":[169],"growth":[171],"shrinkage,":[173],"rupture,":[175],"feedback":[177],"onto":[180],"recapitulates":[183],"multiple":[184],"behaviours,":[186],"for":[187,252],"subsets":[190],"various":[192],"substrates.":[193],"With":[194],"increasing":[196],"area":[198],"increased":[200],"strength,":[202],"cells'":[204],"speed":[205],"persistence":[207],"decreases.":[208],"Additionally,":[209],"predicts":[212],"short-term":[216],"but":[218],"long-term":[219],"subdiffusive":[220],"properties":[221],"resulting":[222],"in":[223],"type":[226],"motility.":[228,245,299],"For":[229],"small":[230],"areas,":[232],"spatial":[234],"emerges":[238],"key":[241],"factor":[242],"influencing":[243],"Small":[246],"at":[248,259],"front":[250],"allow":[251],"than":[256],"larger":[257],"clusters":[258],"back,":[261],"despite":[262],"similar":[264],"total":[265],"area.":[267],"In":[268],"conclusion,":[269],"present":[271],"integrated":[273],"framework":[274],"simulate":[276],"effects":[278],"proteins":[281],"dynamics.":[285],"reveals":[288],"sufficient":[290],"set":[291],"principles":[293],"explaining":[294],"plasticity":[296]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":21},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3}],"updated_date":"2026-08-01T09:00:35.917206","created_date":"2025-10-10T00:00:00"}