{"id":"https://openalex.org/W3186883115","doi":"https://doi.org/10.1371/journal.pcbi.1009140","title":"Spatio-temporal modeling of the crowding conditions and metabolic variability in microbial communities","display_name":"Spatio-temporal modeling of the crowding conditions and metabolic variability in microbial communities","publication_year":2021,"publication_date":"2021-07-22","ids":{"openalex":"https://openalex.org/W3186883115","doi":"https://doi.org/10.1371/journal.pcbi.1009140","mag":"3186883115","pmid":"https://pubmed.ncbi.nlm.nih.gov/34292935"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1009140","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009140","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009140&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009140&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004560215","display_name":"Liliana Angeles-Martinez","orcid":null},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Liliana Angeles-Martinez","raw_affiliation_strings":["Laboratory of Computational Systems Biotechnology, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, EPFL, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Computational Systems Biotechnology, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, EPFL, Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056011141","display_name":"Vassily Hatzimanikatis","orcid":"https://orcid.org/0000-0001-6432-4694"},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Vassily Hatzimanikatis","raw_affiliation_strings":["Laboratory of Computational Systems Biotechnology, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, EPFL, Lausanne, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-6432-4694","affiliations":[{"raw_affiliation_string":"Laboratory of Computational Systems Biotechnology, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, EPFL, Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5056011141"],"corresponding_institution_ids":["https://openalex.org/I5124864"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.6284,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.84008442,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"17","issue":"7","first_page":"e1009140","last_page":"e1009140"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9952999949455261,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9890999794006348,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/competition","display_name":"Competition (biology)","score":0.6385205984115601},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5631269216537476},{"id":"https://openalex.org/keywords/nutrient","display_name":"Nutrient","score":0.5520265698432922},{"id":"https://openalex.org/keywords/extracellular","display_name":"Extracellular","score":0.49206823110580444},{"id":"https://openalex.org/keywords/salmonella-enterica","display_name":"Salmonella enterica","score":0.4858786463737488},{"id":"https://openalex.org/keywords/microbial-population-biology","display_name":"Microbial population biology","score":0.47150200605392456},{"id":"https://openalex.org/keywords/mutant","display_name":"Mutant","score":0.4643447995185852},{"id":"https://openalex.org/keywords/microbial-metabolism","display_name":"Microbial metabolism","score":0.43744540214538574},{"id":"https://openalex.org/keywords/flux","display_name":"Flux (metallurgy)","score":0.4188944697380066},{"id":"https://openalex.org/keywords/crowding","display_name":"Crowding","score":0.4188220500946045},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.4014946222305298},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.3913153111934662},{"id":"https://openalex.org/keywords/biochemical-engineering","display_name":"Biochemical engineering","score":0.3687228560447693},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.36699730157852173},{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.35719650983810425},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2864687740802765},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.24405798316001892},{"id":"https://openalex.org/keywords/bacteria","display_name":"Bacteria","score":0.22120660543441772},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.15774747729301453},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.12849292159080505}],"concepts":[{"id":"https://openalex.org/C91306197","wikidata":"https://www.wikidata.org/wiki/Q45767","display_name":"Competition (biology)","level":2,"score":0.6385205984115601},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5631269216537476},{"id":"https://openalex.org/C142796444","wikidata":"https://www.wikidata.org/wiki/Q181394","display_name":"Nutrient","level":2,"score":0.5520265698432922},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.49206823110580444},{"id":"https://openalex.org/C2779607309","wikidata":"https://www.wikidata.org/wiki/Q2264864","display_name":"Salmonella enterica","level":4,"score":0.4858786463737488},{"id":"https://openalex.org/C81407943","wikidata":"https://www.wikidata.org/wiki/Q17149178","display_name":"Microbial population biology","level":3,"score":0.47150200605392456},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4643447995185852},{"id":"https://openalex.org/C101014631","wikidata":"https://www.wikidata.org/wiki/Q4889568","display_name":"Microbial metabolism","level":3,"score":0.43744540214538574},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.4188944697380066},{"id":"https://openalex.org/C149333683","wikidata":"https://www.wikidata.org/wiki/Q5189188","display_name":"Crowding","level":2,"score":0.4188220500946045},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.4014946222305298},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.3913153111934662},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.3687228560447693},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.36699730157852173},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.35719650983810425},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2864687740802765},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.24405798316001892},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.22120660543441772},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15774747729301453},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12849292159080505},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019779","descriptor_name":"Salmonella enterica","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019779","descriptor_name":"Salmonella enterica","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019779","descriptor_name":"Salmonella enterica","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019779","descriptor_name":"Salmonella enterica","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019779","descriptor_name":"Salmonella enterica","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019779","descriptor_name":"Salmonella enterica","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D056265","descriptor_name":"Microbial Interactions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D056265","descriptor_name":"Microbial Interactions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D056265","descriptor_name":"Microbial Interactions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D062211","descriptor_name":"Spatio-Temporal Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062211","descriptor_name":"Spatio-Temporal Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062211","descriptor_name":"Spatio-Temporal Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1009140","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009140","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009140&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:34292935","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34292935","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:30ecdf439cf542fba4a4682184a197ed","is_oa":true,"landing_page_url":"https://doaj.org/article/30ecdf439cf542fba4a4682184a197ed","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 17, Iss 7, p e1009140 (2021)","raw_type":"article"},{"id":"pmh:oai:infoscience.epfl.ch:287796","is_oa":true,"landing_page_url":"https://infoscience.epfl.ch/handle/20.500.14299/180547","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"research article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8297787","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8297787","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1009140","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009140","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009140&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F8269005443","display_name":"NCCR Catalysis","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3186883115.pdf","grobid_xml":"https://content.openalex.org/works/W3186883115.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1512810258","https://openalex.org/W1597762351","https://openalex.org/W1850248491","https://openalex.org/W1911386425","https://openalex.org/W1963727947","https://openalex.org/W1985161570","https://openalex.org/W1985618381","https://openalex.org/W1986419282","https://openalex.org/W1996064131","https://openalex.org/W2002016471","https://openalex.org/W2019347117","https://openalex.org/W2027886127","https://openalex.org/W2033404042","https://openalex.org/W2037161130","https://openalex.org/W2041663932","https://openalex.org/W2048596643","https://openalex.org/W2051702209","https://openalex.org/W2059685380","https://openalex.org/W2081554913","https://openalex.org/W2086655099","https://openalex.org/W2103374038","https://openalex.org/W2107409961","https://openalex.org/W2119608865","https://openalex.org/W2122093325","https://openalex.org/W2122836009","https://openalex.org/W2123966372","https://openalex.org/W2124737787","https://openalex.org/W2129239774","https://openalex.org/W2131718032","https://openalex.org/W2133466562","https://openalex.org/W2136004458","https://openalex.org/W2145945191","https://openalex.org/W2152567033","https://openalex.org/W2164683004","https://openalex.org/W2480010979","https://openalex.org/W2480077488","https://openalex.org/W2508183490","https://openalex.org/W2617261748","https://openalex.org/W2737180538","https://openalex.org/W2750504617","https://openalex.org/W2794432101","https://openalex.org/W2940184083","https://openalex.org/W2952948582","https://openalex.org/W2967764163","https://openalex.org/W2984596163","https://openalex.org/W3000663720","https://openalex.org/W3005423028"],"related_works":["https://openalex.org/W2584918788","https://openalex.org/W2301853039","https://openalex.org/W2060595584","https://openalex.org/W4389606712","https://openalex.org/W2024568236","https://openalex.org/W3108832033","https://openalex.org/W2730403860","https://openalex.org/W2995724145","https://openalex.org/W2943389298","https://openalex.org/W2895010771"],"abstract_inverted_index":{"The":[0,258],"metabolic":[1,22,59],"capabilities":[2],"of":[3,21,49,66,100,103,143,166,173,234,238,260,276],"the":[4,7,11,19,25,28,47,55,64,94,98,101,107,151,155,164,171,176,183,199,202,212,215,227,235,242,248,256,264,269,274],"species":[5],"and":[6,58,87,97,123,134,222,263,273],"local":[8,283],"environment":[9,43],"shape":[10,63],"microbial":[12,67,118],"interactions":[13,262],"in":[14,34,255],"a":[15,41,74,282,298],"community":[16],"either":[17,289],"through":[18],"exchange":[20],"products":[23],"or":[24,278,295],"competition":[26,185,200],"for":[27,150],"resources.":[29],"Cells":[30],"are":[31,180],"often":[32],"arranged":[33],"close":[35],"proximity":[36],"to":[37,91,114,220,226,286],"each":[38,129],"other,":[39],"creating":[40,206,297],"crowded":[42],"that":[44,77,126,148,161,193,217],"unevenly":[45],"reduce":[46],"diffusion":[48],"nutrients.":[50,153],"Herein,":[51],"we":[52,71,190],"investigated":[53],"how":[54],"crowding":[56,162,249],"conditions":[57],"variability":[60],"among":[61,214],"cells":[62,204,240],"dynamics":[65],"communities.":[68],"For":[69],"this,":[70],"developed":[72],"CROMICS,":[73],"spatio-temporal":[75],"framework":[76,111],"combines":[78],"techniques":[79],"such":[80],"as":[81],"individual-based":[82],"modeling,":[83],"scaled":[84],"particle":[85],"theory,":[86],"thermodynamic":[88],"flux":[89],"analysis":[90],"explicitly":[92],"incorporate":[93],"cell":[95],"metabolism":[96],"impact":[99],"presence":[102],"macromolecular":[104],"components":[105],"on":[106],"nutrients":[108],"diffusion.":[109],"This":[110],"was":[112,251],"used":[113],"study":[115],"two":[116,136],"archetypical":[117],"communities":[119],"(i)":[120],"Escherichia":[121],"coli":[122,138,195],"Salmonella":[124],"enterica":[125],"cooperate":[127],"with":[128,139,186],"other":[130],"by":[131,169,205,290,296],"exchanging":[132],"metabolites,":[133],"(ii)":[135],"E.":[137,194],"different":[140],"production":[141],"level":[142],"extracellular":[144],"polymeric":[145],"substances":[146],"(EPS)":[147],"compete":[149],"same":[152],"In":[154],"mutualistic":[156],"community,":[157],"our":[158],"results":[159],"demonstrate":[160],"enhanced":[163],"fitness":[165,237],"cooperative":[167],"mutants":[168,197,219],"reducing":[170],"leakage":[172],"metabolites":[174,277,294],"from":[175,268],"region":[177],"where":[178],"they":[179],"produced,":[181],"avoiding":[182],"resource":[184],"non-cooperative":[187],"cells.":[188],"Moreover,":[189],"also":[191],"show":[192],"EPS-secreting":[196,239],"won":[198],"against":[201],"non-secreting":[203,243],"less":[207,299],"dense":[208,300],"structures":[209],"(i.e.":[210],"increasing":[211],"spacing":[213],"cells)":[216],"allow":[218],"expand":[221],"reach":[223],"regions":[224],"closer":[225],"nutrient":[228],"supply":[229],"point.":[230],"A":[231],"modest":[232],"enhancement":[233],"relative":[236],"over":[241],"ones":[244],"were":[245],"found":[246],"when":[247],"effect":[250],"taken":[252],"into":[253],"account":[254],"simulations.":[257],"emergence":[259],"cell-cell":[261],"intracellular":[265],"conflicts":[266],"arising":[267],"trade-off":[270],"between":[271],"growth":[272],"secretion":[275],"EPS":[279],"could":[280],"provide":[281],"competitive":[284],"advantage":[285],"one":[287],"species,":[288],"supplying":[291],"more":[292],"cross-feeding":[293],"neighborhood.":[301]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-06-23T13:55:30.953635","created_date":"2025-10-10T00:00:00"}