{"id":"https://openalex.org/W3182247502","doi":"https://doi.org/10.1371/journal.pcbi.1009128","title":"Why are viral genomes so fragile? The bottleneck hypothesis","display_name":"Why are viral genomes so fragile? The bottleneck hypothesis","publication_year":2021,"publication_date":"2021-07-08","ids":{"openalex":"https://openalex.org/W3182247502","doi":"https://doi.org/10.1371/journal.pcbi.1009128","mag":"3182247502","pmid":"https://pubmed.ncbi.nlm.nih.gov/34237053"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1009128","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009128","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1009128","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090059320","display_name":"Nono S. C. Merleau","orcid":"https://orcid.org/0000-0003-3150-6250"},"institutions":[{"id":"https://openalex.org/I4210091327","display_name":"Max Planck Institute for Mathematics in the Sciences","ror":"https://ror.org/00ez2he07","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210091327"]},{"id":"https://openalex.org/I4210119712","display_name":"Max Planck Institute for Mathematics","ror":"https://ror.org/02dh8ja68","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210119712"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nono S. C. Merleau","raw_affiliation_strings":["Max Planck Institute for Mathematics in the Sciences, Leipzig, Germany"],"raw_orcid":"https://orcid.org/0000-0003-3150-6250","affiliations":[{"raw_affiliation_string":"Max Planck Institute for Mathematics in the Sciences, Leipzig, Germany","institution_ids":["https://openalex.org/I4210119712","https://openalex.org/I4210091327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069688460","display_name":"Sophie P\u00e9nisson","orcid":"https://orcid.org/0000-0002-6268-3842"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I197681013","display_name":"Universit\u00e9 Paris-Est Cr\u00e9teil","ror":"https://ror.org/05ggc9x40","country_code":"FR","type":"education","lineage":["https://openalex.org/I197681013"]},{"id":"https://openalex.org/I4210144844","display_name":"Laboratoire d\u2019Analyse et de Math\u00e9matiques Appliqu\u00e9es","ror":"https://ror.org/0581g8849","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I197681013","https://openalex.org/I4210141950","https://openalex.org/I4210144844","https://openalex.org/I4210154111"]},{"id":"https://openalex.org/I4210154111","display_name":"Universit\u00e9 Gustave Eiffel","ror":"https://ror.org/03x42jk29","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210154111"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sophie P\u00e9nisson","raw_affiliation_strings":["Universit\u00e9 Gustave Eiffel, LAMA, Marne-la-Vall\u00e9e, France","Universit\u00e9 Paris Est Cr\u00e9teil, CNRS, LAMA, Creteil, France"],"raw_orcid":"https://orcid.org/0000-0002-6268-3842","affiliations":[{"raw_affiliation_string":"Universit\u00e9 Gustave Eiffel, LAMA, Marne-la-Vall\u00e9e, France","institution_ids":["https://openalex.org/I4210144844","https://openalex.org/I4210154111"]},{"raw_affiliation_string":"Universit\u00e9 Paris Est Cr\u00e9teil, CNRS, LAMA, Creteil, France","institution_ids":["https://openalex.org/I4210144844","https://openalex.org/I197681013","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009343572","display_name":"Philip J. Gerrish","orcid":"https://orcid.org/0000-0001-6393-0553"},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip J. Gerrish","raw_affiliation_strings":["University of New Mexico, Albuquerque, New Mexico, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of New Mexico, Albuquerque, New Mexico, United States of America","institution_ids":["https://openalex.org/I169521973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001395924","display_name":"Santiago F. Elena","orcid":"https://orcid.org/0000-0001-8249-5593"},"institutions":[{"id":"https://openalex.org/I1308548392","display_name":"Santa Fe Institute","ror":"https://ror.org/01arysc35","country_code":"US","type":"funder","lineage":["https://openalex.org/I1308548392"]},{"id":"https://openalex.org/I16097986","display_name":"Universitat de Val\u00e8ncia","ror":"https://ror.org/043nxc105","country_code":"ES","type":"education","lineage":["https://openalex.org/I16097986"]},{"id":"https://openalex.org/I4210152685","display_name":"Institute for Integrative Systems Biology","ror":"https://ror.org/05jw4kp39","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I16097986","https://openalex.org/I4210152685"]}],"countries":["ES","US"],"is_corresponding":false,"raw_author_name":"Santiago F. Elena","raw_affiliation_strings":["Instituto de Biolog\u00eda Integrativa de Sistemas (I2SysBio), CSIC-Universitat de Val\u00e8ncia, Val\u00e8ncia, Spain","Santa Fe Institute, Santa Fe, New Mexico, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-8249-5593","affiliations":[{"raw_affiliation_string":"Instituto de Biolog\u00eda Integrativa de Sistemas (I2SysBio), CSIC-Universitat de Val\u00e8ncia, Val\u00e8ncia, Spain","institution_ids":["https://openalex.org/I4210152685","https://openalex.org/I16097986"]},{"raw_affiliation_string":"Santa Fe Institute, Santa Fe, New Mexico, United States of America","institution_ids":["https://openalex.org/I1308548392"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072262870","display_name":"Matteo Smerlak","orcid":"https://orcid.org/0000-0002-0844-8868"},"institutions":[{"id":"https://openalex.org/I4210091327","display_name":"Max Planck Institute for Mathematics in the Sciences","ror":"https://ror.org/00ez2he07","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210091327"]},{"id":"https://openalex.org/I4210119712","display_name":"Max Planck Institute for Mathematics","ror":"https://ror.org/02dh8ja68","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210119712"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Matteo Smerlak","raw_affiliation_strings":["Max Planck Institute for Mathematics in the Sciences, Leipzig, Germany"],"raw_orcid":"https://orcid.org/0000-0002-0844-8868","affiliations":[{"raw_affiliation_string":"Max Planck Institute for Mathematics in the Sciences, Leipzig, Germany","institution_ids":["https://openalex.org/I4210119712","https://openalex.org/I4210091327"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5072262870"],"corresponding_institution_ids":["https://openalex.org/I4210091327","https://openalex.org/I4210119712"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.1571,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.80389294,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"17","issue":"7","first_page":"e1009128","last_page":"e1009128"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10482","display_name":"Mathematical and Theoretical Epidemiology and Ecology Models","score":0.9947999715805054,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10494","display_name":"Plant Virus Research Studies","score":0.9801999926567078,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.8055332899093628},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.6226007342338562},{"id":"https://openalex.org/keywords/viral-quasispecies","display_name":"Viral quasispecies","score":0.5475285649299622},{"id":"https://openalex.org/keywords/mutation-rate","display_name":"Mutation rate","score":0.5180540084838867},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.5169560313224792},{"id":"https://openalex.org/keywords/viral-evolution","display_name":"Viral evolution","score":0.5151563882827759},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.5137108564376831},{"id":"https://openalex.org/keywords/fragility","display_name":"Fragility","score":0.47983500361442566},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.4780452847480774},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.4762934744358063},{"id":"https://openalex.org/keywords/genetic-fitness","display_name":"Genetic Fitness","score":0.4655991494655609},{"id":"https://openalex.org/keywords/viral-replication","display_name":"Viral replication","score":0.4344458281993866},{"id":"https://openalex.org/keywords/experimental-evolution","display_name":"Experimental evolution","score":0.4107283651828766},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.28856968879699707},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.21679943799972534}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8055332899093628},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6226007342338562},{"id":"https://openalex.org/C14500911","wikidata":"https://www.wikidata.org/wiki/Q3413375","display_name":"Viral quasispecies","level":4,"score":0.5475285649299622},{"id":"https://openalex.org/C98638677","wikidata":"https://www.wikidata.org/wiki/Q2067051","display_name":"Mutation rate","level":3,"score":0.5180540084838867},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5169560313224792},{"id":"https://openalex.org/C8769409","wikidata":"https://www.wikidata.org/wiki/Q2066554","display_name":"Viral evolution","level":4,"score":0.5151563882827759},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5137108564376831},{"id":"https://openalex.org/C80191262","wikidata":"https://www.wikidata.org/wiki/Q5477668","display_name":"Fragility","level":2,"score":0.47983500361442566},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.4780452847480774},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.4762934744358063},{"id":"https://openalex.org/C2910387474","wikidata":"https://www.wikidata.org/wiki/Q331710","display_name":"Genetic Fitness","level":3,"score":0.4655991494655609},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.4344458281993866},{"id":"https://openalex.org/C87590526","wikidata":"https://www.wikidata.org/wiki/Q3592884","display_name":"Experimental evolution","level":3,"score":0.4107283651828766},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.28856968879699707},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21679943799972534},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016679","descriptor_name":"Genome, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016679","descriptor_name":"Genome, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016679","descriptor_name":"Genome, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042822","descriptor_name":"Genomic Instability","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D042822","descriptor_name":"Genomic Instability","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D042822","descriptor_name":"Genomic Instability","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1009128","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009128","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:34237053","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34237053","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:HAL:hal-03874773v1","is_oa":false,"landing_page_url":"https://cnrs.hal.science/hal-03874773","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, 2021, 17 (7), pp.e1009128. ⟨10.1371/journal.pcbi.1009128⟩","raw_type":"Journal articles"},{"id":"pmh:oai:digital.csic.es:10261/262408","is_oa":true,"landing_page_url":"http://hdl.handle.net/10261/262408","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"art\u00edculo"},{"id":"pmh:oai:doaj.org/article:5cb2c75b535f4d34b1a1e02a06a24f53","is_oa":true,"landing_page_url":"https://doaj.org/article/5cb2c75b535f4d34b1a1e02a06a24f53","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 17, Iss 7, p e1009128 (2021)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8291636","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8291636","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1009128","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009128","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4099999964237213,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G2684083780","display_name":null,"funder_award_id":"PROMETEO2019/012","funder_id":"https://openalex.org/F4320321864","funder_display_name":"Generalitat Valenciana"}],"funders":[{"id":"https://openalex.org/F4320308269","display_name":"Alexander von Humboldt-Stiftung","ror":"https://ror.org/012kf4317"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"},{"id":"https://openalex.org/F4320321864","display_name":"Generalitat Valenciana","ror":"https://ror.org/0097mvx21"},{"id":"https://openalex.org/F4320327897","display_name":"Max-Planck-Institut f\u00fcr Mathematik in den Naturwissenschaften","ror":"https://ror.org/00ez2he07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W1559984321","https://openalex.org/W1647676779","https://openalex.org/W1661927664","https://openalex.org/W1951480739","https://openalex.org/W1965501302","https://openalex.org/W1973053780","https://openalex.org/W1977124799","https://openalex.org/W1983153145","https://openalex.org/W1989530362","https://openalex.org/W1989600727","https://openalex.org/W1990261344","https://openalex.org/W1992973689","https://openalex.org/W1999852713","https://openalex.org/W2001505139","https://openalex.org/W2004413619","https://openalex.org/W2010242629","https://openalex.org/W2025788954","https://openalex.org/W2032402861","https://openalex.org/W2036128117","https://openalex.org/W2044317391","https://openalex.org/W2045716211","https://openalex.org/W2055633360","https://openalex.org/W2065758222","https://openalex.org/W2065915320","https://openalex.org/W2066227234","https://openalex.org/W2072971198","https://openalex.org/W2080449796","https://openalex.org/W2082676515","https://openalex.org/W2094339562","https://openalex.org/W2097295643","https://openalex.org/W2108670087","https://openalex.org/W2109970745","https://openalex.org/W2110828961","https://openalex.org/W2116561779","https://openalex.org/W2118489430","https://openalex.org/W2121105996","https://openalex.org/W2126074998","https://openalex.org/W2126280636","https://openalex.org/W2136201786","https://openalex.org/W2143483384","https://openalex.org/W2143958721","https://openalex.org/W2147819170","https://openalex.org/W2149029025","https://openalex.org/W2159573893","https://openalex.org/W2159690951","https://openalex.org/W2166236011","https://openalex.org/W2166871450","https://openalex.org/W2167406812","https://openalex.org/W2167820346","https://openalex.org/W2168338628","https://openalex.org/W2241496350","https://openalex.org/W2321397969","https://openalex.org/W2516984515","https://openalex.org/W2620052976","https://openalex.org/W2762187001","https://openalex.org/W2952153737","https://openalex.org/W3028518542","https://openalex.org/W3103014430","https://openalex.org/W3153753136","https://openalex.org/W4206712614","https://openalex.org/W4231137976","https://openalex.org/W4235035462","https://openalex.org/W4249578022"],"related_works":["https://openalex.org/W2003574450","https://openalex.org/W4212841392","https://openalex.org/W4400470248","https://openalex.org/W1986863138","https://openalex.org/W2939690863","https://openalex.org/W2060809008","https://openalex.org/W2050960315","https://openalex.org/W2075380571","https://openalex.org/W4283515460","https://openalex.org/W4291824845"],"abstract_inverted_index":{"If":[0],"they":[1],"undergo":[2],"new":[3],"mutations":[4,18],"at":[5,52,75,114],"each":[6],"replication":[7],"cycle,":[8],"why":[9],"are":[10],"RNA":[11],"viral":[12,50,61,104,139],"genomes":[13],"so":[14],"fragile,":[15],"with":[16],"most":[17],"being":[19],"either":[20],"strongly":[21],"deleterious":[22],"or":[23],"lethal?":[24],"Here":[25],"we":[26,67,96],"provide":[27],"theoretical":[28],"and":[29,80,117],"numerical":[30],"evidence":[31],"for":[32],"the":[33,44,73,82,89,99,124,135],"hypothesis":[34],"that":[35,69,98,108],"genetic":[36,136],"fragility":[37,71],"is":[38],"partly":[39],"an":[40],"evolutionary":[41],"response":[42],"to":[43],"multiple":[45,86],"population":[46],"bottlenecks":[47,132],"experienced":[48],"by":[49],"populations":[51,62],"various":[53],"stages":[54],"of":[55,91,102,109,126,138],"their":[56],"life":[57],"cycles.":[58],"Modelling":[59],"within-host":[60],"as":[63,130],"multi-type":[64],"branching":[65],"processes,":[66],"show":[68],"mutational":[70],"lowers":[72],"rate":[74,101],"which":[76],"Muller's":[77],"ratchet":[78],"clicks":[79],"increases":[81],"survival":[83],"probability":[84],"through":[85],"bottlenecks.":[87],"In":[88],"context":[90],"a":[92],"susceptible-exposed-infectious-recovered":[93],"epidemiological":[94],"model,":[95],"find":[97],"attack":[100],"fragile":[103],"strains":[105],"can":[106],"exceed":[107],"more":[110],"robust":[111],"strains,":[112],"particularly":[113],"low":[115],"infectivities":[116],"high":[118],"mutation":[119],"rates.":[120],"Our":[121],"findings":[122],"highlight":[123],"importance":[125],"demographic":[127],"events":[128],"such":[129],"transmission":[131],"in":[133],"shaping":[134],"architecture":[137],"pathogens.":[140]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}