{"id":"https://openalex.org/W4291008671","doi":"https://doi.org/10.1371/journal.pcbi.1009100","title":"Scelestial: Fast and accurate single-cell lineage tree inference based on a Steiner tree approximation algorithm","display_name":"Scelestial: Fast and accurate single-cell lineage tree inference based on a Steiner tree approximation algorithm","publication_year":2022,"publication_date":"2022-08-11","ids":{"openalex":"https://openalex.org/W4291008671","doi":"https://doi.org/10.1371/journal.pcbi.1009100","pmid":"https://pubmed.ncbi.nlm.nih.gov/35951662"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1009100","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009100","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009100&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009100&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103004122","display_name":"Mohammad-Hadi Foroughmand-Araabi","orcid":"https://orcid.org/0000-0002-9976-1138"},"institutions":[{"id":"https://openalex.org/I4210124929","display_name":"Helmholtz Centre for Infection Research","ror":"https://ror.org/03d0p2685","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929"]},{"id":"https://openalex.org/I94509681","display_name":"Technische Universit\u00e4t Braunschweig","ror":"https://ror.org/010nsgg66","country_code":"DE","type":"education","lineage":["https://openalex.org/I94509681"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mohammad-Hadi Foroughmand-Araabi","raw_affiliation_strings":["Braunschweig Integrated Centre of Systems Biology (BRICS), Technische Universit\u00e4t Braunschweig, Braunschweig, Germany","Computational Biology of Infection Research, Helmholtz Centre for Infection Research, Braunschweig, Germany"],"raw_orcid":"https://orcid.org/0000-0002-9976-1138","affiliations":[{"raw_affiliation_string":"Braunschweig Integrated Centre of Systems Biology (BRICS), Technische Universit\u00e4t Braunschweig, Braunschweig, Germany","institution_ids":["https://openalex.org/I94509681"]},{"raw_affiliation_string":"Computational Biology of Infection Research, Helmholtz Centre for Infection Research, Braunschweig, Germany","institution_ids":["https://openalex.org/I4210124929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047358144","display_name":"Sama Goliaei","orcid":"https://orcid.org/0000-0001-6275-2783"},"institutions":[{"id":"https://openalex.org/I4210124929","display_name":"Helmholtz Centre for Infection Research","ror":"https://ror.org/03d0p2685","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929"]},{"id":"https://openalex.org/I94509681","display_name":"Technische Universit\u00e4t Braunschweig","ror":"https://ror.org/010nsgg66","country_code":"DE","type":"education","lineage":["https://openalex.org/I94509681"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sama Goliaei","raw_affiliation_strings":["Braunschweig Integrated Centre of Systems Biology (BRICS), Technische Universit\u00e4t Braunschweig, Braunschweig, Germany","Computational Biology of Infection Research, Helmholtz Centre for Infection Research, Braunschweig, Germany"],"raw_orcid":"https://orcid.org/0000-0001-6275-2783","affiliations":[{"raw_affiliation_string":"Braunschweig Integrated Centre of Systems Biology (BRICS), Technische Universit\u00e4t Braunschweig, Braunschweig, Germany","institution_ids":["https://openalex.org/I94509681"]},{"raw_affiliation_string":"Computational Biology of Infection Research, Helmholtz Centre for Infection Research, Braunschweig, Germany","institution_ids":["https://openalex.org/I4210124929"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081103408","display_name":"Alice C. McHardy","orcid":"https://orcid.org/0000-0003-2370-3430"},"institutions":[{"id":"https://openalex.org/I4210124929","display_name":"Helmholtz Centre for Infection Research","ror":"https://ror.org/03d0p2685","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929"]},{"id":"https://openalex.org/I94509681","display_name":"Technische Universit\u00e4t Braunschweig","ror":"https://ror.org/010nsgg66","country_code":"DE","type":"education","lineage":["https://openalex.org/I94509681"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Alice C. McHardy","raw_affiliation_strings":["Braunschweig Integrated Centre of Systems Biology (BRICS), Technische Universit\u00e4t Braunschweig, Braunschweig, Germany","Computational Biology of Infection Research, Helmholtz Centre for Infection Research, Braunschweig, Germany"],"raw_orcid":"https://orcid.org/0000-0003-2370-3430","affiliations":[{"raw_affiliation_string":"Braunschweig Integrated Centre of Systems Biology (BRICS), Technische Universit\u00e4t Braunschweig, Braunschweig, Germany","institution_ids":["https://openalex.org/I94509681"]},{"raw_affiliation_string":"Computational Biology of Infection Research, Helmholtz Centre for Infection Research, Braunschweig, Germany","institution_ids":["https://openalex.org/I4210124929"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5081103408"],"corresponding_institution_ids":["https://openalex.org/I4210124929","https://openalex.org/I94509681"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.11594336,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"8","first_page":"e1009100","last_page":"e1009100"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9864000082015991,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tree","display_name":"Tree (set theory)","score":0.676924467086792},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5948666334152222},{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.5933517813682556},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.5867774486541748},{"id":"https://openalex.org/keywords/lineage","display_name":"Lineage (genetic)","score":0.5611069798469543},{"id":"https://openalex.org/keywords/steiner-tree-problem","display_name":"Steiner tree problem","score":0.5210004448890686},{"id":"https://openalex.org/keywords/interval-tree","display_name":"Interval tree","score":0.4590396583080292},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.4131557047367096},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.39212244749069214},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.29943597316741943},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.27568602561950684},{"id":"https://openalex.org/keywords/search-tree","display_name":"Search tree","score":0.26737135648727417},{"id":"https://openalex.org/keywords/search-algorithm","display_name":"Search algorithm","score":0.2622653543949127},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2577402591705322},{"id":"https://openalex.org/keywords/combinatorics","display_name":"Combinatorics","score":0.18050259351730347},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.16681361198425293},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1291806399822235}],"concepts":[{"id":"https://openalex.org/C113174947","wikidata":"https://www.wikidata.org/wiki/Q2859736","display_name":"Tree (set theory)","level":2,"score":0.676924467086792},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5948666334152222},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.5933517813682556},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.5867774486541748},{"id":"https://openalex.org/C2776817793","wikidata":"https://www.wikidata.org/wiki/Q6553369","display_name":"Lineage (genetic)","level":3,"score":0.5611069798469543},{"id":"https://openalex.org/C76220878","wikidata":"https://www.wikidata.org/wiki/Q1764144","display_name":"Steiner tree problem","level":2,"score":0.5210004448890686},{"id":"https://openalex.org/C84927040","wikidata":"https://www.wikidata.org/wiki/Q6057306","display_name":"Interval tree","level":4,"score":0.4590396583080292},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4131557047367096},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.39212244749069214},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29943597316741943},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.27568602561950684},{"id":"https://openalex.org/C207024777","wikidata":"https://www.wikidata.org/wiki/Q621673","display_name":"Search tree","level":3,"score":0.26737135648727417},{"id":"https://openalex.org/C125583679","wikidata":"https://www.wikidata.org/wiki/Q755673","display_name":"Search algorithm","level":2,"score":0.2622653543949127},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2577402591705322},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.18050259351730347},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16681361198425293},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1291806399822235}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1009100","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009100","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009100&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:35951662","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35951662","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1009100","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1009100","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:17d5e839ec614d2cb2f00f7ae71be767","is_oa":true,"landing_page_url":"https://doaj.org/article/17d5e839ec614d2cb2f00f7ae71be767","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 8, p e1009100 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9426887","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9426887","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1009100","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009100","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009100&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4291008671.pdf","grobid_xml":"https://content.openalex.org/works/W4291008671.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1531591475","https://openalex.org/W1558703235","https://openalex.org/W1591012225","https://openalex.org/W1967304777","https://openalex.org/W2003882909","https://openalex.org/W2027515293","https://openalex.org/W2029069882","https://openalex.org/W2029990894","https://openalex.org/W2056824842","https://openalex.org/W2079392189","https://openalex.org/W2086709935","https://openalex.org/W2116402280","https://openalex.org/W2152684097","https://openalex.org/W2156411023","https://openalex.org/W2159065207","https://openalex.org/W2165112989","https://openalex.org/W2170052973","https://openalex.org/W2340974016","https://openalex.org/W2346273585","https://openalex.org/W2586389371","https://openalex.org/W2618389271","https://openalex.org/W2741508285","https://openalex.org/W2754025713","https://openalex.org/W2795499463","https://openalex.org/W2890035501","https://openalex.org/W2898789672","https://openalex.org/W2903388206","https://openalex.org/W2949688529","https://openalex.org/W2980515223","https://openalex.org/W2980586637","https://openalex.org/W2994966800","https://openalex.org/W3005127469","https://openalex.org/W3023942689","https://openalex.org/W3075371075","https://openalex.org/W3213961185","https://openalex.org/W4214695391"],"related_works":["https://openalex.org/W2578129866","https://openalex.org/W2227684440","https://openalex.org/W272774291","https://openalex.org/W1521720839","https://openalex.org/W2156833871","https://openalex.org/W2304323820","https://openalex.org/W2007609084","https://openalex.org/W3128587426","https://openalex.org/W2083751087","https://openalex.org/W2359807192"],"abstract_inverted_index":{"Single-cell":[0],"genome":[1,23],"sequencing":[2],"provides":[3],"a":[4,27,57,67,87,111,124,150],"highly":[5],"granular":[6],"view":[7],"of":[8,44,59,70,78,113,127,136,181],"biological":[9],"systems":[10],"but":[11],"is":[12,49,98,110,193],"affected":[13],"by":[14,143],"high":[15],"error":[16],"rates,":[17],"allelic":[18],"amplification":[19],"bias,":[20],"and":[21,73,109,139,165,168,183],"uneven":[22],"coverage.":[24],"This":[25],"creates":[26],"need":[28],"for":[29,33,37,81,90,104],"data-specific":[30],"computational":[31],"methods,":[32],"purposes":[34],"such":[35],"as":[36,75,77,130,196],"cell":[38,45,61],"lineage":[39,46,91,144,156],"tree":[40,47,92,107,157],"inference.":[41],"The":[42],"objective":[43],"reconstruction":[48,93,158],"to":[50,121,140],"infer":[51],"the":[52,105,114,119,134],"evolutionary":[53],"process":[54],"that":[55],"generated":[56],"set":[58],"observed":[60],"genomes.":[62],"Lineage":[63],"trees":[64,178],"may":[65],"enable":[66],"better":[68],"understanding":[69],"tumor":[71,171],"formation":[72],"growth,":[74],"well":[76],"organ":[79],"development":[80],"healthy":[82],"body":[83],"cells.":[84],"We":[85,117],"describe":[86],"method,":[88],"Scelestial,":[89],"from":[94],"single-cell":[95,155,170],"data,":[96],"which":[97],"based":[99],"on":[100],"an":[101,197],"approximation":[102],"algorithm":[103,120],"Steiner":[106],"problem":[108],"generalization":[112],"neighbor-joining":[115],"method.":[116],"adapt":[118],"efficiently":[122],"select":[123],"limited":[125],"subset":[126],"potential":[128],"sequences":[129],"internal":[131],"nodes,":[132],"in":[133,179,190],"presence":[135],"missing":[137,146],"values,":[138],"minimize":[141],"cost":[142],"tree-based":[145],"value":[147],"imputation.":[148],"In":[149],"comparison":[151],"against":[152],"seven":[153],"state-of-the-art":[154],"algorithms-BitPhylogeny,":[159],"OncoNEM,":[160],"SCITE,":[161],"SiFit,":[162],"SASC,":[163],"SCIPhI,":[164],"SiCloneFit-on":[166],"simulated":[167],"real":[169],"samples,":[172],"Scelestial":[173,186],"performed":[174],"best":[175],"at":[176],"reconstructing":[177],"terms":[180],"accuracy":[182],"run":[184],"time.":[185],"has":[187],"been":[188],"implemented":[189],"C++.":[191],"It":[192],"also":[194],"available":[195],"R":[198],"package":[199],"named":[200],"RScelestial.":[201]},"counts_by_year":[],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}