{"id":"https://openalex.org/W3170512748","doi":"https://doi.org/10.1371/journal.pcbi.1009019","title":"Ion dynamics at the energy-deprived tripartite synapse","display_name":"Ion dynamics at the energy-deprived tripartite synapse","publication_year":2021,"publication_date":"2021-06-18","ids":{"openalex":"https://openalex.org/W3170512748","doi":"https://doi.org/10.1371/journal.pcbi.1009019","mag":"3170512748","pmid":"https://pubmed.ncbi.nlm.nih.gov/34143772"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1009019","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009019","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009019&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009019&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077019881","display_name":"Manu Kalia","orcid":"https://orcid.org/0000-0001-6916-6533"},"institutions":[{"id":"https://openalex.org/I94624287","display_name":"University of Twente","ror":"https://ror.org/006hf6230","country_code":"NL","type":"education","lineage":["https://openalex.org/I94624287"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Manu Kalia","raw_affiliation_strings":["Applied Analysis, Department of Applied Mathematics, University of Twente, Enschede, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0001-6916-6533","affiliations":[{"raw_affiliation_string":"Applied Analysis, Department of Applied Mathematics, University of Twente, Enschede, The Netherlands","institution_ids":["https://openalex.org/I94624287"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062882766","display_name":"Hil G. E. Meijer","orcid":"https://orcid.org/0000-0003-1526-3762"},"institutions":[{"id":"https://openalex.org/I94624287","display_name":"University of Twente","ror":"https://ror.org/006hf6230","country_code":"NL","type":"education","lineage":["https://openalex.org/I94624287"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Hil G. E. Meijer","raw_affiliation_strings":["Applied Analysis, Department of Applied Mathematics, University of Twente, Enschede, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0003-1526-3762","affiliations":[{"raw_affiliation_string":"Applied Analysis, Department of Applied Mathematics, University of Twente, Enschede, The Netherlands","institution_ids":["https://openalex.org/I94624287"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026311408","display_name":"Stephan A. van Gils","orcid":"https://orcid.org/0000-0003-0528-4324"},"institutions":[{"id":"https://openalex.org/I94624287","display_name":"University of Twente","ror":"https://ror.org/006hf6230","country_code":"NL","type":"education","lineage":["https://openalex.org/I94624287"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Stephan A. van Gils","raw_affiliation_strings":["Applied Analysis, Department of Applied Mathematics, University of Twente, Enschede, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Analysis, Department of Applied Mathematics, University of Twente, Enschede, The Netherlands","institution_ids":["https://openalex.org/I94624287"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064975531","display_name":"Michel J. A. M. van Putten","orcid":"https://orcid.org/0000-0001-8319-3626"},"institutions":[{"id":"https://openalex.org/I94624287","display_name":"University of Twente","ror":"https://ror.org/006hf6230","country_code":"NL","type":"education","lineage":["https://openalex.org/I94624287"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Michel J. A. M. van Putten","raw_affiliation_strings":["Department of Clinical Neurophysiology, University of Twente, Enschede, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0001-8319-3626","affiliations":[{"raw_affiliation_string":"Department of Clinical Neurophysiology, University of Twente, Enschede, The Netherlands","institution_ids":["https://openalex.org/I94624287"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004662891","display_name":"Christine R. Rose","orcid":"https://orcid.org/0000-0002-9684-3592"},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christine R. Rose","raw_affiliation_strings":["Institute of Neurobiology, Heinrich Heine University D\u00fcsseldorf, D\u00fcsseldorf, Germany"],"raw_orcid":"https://orcid.org/0000-0002-9684-3592","affiliations":[{"raw_affiliation_string":"Institute of Neurobiology, Heinrich Heine University D\u00fcsseldorf, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5077019881"],"corresponding_institution_ids":["https://openalex.org/I94624287"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.7596,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.83501259,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"17","issue":"6","first_page":"e1009019","last_page":"e1009019"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dynamics","display_name":"Dynamics (music)","score":0.5130854845046997},{"id":"https://openalex.org/keywords/ion","display_name":"Ion","score":0.5081727504730225},{"id":"https://openalex.org/keywords/synapse","display_name":"Synapse","score":0.4211367964744568},{"id":"https://openalex.org/keywords/energy","display_name":"Energy (signal processing)","score":0.41557180881500244},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.37132275104522705},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.36477404832839966},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.35994642972946167},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.354925274848938},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.3287857174873352},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.30572709441185},{"id":"https://openalex.org/keywords/quantum-mechanics","display_name":"Quantum mechanics","score":0.07938393950462341}],"concepts":[{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.5130854845046997},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.5081727504730225},{"id":"https://openalex.org/C127445978","wikidata":"https://www.wikidata.org/wiki/Q187181","display_name":"Synapse","level":2,"score":0.4211367964744568},{"id":"https://openalex.org/C186370098","wikidata":"https://www.wikidata.org/wiki/Q442787","display_name":"Energy (signal processing)","level":2,"score":0.41557180881500244},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.37132275104522705},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.36477404832839966},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35994642972946167},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.354925274848938},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3287857174873352},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.30572709441185},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.07938393950462341},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007477","descriptor_name":"Ions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007477","descriptor_name":"Ions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007477","descriptor_name":"Ions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050491","descriptor_name":"Glutamate Plasma Membrane Transport Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D050491","descriptor_name":"Glutamate Plasma Membrane Transport Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D050491","descriptor_name":"Glutamate Plasma Membrane Transport Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1009019","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009019","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009019&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:34143772","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34143772","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:ris.utwente.nl:openaire/40399db8-96db-46e1-830e-a0d29653b02f","is_oa":true,"landing_page_url":"https://research.utwente.nl/en/publications/40399db8-96db-46e1-830e-a0d29653b02f","pdf_url":null,"source":{"id":"https://openalex.org/S4406922991","display_name":"University of Twente Research Information","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kalia, M, Meijer, H G E, van Gils, S A, van Putten, M J A M & Rose, C R 2021, 'Ion dynamics at the energy-deprived tripartite synapse', PLoS Computational Biology, vol. 17, no. 6, e1009019. https://doi.org/10.1371/journal.pcbi.1009019","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:doaj.org/article:1d16ace684d844c58ae0cd7e499fe292","is_oa":true,"landing_page_url":"https://doaj.org/article/1d16ace684d844c58ae0cd7e499fe292","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 17, Iss 6, p e1009019 (2021)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8244923","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8244923","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1009019","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009019","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1009019&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/7","score":0.8199999928474426,"display_name":"Affordable and clean energy"}],"awards":[{"id":"https://openalex.org/G1401160867","display_name":null,"funder_award_id":"Ro2327/14-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G2706523471","display_name":null,"funder_award_id":"FOR2795","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G6304479148","display_name":null,"funder_award_id":"Ro2327/13-1 and Ro2327/14-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3170512748.pdf","grobid_xml":"https://content.openalex.org/works/W3170512748.grobid-xml"},"referenced_works_count":92,"referenced_works":["https://openalex.org/W1134182094","https://openalex.org/W1533616161","https://openalex.org/W1540478364","https://openalex.org/W1552174187","https://openalex.org/W1681263274","https://openalex.org/W1843850325","https://openalex.org/W1864807353","https://openalex.org/W1915126090","https://openalex.org/W1969526225","https://openalex.org/W1970536698","https://openalex.org/W1973195879","https://openalex.org/W1976465328","https://openalex.org/W1978553624","https://openalex.org/W1978985709","https://openalex.org/W1979331987","https://openalex.org/W1980680281","https://openalex.org/W1981893433","https://openalex.org/W1982678041","https://openalex.org/W1982950909","https://openalex.org/W1985221995","https://openalex.org/W1990216374","https://openalex.org/W1995537895","https://openalex.org/W2004775079","https://openalex.org/W2006338283","https://openalex.org/W2007474124","https://openalex.org/W2021337708","https://openalex.org/W2021459159","https://openalex.org/W2024434386","https://openalex.org/W2031543773","https://openalex.org/W2032570560","https://openalex.org/W2036722707","https://openalex.org/W2044730840","https://openalex.org/W2051429876","https://openalex.org/W2053739364","https://openalex.org/W2053831933","https://openalex.org/W2063541896","https://openalex.org/W2068608250","https://openalex.org/W2074841206","https://openalex.org/W2075682801","https://openalex.org/W2079773821","https://openalex.org/W2083252150","https://openalex.org/W2088607178","https://openalex.org/W2088931724","https://openalex.org/W2099218390","https://openalex.org/W2099771668","https://openalex.org/W2101543514","https://openalex.org/W2102104646","https://openalex.org/W2103230981","https://openalex.org/W2106495485","https://openalex.org/W2112260438","https://openalex.org/W2119506841","https://openalex.org/W2121759245","https://openalex.org/W2122964729","https://openalex.org/W2128790805","https://openalex.org/W2129896258","https://openalex.org/W2133100820","https://openalex.org/W2135771733","https://openalex.org/W2148578075","https://openalex.org/W2162813640","https://openalex.org/W2164554425","https://openalex.org/W2167970717","https://openalex.org/W2227238226","https://openalex.org/W2295094545","https://openalex.org/W2300320813","https://openalex.org/W2317176447","https://openalex.org/W2328001100","https://openalex.org/W2339728065","https://openalex.org/W2415944637","https://openalex.org/W2469777502","https://openalex.org/W2551579452","https://openalex.org/W2556335366","https://openalex.org/W2587305225","https://openalex.org/W2587950333","https://openalex.org/W2764230521","https://openalex.org/W2767487654","https://openalex.org/W2777525962","https://openalex.org/W2796453918","https://openalex.org/W2804386241","https://openalex.org/W2887174624","https://openalex.org/W2897572680","https://openalex.org/W2913944576","https://openalex.org/W2968768229","https://openalex.org/W3011621535","https://openalex.org/W3019363372","https://openalex.org/W3024746983","https://openalex.org/W3092615318","https://openalex.org/W3098581270","https://openalex.org/W3098919445","https://openalex.org/W3189715865","https://openalex.org/W3196492948","https://openalex.org/W4210979710","https://openalex.org/W4388117959"],"related_works":["https://openalex.org/W2373011427","https://openalex.org/W2074711307","https://openalex.org/W1991247872","https://openalex.org/W2949844983","https://openalex.org/W3083560605","https://openalex.org/W1980247835","https://openalex.org/W1636325709","https://openalex.org/W2025759951","https://openalex.org/W2724817865","https://openalex.org/W2400992695"],"abstract_inverted_index":{"The":[0,43,61],"anatomical":[1],"and":[2,7,40,47,70,138,140,160,175,201,264],"functional":[3],"organization":[4],"of":[5,33,57,63,104,112,128,151,266],"neurons":[6],"astrocytes":[8],"at":[9],"'tripartite":[10],"synapses'":[11],"is":[12,120,141,214,221],"essential":[13],"for":[14,82,262],"reliable":[15],"neurotransmission,":[16],"which":[17,75,193],"critically":[18],"depends":[19,66],"on":[20,67,122],"ATP.":[21],"In":[22,90],"low":[23],"energy":[24,116,179,257],"conditions,":[25],"synaptic":[26,113],"transmission":[27],"fails,":[28],"accompanied":[29],"by":[30,98],"a":[31,76,100,105,187],"breakdown":[32],"ion":[34,156],"gradients,":[35,157],"changes":[36],"in":[37,74,154,225],"membrane":[38,158],"potentials":[39,159],"cell":[41,48,161],"swelling.":[42],"resulting":[44],"cellular":[45],"damage":[46,65],"death":[49],"are":[50,86],"causal":[51],"to":[52,108,189,210,242,254],"the":[53,68,71,80,91,129,148,152,167,181,190,208,211,217,226,239,251],"often":[54],"devastating":[55],"consequences":[56],"an":[58],"ischemic":[59,64,243,267],"stroke.":[60],"severity":[62],"age":[69],"brain":[72],"region":[73],"stroke":[77],"occurs,":[78],"but":[79],"reasons":[81],"this":[83,96],"differential":[84],"vulnerability":[85],"far":[87],"from":[88,256],"understood.":[89],"present":[92],"study,":[93],"we":[94],"address":[95],"question":[97],"developing":[99],"comprehensive":[101],"biophysical":[102,124],"model":[103,119,205],"glutamatergic":[106],"synapse":[107],"identify":[109],"key":[110],"determinants":[111],"failure":[114],"during":[115],"deprivation.":[117],"Our":[118,163,204,245],"based":[121],"fundamental":[123],"principles,":[125],"includes":[126],"dynamics":[127],"most":[130],"relevant":[131],"ions,":[132],"i.e.,":[133],"Na+,":[134],"K+,":[135],"Ca2+,":[136],"Cl-":[137],"glutamate,":[139],"calibrated":[142],"with":[143,234,259],"experimental":[144],"data.":[145],"It":[146],"confirms":[147],"critical":[149],"role":[150],"Na+/K+-ATPase":[153],"maintaining":[155],"volumes.":[162],"simulations":[164],"demonstrate":[165],"that":[166,207],"system":[168],"exhibits":[169],"two":[170],"stable":[171],"states,":[172],"one":[173,176],"physiological":[174,182],"pathological.":[177],"During":[178],"deprivation,":[180,258],"state":[183,213],"may":[184],"disappear,":[185],"forcing":[186],"transit":[188],"pathological":[191,212],"state,":[192],"can":[194],"be":[195],"reverted":[196],"when":[197],"blocking":[198],"voltage-gated":[199],"Na+":[200],"K+":[202],"channels.":[203],"predicts":[206],"transition":[209],"favoured":[215],"if":[216],"extracellular":[218,227],"space":[219,228],"fraction":[220],"small.":[222],"A":[223],"reduction":[224],"volume":[229],"fraction,":[230],"as,":[231],"e.g.":[232],"observed":[233],"ageing,":[235],"will":[236],"thus":[237],"promote":[238],"brain's":[240,252],"susceptibility":[241],"damage.":[244],"work":[246],"provides":[247],"new":[248],"insights":[249],"into":[250],"ability":[253],"recover":[255],"translational":[260],"relevance":[261],"diagnosis":[263],"treatment":[265],"strokes.":[268]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":2}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}