{"id":"https://openalex.org/W4226069058","doi":"https://doi.org/10.1371/journal.pcbi.1008933","title":"Extracting temporal relationships between weakly coupled peptidergic and motoneuronal signaling: Application to Drosophila ecdysis behavior","display_name":"Extracting temporal relationships between weakly coupled peptidergic and motoneuronal signaling: Application to Drosophila ecdysis behavior","publication_year":2021,"publication_date":"2021-12-15","ids":{"openalex":"https://openalex.org/W4226069058","doi":"https://doi.org/10.1371/journal.pcbi.1008933","pmid":"https://pubmed.ncbi.nlm.nih.gov/34910730"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1008933","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008933","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1008933","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5097656377","display_name":"Miguel Pi\u00f1eiro","orcid":"https://orcid.org/0000-0003-2914-7818"},"institutions":[{"id":"https://openalex.org/I79274474","display_name":"University of Valpara\u00edso","ror":"https://ror.org/00h9jrb69","country_code":"CL","type":"education","lineage":["https://openalex.org/I79274474"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Miguel Pi\u00f1eiro","raw_affiliation_strings":["Centro Interdisciplinario de Neurociencia de Valpara\u00edso, Universidad de Valpara\u00edso, Valpara\u00edso, Chile"],"raw_orcid":"https://orcid.org/0000-0003-2914-7818","affiliations":[{"raw_affiliation_string":"Centro Interdisciplinario de Neurociencia de Valpara\u00edso, Universidad de Valpara\u00edso, Valpara\u00edso, Chile","institution_ids":["https://openalex.org/I79274474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076806775","display_name":"Wilson Mena","orcid":null},"institutions":[{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]},{"id":"https://openalex.org/I79274474","display_name":"University of Valpara\u00edso","ror":"https://ror.org/00h9jrb69","country_code":"CL","type":"education","lineage":["https://openalex.org/I79274474"]}],"countries":["CL","FR"],"is_corresponding":false,"raw_author_name":"Wilson Mena","raw_affiliation_strings":["Centro Interdisciplinario de Neurociencia de Valpara\u00edso, Universidad de Valpara\u00edso, Valpara\u00edso, Chile","Department of Neuroscience, Institut Pasteur, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Interdisciplinario de Neurociencia de Valpara\u00edso, Universidad de Valpara\u00edso, Valpara\u00edso, Chile","institution_ids":["https://openalex.org/I79274474"]},{"raw_affiliation_string":"Department of Neuroscience, Institut Pasteur, Paris, France","institution_ids":["https://openalex.org/I157536573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051401003","display_name":"John Ewer","orcid":"https://orcid.org/0000-0002-6806-3628"},"institutions":[{"id":"https://openalex.org/I79274474","display_name":"University of Valpara\u00edso","ror":"https://ror.org/00h9jrb69","country_code":"CL","type":"education","lineage":["https://openalex.org/I79274474"]}],"countries":["CL"],"is_corresponding":true,"raw_author_name":"John Ewer","raw_affiliation_strings":["Centro Interdisciplinario de Neurociencia de Valpara\u00edso, Universidad de Valpara\u00edso, Valpara\u00edso, Chile","Instituto de Neurociencias, Facultad de Ciencias, Universidad de Valpara\u00edso, Valpara\u00edso, Chile"],"raw_orcid":"https://orcid.org/0000-0002-6806-3628","affiliations":[{"raw_affiliation_string":"Centro Interdisciplinario de Neurociencia de Valpara\u00edso, Universidad de Valpara\u00edso, Valpara\u00edso, Chile","institution_ids":["https://openalex.org/I79274474"]},{"raw_affiliation_string":"Instituto de Neurociencias, Facultad de Ciencias, Universidad de Valpara\u00edso, Valpara\u00edso, Chile","institution_ids":["https://openalex.org/I79274474"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042230025","display_name":"Patricio Orio","orcid":"https://orcid.org/0000-0003-0332-8098"},"institutions":[{"id":"https://openalex.org/I79274474","display_name":"University of Valpara\u00edso","ror":"https://ror.org/00h9jrb69","country_code":"CL","type":"education","lineage":["https://openalex.org/I79274474"]}],"countries":["CL"],"is_corresponding":true,"raw_author_name":"Patricio Orio","raw_affiliation_strings":["Centro Interdisciplinario de Neurociencia de Valpara\u00edso, Universidad de Valpara\u00edso, Valpara\u00edso, Chile","Instituto de Neurociencias, Facultad de Ciencias, Universidad de Valpara\u00edso, Valpara\u00edso, Chile"],"raw_orcid":"https://orcid.org/0000-0003-0332-8098","affiliations":[{"raw_affiliation_string":"Centro Interdisciplinario de Neurociencia de Valpara\u00edso, Universidad de Valpara\u00edso, Valpara\u00edso, Chile","institution_ids":["https://openalex.org/I79274474"]},{"raw_affiliation_string":"Instituto de Neurociencias, Facultad de Ciencias, Universidad de Valpara\u00edso, Valpara\u00edso, Chile","institution_ids":["https://openalex.org/I79274474"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5042230025","https://openalex.org/A5051401003"],"corresponding_institution_ids":["https://openalex.org/I79274474"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17553526,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"12","first_page":"e1008933","last_page":"e1008933"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10702","display_name":"Insect and Arachnid Ecology and Behavior","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10174","display_name":"Animal Behavior and Reproduction","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1105","display_name":"Ecology, Evolution, Behavior and Systematics"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ecdysis","display_name":"Ecdysis","score":0.8624989986419678},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.7657923698425293},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6467134356498718},{"id":"https://openalex.org/keywords/biological-neural-network","display_name":"Biological neural network","score":0.5725381374359131},{"id":"https://openalex.org/keywords/calcium-imaging","display_name":"Calcium imaging","score":0.5686298608779907},{"id":"https://openalex.org/keywords/neuropeptide","display_name":"Neuropeptide","score":0.44272381067276},{"id":"https://openalex.org/keywords/nervous-system","display_name":"Nervous system","score":0.4405524730682373},{"id":"https://openalex.org/keywords/calcium","display_name":"Calcium","score":0.2910328209400177},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.20645281672477722},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.08984974026679993},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.06403329968452454}],"concepts":[{"id":"https://openalex.org/C91151737","wikidata":"https://www.wikidata.org/wiki/Q13389887","display_name":"Ecdysis","level":4,"score":0.8624989986419678},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7657923698425293},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6467134356498718},{"id":"https://openalex.org/C118403218","wikidata":"https://www.wikidata.org/wiki/Q43283","display_name":"Biological neural network","level":2,"score":0.5725381374359131},{"id":"https://openalex.org/C2776032975","wikidata":"https://www.wikidata.org/wiki/Q5018833","display_name":"Calcium imaging","level":3,"score":0.5686298608779907},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.44272381067276},{"id":"https://openalex.org/C545706735","wikidata":"https://www.wikidata.org/wiki/Q9404","display_name":"Nervous system","level":2,"score":0.4405524730682373},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.2910328209400177},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.20645281672477722},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08984974026679993},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06403329968452454},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C41905685","wikidata":"https://www.wikidata.org/wiki/Q381084","display_name":"Moulting","level":3,"score":0.0},{"id":"https://openalex.org/C173758957","wikidata":"https://www.wikidata.org/wiki/Q129270","display_name":"Larva","level":2,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018978","descriptor_name":"Molting","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018978","descriptor_name":"Molting","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018978","descriptor_name":"Molting","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1008933","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008933","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:34910730","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34910730","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:569c4ea12d184ed5bed3c02d4cfe586e","is_oa":true,"landing_page_url":"https://doaj.org/article/569c4ea12d184ed5bed3c02d4cfe586e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 17, Iss 12, p e1008933 (2021)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8716061","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8716061","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1008933","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008933","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/14","display_name":"Life below water","score":0.6100000143051147}],"awards":[{"id":"https://openalex.org/G2314664981","display_name":"GENETIC ANALYSIS OF NEUROPEPTIDE FUNCTION IN DROSOPHILA","funder_award_id":"1180403","funder_id":"https://openalex.org/F4320331146","funder_display_name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo"},{"id":"https://openalex.org/G2508777116","display_name":null,"funder_award_id":"ECM-02","funder_id":"https://openalex.org/F4320331146","funder_display_name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo"},{"id":"https://openalex.org/G4594562251","display_name":null,"funder_award_id":"1180403","funder_id":"https://openalex.org/F4320338073","funder_display_name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico"},{"id":"https://openalex.org/G6147097680","display_name":null,"funder_award_id":"FB0008","funder_id":"https://openalex.org/F4320331146","funder_display_name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo"},{"id":"https://openalex.org/G6150891528","display_name":null,"funder_award_id":"1181076","funder_id":"https://openalex.org/F4320338073","funder_display_name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico"},{"id":"https://openalex.org/G7759972462","display_name":null,"funder_award_id":"ICN09-022","funder_id":"https://openalex.org/F4320331146","funder_display_name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo"},{"id":"https://openalex.org/G8457192078","display_name":"CHAOS VERSUS NOISE AS DRIVERS OF MULTISTABILITY IN NEURAL NETWORKS","funder_award_id":"1181076","funder_id":"https://openalex.org/F4320331146","funder_display_name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo"},{"id":"https://openalex.org/G8492031397","display_name":null,"funder_award_id":"ICN09_022","funder_id":"https://openalex.org/F4320331146","funder_display_name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo"}],"funders":[{"id":"https://openalex.org/F4320324389","display_name":"Instituto Millenium","ror":"https://ror.org/05bcewb51"},{"id":"https://openalex.org/F4320331146","display_name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","ror":null},{"id":"https://openalex.org/F4320338073","display_name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","ror":"https://ror.org/02ap3w078"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W613851713","https://openalex.org/W1469131402","https://openalex.org/W1841522915","https://openalex.org/W1868105705","https://openalex.org/W1894928878","https://openalex.org/W1963860447","https://openalex.org/W1975012692","https://openalex.org/W1982848535","https://openalex.org/W1987446232","https://openalex.org/W1990432147","https://openalex.org/W1991227743","https://openalex.org/W1997078804","https://openalex.org/W1999104896","https://openalex.org/W2007560803","https://openalex.org/W2013455564","https://openalex.org/W2016910258","https://openalex.org/W2027788675","https://openalex.org/W2036438911","https://openalex.org/W2045542193","https://openalex.org/W2048419276","https://openalex.org/W2051616273","https://openalex.org/W2053983287","https://openalex.org/W2054776784","https://openalex.org/W2058491602","https://openalex.org/W2063341797","https://openalex.org/W2070793443","https://openalex.org/W2071966958","https://openalex.org/W2072511595","https://openalex.org/W2082347245","https://openalex.org/W2090689542","https://openalex.org/W2099540110","https://openalex.org/W2101098997","https://openalex.org/W2115539415","https://openalex.org/W2115668363","https://openalex.org/W2122328158","https://openalex.org/W2127384776","https://openalex.org/W2129645512","https://openalex.org/W2139919351","https://openalex.org/W2142635246","https://openalex.org/W2143669567","https://openalex.org/W2150026705","https://openalex.org/W2150781455","https://openalex.org/W2152074080","https://openalex.org/W2197306928","https://openalex.org/W2244057329","https://openalex.org/W2270890899","https://openalex.org/W2288653959","https://openalex.org/W2296682098","https://openalex.org/W2441241804","https://openalex.org/W2561134813","https://openalex.org/W2622534231","https://openalex.org/W2767513918","https://openalex.org/W2769408991","https://openalex.org/W2790386501","https://openalex.org/W6687555070"],"related_works":["https://openalex.org/W2743316157","https://openalex.org/W2912014508","https://openalex.org/W2489790891","https://openalex.org/W2047763938","https://openalex.org/W2052139633","https://openalex.org/W2113207889","https://openalex.org/W2786507638","https://openalex.org/W2955703866","https://openalex.org/W2900745105","https://openalex.org/W2097921303"],"abstract_inverted_index":{"Neuromodulators,":[0],"such":[1],"as":[2],"neuropeptides,":[3,33],"can":[4,162],"regulate":[5],"and":[6,20,34,61,84,98,173,204],"reconfigure":[7],"neural":[8,186],"circuits":[9],"to":[10,48,154,193,208,254],"alter":[11],"their":[12,30,206],"output,":[13],"affecting":[14],"in":[15,81,129,159,169,174,199],"this":[16,145],"way":[17],"animal":[18,227],"physiology":[19],"behavior.":[21],"The":[22],"interplay":[23],"between":[24,52],"the":[25,35,50,53,82,120,138,164,184,195,209,221,225,232,244,247],"activity":[26,57,121,214,223,234],"of":[27,56,58,62,91,122,140,166,179,183,201,211,224,246,249],"neuronal":[28,124,212],"circuits,":[29],"modulation":[31],"by":[32,113],"resulting":[36],"behavior,":[37,67],"is":[38,74,126,228],"still":[39],"poorly":[40],"understood.":[41],"Here,":[42],"we":[43,148,189],"present":[44],"a":[45,68,130,150,170,175,256],"quantitative":[46],"framework":[47],"study":[49],"relationships":[51],"temporal":[54],"pattern":[55],"peptidergic":[59,92],"neurons":[60,97,136,161],"motoneurons":[63,99],"during":[64,240],"Drosophila":[65],"ecdysis":[66,108,242],"highly":[69],"stereotyped":[70],"motor":[71,196,222],"sequence":[72],"that":[73,119,134,156,220],"critical":[75],"for":[76],"insect":[77],"growth.":[78],"We":[79,117,218],"analyzed,":[80],"time":[83],"frequency":[85,139],"domains,":[86],"simultaneous":[87],"intracellular":[88],"calcium":[89,157,213],"recordings":[90],"CCAP":[93,135,160],"(crustacean":[94],"cardioactive":[95],"peptide)":[96],"obtained":[100],"from":[101,236],"isolated":[102],"central":[103],"nervous":[104],"systems":[105],"throughout":[106],"fictive":[107,241],"behavior":[109,197],"induced":[110],"ex":[111,216,237],"vivo":[112,238],"Ecdysis":[114],"triggering":[115],"hormone.":[116],"found":[118,219],"both":[123,168],"populations":[125],"tightly":[127],"coupled":[128],"cross-frequency":[131],"manner,":[132],"suggesting":[133],"modulate":[137],"motoneuron":[141],"firing.":[142],"To":[143],"explore":[144],"idea":[146],"further,":[147],"used":[149],"probabilistic":[151],"logistic":[152],"model":[153,172,177],"show":[155],"dynamics":[158],"predict":[163],"oscillation":[165],"motoneurons,":[167],"simple":[171],"conductance-based":[176],"capable":[178],"simulating":[180],"many":[181],"features":[182,207],"observed":[185,198],"dynamics.":[187],"Finally,":[188],"developed":[190],"an":[191],"algorithm":[192],"quantify":[194],"videos":[200],"pupal":[202],"ecdysis,":[203],"compared":[205],"patterns":[210,248],"recorded":[215,235],"vivo.":[217],"intact":[226],"more":[229],"regular":[230],"than":[231],"motoneuronal":[233],"preparations":[239],"behavior;":[243],"analysis":[245],"movement":[250],"also":[251],"allowed":[252],"us":[253],"identify":[255],"new":[257],"post-ecdysis":[258],"phase.":[259]},"counts_by_year":[],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}