{"id":"https://openalex.org/W3142728679","doi":"https://doi.org/10.1371/journal.pcbi.1008898","title":"Machine learning-based investigation of the cancer protein secretory pathway","display_name":"Machine learning-based investigation of the cancer protein secretory pathway","publication_year":2021,"publication_date":"2021-04-05","ids":{"openalex":"https://openalex.org/W3142728679","doi":"https://doi.org/10.1371/journal.pcbi.1008898","mag":"3142728679","pmid":"https://pubmed.ncbi.nlm.nih.gov/33819271"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1008898","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008898","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008898&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008898&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029195076","display_name":"Rasool Saghaleyni","orcid":"https://orcid.org/0000-0003-0956-039X"},"institutions":[{"id":"https://openalex.org/I66862912","display_name":"Chalmers University of Technology","ror":"https://ror.org/040wg7k59","country_code":"SE","type":"education","lineage":["https://openalex.org/I66862912"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Rasool Saghaleyni","raw_affiliation_strings":["Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden"],"raw_orcid":"https://orcid.org/0000-0003-0956-039X","affiliations":[{"raw_affiliation_string":"Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden","institution_ids":["https://openalex.org/I66862912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026153657","display_name":"Azam Sheikh Muhammad","orcid":"https://orcid.org/0000-0001-6037-7019"},"institutions":[{"id":"https://openalex.org/I66862912","display_name":"Chalmers University of Technology","ror":"https://ror.org/040wg7k59","country_code":"SE","type":"education","lineage":["https://openalex.org/I66862912"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Azam Sheikh Muhammad","raw_affiliation_strings":["Department of Computer Science and Engineering, Chalmers University of Technology, Gothenburg, Sweden"],"raw_orcid":"https://orcid.org/0000-0001-6037-7019","affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, Chalmers University of Technology, Gothenburg, Sweden","institution_ids":["https://openalex.org/I66862912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112942012","display_name":"Pramod Bangalore","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pramod Bangalore","raw_affiliation_strings":["Greenbyte AB, Gothenburg, Sweden"],"raw_orcid":"https://orcid.org/0000-0002-5308-7061","affiliations":[{"raw_affiliation_string":"Greenbyte AB, Gothenburg, Sweden","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083238115","display_name":"Jens Nielsen","orcid":"https://orcid.org/0000-0002-9955-6003"},"institutions":[{"id":"https://openalex.org/I4210146628","display_name":"BioInnovation Institute","ror":"https://ror.org/048b3qc73","country_code":"DK","type":"nonprofit","lineage":["https://openalex.org/I4210146628"]},{"id":"https://openalex.org/I66862912","display_name":"Chalmers University of Technology","ror":"https://ror.org/040wg7k59","country_code":"SE","type":"education","lineage":["https://openalex.org/I66862912"]}],"countries":["DK","SE"],"is_corresponding":false,"raw_author_name":"Jens Nielsen","raw_affiliation_strings":["BioInnovation Institute, Copenhagen, Denmark","Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden","Wallenberg Center for Protein Research, Chalmers University of Technology, Gothenburg, Sweden"],"raw_orcid":"https://orcid.org/0000-0002-9955-6003","affiliations":[{"raw_affiliation_string":"BioInnovation Institute, Copenhagen, Denmark","institution_ids":["https://openalex.org/I4210146628"]},{"raw_affiliation_string":"Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden","institution_ids":["https://openalex.org/I66862912"]},{"raw_affiliation_string":"Wallenberg Center for Protein Research, Chalmers University of Technology, Gothenburg, Sweden","institution_ids":["https://openalex.org/I66862912"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090227920","display_name":"Jonathan L. Robinson","orcid":"https://orcid.org/0000-0001-8567-5960"},"institutions":[{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]},{"id":"https://openalex.org/I66862912","display_name":"Chalmers University of Technology","ror":"https://ror.org/040wg7k59","country_code":"SE","type":"education","lineage":["https://openalex.org/I66862912"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Jonathan L. Robinson","raw_affiliation_strings":["Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden","Department of Biology and Biological Engineering, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Chalmers University of Technology, Gothenburg, Sweden","Wallenberg Center for Protein Research, Chalmers University of Technology, Gothenburg, Sweden"],"raw_orcid":"https://orcid.org/0000-0001-8567-5960","affiliations":[{"raw_affiliation_string":"Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden","institution_ids":["https://openalex.org/I66862912"]},{"raw_affiliation_string":"Department of Biology and Biological Engineering, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Chalmers University of Technology, Gothenburg, Sweden","institution_ids":["https://openalex.org/I2800139495","https://openalex.org/I66862912"]},{"raw_affiliation_string":"Wallenberg Center for Protein Research, Chalmers University of Technology, Gothenburg, Sweden","institution_ids":["https://openalex.org/I66862912"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5090227920"],"corresponding_institution_ids":["https://openalex.org/I2800139495","https://openalex.org/I66862912"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.7229,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.72679604,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"17","issue":"4","first_page":"e1008898","last_page":"e1008898"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9909999966621399,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9909999966621399,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9889000058174133,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.6280679702758789},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5355510711669922},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5318640470504761},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4565749168395996},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.44041240215301514},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.44024786353111267},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.41692623496055603},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.36459770798683167},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.20303991436958313},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.17096033692359924}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6280679702758789},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5355510711669922},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5318640470504761},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4565749168395996},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.44041240215301514},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.44024786353111267},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.41692623496055603},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36459770798683167},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.20303991436958313},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17096033692359924}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055571","descriptor_name":"Secretory Pathway","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055571","descriptor_name":"Secretory Pathway","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055571","descriptor_name":"Secretory Pathway","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1008898","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008898","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008898&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:33819271","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33819271","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:bb7281432f284142ad475ee895eb4178","is_oa":true,"landing_page_url":"https://doaj.org/article/bb7281432f284142ad475ee895eb4178","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 17, Iss 4, p e1008898 (2021)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8049480","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8049480","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:research.chalmers.se:523732","is_oa":false,"landing_page_url":"https://research.chalmers.se/en/publication/523732","pdf_url":null,"source":{"id":"https://openalex.org/S4306402469","display_name":"Chalmers Research (Chalmers University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I66862912","host_organization_name":"Chalmers University of Technology","host_organization_lineage":["https://openalex.org/I66862912"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":""}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1008898","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008898","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008898&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7099999785423279,"display_name":"Good health and well-being"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321523","display_name":"Chalmers Tekniska H\u00f6gskola","ror":"https://ror.org/040wg7k59"},{"id":"https://openalex.org/F4320322327","display_name":"Knut och Alice Wallenbergs Stiftelse","ror":"https://ror.org/004hzzk67"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3142728679.pdf","grobid_xml":"https://content.openalex.org/works/W3142728679.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W801437949","https://openalex.org/W1525145973","https://openalex.org/W1930624869","https://openalex.org/W1943756471","https://openalex.org/W1966680971","https://openalex.org/W1988790447","https://openalex.org/W1990332595","https://openalex.org/W2000302106","https://openalex.org/W2009117616","https://openalex.org/W2013437078","https://openalex.org/W2033036939","https://openalex.org/W2042304168","https://openalex.org/W2044727564","https://openalex.org/W2056132907","https://openalex.org/W2069361749","https://openalex.org/W2069649792","https://openalex.org/W2072683008","https://openalex.org/W2074447982","https://openalex.org/W2076100752","https://openalex.org/W2079541630","https://openalex.org/W2083260383","https://openalex.org/W2084831115","https://openalex.org/W2087347434","https://openalex.org/W2101234009","https://openalex.org/W2114104545","https://openalex.org/W2117692326","https://openalex.org/W2135046866","https://openalex.org/W2137219016","https://openalex.org/W2138601221","https://openalex.org/W2156472837","https://openalex.org/W2168631000","https://openalex.org/W2194064760","https://openalex.org/W2230320310","https://openalex.org/W2253060366","https://openalex.org/W2295598076","https://openalex.org/W2497303707","https://openalex.org/W2563485231","https://openalex.org/W2592727918","https://openalex.org/W2596553151","https://openalex.org/W2607054868","https://openalex.org/W2618245351","https://openalex.org/W2740930667","https://openalex.org/W2746577258","https://openalex.org/W2766527179","https://openalex.org/W2778455075","https://openalex.org/W2792598217","https://openalex.org/W2805627121","https://openalex.org/W2900569176","https://openalex.org/W2915554894","https://openalex.org/W2918259518","https://openalex.org/W2943539121","https://openalex.org/W2947400018","https://openalex.org/W2951934944","https://openalex.org/W2968752241","https://openalex.org/W2989951885","https://openalex.org/W2990646888","https://openalex.org/W2997477803","https://openalex.org/W3001981221","https://openalex.org/W3102476541","https://openalex.org/W3136918052","https://openalex.org/W4230040612","https://openalex.org/W6640462745","https://openalex.org/W6675354045"],"related_works":["https://openalex.org/W2385218532","https://openalex.org/W4390006811","https://openalex.org/W3030709494","https://openalex.org/W2348256361","https://openalex.org/W2387038527","https://openalex.org/W2387959046","https://openalex.org/W2372329781","https://openalex.org/W2378781693","https://openalex.org/W2137322585","https://openalex.org/W160919559"],"abstract_inverted_index":{"Deregulation":[0],"of":[1,12,25,46,59,105,227,249],"the":[2,30,34,56,60,67,120,157,163,170,180,224],"protein":[3,57],"secretory":[4,61,71],"pathway":[5,72],"(PSP)":[6],"is":[7,36],"linked":[8],"to":[9,40,92,122,128,135,149,247],"many":[10,75],"hallmarks":[11],"cancer,":[13],"such":[14],"as":[15,33,43],"promoting":[16],"tissue":[17],"invasion":[18],"and":[19,89,109,127,154,167,175,232,241],"modulating":[20],"cell-cell":[21],"signaling.":[22],"The":[23,138],"collection":[24],"secreted":[26],"proteins":[27],"processed":[28],"by":[29,144,152],"PSP,":[31],"known":[32,148],"secretome,":[35],"often":[37],"studied":[38],"due":[39],"its":[41],"potential":[42,255],"a":[44,82,210,228],"reservoir":[45],"tumor":[47,102,110,188,205,250],"biomarkers.":[48],"However,":[49,190],"there":[50],"has":[51],"been":[52],"less":[53],"focus":[54,129],"on":[55,130],"components":[58,73,245],"machinery":[62],"itself.":[63],"We":[64],"therefore":[65],"investigated":[66],"expression":[68,87,97,159,199,231,239],"changes":[69],"in":[70,119],"across":[74,204],"different":[76,113,164],"cancer":[77,107,168,193],"types.":[78],"Specifically,":[79],"we":[80],"implemented":[81],"dual":[83],"approach":[84,141,235],"involving":[85],"differential":[86,158,230],"analysis":[88,121,160,165],"machine":[90,114,139,233],"learning":[91,115,140,234],"identify":[93],"PSP":[94,146,244],"genes":[95,147,182],"whose":[96],"was":[98,142],"associated":[99,183],"with":[100,184,216],"key":[101,243],"characteristics:":[103],"mutation":[104],"p53,":[106,153],"status,":[108],"stage.":[111,189],"Eight":[112],"algorithms":[116],"were":[117,133,177],"included":[118],"enable":[123],"comparison":[124],"between":[125],"methods":[126,166],"signals":[131],"that":[132,200,214,252],"robust":[134],"algorithm":[136],"type.":[137],"validated":[143],"identifying":[145],"be":[150],"regulated":[151],"even":[155],"outperformed":[156],"approach.":[161],"Among":[162],"types,":[169],"kinesin":[171],"family":[172],"members":[173],"KIF20A":[174,198],"KIF23":[176],"consistently":[178],"among":[179],"top":[181],"malignant":[185],"transformation":[186],"or":[187],"unlike":[191],"most":[192],"types":[194],"which":[195],"exhibited":[196],"elevated":[197],"remained":[201],"relatively":[202],"constant":[203],"stages,":[206],"renal":[207],"carcinomas":[208],"displayed":[209],"more":[211],"gradual":[212],"increase":[213],"continued":[215],"increasing":[217],"disease":[218],"severity.":[219],"Collectively,":[220],"our":[221],"study":[222],"demonstrates":[223],"complementary":[225],"nature":[226],"combined":[229],"for":[236],"analyzing":[237],"gene":[238],"data,":[240],"highlights":[242],"relevant":[246],"features":[248],"pathophysiology":[251],"may":[253],"constitute":[254],"therapeutic":[256],"targets.":[257]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}