{"id":"https://openalex.org/W3152014472","doi":"https://doi.org/10.1371/journal.pcbi.1008891","title":"A novel yeast hybrid modeling framework integrating Boolean and enzyme-constrained networks enables exploration of the interplay between signaling and metabolism","display_name":"A novel yeast hybrid modeling framework integrating Boolean and enzyme-constrained networks enables exploration of the interplay between signaling and metabolism","publication_year":2021,"publication_date":"2021-04-09","ids":{"openalex":"https://openalex.org/W3152014472","doi":"https://doi.org/10.1371/journal.pcbi.1008891","mag":"3152014472","pmid":"https://pubmed.ncbi.nlm.nih.gov/33836000"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1008891","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008891","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1008891","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091206106","display_name":"Linnea \u00d6sterberg","orcid":"https://orcid.org/0000-0002-9816-6476"},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]},{"id":"https://openalex.org/I66862912","display_name":"Chalmers University of Technology","ror":"https://ror.org/040wg7k59","country_code":"SE","type":"education","lineage":["https://openalex.org/I66862912"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Linnea \u00d6sterberg","raw_affiliation_strings":["Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden","Department of Mathematical Sciences, Chalmers University of Technology, Gothenburg, Sweden","Department of Mathematical Sciences, University of Gothenburg, Gothenburg, Sweden"],"affiliations":[{"raw_affiliation_string":"Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden","institution_ids":["https://openalex.org/I66862912"]},{"raw_affiliation_string":"Department of Mathematical Sciences, Chalmers University of Technology, Gothenburg, Sweden","institution_ids":["https://openalex.org/I66862912"]},{"raw_affiliation_string":"Department of Mathematical Sciences, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009011251","display_name":"Iv\u00e1n Domenzain","orcid":"https://orcid.org/0000-0002-5322-2040"},"institutions":[{"id":"https://openalex.org/I66862912","display_name":"Chalmers University of Technology","ror":"https://ror.org/040wg7k59","country_code":"SE","type":"education","lineage":["https://openalex.org/I66862912"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Iv\u00e1n Domenzain","raw_affiliation_strings":["Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden","Novo Nordisk Foundation Center for Biosustainability, Chalmers University of Technology, Gothenburg, Sweden"],"affiliations":[{"raw_affiliation_string":"Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden","institution_ids":["https://openalex.org/I66862912"]},{"raw_affiliation_string":"Novo Nordisk Foundation Center for Biosustainability, Chalmers University of Technology, Gothenburg, Sweden","institution_ids":["https://openalex.org/I66862912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044702963","display_name":"Julia M\u00fcnch","orcid":"https://orcid.org/0000-0002-9588-2274"},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]},{"id":"https://openalex.org/I66862912","display_name":"Chalmers University of Technology","ror":"https://ror.org/040wg7k59","country_code":"SE","type":"education","lineage":["https://openalex.org/I66862912"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Julia M\u00fcnch","raw_affiliation_strings":["Department of Mathematical Sciences, Chalmers University of Technology, Gothenburg, Sweden","Department of Mathematical Sciences, University of Gothenburg, Gothenburg, Sweden"],"affiliations":[{"raw_affiliation_string":"Department of Mathematical Sciences, Chalmers University of Technology, Gothenburg, Sweden","institution_ids":["https://openalex.org/I66862912"]},{"raw_affiliation_string":"Department of Mathematical Sciences, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083238115","display_name":"Jens Nielsen","orcid":"https://orcid.org/0000-0002-9955-6003"},"institutions":[{"id":"https://openalex.org/I66862912","display_name":"Chalmers University of Technology","ror":"https://ror.org/040wg7k59","country_code":"SE","type":"education","lineage":["https://openalex.org/I66862912"]},{"id":"https://openalex.org/I4210146628","display_name":"BioInnovation Institute","ror":"https://ror.org/048b3qc73","country_code":"DK","type":"nonprofit","lineage":["https://openalex.org/I4210146628"]}],"countries":["DK","SE"],"is_corresponding":false,"raw_author_name":"Jens Nielsen","raw_affiliation_strings":["BioInnovation Institute, Copenhagen, Denmark","Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden","Novo Nordisk Foundation Center for Biosustainability, Chalmers University of Technology, Gothenburg, Sweden"],"affiliations":[{"raw_affiliation_string":"BioInnovation Institute, Copenhagen, Denmark","institution_ids":["https://openalex.org/I4210146628"]},{"raw_affiliation_string":"Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden","institution_ids":["https://openalex.org/I66862912"]},{"raw_affiliation_string":"Novo Nordisk Foundation Center for Biosustainability, Chalmers University of Technology, Gothenburg, Sweden","institution_ids":["https://openalex.org/I66862912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079347888","display_name":"Stefan Hohmann","orcid":"https://orcid.org/0000-0002-0809-1985"},"institutions":[{"id":"https://openalex.org/I66862912","display_name":"Chalmers University of Technology","ror":"https://ror.org/040wg7k59","country_code":"SE","type":"education","lineage":["https://openalex.org/I66862912"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Stefan Hohmann","raw_affiliation_strings":["Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden"],"affiliations":[{"raw_affiliation_string":"Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden","institution_ids":["https://openalex.org/I66862912"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026743647","display_name":"Marija Cvijovi\u0107","orcid":"https://orcid.org/0000-0002-5142-5100"},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]},{"id":"https://openalex.org/I66862912","display_name":"Chalmers University of Technology","ror":"https://ror.org/040wg7k59","country_code":"SE","type":"education","lineage":["https://openalex.org/I66862912"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Marija Cvijovic","raw_affiliation_strings":["Department of Mathematical Sciences, Chalmers University of Technology, Gothenburg, Sweden","Department of Mathematical Sciences, University of Gothenburg, Gothenburg, Sweden"],"affiliations":[{"raw_affiliation_string":"Department of Mathematical Sciences, Chalmers University of Technology, Gothenburg, Sweden","institution_ids":["https://openalex.org/I66862912"]},{"raw_affiliation_string":"Department of Mathematical Sciences, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5026743647"],"corresponding_institution_ids":["https://openalex.org/I66862912","https://openalex.org/I881427289"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.6217,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.83748461,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"17","issue":"4","first_page":"e1008891","last_page":"e1008891"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10171","display_name":"Biofuel production and bioconversion","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crosstalk","display_name":"Crosstalk","score":0.7357816100120544},{"id":"https://openalex.org/keywords/interconnectivity","display_name":"Interconnectivity","score":0.7058457732200623},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.56833815574646},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5321456789970398},{"id":"https://openalex.org/keywords/nutrient-sensing","display_name":"Nutrient sensing","score":0.5190442204475403},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.5190130472183228},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.4956616163253784},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.47406405210494995},{"id":"https://openalex.org/keywords/cell-signaling","display_name":"Cell signaling","score":0.43230140209198},{"id":"https://openalex.org/keywords/yeast","display_name":"Yeast","score":0.37975120544433594},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.3347221612930298},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3056730628013611},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.25530344247817993}],"concepts":[{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.7357816100120544},{"id":"https://openalex.org/C25516864","wikidata":"https://www.wikidata.org/wiki/Q1665949","display_name":"Interconnectivity","level":2,"score":0.7058457732200623},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.56833815574646},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5321456789970398},{"id":"https://openalex.org/C2776030549","wikidata":"https://www.wikidata.org/wiki/Q7829395","display_name":"Nutrient sensing","level":3,"score":0.5190442204475403},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.5190130472183228},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4956616163253784},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.47406405210494995},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.43230140209198},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.37975120544433594},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3347221612930298},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3056730628013611},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25530344247817993},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009584","descriptor_name":"Nitrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009584","descriptor_name":"Nitrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009584","descriptor_name":"Nitrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1008891","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008891","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:33836000","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33836000","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:5f5425c6b1434c4d81ee883f5d9026a1","is_oa":true,"landing_page_url":"https://doaj.org/article/5f5425c6b1434c4d81ee883f5d9026a1","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 17, Iss 4, p e1008891 (2021)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8059808","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8059808","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:research.chalmers.se:523742","is_oa":false,"landing_page_url":"https://research.chalmers.se/en/publication/523742","pdf_url":null,"source":{"id":"https://openalex.org/S4306402469","display_name":"Chalmers Research (Chalmers University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I66862912","host_organization_name":"Chalmers University of Technology","host_organization_lineage":["https://openalex.org/I66862912"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":""}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1008891","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008891","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4034087583","display_name":null,"funder_award_id":"VR2016-03744","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G4398951144","display_name":null,"funder_award_id":"720824","funder_id":"https://openalex.org/F4320338335","funder_display_name":"H2020 European Research Council"},{"id":"https://openalex.org/G7487764504","display_name":null,"funder_award_id":"FFL15-0238","funder_id":"https://openalex.org/F4320320940","funder_display_name":"Stiftelsen f\u00f6r\u00a0Strategisk Forskning"},{"id":"https://openalex.org/G7701966108","display_name":null,"funder_award_id":"NNF10CC1016517","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320940","display_name":"Stiftelsen f\u00f6r\u00a0Strategisk Forskning","ror":"https://ror.org/044wr7g58"},{"id":"https://openalex.org/F4320322327","display_name":"Knut och Alice Wallenbergs Stiftelse","ror":"https://ror.org/004hzzk67"},{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320325957","display_name":"Novo Nordisk Fonden","ror":"https://ror.org/04txyc737"},{"id":"https://openalex.org/F4320338335","display_name":"H2020 European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":147,"referenced_works":["https://openalex.org/W22186556","https://openalex.org/W365193969","https://openalex.org/W1495274944","https://openalex.org/W1539988911","https://openalex.org/W1584312402","https://openalex.org/W1599051410","https://openalex.org/W1614347411","https://openalex.org/W1717375378","https://openalex.org/W1897167776","https://openalex.org/W1902685772","https://openalex.org/W1938497882","https://openalex.org/W1966813886","https://openalex.org/W1967097528","https://openalex.org/W1969976773","https://openalex.org/W1971637500","https://openalex.org/W1972718290","https://openalex.org/W1974605099","https://openalex.org/W1975438614","https://openalex.org/W1975471112","https://openalex.org/W1981592350","https://openalex.org/W1988737528","https://openalex.org/W1991445188","https://openalex.org/W1997241169","https://openalex.org/W1997902769","https://openalex.org/W1998576182","https://openalex.org/W1999231088","https://openalex.org/W2005034482","https://openalex.org/W2008014792","https://openalex.org/W2012665233","https://openalex.org/W2025505237","https://openalex.org/W2026059959","https://openalex.org/W2026089579","https://openalex.org/W2028403255","https://openalex.org/W2031070745","https://openalex.org/W2035360701","https://openalex.org/W2043296955","https://openalex.org/W2046484554","https://openalex.org/W2047373064","https://openalex.org/W2050625863","https://openalex.org/W2051919126","https://openalex.org/W2058333934","https://openalex.org/W2059085198","https://openalex.org/W2059382856","https://openalex.org/W2059825898","https://openalex.org/W2061104439","https://openalex.org/W2062245653","https://openalex.org/W2064295826","https://openalex.org/W2066951138","https://openalex.org/W2068413127","https://openalex.org/W2070380343","https://openalex.org/W2072693949","https://openalex.org/W2076262841","https://openalex.org/W2078355959","https://openalex.org/W2079052796","https://openalex.org/W2086071302","https://openalex.org/W2086730664","https://openalex.org/W2087440130","https://openalex.org/W2094125753","https://openalex.org/W2094517081","https://openalex.org/W2095465853","https://openalex.org/W2097016419","https://openalex.org/W2098337864","https://openalex.org/W2099600512","https://openalex.org/W2102284511","https://openalex.org/W2105740329","https://openalex.org/W2109206426","https://openalex.org/W2111020654","https://openalex.org/W2111322904","https://openalex.org/W2111421616","https://openalex.org/W2112247858","https://openalex.org/W2112933558","https://openalex.org/W2113329733","https://openalex.org/W2114512247","https://openalex.org/W2115168068","https://openalex.org/W2124479692","https://openalex.org/W2129119944","https://openalex.org/W2129151536","https://openalex.org/W2132251545","https://openalex.org/W2132416603","https://openalex.org/W2134957504","https://openalex.org/W2137372494","https://openalex.org/W2137828458","https://openalex.org/W2141450355","https://openalex.org/W2145272227","https://openalex.org/W2146769694","https://openalex.org/W2147286372","https://openalex.org/W2149167347","https://openalex.org/W2150551377","https://openalex.org/W2153352656","https://openalex.org/W2153477621","https://openalex.org/W2154303441","https://openalex.org/W2157305458","https://openalex.org/W2157457604","https://openalex.org/W2160500166","https://openalex.org/W2160541874","https://openalex.org/W2163823651","https://openalex.org/W2167577928","https://openalex.org/W2168797545","https://openalex.org/W2216418212","https://openalex.org/W2255671650","https://openalex.org/W2307026163","https://openalex.org/W2312280072","https://openalex.org/W2339493109","https://openalex.org/W2346094579","https://openalex.org/W2491691281","https://openalex.org/W2549976854","https://openalex.org/W2573984017","https://openalex.org/W2582663044","https://openalex.org/W2586394106","https://openalex.org/W2594933406","https://openalex.org/W2605338423","https://openalex.org/W2621504176","https://openalex.org/W2739552165","https://openalex.org/W2743063996","https://openalex.org/W2762723870","https://openalex.org/W2764202526","https://openalex.org/W2781174748","https://openalex.org/W2793598149","https://openalex.org/W2794900708","https://openalex.org/W2810661705","https://openalex.org/W2884161216","https://openalex.org/W2896863696","https://openalex.org/W2909863016","https://openalex.org/W2911805374","https://openalex.org/W2913135442","https://openalex.org/W2965590414","https://openalex.org/W2973960665","https://openalex.org/W2999773453","https://openalex.org/W3003224093","https://openalex.org/W3023269715","https://openalex.org/W3105982350","https://openalex.org/W3124791515","https://openalex.org/W3136918052","https://openalex.org/W3139470614","https://openalex.org/W4211251240","https://openalex.org/W4231624227","https://openalex.org/W4237327807","https://openalex.org/W4237440937","https://openalex.org/W4239824378","https://openalex.org/W4242025860","https://openalex.org/W4251739335","https://openalex.org/W4253199145","https://openalex.org/W4253868872","https://openalex.org/W6656989551","https://openalex.org/W6703695517","https://openalex.org/W6734340333","https://openalex.org/W6966414819"],"related_works":["https://openalex.org/W2238467432","https://openalex.org/W4385588055","https://openalex.org/W3022555688","https://openalex.org/W2546463226","https://openalex.org/W2076883893","https://openalex.org/W2288499012","https://openalex.org/W4223418040","https://openalex.org/W2061636318","https://openalex.org/W4388293120","https://openalex.org/W2989659800"],"abstract_inverted_index":{"The":[0,155,187],"interplay":[1,266],"between":[2,109,267,273],"nutrient-induced":[3],"signaling":[4,42,61,99,111,268,276],"and":[5,14,32,44,62,79,91,112,132,135,168,184,209,231,269,278],"metabolism":[6,63,113,144],"plays":[7],"an":[8,136],"important":[9],"role":[10,38],"in":[11,20,80,97,114,175,199,204],"maintaining":[12],"homeostasis":[13],"its":[15],"malfunction":[16],"has":[17,195],"been":[18,65,282],"implicated":[19],"many":[21],"different":[22],"human":[23],"diseases":[24],"such":[25],"as":[26,41,152,234,236],"obesity,":[27],"type":[28],"2":[29],"diabetes,":[30],"cancer,":[31],"neurological":[33],"disorders.":[34],"Therefore,":[35],"unraveling":[36],"the":[37,86,89,92,95,98,107,127,141,176,215,221,228,258,261,265,274],"of":[39,55,88,94,106,130,145,166,178,219,260,264,287],"nutrients":[40],"molecules":[43],"metabolites":[45],"together":[46],"with":[47,227,240],"their":[48],"interconnectivity":[49,108],"may":[50],"provide":[51],"a":[52,103,119,123,149,153,163,196,254],"deeper":[53],"understanding":[54,105],"how":[56],"these":[57],"conditions":[58,207],"occur.":[59],"Both":[60],"have":[64,281],"extensively":[66],"studied":[67,77],"using":[68,148],"various":[69],"systems":[70],"biology":[71],"approaches.":[72],"However,":[73],"they":[74],"are":[75,211,225],"mainly":[76],"individually":[78],"addition,":[81,214],"current":[82],"models":[83,174],"lack":[84],"both":[85,182],"complexity":[87],"dynamics":[90],"effects":[93,223,238,263],"crosstalk":[96],"system.":[100],"To":[101],"gain":[102],"better":[104],"nutrient":[110],"yeast":[115,288],"cells,":[116],"we":[117,247],"developed":[118],"hybrid":[120,157,251],"model,":[121],"combining":[122],"Boolean":[124],"module,":[125],"describing":[126],"main":[128],"pathways":[129,277],"glucose":[131,206,232],"nitrogen":[133],"signaling,":[134],"enzyme-constrained":[137],"model":[138,158,188,216,252],"accounting":[139],"for":[140,181,257],"central":[142],"carbon":[143],"Saccharomyces":[146],"cerevisiae,":[147],"regulatory":[150,222,237],"network":[151],"link.":[154],"resulting":[156],"was":[159,217],"able":[160],"to":[161,169,284],"capture":[162],"diverse":[164],"utalization":[165],"isoenzymes":[167],"our":[170,250],"knowledge":[171],"outperforms":[172],"constraint-based":[173],"prediction":[177],"individual":[179],"enzymes":[180],"respiratory":[183],"mixed":[185],"metabolism.":[186],"showed":[189],"that":[190,224,249,280],"during":[191,243],"fermentation,":[192],"enzyme":[193],"utilization":[194],"major":[197],"contribution":[198],"governing":[200],"protein":[201],"allocation,":[202],"while":[203],"low":[205],"robustness":[208],"control":[210],"prioritized.":[212],"In":[213],"capable":[218],"reproducing":[220],"associated":[226,239],"Crabtree":[229],"effect":[230],"repression,":[233],"well":[235],"lifespan":[241,286],"increase":[242],"caloric":[244],"restriction.":[245],"Overall,":[246],"show":[248],"provides":[253],"comprehensive":[255],"framework":[256],"study":[259],"non-trivial":[262],"metabolism,":[270],"suggesting":[271],"connections":[272],"Snf1":[275],"processes":[279],"related":[283],"chronological":[285],"cells.":[289]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":6}],"updated_date":"2026-03-04T09:10:02.777135","created_date":"2025-10-10T00:00:00"}
