{"id":"https://openalex.org/W3153405385","doi":"https://doi.org/10.1371/journal.pcbi.1008878","title":"Accurate cancer phenotype prediction with AKLIMATE, a stacked kernel learner integrating multimodal genomic data and pathway knowledge","display_name":"Accurate cancer phenotype prediction with AKLIMATE, a stacked kernel learner integrating multimodal genomic data and pathway knowledge","publication_year":2021,"publication_date":"2021-04-16","ids":{"openalex":"https://openalex.org/W3153405385","doi":"https://doi.org/10.1371/journal.pcbi.1008878","mag":"3153405385","pmid":"https://pubmed.ncbi.nlm.nih.gov/33861732"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1008878","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008878","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008878&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008878&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073711524","display_name":"Vladislav Uzunangelov","orcid":"https://orcid.org/0000-0002-1962-0977"},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Vladislav Uzunangelov","raw_affiliation_strings":["Department of Biomolecular Engineering, University of California, Santa Cruz, California, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-1962-0977","affiliations":[{"raw_affiliation_string":"Department of Biomolecular Engineering, University of California, Santa Cruz, California, United States of America","institution_ids":["https://openalex.org/I185103710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058879050","display_name":"Christopher K. Wong","orcid":null},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christopher K. Wong","raw_affiliation_strings":["Department of Biomolecular Engineering, University of California, Santa Cruz, California, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-6012-7001","affiliations":[{"raw_affiliation_string":"Department of Biomolecular Engineering, University of California, Santa Cruz, California, United States of America","institution_ids":["https://openalex.org/I185103710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029096739","display_name":"Joshua M. Stuart","orcid":"https://orcid.org/0000-0002-2171-565X"},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joshua M. Stuart","raw_affiliation_strings":["Department of Biomolecular Engineering, University of California, Santa Cruz, California, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-2171-565X","affiliations":[{"raw_affiliation_string":"Department of Biomolecular Engineering, University of California, Santa Cruz, California, United States of America","institution_ids":["https://openalex.org/I185103710"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5029096739","https://openalex.org/A5058879050","https://openalex.org/A5073711524"],"corresponding_institution_ids":["https://openalex.org/I185103710"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.0575,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.75729608,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"17","issue":"4","first_page":"e1008878","last_page":"e1008878"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5529190301895142},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.509529173374176},{"id":"https://openalex.org/keywords/leverage","display_name":"Leverage (statistics)","score":0.4523440897464752},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.451416015625},{"id":"https://openalex.org/keywords/random-forest","display_name":"Random forest","score":0.4486914277076721},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.4377244710922241},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.41362473368644714},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.41038239002227783},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3528326153755188},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.31651490926742554},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.14818087220191956}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5529190301895142},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.509529173374176},{"id":"https://openalex.org/C153083717","wikidata":"https://www.wikidata.org/wiki/Q6535263","display_name":"Leverage (statistics)","level":2,"score":0.4523440897464752},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.451416015625},{"id":"https://openalex.org/C169258074","wikidata":"https://www.wikidata.org/wiki/Q245748","display_name":"Random forest","level":2,"score":0.4486914277076721},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4377244710922241},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.41362473368644714},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.41038239002227783},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3528326153755188},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.31651490926742554},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14818087220191956}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1008878","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008878","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008878&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:33861732","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33861732","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:ark:/13030/qt81b1t4zg","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:doaj.org/article:6f69edcd31c5403fa6672de66cc7316e","is_oa":true,"landing_page_url":"https://doaj.org/article/6f69edcd31c5403fa6672de66cc7316e","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 17, Iss 4, p e1008878 (2021)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt81b1t4zg","is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/81b1t4zg","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS computational biology, vol 17, iss 4","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8081343","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8081343","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1008878","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008878","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008878&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4209064538","display_name":null,"funder_award_id":"1R01CA180778","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4326566008","display_name":null,"funder_award_id":"U24-CA143858","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7629277675","display_name":null,"funder_award_id":"5U54HG006097","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G8468654962","display_name":null,"funder_award_id":"5R01GM109031","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3153405385.pdf","grobid_xml":"https://content.openalex.org/works/W3153405385.grobid-xml"},"referenced_works_count":91,"referenced_works":["https://openalex.org/W1041910","https://openalex.org/W28412257","https://openalex.org/W1510073064","https://openalex.org/W1516082955","https://openalex.org/W1560724230","https://openalex.org/W1582548030","https://openalex.org/W1871096589","https://openalex.org/W1875028359","https://openalex.org/W1875061881","https://openalex.org/W1965997942","https://openalex.org/W1966090011","https://openalex.org/W1967220865","https://openalex.org/W1970554427","https://openalex.org/W1984838032","https://openalex.org/W1986280275","https://openalex.org/W1996624321","https://openalex.org/W1998767819","https://openalex.org/W1999390452","https://openalex.org/W2005895632","https://openalex.org/W2010457001","https://openalex.org/W2010714248","https://openalex.org/W2015904350","https://openalex.org/W2031823405","https://openalex.org/W2034235577","https://openalex.org/W2034926402","https://openalex.org/W2042126900","https://openalex.org/W2043398720","https://openalex.org/W2056132907","https://openalex.org/W2080896439","https://openalex.org/W2087257760","https://openalex.org/W2096766502","https://openalex.org/W2097360283","https://openalex.org/W2101895213","https://openalex.org/W2102636708","https://openalex.org/W2108933868","https://openalex.org/W2109384743","https://openalex.org/W2109743529","https://openalex.org/W2112289645","https://openalex.org/W2116063398","https://openalex.org/W2116443392","https://openalex.org/W2116802246","https://openalex.org/W2122825543","https://openalex.org/W2124833832","https://openalex.org/W2132619562","https://openalex.org/W2135046866","https://openalex.org/W2138019504","https://openalex.org/W2141287957","https://openalex.org/W2154164391","https://openalex.org/W2157121418","https://openalex.org/W2157395790","https://openalex.org/W2157852151","https://openalex.org/W2159415114","https://openalex.org/W2161444669","https://openalex.org/W2163042952","https://openalex.org/W2164298117","https://openalex.org/W2166018709","https://openalex.org/W2169622100","https://openalex.org/W2216192020","https://openalex.org/W2280966365","https://openalex.org/W2293825098","https://openalex.org/W2298480233","https://openalex.org/W2330820318","https://openalex.org/W2527974276","https://openalex.org/W2565007457","https://openalex.org/W2603868227","https://openalex.org/W2624701078","https://openalex.org/W2745658163","https://openalex.org/W2762295733","https://openalex.org/W2795123374","https://openalex.org/W2795941120","https://openalex.org/W2796153844","https://openalex.org/W2802643674","https://openalex.org/W2884724578","https://openalex.org/W2889571716","https://openalex.org/W2911964244","https://openalex.org/W2912393903","https://openalex.org/W2914369697","https://openalex.org/W2950230334","https://openalex.org/W3004463615","https://openalex.org/W3016919992","https://openalex.org/W3039953684","https://openalex.org/W3085162807","https://openalex.org/W3102027041","https://openalex.org/W3104091918","https://openalex.org/W3104974184","https://openalex.org/W4233056867","https://openalex.org/W4240294902","https://openalex.org/W4294541781","https://openalex.org/W4399612312","https://openalex.org/W6640859660","https://openalex.org/W6751481771"],"related_works":["https://openalex.org/W4386259002","https://openalex.org/W1546989560","https://openalex.org/W3193043704","https://openalex.org/W3171520305","https://openalex.org/W1924178503","https://openalex.org/W4308716060","https://openalex.org/W4280648719","https://openalex.org/W3135126032","https://openalex.org/W3033346322","https://openalex.org/W3125561743"],"abstract_inverted_index":{"Advancements":[0],"in":[1,45,108,134,173,179],"sequencing":[2],"have":[3,23],"led":[4],"to":[5,49,56,66,88,161,186,195,206],"the":[6,58,81,109,130],"proliferation":[7],"of":[8,11,31,63,83,111,209,215],"multi-omic":[9],"profiles":[10],"human":[12],"cells":[13],"under":[14],"different":[15],"conditions":[16],"and":[17,28,38,61,86,175,182,212,217],"perturbations.":[18],"In":[19],"addition,":[20],"many":[21],"databases":[22],"amassed":[24],"information":[25,107],"about":[26,53],"pathways":[27,87,112,205],"gene":[29,32,54,143,187],"\"signatures\"-patterns":[30],"expression":[33],"associated":[34],"with":[35,105],"specific":[36,141],"cellular":[37],"phenotypic":[39],"contexts.":[40],"An":[41],"important":[42],"current":[43],"challenge":[44],"systems":[46],"biology":[47],"is":[48,193],"leverage":[50],"such":[51,71],"knowledge":[52],"coordination":[55],"maximize":[57],"predictive":[59],"power":[60],"generalization":[62],"models":[64],"applied":[65],"high-throughput":[67],"datasets.":[68],"However,":[69],"few":[70],"integrative":[72],"approaches":[73],"exist":[74],"that":[75,99,145],"also":[76],"provide":[77],"interpretable":[78],"results":[79],"quantifying":[80],"importance":[82],"individual":[84,127],"genes":[85],"model":[89],"accuracy.":[90],"We":[91,189],"introduce":[92],"AKLIMATE,":[93],"a":[94,121,140],"first":[95],"kernel-based":[96],"stacked":[97],"learner":[98],"seamlessly":[100],"incorporates":[101],"multi-omics":[102],"feature":[103,197],"data":[104,149,198,200],"prior":[106],"form":[110],"for":[113,150],"either":[114],"regression":[115],"or":[116,157],"classification":[117],"tasks.":[118],"AKLIMATE":[119,154,192],"uses":[120],"novel":[122,213],"multiple-kernel":[123],"learning":[124,167],"framework":[125],"where":[126],"kernels":[128],"capture":[129],"prediction":[131],"propensities":[132],"recorded":[133],"random":[135],"forests,":[136],"each":[137],"built":[138],"from":[139],"pathway":[142],"set":[144],"integrates":[146],"all":[147],"omics":[148],"its":[151],"member":[152],"genes.":[153],"has":[155],"comparable":[156],"improved":[158],"performance":[159],"relative":[160],"state-of-the-art":[162],"methods":[163],"on":[164],"diverse":[165],"phenotype":[166],"tasks,":[168],"including":[169],"predicting":[170],"microsatellite":[171],"instability":[172],"endometrial":[174],"colorectal":[176],"cancer,":[177,181],"survival":[178],"breast":[180],"cell":[183],"line":[184],"response":[185],"knockdowns.":[188],"show":[190],"how":[191],"able":[194],"connect":[196],"across":[199],"platforms":[201],"through":[202],"their":[203],"common":[204],"identify":[207],"examples":[208],"several":[210],"known":[211],"contributors":[214],"cancer":[216],"synthetic":[218],"lethality.":[219]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}