{"id":"https://openalex.org/W3148768901","doi":"https://doi.org/10.1371/journal.pcbi.1008870","title":"Apoptosis mapping in space and time of 3D tumor ecosystems reveals transmissibility of cytotoxic cancer death","display_name":"Apoptosis mapping in space and time of 3D tumor ecosystems reveals transmissibility of cytotoxic cancer death","publication_year":2021,"publication_date":"2021-03-30","ids":{"openalex":"https://openalex.org/W3148768901","doi":"https://doi.org/10.1371/journal.pcbi.1008870","mag":"3148768901","pmid":"https://pubmed.ncbi.nlm.nih.gov/33784299"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1008870","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008870","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1008870","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058845577","display_name":"Irina Veith","orcid":"https://orcid.org/0000-0002-4654-2265"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I4210107416","display_name":"Roche (France)","ror":"https://ror.org/01mqmer16","country_code":"FR","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4210107416"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Irina Veith","raw_affiliation_strings":["Institut Curie, INSERM U830, Stress and Cancer Laboratory, PSL Research University, Paris, France","Institut Roche, 4 cours de l'Ile Seguin, Boulogne-Billancourt, France","U830 - Unit\u00e9 de g\u00e9n\u00e9tique et biologie des cancers (Institut Curie \r\n26, rue d'Ulm section de recherche \r\n75248 Paris cedex 05 - France)"],"raw_orcid":"https://orcid.org/0000-0002-4654-2265","affiliations":[{"raw_affiliation_string":"Institut Curie, INSERM U830, Stress and Cancer Laboratory, PSL Research University, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2746051580"]},{"raw_affiliation_string":"Institut Roche, 4 cours de l'Ile Seguin, Boulogne-Billancourt, France","institution_ids":["https://openalex.org/I4210107416"]},{"raw_affiliation_string":"U830 - Unit\u00e9 de g\u00e9n\u00e9tique et biologie des cancers (Institut Curie \r\n26, rue d'Ulm section de recherche \r\n75248 Paris cedex 05 - France)","institution_ids":["https://openalex.org/I80043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014451390","display_name":"Arianna Mencattini","orcid":"https://orcid.org/0000-0002-3753-0457"},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Arianna Mencattini","raw_affiliation_strings":["Department of Electronic Engineering, University of Rome Tor Vergata, Rome, Italy","Universit\u00e0 degli Studi di Roma Tor Vergata [Roma, Italia] = University of Rome Tor Vergata [Rome, Italy] = Universit\u00e9 de Rome Tor Vergata [Rome, Italie] (Via Cracovia n. 50 - 00133 Roma - Italy)"],"raw_orcid":"https://orcid.org/0000-0002-3753-0457","affiliations":[{"raw_affiliation_string":"Department of Electronic Engineering, University of Rome Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]},{"raw_affiliation_string":"Universit\u00e0 degli Studi di Roma Tor Vergata [Roma, Italia] = University of Rome Tor Vergata [Rome, Italy] = Universit\u00e9 de Rome Tor Vergata [Rome, Italie] (Via Cracovia n. 50 - 00133 Roma - Italy)","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049392077","display_name":"Valentin Picant","orcid":"https://orcid.org/0000-0001-9514-0492"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Valentin Picant","raw_affiliation_strings":["Institut Curie, INSERM U830, Stress and Cancer Laboratory, PSL Research University, Paris, France","U830 - Unit\u00e9 de g\u00e9n\u00e9tique et biologie des cancers (Institut Curie \r\n26, rue d'Ulm section de recherche \r\n75248 Paris cedex 05 - France)"],"raw_orcid":"https://orcid.org/0000-0001-9514-0492","affiliations":[{"raw_affiliation_string":"Institut Curie, INSERM U830, Stress and Cancer Laboratory, PSL Research University, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2746051580"]},{"raw_affiliation_string":"U830 - Unit\u00e9 de g\u00e9n\u00e9tique et biologie des cancers (Institut Curie \r\n26, rue d'Ulm section de recherche \r\n75248 Paris cedex 05 - France)","institution_ids":["https://openalex.org/I80043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075511662","display_name":"Marco Serra","orcid":"https://orcid.org/0000-0001-8786-5469"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I4210160133","display_name":"Physique des Cellules et Cancers","ror":"https://ror.org/055ss7a31","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210160133","https://openalex.org/I80043"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marco Serra","raw_affiliation_strings":["Institut Curie, CNRS UMR168, Laboratoire Physico Chimie Curie, Institut Pierre-Gilles de Gennes, PSL Research University, Paris, France","PCC - Laboratoire Physico-Chimie Curie [Institut Curie] (11 rue Pierre et Marie Curie\r\n75005 Paris - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Curie, CNRS UMR168, Laboratoire Physico Chimie Curie, Institut Pierre-Gilles de Gennes, PSL Research University, Paris, France","institution_ids":["https://openalex.org/I2746051580","https://openalex.org/I1294671590","https://openalex.org/I4210160133"]},{"raw_affiliation_string":"PCC - Laboratoire Physico-Chimie Curie [Institut Curie] (11 rue Pierre et Marie Curie\r\n75005 Paris - France)","institution_ids":["https://openalex.org/I4210160133","https://openalex.org/I80043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001771546","display_name":"Marine Leclerc","orcid":"https://orcid.org/0000-0003-2165-5244"},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]},{"id":"https://openalex.org/I4210133830","display_name":"Laboratoire d\u2019immunologie int\u00e9grative du cancer","ror":"https://ror.org/03cqwn895","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I39804081","https://openalex.org/I4210092322","https://openalex.org/I4210133830"]},{"id":"https://openalex.org/I4387152196","display_name":"Immunologie int\u00e9grative des tumeurs et immunoth\u00e9rapie du cancer","ror":"https://ror.org/0266c5p67","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I2801843802","https://openalex.org/I4387152196"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marine Leclerc","raw_affiliation_strings":["INSERM UMR 1186, Integrative Tumor Immunology and Immunotherapy, Gustave Roussy, Fac. de M\u00e9decine-Univ. Paris-Sud, Universit\u00e9 Paris-Saclay, Villejuif, France","UMR 1186 - Immunologie int\u00e9grative des tumeurs (Gustave Roussy\r\nPavillon de recherche 1\r\n114, rue \u00c9douard-Vaillant 94805 Villejuif Cedex -France - France)","INTIM - Immunologie int\u00e9grative des tumeurs et immunoth\u00e9rapie des cancers (114 rue Edouard Vaillant, 94805, Villejuif cedex - France)"],"raw_orcid":"https://orcid.org/0000-0003-2165-5244","affiliations":[{"raw_affiliation_string":"INSERM UMR 1186, Integrative Tumor Immunology and Immunotherapy, Gustave Roussy, Fac. de M\u00e9decine-Univ. Paris-Sud, Universit\u00e9 Paris-Saclay, Villejuif, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I102197404","https://openalex.org/I2801843802"]},{"raw_affiliation_string":"UMR 1186 - Immunologie int\u00e9grative des tumeurs (Gustave Roussy\r\nPavillon de recherche 1\r\n114, rue \u00c9douard-Vaillant 94805 Villejuif Cedex -France - France)","institution_ids":["https://openalex.org/I2801843802"]},{"raw_affiliation_string":"INTIM - Immunologie int\u00e9grative des tumeurs et immunoth\u00e9rapie des cancers (114 rue Edouard Vaillant, 94805, Villejuif cedex - France)","institution_ids":["https://openalex.org/I4210133830","https://openalex.org/I4387152196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013466066","display_name":"Maria Colomba Comes","orcid":"https://orcid.org/0000-0003-2903-4389"},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Colomba Comes","raw_affiliation_strings":["Department of Electronic Engineering, University of Rome Tor Vergata, Rome, Italy","Universit\u00e0 degli Studi di Roma Tor Vergata [Roma, Italia] = University of Rome Tor Vergata [Rome, Italy] = Universit\u00e9 de Rome Tor Vergata [Rome, Italie] (Via Cracovia n. 50 - 00133 Roma - Italy)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electronic Engineering, University of Rome Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]},{"raw_affiliation_string":"Universit\u00e0 degli Studi di Roma Tor Vergata [Roma, Italia] = University of Rome Tor Vergata [Rome, Italy] = Universit\u00e9 de Rome Tor Vergata [Rome, Italie] (Via Cracovia n. 50 - 00133 Roma - Italy)","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061495123","display_name":"Fathia Mami\u2010Chouaib","orcid":"https://orcid.org/0000-0001-9685-6011"},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]},{"id":"https://openalex.org/I4210133830","display_name":"Laboratoire d\u2019immunologie int\u00e9grative du cancer","ror":"https://ror.org/03cqwn895","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I39804081","https://openalex.org/I4210092322","https://openalex.org/I4210133830"]},{"id":"https://openalex.org/I4387152196","display_name":"Immunologie int\u00e9grative des tumeurs et immunoth\u00e9rapie du cancer","ror":"https://ror.org/0266c5p67","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I2801843802","https://openalex.org/I4387152196"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fathia Mami-Chouaib","raw_affiliation_strings":["INSERM UMR 1186, Integrative Tumor Immunology and Immunotherapy, Gustave Roussy, Fac. de M\u00e9decine-Univ. Paris-Sud, Universit\u00e9 Paris-Saclay, Villejuif, France","INTIM - Immunologie int\u00e9grative des tumeurs et immunoth\u00e9rapie des cancers (114 rue Edouard Vaillant, 94805, Villejuif cedex - France)","U830 - Unit\u00e9 de g\u00e9n\u00e9tique et biologie des cancers (Institut Curie \r\n26, rue d'Ulm section de recherche \r\n75248 Paris cedex 05 - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM UMR 1186, Integrative Tumor Immunology and Immunotherapy, Gustave Roussy, Fac. de M\u00e9decine-Univ. Paris-Sud, Universit\u00e9 Paris-Saclay, Villejuif, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I102197404","https://openalex.org/I2801843802"]},{"raw_affiliation_string":"INTIM - Immunologie int\u00e9grative des tumeurs et immunoth\u00e9rapie des cancers (114 rue Edouard Vaillant, 94805, Villejuif cedex - France)","institution_ids":["https://openalex.org/I4210133830","https://openalex.org/I4387152196"]},{"raw_affiliation_string":"U830 - Unit\u00e9 de g\u00e9n\u00e9tique et biologie des cancers (Institut Curie \r\n26, rue d'Ulm section de recherche \r\n75248 Paris cedex 05 - France)","institution_ids":["https://openalex.org/I80043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008047411","display_name":"Jacques Camonis","orcid":"https://orcid.org/0000-0003-2047-4150"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jacques Camonis","raw_affiliation_strings":["Institut Curie, INSERM U830, Stress and Cancer Laboratory, PSL Research University, Paris, France","U830 - Unit\u00e9 de g\u00e9n\u00e9tique et biologie des cancers (Institut Curie \r\n26, rue d'Ulm section de recherche \r\n75248 Paris cedex 05 - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Curie, INSERM U830, Stress and Cancer Laboratory, PSL Research University, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2746051580"]},{"raw_affiliation_string":"U830 - Unit\u00e9 de g\u00e9n\u00e9tique et biologie des cancers (Institut Curie \r\n26, rue d'Ulm section de recherche \r\n75248 Paris cedex 05 - France)","institution_ids":["https://openalex.org/I80043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010656717","display_name":"St\u00e9phanie Descroix","orcid":"https://orcid.org/0000-0003-0027-352X"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I4210160133","display_name":"Physique des Cellules et Cancers","ror":"https://ror.org/055ss7a31","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210160133","https://openalex.org/I80043"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"St\u00e9phanie Descroix","raw_affiliation_strings":["Institut Curie, CNRS UMR168, Laboratoire Physico Chimie Curie, Institut Pierre-Gilles de Gennes, PSL Research University, Paris, France","PCC - Laboratoire Physico-Chimie Curie [Institut Curie] (11 rue Pierre et Marie Curie\r\n75005 Paris - France)"],"raw_orcid":"https://orcid.org/0000-0003-0027-352X","affiliations":[{"raw_affiliation_string":"Institut Curie, CNRS UMR168, Laboratoire Physico Chimie Curie, Institut Pierre-Gilles de Gennes, PSL Research University, Paris, France","institution_ids":["https://openalex.org/I2746051580","https://openalex.org/I1294671590","https://openalex.org/I4210160133"]},{"raw_affiliation_string":"PCC - Laboratoire Physico-Chimie Curie [Institut Curie] (11 rue Pierre et Marie Curie\r\n75005 Paris - France)","institution_ids":["https://openalex.org/I4210160133","https://openalex.org/I80043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050477807","display_name":"Hamasseh Shirvani","orcid":null},"institutions":[{"id":"https://openalex.org/I4210107416","display_name":"Roche (France)","ror":"https://ror.org/01mqmer16","country_code":"FR","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4210107416"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Hamasseh Shirvani","raw_affiliation_strings":["Institut Roche, 4 cours de l'Ile Seguin, Boulogne-Billancourt, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Roche, 4 cours de l'Ile Seguin, Boulogne-Billancourt, France","institution_ids":["https://openalex.org/I4210107416"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077434013","display_name":"Fatima Mechta\u2010Grigoriou","orcid":"https://orcid.org/0000-0002-3751-6989"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fatima Mechta-Grigoriou","raw_affiliation_strings":["Institut Curie, INSERM U830, Stress and Cancer Laboratory, PSL Research University, Paris, France","U830 - Unit\u00e9 de g\u00e9n\u00e9tique et biologie des cancers (Institut Curie \r\n26, rue d'Ulm section de recherche \r\n75248 Paris cedex 05 - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Curie, INSERM U830, Stress and Cancer Laboratory, PSL Research University, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2746051580"]},{"raw_affiliation_string":"U830 - Unit\u00e9 de g\u00e9n\u00e9tique et biologie des cancers (Institut Curie \r\n26, rue d'Ulm section de recherche \r\n75248 Paris cedex 05 - France)","institution_ids":["https://openalex.org/I80043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063103135","display_name":"G\u00e9rard Zalcman","orcid":"https://orcid.org/0000-0002-0343-9575"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Universit\u00e9 Claude Bernard Lyon 1","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I4210145170","display_name":"H\u00f4pital Bichat-Claude-Bernard","ror":"https://ror.org/03fdnmv92","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210145170"]},{"id":"https://openalex.org/I4210150021","display_name":"Centre d'Investigation Clinique - Innovation Technologique","ror":"https://ror.org/04fmayc82","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210150021"]},{"id":"https://openalex.org/I4403386480","display_name":"Centre d'Investigation Clinique Bichat","ror":"https://ror.org/04dtbh109","country_code":null,"type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4403386480"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"G\u00e9rard Zalcman","raw_affiliation_strings":["CIC INSERM 1425, Thoracic Oncology Department, University Hospital Bichat-Claude Bernard, Universit\u00e9 de Paris, Paris, France","Institut Curie, INSERM U830, Stress and Cancer Laboratory, PSL Research University, Paris, France","U830 - Unit\u00e9 de g\u00e9n\u00e9tique et biologie des cancers (Institut Curie \r\n26, rue d'Ulm section de recherche \r\n75248 Paris cedex 05 - France)","CIC 1425 - Centre d'investigation Clinique [CHU Bichat] - \u00c9pid\u00e9miologie clinique (France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CIC INSERM 1425, Thoracic Oncology Department, University Hospital Bichat-Claude Bernard, Universit\u00e9 de Paris, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210145170","https://openalex.org/I100532134"]},{"raw_affiliation_string":"Institut Curie, INSERM U830, Stress and Cancer Laboratory, PSL Research University, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2746051580"]},{"raw_affiliation_string":"U830 - Unit\u00e9 de g\u00e9n\u00e9tique et biologie des cancers (Institut Curie \r\n26, rue d'Ulm section de recherche \r\n75248 Paris cedex 05 - France)","institution_ids":["https://openalex.org/I80043"]},{"raw_affiliation_string":"CIC 1425 - Centre d'investigation Clinique [CHU Bichat] - \u00c9pid\u00e9miologie clinique (France)","institution_ids":["https://openalex.org/I4210150021","https://openalex.org/I4403386480"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063922043","display_name":"Maria Carla Parrini","orcid":"https://orcid.org/0000-0002-7082-9792"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Maria Carla Parrini","raw_affiliation_strings":["Institut Curie, INSERM U830, Stress and Cancer Laboratory, PSL Research University, Paris, France","U830 - Unit\u00e9 de g\u00e9n\u00e9tique et biologie des cancers (Institut Curie \r\n26, rue d'Ulm section de recherche \r\n75248 Paris cedex 05 - France)"],"raw_orcid":"https://orcid.org/0000-0002-7082-9792","affiliations":[{"raw_affiliation_string":"Institut Curie, INSERM U830, Stress and Cancer Laboratory, PSL Research University, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2746051580"]},{"raw_affiliation_string":"U830 - Unit\u00e9 de g\u00e9n\u00e9tique et biologie des cancers (Institut Curie \r\n26, rue d'Ulm section de recherche \r\n75248 Paris cedex 05 - France)","institution_ids":["https://openalex.org/I80043"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062989429","display_name":"Eugenio Martinelli","orcid":"https://orcid.org/0000-0002-6673-2066"},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Eugenio Martinelli","raw_affiliation_strings":["Department of Electronic Engineering, University of Rome Tor Vergata, Rome, Italy","Universit\u00e0 degli Studi di Roma Tor Vergata [Roma, Italia] = University of Rome Tor Vergata [Rome, Italy] = Universit\u00e9 de Rome Tor Vergata [Rome, Italie] (Via Cracovia n. 50 - 00133 Roma - Italy)"],"raw_orcid":"https://orcid.org/0000-0002-6673-2066","affiliations":[{"raw_affiliation_string":"Department of Electronic Engineering, University of Rome Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]},{"raw_affiliation_string":"Universit\u00e0 degli Studi di Roma Tor Vergata [Roma, Italia] = University of Rome Tor Vergata [Rome, Italy] = Universit\u00e9 de Rome Tor Vergata [Rome, Italie] (Via Cracovia n. 50 - 00133 Roma - Italy)","institution_ids":["https://openalex.org/I116067653"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5050477807"],"corresponding_institution_ids":["https://openalex.org/I4210107416"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.1886,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.7581894,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"17","issue":"3","first_page":"e1008870","last_page":"e1008870"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytotoxic-t-cell","display_name":"Cytotoxic T cell","score":0.691593587398529},{"id":"https://openalex.org/keywords/cancer-cell","display_name":"Cancer cell","score":0.6239901781082153},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.49610790610313416},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.4740940034389496},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.46534502506256104},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"Tumor microenvironment","score":0.4498162567615509},{"id":"https://openalex.org/keywords/programmed-cell-death","display_name":"Programmed cell death","score":0.44879287481307983},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.38315409421920776},{"id":"https://openalex.org/keywords/apoptosis","display_name":"Apoptosis","score":0.3671654760837555},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.33739709854125977},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.29137808084487915},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.26179826259613037},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.15514609217643738},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.11607366800308228}],"concepts":[{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.691593587398529},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.6239901781082153},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49610790610313416},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4740940034389496},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.46534502506256104},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.4498162567615509},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.44879287481307983},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38315409421920776},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3671654760837555},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33739709854125977},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29137808084487915},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.26179826259613037},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.15514609217643738},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11607366800308228},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018715","descriptor_name":"Microscopy, Video","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018715","descriptor_name":"Microscopy, Video","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018715","descriptor_name":"Microscopy, Video","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1008870","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008870","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:33784299","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33784299","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:HAL:hal-03209127v1","is_oa":false,"landing_page_url":"https://hal.sorbonne-universite.fr/hal-03209127","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, 2021, 17 (3), pp.e1008870. &#x27E8;10.1371/journal.pcbi.1008870&#x27E9;","raw_type":"Journal articles"},{"id":"pmh:oai:art.torvergata.it:2108/289509","is_oa":false,"landing_page_url":"http://hdl.handle.net/2108/289509","pdf_url":null,"source":{"id":"https://openalex.org/S4306400993","display_name":"Cineca Institutional Research Information System (Tor Vergata University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I116067653","host_organization_name":"University of Rome Tor Vergata","host_organization_lineage":["https://openalex.org/I116067653"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:d4d573bdd894482490dd39ca226cb5d1","is_oa":true,"landing_page_url":"https://doaj.org/article/d4d573bdd894482490dd39ca226cb5d1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 17, Iss 3, p e1008870 (2021)","raw_type":"article"},{"id":"pmh:oai:oskar-bordeaux.fr:20.500.12278/39398","is_oa":false,"landing_page_url":"https://oskar-bordeaux.fr/handle/20.500.12278/39398","pdf_url":null,"source":{"id":"https://openalex.org/S4306402569","display_name":"Oskar-Bordeaux (Universite de Bordeaux)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article de revue"},{"id":"pmh:oai:pubmedcentral.nih.gov:8034728","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8034728","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1008870","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008870","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6000000238418579}],"awards":[{"id":"https://openalex.org/G839173786","display_name":null,"funder_award_id":"PGA1 RF20180206991","funder_id":"https://openalex.org/F4320322361","funder_display_name":"Fondation ARC pour la Recherche sur le Cancer"}],"funders":[{"id":"https://openalex.org/F4320321663","display_name":"Association Nationale de la Recherche et de la Technologie","ror":"https://ror.org/00ht2ab73"},{"id":"https://openalex.org/F4320322361","display_name":"Fondation ARC pour la Recherche sur le Cancer","ror":"https://ror.org/0489qz649"},{"id":"https://openalex.org/F4320322727","display_name":"Minist\u00e8re de l'Education Nationale, de l'Enseignement Superieur et de la Recherche","ror":"https://ror.org/03sjk9a61"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W614733133","https://openalex.org/W1541960437","https://openalex.org/W1955893089","https://openalex.org/W1966549549","https://openalex.org/W1970465498","https://openalex.org/W2032417358","https://openalex.org/W2061454786","https://openalex.org/W2071969343","https://openalex.org/W2082829054","https://openalex.org/W2084040499","https://openalex.org/W2087481222","https://openalex.org/W2094816543","https://openalex.org/W2121753159","https://openalex.org/W2141461755","https://openalex.org/W2279226389","https://openalex.org/W2385172485","https://openalex.org/W2414236267","https://openalex.org/W2488088692","https://openalex.org/W2588975115","https://openalex.org/W2606007772","https://openalex.org/W2610860012","https://openalex.org/W2741447665","https://openalex.org/W2758927689","https://openalex.org/W2766354837","https://openalex.org/W2774854449","https://openalex.org/W2785291766","https://openalex.org/W2786031287","https://openalex.org/W2788640168","https://openalex.org/W2794353934","https://openalex.org/W2797015192","https://openalex.org/W2906206485","https://openalex.org/W2909633774","https://openalex.org/W2911649965","https://openalex.org/W2943011330","https://openalex.org/W2947971132","https://openalex.org/W3002684299","https://openalex.org/W3010799115","https://openalex.org/W3010985052","https://openalex.org/W3022107493","https://openalex.org/W4256068510","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2414729062","https://openalex.org/W1497833379","https://openalex.org/W1964266791","https://openalex.org/W4313313459","https://openalex.org/W2040631670","https://openalex.org/W2049624095","https://openalex.org/W2110968275","https://openalex.org/W2384087372","https://openalex.org/W3013564512","https://openalex.org/W3006386809"],"abstract_inverted_index":{"The":[0,138,182],"emerging":[1],"tumor-on-chip":[2],"(ToC)":[3],"approaches":[4],"allow":[5],"to":[6,80,114,133,175,194,213,218,223,250,264],"address":[7],"biomedical":[8],"questions":[9],"out":[10],"of":[11,29,56,157,186,208,239,254,283,290],"reach":[12],"with":[13],"classical":[14],"cell":[15,39,66,136,196],"culture":[16],"techniques:":[17],"in":[18,64,166,245,248,277],"biomimetic":[19],"3D":[20],"hydrogels":[21],"they":[22],"partially":[23],"reconstitute":[24],"ex":[25],"vivo":[26],"the":[27,30,34,52,57,65,83,117,150,154,167,173,187,205,237,252,281,288,295],"complexity":[28],"tumor":[31],"microenvironment":[32],"and":[33,54,74,91,122,153,162,170,184,198,227,247],"cellular":[35],"dynamics":[36],"involving":[37],"multiple":[38],"types":[40],"(cancer":[41],"cells,":[42,44,286],"immune":[43],"fibroblasts,":[45],"etc.).":[46],"However,":[47],"a":[48,123,220,234],"clear":[49],"bottleneck":[50],"is":[51,112,131,189,243,275],"extraction":[53],"interpretation":[55],"rich":[58],"biological":[59],"information":[60],"contained,":[61],"sometime":[62],"hidden,":[63],"co-culture":[67,199],"videos.":[68],"In":[69],"this":[70,202],"work,":[71],"we":[72,232],"develop":[73],"apply":[75],"novel":[76],"video":[77],"analysis":[78],"algorithms":[79],"automatically":[81],"measure":[82],"cytotoxic":[84,103,297],"effects":[85],"on":[86,257],"human":[87],"cancer":[88,118,158,164,215,267,285],"cells":[89,119,165,256],"(lung":[90],"breast)":[92],"induced":[93,269],"either":[94],"by":[95,100,160,171,191,270,273],"doxorubicin":[96],"chemotherapy":[97,271],"drug":[98,228],"or":[99,272],"autologous":[101],"tumor-infiltrating":[102],"T":[104],"lymphocytes":[105],"(CTL).":[106],"A":[107],"live":[108,124],"fluorescent":[109,125],"dye":[110],"(red)":[111],"used":[113,132],"selectively":[115],"pre-stain":[116],"before":[120],"co-cultures":[121],"reporter":[126],"for":[127],"caspase":[128],"activity":[129],"(green)":[130],"monitor":[134],"apoptotic":[135],"death.":[137],"here":[139],"described":[140],"open-source":[141],"computational":[142],"method,":[143],"named":[144],"STAMP":[145],"(spatiotemporal":[146],"apoptosis":[147],"mapper),":[148],"extracts":[149],"temporal":[151],"kinetics":[152],"spatial":[155],"maps":[156],"death,":[159,266],"localizing":[161],"tracking":[163],"red":[168,174],"channel,":[169],"counting":[172],"green":[176],"transition":[177],"signals,":[178],"over":[179],"2-3":[180],"days.":[181],"robustness":[183],"versatility":[185],"method":[188],"demonstrated":[190],"its":[192],"application":[193],"different":[195],"models":[197],"combinations.":[200],"Noteworthy,":[201],"approach":[203],"reveals":[204],"strong":[206],"contribution":[207],"primary":[209],"cancer-associated":[210],"fibroblasts":[211],"(CAFs)":[212],"breast":[214],"chemo-resistance,":[216],"proving":[217],"be":[219],"powerful":[221],"strategy":[222],"investigate":[224],"intercellular":[225],"cross-talks":[226],"resistance":[229],"mechanisms.":[230],"Moreover,":[231],"defined":[233],"new":[235],"parameter,":[236],"'potential":[238],"death":[240,268,282],"induction',":[241],"which":[242,293],"computed":[244],"time":[246],"space":[249],"quantify":[251],"impact":[253],"dying":[255],"neighbor":[258],"cells.":[259],"We":[260],"found":[261],"that,":[262],"contrary":[263],"natural":[265],"CTL":[274],"transmissible,":[276],"that":[278],"it":[279],"promotes":[280],"nearby":[284],"suggesting":[287],"release":[289],"diffusible":[291],"factors":[292],"amplify":[294],"initial":[296],"stimulus.":[298]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6}],"updated_date":"2026-06-06T09:05:17.133730","created_date":"2025-10-10T00:00:00"}
