{"id":"https://openalex.org/W3137588455","doi":"https://doi.org/10.1371/journal.pcbi.1008818","title":"Prediction of amphipathic helix\u2014membrane interactions with Rosetta","display_name":"Prediction of amphipathic helix\u2014membrane interactions with Rosetta","publication_year":2021,"publication_date":"2021-03-17","ids":{"openalex":"https://openalex.org/W3137588455","doi":"https://doi.org/10.1371/journal.pcbi.1008818","mag":"3137588455","pmid":"https://pubmed.ncbi.nlm.nih.gov/33730029"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1008818","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008818","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008818&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008818&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019958884","display_name":"Alican Gulsevin","orcid":"https://orcid.org/0000-0002-8724-5777"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alican Gulsevin","raw_affiliation_strings":["Department of Chemistry, Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-8724-5777","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025842562","display_name":"Jens Meiler","orcid":"https://orcid.org/0000-0001-8945-193X"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Jens Meiler","raw_affiliation_strings":["Department of Chemistry, Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America","Institute for Drug Discovery, Leipzig University Medical School, 04103 Leipzig, Germany"],"raw_orcid":"https://orcid.org/0000-0001-8945-193X","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Institute for Drug Discovery, Leipzig University Medical School, 04103 Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5025842562"],"corresponding_institution_ids":["https://openalex.org/I200719446","https://openalex.org/I926574661"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.5699,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.63729134,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"17","issue":"3","first_page":"e1008818","last_page":"e1008818"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9926000237464905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amphiphile","display_name":"Amphiphile","score":0.5988559722900391},{"id":"https://openalex.org/keywords/helix","display_name":"Helix (gastropod)","score":0.5281792879104614},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.45792847871780396},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.4130188226699829},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3953067660331726},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3065120577812195}],"concepts":[{"id":"https://openalex.org/C67407626","wikidata":"https://www.wikidata.org/wiki/Q5723218","display_name":"Amphiphile","level":4,"score":0.5988559722900391},{"id":"https://openalex.org/C2778530040","wikidata":"https://www.wikidata.org/wiki/Q1937315","display_name":"Helix (gastropod)","level":3,"score":0.5281792879104614},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.45792847871780396},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4130188226699829},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3953067660331726},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3065120577812195},{"id":"https://openalex.org/C15920480","wikidata":"https://www.wikidata.org/wiki/Q421281","display_name":"Copolymer","level":3,"score":0.0},{"id":"https://openalex.org/C2779965526","wikidata":"https://www.wikidata.org/wiki/Q308841","display_name":"Snail","level":2,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000072756","descriptor_name":"Protein Conformation, alpha-Helical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000072756","descriptor_name":"Protein Conformation, alpha-Helical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000072756","descriptor_name":"Protein Conformation, alpha-Helical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1008818","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008818","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008818&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:33730029","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33730029","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1008818","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008818","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:465934a3d0804820a4401e4346c360bc","is_oa":true,"landing_page_url":"https://doaj.org/article/465934a3d0804820a4401e4346c360bc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 17, Iss 3, p e1008818 (2021)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8007005","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8007005","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1008818","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008818","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008818&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1182699193","display_name":null,"funder_award_id":"R01 GM080403","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1379016709","display_name":null,"funder_award_id":"GM080403","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G145672378","display_name":null,"funder_award_id":"R01 GM080403","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6222350044","display_name":null,"funder_award_id":"HL144131","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8099155643","display_name":null,"funder_award_id":"R01 HL144131","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8669874586","display_name":null,"funder_award_id":"GM080403","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3137588455.pdf","grobid_xml":"https://content.openalex.org/works/W3137588455.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W135702927","https://openalex.org/W1857017278","https://openalex.org/W1879820513","https://openalex.org/W1967316941","https://openalex.org/W1968077410","https://openalex.org/W1990771438","https://openalex.org/W1996355353","https://openalex.org/W2008968082","https://openalex.org/W2026530461","https://openalex.org/W2027699805","https://openalex.org/W2029653438","https://openalex.org/W2029882655","https://openalex.org/W2034521636","https://openalex.org/W2035557381","https://openalex.org/W2044993462","https://openalex.org/W2056402029","https://openalex.org/W2063102132","https://openalex.org/W2065943239","https://openalex.org/W2067706841","https://openalex.org/W2069863445","https://openalex.org/W2085136523","https://openalex.org/W2088598791","https://openalex.org/W2091622692","https://openalex.org/W2095512917","https://openalex.org/W2101810621","https://openalex.org/W2104434319","https://openalex.org/W2112014931","https://openalex.org/W2114471659","https://openalex.org/W2119993590","https://openalex.org/W2131390096","https://openalex.org/W2140831051","https://openalex.org/W2141500961","https://openalex.org/W2142270082","https://openalex.org/W2147796031","https://openalex.org/W2149529602","https://openalex.org/W2151363352","https://openalex.org/W2151581834","https://openalex.org/W2153654642","https://openalex.org/W2155839962","https://openalex.org/W2162274915","https://openalex.org/W2166137928","https://openalex.org/W2170670602","https://openalex.org/W2265164857","https://openalex.org/W2323104785","https://openalex.org/W2332712348","https://openalex.org/W2335866036","https://openalex.org/W2404280981","https://openalex.org/W2604223107","https://openalex.org/W2767063510","https://openalex.org/W2781883599","https://openalex.org/W2783944345","https://openalex.org/W2809900338","https://openalex.org/W2901361432","https://openalex.org/W2921052393","https://openalex.org/W2936969503","https://openalex.org/W2953362071","https://openalex.org/W2970715101","https://openalex.org/W3011535809"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189","https://openalex.org/W2013243191","https://openalex.org/W2261452124"],"abstract_inverted_index":{"Amphipathic":[0],"helices":[1,112,137],"have":[2],"hydrophobic":[3],"and":[4,101,108,119,124,146,166,176],"hydrophilic/charged":[5],"residues":[6,149],"situated":[7],"on":[8,105],"opposite":[9],"faces":[10],"of":[11,38,79,90,135,142,156],"the":[12,21,35,63,75,86,91,98,117,133,143],"helix.":[13],"They":[14],"can":[15,170],"anchor":[16],"peripheral":[17],"membrane":[18,27,114],"proteins":[19],"to":[20,25,49,57,73,85,158],"membrane,":[22],"be":[23,171],"attached":[24],"integral":[26],"proteins,":[28],"or":[29],"exist":[30],"as":[31,163],"independent":[32],"peptides.":[33],"Despite":[34],"widespread":[36],"presence":[37],"membrane-interacting":[39],"amphipathic":[40,81,111,136],"helices,":[41],"there":[42],"is":[43],"no":[44],"computational":[45],"tool":[46],"within":[47,138],"Rosetta":[48,175],"model":[50],"their":[51],"interactions":[52],"with":[53,66,83,97,150,173],"membranes.":[54],"In":[55],"order":[56],"address":[58],"this":[59],"need,":[60],"we":[61],"developed":[62],"AmphiScan":[64,130,161],"protocol":[65,131,168],"PyRosetta,":[67],"which":[68],"runs":[69],"a":[70,151],"grid":[71],"search":[72],"find":[74],"most":[76],"favorable":[77],"position":[78],"an":[80],"helix":[82],"respect":[84],"membrane.":[87],"The":[88,129],"performance":[89],"algorithm":[92],"was":[93],"tested":[94],"in":[95],"benchmarks":[96],"RosettaMembrane,":[99],"ref2015_memb,":[100],"franklin2019":[102],"score":[103],"functions":[104],"six":[106],"engineered":[107],"44":[109],"naturally-occurring":[110],"using":[113],"coordinates":[115,134],"from":[116],"OPM":[118],"PDBTM":[120],"databases,":[121],"OREMPRO":[122],"server,":[123],"MD":[125],"simulations":[126],"for":[127],"comparison.":[128],"predicted":[132],"less":[139],"than":[140],"3\u00c5":[141],"reference":[144],"structures":[145],"identified":[147],"membrane-embedded":[148],"Matthews":[152],"Correlation":[153],"Constant":[154],"(MCC)":[155],"up":[157],"0.57.":[159],"Overall,":[160],"stands":[162],"fast,":[164],"accurate,":[165],"highly-customizable":[167],"that":[169],"pipelined":[172],"other":[174],"Python":[177],"applications.":[178]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}