{"id":"https://openalex.org/W3135702576","doi":"https://doi.org/10.1371/journal.pcbi.1008771","title":"Aggregation of A\u03b240/42 chains in the presence of cyclic neuropeptides investigated by molecular dynamics simulations","display_name":"Aggregation of A\u03b240/42 chains in the presence of cyclic neuropeptides investigated by molecular dynamics simulations","publication_year":2021,"publication_date":"2021-03-12","ids":{"openalex":"https://openalex.org/W3135702576","doi":"https://doi.org/10.1371/journal.pcbi.1008771","mag":"3135702576","pmid":"https://pubmed.ncbi.nlm.nih.gov/33711010"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1008771","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008771","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008771&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008771&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072606310","display_name":"Min Wu","orcid":"https://orcid.org/0000-0003-0550-5801"},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Min Wu","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of Alberta, Edmonton, Canada"],"raw_orcid":"https://orcid.org/0000-0003-0550-5801","affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Alberta, Edmonton, Canada","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012180460","display_name":"Lyudmyla Dorosh","orcid":"https://orcid.org/0000-0002-5224-4045"},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Lyudmyla Dorosh","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of Alberta, Edmonton, Canada"],"raw_orcid":"https://orcid.org/0000-0002-5224-4045","affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Alberta, Edmonton, Canada","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013832642","display_name":"Gerold Schmitt\u2010Ulms","orcid":"https://orcid.org/0000-0001-6962-0919"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Gerold Schmitt-Ulms","raw_affiliation_strings":["Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada"],"raw_orcid":"https://orcid.org/0000-0001-6962-0919","affiliations":[{"raw_affiliation_string":"Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084432831","display_name":"Holger Wille","orcid":"https://orcid.org/0000-0001-5102-8706"},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]},{"id":"https://openalex.org/I4210131405","display_name":"Women and Children\u2019s Health Research Institute","ror":"https://ror.org/03e04kk51","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210131405"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Holger Wille","raw_affiliation_strings":["Centre for Prions and Protein Folding Diseases, Edmonton, Canada","Department of Biochemistry, University of Alberta, Edmonton, Canada","Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Canada"],"raw_orcid":"https://orcid.org/0000-0001-5102-8706","affiliations":[{"raw_affiliation_string":"Centre for Prions and Protein Folding Diseases, Edmonton, Canada","institution_ids":[]},{"raw_affiliation_string":"Department of Biochemistry, University of Alberta, Edmonton, Canada","institution_ids":["https://openalex.org/I154425047"]},{"raw_affiliation_string":"Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Canada","institution_ids":["https://openalex.org/I4210131405","https://openalex.org/I154425047"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030349620","display_name":"Maria Stepanova","orcid":"https://orcid.org/0000-0002-6324-8965"},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Maria Stepanova","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of Alberta, Edmonton, Canada"],"raw_orcid":"https://orcid.org/0000-0002-6324-8965","affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Alberta, Edmonton, Canada","institution_ids":["https://openalex.org/I154425047"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5030349620"],"corresponding_institution_ids":["https://openalex.org/I154425047"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.7275,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.6840435,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"17","issue":"3","first_page":"e1008771","last_page":"e1008771"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11419","display_name":"Supramolecular Self-Assembly in Materials","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9908999800682068,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.7390234470367432},{"id":"https://openalex.org/keywords/molecular-dynamics","display_name":"Molecular dynamics","score":0.6067635416984558},{"id":"https://openalex.org/keywords/neuropeptide","display_name":"Neuropeptide","score":0.5600703358650208},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.5265386700630188},{"id":"https://openalex.org/keywords/hydrogen-bond","display_name":"Hydrogen bond","score":0.4625598192214966},{"id":"https://openalex.org/keywords/peptide","display_name":"Peptide","score":0.4575127959251404},{"id":"https://openalex.org/keywords/cyclic-peptide","display_name":"Cyclic peptide","score":0.42270755767822266},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"Protein aggregation","score":0.4211381673812866},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.25972551107406616},{"id":"https://openalex.org/keywords/molecule","display_name":"Molecule","score":0.25736695528030396},{"id":"https://openalex.org/keywords/organic-chemistry","display_name":"Organic chemistry","score":0.11598321795463562},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.10350251197814941},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"Computational chemistry","score":0.09444683790206909},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.06894958019256592}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7390234470367432},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.6067635416984558},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.5600703358650208},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5265386700630188},{"id":"https://openalex.org/C112887158","wikidata":"https://www.wikidata.org/wiki/Q169324","display_name":"Hydrogen bond","level":3,"score":0.4625598192214966},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.4575127959251404},{"id":"https://openalex.org/C60984968","wikidata":"https://www.wikidata.org/wiki/Q389172","display_name":"Cyclic peptide","level":3,"score":0.42270755767822266},{"id":"https://openalex.org/C136238340","wikidata":"https://www.wikidata.org/wiki/Q7251455","display_name":"Protein aggregation","level":2,"score":0.4211381673812866},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25972551107406616},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.25736695528030396},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.11598321795463562},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10350251197814941},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.09444683790206909},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06894958019256592}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013004","descriptor_name":"Somatostatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013004","descriptor_name":"Somatostatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013004","descriptor_name":"Somatostatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013004","descriptor_name":"Somatostatin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013004","descriptor_name":"Somatostatin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013004","descriptor_name":"Somatostatin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D066263","descriptor_name":"Protein Aggregation, Pathological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066263","descriptor_name":"Protein Aggregation, Pathological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066263","descriptor_name":"Protein Aggregation, Pathological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1008771","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008771","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008771&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:33711010","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33711010","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:73a11cda2d034f16a12fa103e2750fd0","is_oa":true,"landing_page_url":"https://doaj.org/article/73a11cda2d034f16a12fa103e2750fd0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 17, Iss 3, p e1008771 (2021)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7990313","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7990313","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1008771","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008771","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008771&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G8010179539","display_name":null,"funder_award_id":"201700016","funder_id":"https://openalex.org/F4320337169","funder_display_name":"Alberta Prion Research Institute"}],"funders":[{"id":"https://openalex.org/F4320314000","display_name":"Compute Canada","ror":"https://ror.org/03ty8yr27"},{"id":"https://openalex.org/F4320337169","display_name":"Alberta Prion Research Institute","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3135702576.pdf","grobid_xml":"https://content.openalex.org/works/W3135702576.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W896868469","https://openalex.org/W960784697","https://openalex.org/W1551466091","https://openalex.org/W1553011341","https://openalex.org/W1677883125","https://openalex.org/W1972429626","https://openalex.org/W1974582141","https://openalex.org/W1979502707","https://openalex.org/W1980825524","https://openalex.org/W1981021420","https://openalex.org/W1986934575","https://openalex.org/W2017035284","https://openalex.org/W2029667189","https://openalex.org/W2037346440","https://openalex.org/W2047556742","https://openalex.org/W2049421402","https://openalex.org/W2075443251","https://openalex.org/W2081855136","https://openalex.org/W2137145018","https://openalex.org/W2138995815","https://openalex.org/W2150439945","https://openalex.org/W2161605421","https://openalex.org/W2279613858","https://openalex.org/W2316437991","https://openalex.org/W2339127939","https://openalex.org/W2386517867","https://openalex.org/W2473711714","https://openalex.org/W2487730443","https://openalex.org/W2520521682","https://openalex.org/W2532285703","https://openalex.org/W2548181354","https://openalex.org/W2614053601","https://openalex.org/W2619949586","https://openalex.org/W2722645493","https://openalex.org/W2773321573","https://openalex.org/W2774675034","https://openalex.org/W2790538471","https://openalex.org/W2884062056","https://openalex.org/W2890247534","https://openalex.org/W2921063431","https://openalex.org/W2999847664","https://openalex.org/W3015856745","https://openalex.org/W3017784424","https://openalex.org/W3024506966","https://openalex.org/W3086215371"],"related_works":["https://openalex.org/W2419384258","https://openalex.org/W1556485874","https://openalex.org/W2625137715","https://openalex.org/W2039605138","https://openalex.org/W4394767614","https://openalex.org/W2594502287","https://openalex.org/W2027172161","https://openalex.org/W4394853849","https://openalex.org/W2023156907","https://openalex.org/W2201677815"],"abstract_inverted_index":{"Alzheimer's":[0],"disease":[1],"is":[2],"associated":[3],"with":[4,103,171,214],"the":[5,21,47,69,84,108,120,125,137,143,172,179,183,201,236,250,253],"formation":[6,70,138],"of":[7,10,20,24,71,86,95,98,112,122,127,139,153,175,187,200,221,228,255],"toxic":[8,72],"aggregates":[9,141,170,188,251],"amyloid":[11],"beta":[12],"(A\u03b2)":[13],"peptides.":[14],"Despite":[15],"tremendous":[16],"efforts,":[17],"our":[18],"understanding":[19],"molecular":[22,92],"mechanisms":[23],"aggregation,":[25],"as":[26,28],"well":[27],"cofactors":[29],"that":[30,57,189],"might":[31],"influence":[32],"it,":[33],"remains":[34],"incomplete.":[35],"The":[36,158,226],"small":[37,147,169],"cyclic":[38,133,148],"neuropeptide":[39],"somatostatin-14":[40],"(SST14)":[41],"was":[42,64,230],"recently":[43],"found":[44,66,162,231],"to":[45,67,79,163,178,195,209,232],"be":[46],"most":[48],"selectively":[49],"enriched":[50],"protein":[51],"in":[52,75,124,150,182,211,235,249],"human":[53],"frontal":[54],"lobe":[55],"extracts":[56],"binds":[58],"A\u03b242":[59,73,99,123],"aggregates.":[60,114],"Furthermore,":[61],"SST14's":[62],"presence":[63,126,227],"also":[65,118],"promote":[68],"oligomers":[74],"vitro.":[76],"In":[77],"order":[78],"elucidate":[80],"how":[81],"SST14":[82,104,191,229],"influences":[83],"onset":[85,254],"A\u03b2":[87,144,202,215],"oligomerization,":[88],"we":[89,117],"performed":[90],"all-atom":[91],"dynamics":[93,111,186],"simulations":[94],"model":[96],"mixtures":[97,152,160],"or":[100,192],"A\u03b240":[101],"peptides":[102,149],"molecules":[105],"and":[106,110,146,156,185,217,223],"analyzed":[107,119],"structure":[109],"early-stage":[113],"For":[115],"comparison":[116],"aggregation":[121,234],"arginine":[128],"vasopressin":[129],"(AVP),":[130],"a":[131,240,244],"different":[132],"neuropeptide.":[134],"We":[135],"observed":[136],"self-assembled":[140],"containing":[142],"chains":[145,203],"all":[151],"A\u03b242-SST14,":[154],"A\u03b242-AVP,":[155],"A\u03b240-SST14.":[157],"A\u03b242-SST14":[159,237,256],"were":[161],"develop":[164],"compact,":[165],"dynamically":[166],"stable,":[167],"but":[168],"highest":[173],"exposure":[174],"hydrophobic":[176,224],"residues":[177],"solvent.":[180],"Differences":[181],"morphology":[184],"comprise":[190],"AVP":[193],"appear":[194],"reflect":[196],"distinct":[197],"(1)":[198],"regions":[199],"they":[204],"interact":[205],"with;":[206],"(2)":[207],"propensities":[208],"engage":[210],"hydrogen":[212],"bonds":[213],"peptides;":[216],"(3)":[218],"solvent":[219],"exposures":[220],"hydrophilic":[222],"groups.":[225],"impede":[233],"system":[238],"despite":[239],"high":[241],"hydrophobicity,":[242],"producing":[243],"stronger":[245],"\"sticky":[246],"surface\"":[247],"effect":[248],"at":[252],"oligomerization.":[257]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
