{"id":"https://openalex.org/W3134790283","doi":"https://doi.org/10.1371/journal.pcbi.1008752","title":"Success of prophylactic antiviral therapy for SARS-CoV-2: Predicted critical efficacies and impact of different drug-specific mechanisms of action","display_name":"Success of prophylactic antiviral therapy for SARS-CoV-2: Predicted critical efficacies and impact of different drug-specific mechanisms of action","publication_year":2021,"publication_date":"2021-03-01","ids":{"openalex":"https://openalex.org/W3134790283","doi":"https://doi.org/10.1371/journal.pcbi.1008752","mag":"3134790283","pmid":"https://pubmed.ncbi.nlm.nih.gov/33647008"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1008752","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008752","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1008752","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040455184","display_name":"Peter Czuppon","orcid":"https://orcid.org/0000-0003-1462-7237"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I187986737","display_name":"Coll\u00e8ge de France","ror":"https://ror.org/04ex24z53","country_code":"FR","type":"education","lineage":["https://openalex.org/I187986737"]},{"id":"https://openalex.org/I197681013","display_name":"Universit\u00e9 Paris-Est Cr\u00e9teil","ror":"https://ror.org/05ggc9x40","country_code":"FR","type":"education","lineage":["https://openalex.org/I197681013"]},{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210088668","display_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","ror":"https://ror.org/003vg9w96","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668"]},{"id":"https://openalex.org/I4210113621","display_name":"Centre Interdisciplinaire de Recherche en Biologie","ror":"https://ror.org/01mvzn566","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I187986737","https://openalex.org/I4210096427","https://openalex.org/I4210113621"]},{"id":"https://openalex.org/I4210134846","display_name":"Institut d'\u00e9cologie et des sciences de l'environnement de Paris","ror":"https://ror.org/02s56xp85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1327553481","https://openalex.org/I154202486","https://openalex.org/I197681013","https://openalex.org/I204730241","https://openalex.org/I2799535048","https://openalex.org/I2802818602","https://openalex.org/I39804081","https://openalex.org/I4210088668","https://openalex.org/I4210088668","https://openalex.org/I4210090127","https://openalex.org/I4210107625","https://openalex.org/I4210113730","https://openalex.org/I4210131494","https://openalex.org/I4210134846","https://openalex.org/I4210166444","https://openalex.org/I4405257220"]},{"id":"https://openalex.org/I4210166444","display_name":"Institut de Recherche pour le D\u00e9veloppement","ror":"https://ror.org/05q3vnk25","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1327553481","https://openalex.org/I154202486","https://openalex.org/I2799535048","https://openalex.org/I2802818602","https://openalex.org/I4210088668","https://openalex.org/I4210090127","https://openalex.org/I4210113730","https://openalex.org/I4210131494","https://openalex.org/I4210166444","https://openalex.org/I4405257220"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Peter Czuppon","raw_affiliation_strings":["Center for Interdisciplinary Research in Biology, CNRS, Coll\u00e8ge de France, PSL Research University, Paris, France","Institute of Ecology and Environmental Sciences of Paris, Sorbonne Universit\u00e9, CNRS, UPEC, IRD, INRAE, Paris, France"],"raw_orcid":"https://orcid.org/0000-0003-1462-7237","affiliations":[{"raw_affiliation_string":"Center for Interdisciplinary Research in Biology, CNRS, Coll\u00e8ge de France, PSL Research University, Paris, France","institution_ids":["https://openalex.org/I4210113621","https://openalex.org/I187986737","https://openalex.org/I2746051580","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Institute of Ecology and Environmental Sciences of Paris, Sorbonne Universit\u00e9, CNRS, UPEC, IRD, INRAE, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210166444","https://openalex.org/I39804081","https://openalex.org/I197681013","https://openalex.org/I4210088668","https://openalex.org/I4210134846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026865511","display_name":"Florence D\u00e9barre","orcid":"https://orcid.org/0000-0003-2497-833X"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I197681013","display_name":"Universit\u00e9 Paris-Est Cr\u00e9teil","ror":"https://ror.org/05ggc9x40","country_code":"FR","type":"education","lineage":["https://openalex.org/I197681013"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210088668","display_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","ror":"https://ror.org/003vg9w96","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668"]},{"id":"https://openalex.org/I4210134846","display_name":"Institut d'\u00e9cologie et des sciences de l'environnement de Paris","ror":"https://ror.org/02s56xp85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1327553481","https://openalex.org/I154202486","https://openalex.org/I197681013","https://openalex.org/I204730241","https://openalex.org/I2799535048","https://openalex.org/I2802818602","https://openalex.org/I39804081","https://openalex.org/I4210088668","https://openalex.org/I4210088668","https://openalex.org/I4210090127","https://openalex.org/I4210107625","https://openalex.org/I4210113730","https://openalex.org/I4210131494","https://openalex.org/I4210134846","https://openalex.org/I4210166444","https://openalex.org/I4405257220"]},{"id":"https://openalex.org/I4210166444","display_name":"Institut de Recherche pour le D\u00e9veloppement","ror":"https://ror.org/05q3vnk25","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1327553481","https://openalex.org/I154202486","https://openalex.org/I2799535048","https://openalex.org/I2802818602","https://openalex.org/I4210088668","https://openalex.org/I4210090127","https://openalex.org/I4210113730","https://openalex.org/I4210131494","https://openalex.org/I4210166444","https://openalex.org/I4405257220"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Florence D\u00e9barre","raw_affiliation_strings":["Institute of Ecology and Environmental Sciences of Paris, Sorbonne Universit\u00e9, CNRS, UPEC, IRD, INRAE, Paris, France"],"raw_orcid":"https://orcid.org/0000-0003-2497-833X","affiliations":[{"raw_affiliation_string":"Institute of Ecology and Environmental Sciences of Paris, Sorbonne Universit\u00e9, CNRS, UPEC, IRD, INRAE, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210166444","https://openalex.org/I39804081","https://openalex.org/I197681013","https://openalex.org/I4210088668","https://openalex.org/I4210134846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003970120","display_name":"Ant\u00f3nio Gon\u00e7alves","orcid":"https://orcid.org/0000-0002-8759-2429"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Antonio Gon\u00e7alves","raw_affiliation_strings":["Universit\u00e9 de Paris, INSERM, IAME, Paris, France"],"raw_orcid":"https://orcid.org/0000-0002-8759-2429","affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Paris, INSERM, IAME, Paris, France","institution_ids":["https://openalex.org/I204730241","https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006474715","display_name":"Olivier Tenaillon","orcid":"https://orcid.org/0000-0002-3796-1601"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Olivier Tenaillon","raw_affiliation_strings":["Universit\u00e9 de Paris, INSERM, IAME, Paris, France"],"raw_orcid":"https://orcid.org/0000-0002-3796-1601","affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Paris, INSERM, IAME, Paris, France","institution_ids":["https://openalex.org/I204730241","https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058338534","display_name":"Alan S. Perelson","orcid":"https://orcid.org/0000-0002-2455-0002"},"institutions":[{"id":"https://openalex.org/I1343871089","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I4210120050"]},{"id":"https://openalex.org/I4210110743","display_name":"New Mexico Consortium","ror":"https://ror.org/01qnpp968","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210110743"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alan S. Perelson","raw_affiliation_strings":["New Mexico Consortium, Los Alamos, New Mexico, United States of America","Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-2455-0002","affiliations":[{"raw_affiliation_string":"New Mexico Consortium, Los Alamos, New Mexico, United States of America","institution_ids":["https://openalex.org/I4210110743"]},{"raw_affiliation_string":"Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America","institution_ids":["https://openalex.org/I1343871089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080451499","display_name":"J\u00e9r\u00e9mie Guedj","orcid":"https://orcid.org/0000-0002-5534-5482"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"J\u00e9r\u00e9mie Guedj","raw_affiliation_strings":["Universit\u00e9 de Paris, INSERM, IAME, Paris, France"],"raw_orcid":"https://orcid.org/0000-0002-5534-5482","affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Paris, INSERM, IAME, Paris, France","institution_ids":["https://openalex.org/I204730241","https://openalex.org/I154526488"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016854254","display_name":"Fran\u00e7ois Blanquart","orcid":"https://orcid.org/0000-0003-0591-2466"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I187986737","display_name":"Coll\u00e8ge de France","ror":"https://ror.org/04ex24z53","country_code":"FR","type":"education","lineage":["https://openalex.org/I187986737"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I4210113621","display_name":"Centre Interdisciplinaire de Recherche en Biologie","ror":"https://ror.org/01mvzn566","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I187986737","https://openalex.org/I4210096427","https://openalex.org/I4210113621"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Fran\u00e7ois Blanquart","raw_affiliation_strings":["Center for Interdisciplinary Research in Biology, CNRS, Coll\u00e8ge de France, PSL Research University, Paris, France","Universit\u00e9 de Paris, INSERM, IAME, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Interdisciplinary Research in Biology, CNRS, Coll\u00e8ge de France, PSL Research University, Paris, France","institution_ids":["https://openalex.org/I4210113621","https://openalex.org/I187986737","https://openalex.org/I2746051580","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Universit\u00e9 de Paris, INSERM, IAME, Paris, France","institution_ids":["https://openalex.org/I204730241","https://openalex.org/I154526488"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5003970120","https://openalex.org/A5006474715","https://openalex.org/A5016854254","https://openalex.org/A5026865511","https://openalex.org/A5040455184","https://openalex.org/A5058338534","https://openalex.org/A5080451499"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I1343871089","https://openalex.org/I154526488","https://openalex.org/I187986737","https://openalex.org/I197681013","https://openalex.org/I204730241","https://openalex.org/I2746051580","https://openalex.org/I39804081","https://openalex.org/I4210088668","https://openalex.org/I4210110743","https://openalex.org/I4210113621","https://openalex.org/I4210134846","https://openalex.org/I4210166444"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2088,"currency":"EUR","value_usd":2251},"fwci":3.7157,"has_fulltext":true,"cited_by_count":60,"citation_normalized_percentile":{"value":0.94620457,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"17","issue":"3","first_page":"e1008752","last_page":"e1008752"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10410","display_name":"COVID-19 epidemiological studies","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11581","display_name":"Viral Infections and Outbreaks Research","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/viral-load","display_name":"Viral load","score":0.6853646636009216},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.6229990720748901},{"id":"https://openalex.org/keywords/antiviral-drug","display_name":"Antiviral drug","score":0.6032913327217102},{"id":"https://openalex.org/keywords/viral-entry","display_name":"Viral entry","score":0.5956581830978394},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5384106636047363},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.5371369123458862},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.5180814266204834},{"id":"https://openalex.org/keywords/viral-shedding","display_name":"Viral shedding","score":0.4463226795196533},{"id":"https://openalex.org/keywords/viral-replication","display_name":"Viral replication","score":0.43398240208625793},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.4021632671356201},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.23648491501808167}],"concepts":[{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.6853646636009216},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6229990720748901},{"id":"https://openalex.org/C2779756493","wikidata":"https://www.wikidata.org/wiki/Q846227","display_name":"Antiviral drug","level":3,"score":0.6032913327217102},{"id":"https://openalex.org/C58475186","wikidata":"https://www.wikidata.org/wiki/Q4118894","display_name":"Viral entry","level":4,"score":0.5956581830978394},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5384106636047363},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5371369123458862},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5180814266204834},{"id":"https://openalex.org/C12914427","wikidata":"https://www.wikidata.org/wiki/Q7933612","display_name":"Viral shedding","level":3,"score":0.4463226795196533},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.43398240208625793},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4021632671356201},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.23648491501808167}],"mesh":[{"descriptor_ui":"D000076662","descriptor_name":"Host Microbial Interactions","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000076662","descriptor_name":"Host Microbial Interactions","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000076662","descriptor_name":"Host Microbial Interactions","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000076662","descriptor_name":"Host Microbial Interactions","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000076662","descriptor_name":"Host Microbial Interactions","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000076662","descriptor_name":"Host Microbial Interactions","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000076662","descriptor_name":"Host Microbial Interactions","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000076662","descriptor_name":"Host Microbial Interactions","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011322","descriptor_name":"Primary Prevention","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011322","descriptor_name":"Primary Prevention","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011322","descriptor_name":"Primary Prevention","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011322","descriptor_name":"Primary Prevention","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050936","descriptor_name":"Basic Reproduction Number","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D050936","descriptor_name":"Basic Reproduction Number","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D050936","descriptor_name":"Basic Reproduction Number","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D050936","descriptor_name":"Basic Reproduction Number","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D053586","descriptor_name":"Virus Internalization","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053586","descriptor_name":"Virus Internalization","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053586","descriptor_name":"Virus Internalization","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053586","descriptor_name":"Virus Internalization","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058873","descriptor_name":"Pandemics","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D058873","descriptor_name":"Pandemics","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D058873","descriptor_name":"Pandemics","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D058873","descriptor_name":"Pandemics","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1008752","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008752","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:33647008","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33647008","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:HAL:hal-03003001v3","is_oa":true,"landing_page_url":"https://hal.sorbonne-universite.fr/hal-03003001","pdf_url":"https://hal.sorbonne-universite.fr/hal-03003001v3/file/2020.05.07.20092965v3.full.pdf","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, 2021, 17 (3), pp.e1008752. ⟨10.1371/journal.pcbi.1008752⟩","raw_type":"Journal articles"},{"id":"pmh:oai:osti.gov:1774443","is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1774443","pdf_url":"https://www.osti.gov/servlets/purl/1774443","source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:HAL:hal-03450491v1","is_oa":false,"landing_page_url":"https://hal.inria.fr/hal-03450491","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1553-734X","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:50b40dd9227d45e4be233cd55c023ced","is_oa":true,"landing_page_url":"https://doaj.org/article/50b40dd9227d45e4be233cd55c023ced","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 17, Iss 3, p e1008752 (2021)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7951973","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7951973","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1008752","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008752","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7900000214576721,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G1662563830","display_name":null,"funder_award_id":"ANR-19-CE45-0009-01","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G1734005478","display_name":null,"funder_award_id":"INV- 017335","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"},{"id":"https://openalex.org/G1786618987","display_name":null,"funder_award_id":"ANR-20-COVI-0018","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G1957117371","display_name":null,"funder_award_id":"R01-AI028433","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2356915424","display_name":null,"funder_award_id":"89233218CNA000001","funder_id":"https://openalex.org/F4320337547","funder_display_name":"Laboratory Directed Research and Development"},{"id":"https://openalex.org/G3045303810","display_name":null,"funder_award_id":"844369","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4081147937","display_name":null,"funder_award_id":"R01-OD011095","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4654568811","display_name":null,"funder_award_id":"EQU201903007848","funder_id":"https://openalex.org/F4320321589","funder_display_name":"Fondation pour la Recherche M\u00e9dicale"},{"id":"https://openalex.org/G5842988033","display_name":null,"funder_award_id":"AI028433","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6865977216","display_name":null,"funder_award_id":"844369","funder_id":"https://openalex.org/F4320335254","funder_display_name":"Horizon 2020"},{"id":"https://openalex.org/G6995210142","display_name":null,"funder_award_id":"89233218CNA000001","funder_id":"https://openalex.org/F4320332369","funder_display_name":"National Nuclear Security Administration"},{"id":"https://openalex.org/G722289831","display_name":null,"funder_award_id":"R01-OD011095 and R01-AI028433","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7380237517","display_name":null,"funder_award_id":"Contract 89233218CNA000001","funder_id":"https://openalex.org/F4320338304","funder_display_name":"Los Alamos National Laboratory"},{"id":"https://openalex.org/G7500863821","display_name":null,"funder_award_id":"89233218CNA000001","funder_id":"https://openalex.org/F4320338304","funder_display_name":"Los Alamos National Laboratory"},{"id":"https://openalex.org/G7863193404","display_name":null,"funder_award_id":"INV-017335","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"},{"id":"https://openalex.org/G7878808677","display_name":"Theoretical Exploration of the Feasibility, Challenges and Risks of Synthetic Gene Drives","funder_award_id":"ANR-19-CE45-0009","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G8318455765","display_name":null,"funder_award_id":"ANR-19","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G8659807574","display_name":null,"funder_award_id":"89233218CNA000001","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G8920840650","display_name":null,"funder_award_id":"OD011095","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320306137","display_name":"Bill and Melinda Gates Foundation","ror":"https://ror.org/0456r8d26"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320321589","display_name":"Fondation pour la Recherche M\u00e9dicale","ror":"https://ror.org/04w6kn183"},{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"},{"id":"https://openalex.org/F4320323910","display_name":"Institut National de la Recherche Agronomique","ror":"https://ror.org/01x3gbx83"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332369","display_name":"National Nuclear Security Administration","ror":"https://ror.org/03sk1we31"},{"id":"https://openalex.org/F4320335254","display_name":"Horizon 2020","ror":null},{"id":"https://openalex.org/F4320337547","display_name":"Laboratory Directed Research and Development","ror":"https://ror.org/01e41cf67"},{"id":"https://openalex.org/F4320338304","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":83,"referenced_works":["https://openalex.org/W1496703419","https://openalex.org/W1513148753","https://openalex.org/W1971214320","https://openalex.org/W1999514402","https://openalex.org/W2007537183","https://openalex.org/W2014184548","https://openalex.org/W2014691101","https://openalex.org/W2018340707","https://openalex.org/W2040462912","https://openalex.org/W2092973631","https://openalex.org/W2103562758","https://openalex.org/W2109977701","https://openalex.org/W2117057469","https://openalex.org/W2124252812","https://openalex.org/W2159481668","https://openalex.org/W2911976827","https://openalex.org/W2972562701","https://openalex.org/W3001897055","https://openalex.org/W3003668884","https://openalex.org/W3004894342","https://openalex.org/W3005118804","https://openalex.org/W3006954854","https://openalex.org/W3008047170","https://openalex.org/W3008443627","https://openalex.org/W3008452791","https://openalex.org/W3009410758","https://openalex.org/W3010131837","https://openalex.org/W3010338568","https://openalex.org/W3010383561","https://openalex.org/W3011534780","https://openalex.org/W3012756997","https://openalex.org/W3012868172","https://openalex.org/W3013186573","https://openalex.org/W3013215798","https://openalex.org/W3013525829","https://openalex.org/W3013562179","https://openalex.org/W3013649871","https://openalex.org/W3013893137","https://openalex.org/W3013967887","https://openalex.org/W3014271510","https://openalex.org/W3014481693","https://openalex.org/W3014708904","https://openalex.org/W3015571324","https://openalex.org/W3015848059","https://openalex.org/W3016746341","https://openalex.org/W3019620648","https://openalex.org/W3020184843","https://openalex.org/W3021969659","https://openalex.org/W3022285953","https://openalex.org/W3023441241","https://openalex.org/W3025090814","https://openalex.org/W3025271273","https://openalex.org/W3026480087","https://openalex.org/W3027630905","https://openalex.org/W3029754491","https://openalex.org/W3035125447","https://openalex.org/W3035973582","https://openalex.org/W3042116711","https://openalex.org/W3045220852","https://openalex.org/W3045997785","https://openalex.org/W3046896341","https://openalex.org/W3048334038","https://openalex.org/W3087726397","https://openalex.org/W3089187216","https://openalex.org/W3091654554","https://openalex.org/W3092503590","https://openalex.org/W3092982314","https://openalex.org/W3093988179","https://openalex.org/W3094302944","https://openalex.org/W3096658347","https://openalex.org/W3108686166","https://openalex.org/W3110466220","https://openalex.org/W3112361162","https://openalex.org/W3117526331","https://openalex.org/W3128448500","https://openalex.org/W3195610020","https://openalex.org/W3215821473","https://openalex.org/W4210984395","https://openalex.org/W4246112579","https://openalex.org/W6773811151","https://openalex.org/W6774360382","https://openalex.org/W6775140953","https://openalex.org/W6776190247"],"related_works":["https://openalex.org/W2587999459","https://openalex.org/W3045863127","https://openalex.org/W2416583051","https://openalex.org/W4386554239","https://openalex.org/W3090012918","https://openalex.org/W2102326449","https://openalex.org/W4281492369","https://openalex.org/W3207308314","https://openalex.org/W2032099305","https://openalex.org/W2738322136"],"abstract_inverted_index":{"Repurposed":[0],"drugs":[1,25,84,137,188,219],"that":[2,62,68,138,166],"are":[3,26],"safe":[4],"and":[5,102,240],"immediately":[6],"available":[7],"constitute":[8],"a":[9,38,65,69,81,95,103,196],"first":[10],"line":[11],"of":[12,41,49,83,94,114,133,150,158,189,213,228],"defense":[13],"against":[14,22],"new":[15],"viral":[16,58,77,98,106,122,128,140,171,180,197,208,214,221,234],"infections.":[17],"Despite":[18],"limited":[19],"antiviral":[20,244],"activity":[21],"SARS-CoV-2,":[23],"several":[24],"being":[27],"tested":[28],"as":[29,32,167,169],"medication":[30],"or":[31,126,256],"prophylaxis":[33],"to":[34,56,75,206,254],"prevent":[35,57,255],"infection.":[36,59,160],"Using":[37],"stochastic":[39],"model":[40],"early":[42],"phase":[43],"infection,":[44],"we":[45,164],"evaluate":[46],"the":[47,86,92,109,112,131,147,153,170,204,232],"success":[48],"prophylactic":[50],"treatment":[51,70],"with":[52,187,247],"different":[53],"drug":[54,96,104],"types":[55],"We":[60],"find":[61,165],"there":[63],"exists":[64],"critical":[66,87,110],"efficacy":[67,191],"must":[71],"reach":[72],"in":[73,142,223,259],"order":[74],"block":[76],"establishment.":[78],"Treatment":[79],"by":[80,91,218],"combination":[82,93],"reduces":[85],"efficacy,":[88,111,249],"most":[89],"effectively":[90],"blocking":[97,121],"entry":[99,123],"into":[100,124],"cells":[101,125],"increasing":[105],"clearance.":[107],"Below":[108],"risk":[113,132],"infection":[115,134,181,198,215,230,258],"can":[116,182],"nonetheless":[117],"be":[118,183,200,251],"reduced.":[119],"Drugs":[120],"enhancing":[127],"clearance":[129],"reduce":[130,139],"more":[135],"than":[136,175],"production":[141,222],"infected":[143,224],"cells.":[144,225],"The":[145,210],"larger":[146],"initial":[148],"inoculum":[149,172],"infectious":[151,177],"virus,":[152],"less":[154],"likely":[155],"is":[156,173,216],"prevention":[157],"an":[159],"In":[161],"our":[162],"model,":[163],"long":[168],"smaller":[174],"10":[176],"virus":[178,229],"particles,":[179],"prevented":[184],"almost":[185],"certainly":[186],"90%":[190],"(or":[192],"more).":[193],"Even":[194],"when":[195],"cannot":[199],"prevented,":[201],"antivirals":[202],"delay":[203,212,227],"time":[205],"detectable":[207],"loads.":[209],"largest":[211],"achieved":[217],"reducing":[220,238],"A":[226],"flattens":[231],"within-host":[233],"dynamic":[235],"curve,":[236],"possibly":[237],"transmission":[239],"symptom":[241],"severity.":[242],"Thus,":[243],"prophylaxis,":[245],"even":[246],"reduced":[248],"could":[250],"efficiently":[252],"used":[253],"alleviate":[257],"people":[260],"at":[261],"high":[262],"risk.":[263]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":2}],"updated_date":"2026-06-03T09:05:47.796612","created_date":"2025-10-10T00:00:00"}