{"id":"https://openalex.org/W3129927356","doi":"https://doi.org/10.1371/journal.pcbi.1008729","title":"An antigenic diversification threshold for falciparum malaria transmission at high endemicity","display_name":"An antigenic diversification threshold for falciparum malaria transmission at high endemicity","publication_year":2021,"publication_date":"2021-02-19","ids":{"openalex":"https://openalex.org/W3129927356","doi":"https://doi.org/10.1371/journal.pcbi.1008729","mag":"3129927356","pmid":"https://pubmed.ncbi.nlm.nih.gov/33606682"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1008729","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008729","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008729&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008729&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028427304","display_name":"Qixin He","orcid":"https://orcid.org/0000-0003-1696-8203"},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qixin He","raw_affiliation_strings":["Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-1696-8203","affiliations":[{"raw_affiliation_string":"Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059708665","display_name":"Mercedes Pascual","orcid":"https://orcid.org/0000-0003-3575-7233"},"institutions":[{"id":"https://openalex.org/I1308548392","display_name":"Santa Fe Institute","ror":"https://ror.org/01arysc35","country_code":"US","type":"funder","lineage":["https://openalex.org/I1308548392"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mercedes Pascual","raw_affiliation_strings":["Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, United States of America","Santa Fe Institute, Santa Fe, New Mexico, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-3575-7233","affiliations":[{"raw_affiliation_string":"Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Santa Fe Institute, Santa Fe, New Mexico, United States of America","institution_ids":["https://openalex.org/I1308548392"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5059708665"],"corresponding_institution_ids":["https://openalex.org/I1308548392","https://openalex.org/I40347166"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.7768,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.84231123,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"17","issue":"2","first_page":"e1008729","last_page":"e1008729"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9957000017166138,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/malaria","display_name":"Malaria","score":0.8184044361114502},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6769219636917114},{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.6054546236991882},{"id":"https://openalex.org/keywords/antigenic-variation","display_name":"Antigenic variation","score":0.5831268429756165},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.5619581937789917},{"id":"https://openalex.org/keywords/diversification","display_name":"Diversification (marketing strategy)","score":0.5552416443824768},{"id":"https://openalex.org/keywords/transmission","display_name":"Transmission (telecommunications)","score":0.5534855127334595},{"id":"https://openalex.org/keywords/antigen","display_name":"Antigen","score":0.47432443499565125},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4310915470123291},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.3866700530052185},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.3767881691455841},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.1384316384792328}],"concepts":[{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.8184044361114502},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6769219636917114},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.6054546236991882},{"id":"https://openalex.org/C191942190","wikidata":"https://www.wikidata.org/wiki/Q4774739","display_name":"Antigenic variation","level":3,"score":0.5831268429756165},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.5619581937789917},{"id":"https://openalex.org/C180916674","wikidata":"https://www.wikidata.org/wiki/Q3711935","display_name":"Diversification (marketing strategy)","level":2,"score":0.5552416443824768},{"id":"https://openalex.org/C761482","wikidata":"https://www.wikidata.org/wiki/Q118093","display_name":"Transmission (telecommunications)","level":2,"score":0.5534855127334595},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.47432443499565125},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4310915470123291},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3866700530052185},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3767881691455841},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1384316384792328},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.0},{"id":"https://openalex.org/C162853370","wikidata":"https://www.wikidata.org/wiki/Q39809","display_name":"Marketing","level":1,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000940","descriptor_name":"Antigenic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000940","descriptor_name":"Antigenic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000940","descriptor_name":"Antigenic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006790","descriptor_name":"Host-Parasite Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006790","descriptor_name":"Host-Parasite Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006790","descriptor_name":"Host-Parasite Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":false},{"descriptor_ui":"D050936","descriptor_name":"Basic Reproduction Number","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050936","descriptor_name":"Basic Reproduction Number","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050936","descriptor_name":"Basic Reproduction Number","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1008729","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008729","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008729&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:33606682","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33606682","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:uchicago.tind.io:5970","is_oa":true,"landing_page_url":"http://knowledge.uchicago.edu/record/5970","pdf_url":null,"source":{"id":"https://openalex.org/S4306402460","display_name":"Knowledge@UChicago (University of Chicago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I40347166","host_organization_name":"University of Chicago","host_organization_lineage":["https://openalex.org/I40347166"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://knowledge.uchicago.edu/record/5970","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:de78d700c2bc4a6f8210f2ebd57412f8","is_oa":true,"landing_page_url":"https://doaj.org/article/de78d700c2bc4a6f8210f2ebd57412f8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 17, Iss 2, p e1008729 (2021)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7928509","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7928509","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1008729","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008729","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008729&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G7319059398","display_name":null,"funder_award_id":"R01 AI149779","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306183","display_name":"James S. McDonnell Foundation","ror":"https://ror.org/03dy4aq19"},{"id":"https://openalex.org/F4320309626","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28"},{"id":"https://openalex.org/F4320312777","display_name":"Santa Fe Institute","ror":"https://ror.org/01arysc35"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332299","display_name":"National Institute of Food and Agriculture","ror":"https://ror.org/05qx3fv49"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3129927356.pdf","grobid_xml":"https://content.openalex.org/works/W3129927356.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W304566375","https://openalex.org/W1781976779","https://openalex.org/W1964020301","https://openalex.org/W1968841173","https://openalex.org/W1978531815","https://openalex.org/W1981873171","https://openalex.org/W1983226220","https://openalex.org/W1989788976","https://openalex.org/W1993441829","https://openalex.org/W1996974432","https://openalex.org/W2001488223","https://openalex.org/W2014094060","https://openalex.org/W2016808064","https://openalex.org/W2026708814","https://openalex.org/W2029582065","https://openalex.org/W2034578716","https://openalex.org/W2042321087","https://openalex.org/W2049038152","https://openalex.org/W2052523483","https://openalex.org/W2062677544","https://openalex.org/W2064372870","https://openalex.org/W2073725159","https://openalex.org/W2075935548","https://openalex.org/W2078734278","https://openalex.org/W2081531014","https://openalex.org/W2118055782","https://openalex.org/W2118944684","https://openalex.org/W2125780462","https://openalex.org/W2135497680","https://openalex.org/W2148475424","https://openalex.org/W2153212297","https://openalex.org/W2162975275","https://openalex.org/W2165158644","https://openalex.org/W2171201196","https://openalex.org/W2205470162","https://openalex.org/W2289660161","https://openalex.org/W2336475824","https://openalex.org/W2342129779","https://openalex.org/W2577818097","https://openalex.org/W2581071829","https://openalex.org/W2611961786","https://openalex.org/W2616923088","https://openalex.org/W2753216119","https://openalex.org/W2753961871","https://openalex.org/W2801701694","https://openalex.org/W2890016357","https://openalex.org/W2902011845","https://openalex.org/W2949790187","https://openalex.org/W2950972892","https://openalex.org/W2951429011","https://openalex.org/W2962225605","https://openalex.org/W4230979337"],"related_works":["https://openalex.org/W2115261803","https://openalex.org/W4367362025","https://openalex.org/W2108574175","https://openalex.org/W2347627655","https://openalex.org/W2094649888","https://openalex.org/W1972675143","https://openalex.org/W2374601323","https://openalex.org/W1989788976","https://openalex.org/W2041444448","https://openalex.org/W2156165519"],"abstract_inverted_index":{"In":[0],"malaria":[1,22,138,202],"and":[2,59,127,164,189,204],"several":[3],"other":[4,209],"important":[5],"infectious":[6,177],"diseases,":[7,178],"high":[8],"prevalence":[9],"occurs":[10,99],"concomitantly":[11],"with":[12,211],"incomplete":[13],"immunity.":[14],"This":[15,46,150,193],"apparent":[16],"paradox":[17],"poses":[18],"major":[19,143],"challenges":[20],"to":[21,129,153,208],"elimination":[23],"in":[24,49,72,81],"highly":[25],"endemic":[26],"regions,":[27],"where":[28],"asymptomatic":[29],"Plasmodium":[30],"falciparum":[31],"infections":[32],"are":[33],"present":[34,65],"across":[35],"all":[36],"age":[37],"classes":[38],"creating":[39],"a":[40,70,78,133],"large":[41,188,212],"reservoir":[42,47],"that":[43,76,115,140],"maintains":[44],"transmission.":[45],"is":[48,125,161,184],"turn":[50],"enabled":[51],"by":[52,90,170],"extreme":[53],"antigenic":[54,214],"diversity":[55,104],"of":[56,61,69,105,137,176],"the":[57,67,142,167,171],"parasite":[58],"turnover":[60],"new":[62,86,194],"variants.":[63],"We":[64],"here":[66],"concept":[68,196],"threshold":[71,124,151,195],"local":[73],"pathogen":[74],"diversification":[75],"defines":[77],"sharp":[79],"transition":[80],"transmission":[82,139],"intensity":[83],"below":[84,100],"which":[85,180],"antigen-encoding":[87,144],"genes":[88,107],"generated":[89],"either":[91],"recombination":[92],"or":[93],"migration":[94],"cannot":[95],"establish.":[96],"Transmission":[97],"still":[98],"this":[101,123],"threshold,":[102],"but":[103],"these":[106],"can":[108,197],"neither":[109],"accumulate":[110],"nor":[111],"recover":[112],"from":[113,132],"interventions":[114],"further":[116],"reduce":[117],"it.":[118],"An":[119],"analytical":[120],"expectation":[121],"for":[122,200],"derived":[126],"compared":[128],"numerical":[130],"results":[131],"stochastic":[134],"individual-based":[135],"model":[136],"incorporates":[141],"multigene":[145],"family":[146],"known":[147],"as":[148],"var.":[149],"corresponds":[152],"an":[154],"\"innovation\"":[155],"number":[156,175],"we":[157],"call":[158],"Rdiv;":[159],"it":[160],"different":[162],"from,":[163],"complementary":[165],"to,":[166],"one":[168],"defined":[169],"classic":[172],"basic":[173],"reproductive":[174],"R0,":[179],"does":[181],"not":[182],"readily":[183],"better":[185],"apply":[186],"under":[187],"dynamic":[190],"strain":[191],"diversity.":[192,215],"be":[198],"exploited":[199],"effective":[201],"control":[203],"applied":[205],"more":[206],"broadly":[207],"pathogens":[210],"multilocus":[213]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
