{"id":"https://openalex.org/W3134799433","doi":"https://doi.org/10.1371/journal.pcbi.1008704","title":"A kinetic model of the central carbon metabolism for acrylic acid production in Escherichia coli","display_name":"A kinetic model of the central carbon metabolism for acrylic acid production in Escherichia coli","publication_year":2021,"publication_date":"2021-03-08","ids":{"openalex":"https://openalex.org/W3134799433","doi":"https://doi.org/10.1371/journal.pcbi.1008704","mag":"3134799433","pmid":"https://pubmed.ncbi.nlm.nih.gov/33684125"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1008704","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008704","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1008704","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039886913","display_name":"Alexandre Oliveira","orcid":"https://orcid.org/0000-0002-2255-8983"},"institutions":[{"id":"https://openalex.org/I99682543","display_name":"University of Minho","ror":"https://ror.org/037wpkx04","country_code":"PT","type":"education","lineage":["https://openalex.org/I99682543"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Alexandre Oliveira","raw_affiliation_strings":["Centre of Biological Engineering, University of Minho, Braga, Portugal"],"raw_orcid":"https://orcid.org/0000-0002-2255-8983","affiliations":[{"raw_affiliation_string":"Centre of Biological Engineering, University of Minho, Braga, Portugal","institution_ids":["https://openalex.org/I99682543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010103352","display_name":"Joana L. Rodrigues","orcid":"https://orcid.org/0000-0002-3217-2320"},"institutions":[{"id":"https://openalex.org/I99682543","display_name":"University of Minho","ror":"https://ror.org/037wpkx04","country_code":"PT","type":"education","lineage":["https://openalex.org/I99682543"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Joana Rodrigues","raw_affiliation_strings":["Centre of Biological Engineering, University of Minho, Braga, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre of Biological Engineering, University of Minho, Braga, Portugal","institution_ids":["https://openalex.org/I99682543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064824604","display_name":"Eug\u00e9nio C. Ferreira","orcid":"https://orcid.org/0000-0002-5400-3333"},"institutions":[{"id":"https://openalex.org/I99682543","display_name":"University of Minho","ror":"https://ror.org/037wpkx04","country_code":"PT","type":"education","lineage":["https://openalex.org/I99682543"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Eug\u00e9nio Campos Ferreira","raw_affiliation_strings":["Centre of Biological Engineering, University of Minho, Braga, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre of Biological Engineering, University of Minho, Braga, Portugal","institution_ids":["https://openalex.org/I99682543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021667092","display_name":"L. R. Rodrigues","orcid":"https://orcid.org/0000-0001-9265-0630"},"institutions":[{"id":"https://openalex.org/I99682543","display_name":"University of Minho","ror":"https://ror.org/037wpkx04","country_code":"PT","type":"education","lineage":["https://openalex.org/I99682543"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"L\u00edgia Rodrigues","raw_affiliation_strings":["Centre of Biological Engineering, University of Minho, Braga, Portugal"],"raw_orcid":"https://orcid.org/0000-0001-9265-0630","affiliations":[{"raw_affiliation_string":"Centre of Biological Engineering, University of Minho, Braga, Portugal","institution_ids":["https://openalex.org/I99682543"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044535959","display_name":"\u00d3scar Dias","orcid":"https://orcid.org/0000-0002-1765-7178"},"institutions":[{"id":"https://openalex.org/I99682543","display_name":"University of Minho","ror":"https://ror.org/037wpkx04","country_code":"PT","type":"education","lineage":["https://openalex.org/I99682543"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Oscar Dias","raw_affiliation_strings":["Centre of Biological Engineering, University of Minho, Braga, Portugal"],"raw_orcid":"https://orcid.org/0000-0002-1765-7178","affiliations":[{"raw_affiliation_string":"Centre of Biological Engineering, University of Minho, Braga, Portugal","institution_ids":["https://openalex.org/I99682543"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5044535959"],"corresponding_institution_ids":["https://openalex.org/I99682543"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.3028,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.79513173,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"17","issue":"3","first_page":"e1008704","last_page":"e1008704"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10171","display_name":"Biofuel production and bioconversion","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glycerol","display_name":"Glycerol","score":0.7078074216842651},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.5696148872375488},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5667722225189209},{"id":"https://openalex.org/keywords/metabolic-engineering","display_name":"Metabolic engineering","score":0.5356990694999695},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.48204049468040466},{"id":"https://openalex.org/keywords/metabolic-pathway","display_name":"Metabolic pathway","score":0.47983619570732117},{"id":"https://openalex.org/keywords/alanine","display_name":"Alanine","score":0.42320960760116577},{"id":"https://openalex.org/keywords/pyruvate-carboxylase","display_name":"Pyruvate carboxylase","score":0.4136319160461426},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.39273956418037415},{"id":"https://openalex.org/keywords/amino-acid","display_name":"Amino acid","score":0.15810680389404297}],"concepts":[{"id":"https://openalex.org/C2780881558","wikidata":"https://www.wikidata.org/wiki/Q132501","display_name":"Glycerol","level":2,"score":0.7078074216842651},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5696148872375488},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5667722225189209},{"id":"https://openalex.org/C6350086","wikidata":"https://www.wikidata.org/wiki/Q6822347","display_name":"Metabolic engineering","level":3,"score":0.5356990694999695},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.48204049468040466},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.47983619570732117},{"id":"https://openalex.org/C2779856020","wikidata":"https://www.wikidata.org/wiki/Q218642","display_name":"Alanine","level":3,"score":0.42320960760116577},{"id":"https://openalex.org/C140137476","wikidata":"https://www.wikidata.org/wiki/Q21114968","display_name":"Pyruvate carboxylase","level":3,"score":0.4136319160461426},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.39273956418037415},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.15810680389404297},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000179","descriptor_name":"Acrylates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000179","descriptor_name":"Acrylates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000179","descriptor_name":"Acrylates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000179","descriptor_name":"Acrylates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002244","descriptor_name":"Carbon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002244","descriptor_name":"Carbon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002244","descriptor_name":"Carbon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002244","descriptor_name":"Carbon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005990","descriptor_name":"Glycerol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005990","descriptor_name":"Glycerol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005990","descriptor_name":"Glycerol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005990","descriptor_name":"Glycerol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053898","descriptor_name":"Biosynthetic Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053898","descriptor_name":"Biosynthetic Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053898","descriptor_name":"Biosynthetic Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053898","descriptor_name":"Biosynthetic Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060847","descriptor_name":"Metabolic Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060847","descriptor_name":"Metabolic Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060847","descriptor_name":"Metabolic Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060847","descriptor_name":"Metabolic Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":10,"locations":[{"id":"doi:10.1371/journal.pcbi.1008704","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008704","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:33684125","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33684125","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:repositorium.uminho.pt:1822/71048","is_oa":true,"landing_page_url":"https://hdl.handle.net/1822/71048","pdf_url":null,"source":null,"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:RePEc:plo:pcbi00:1008704","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008704","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:e2c1a45466a1492392a06db627570a9b","is_oa":true,"landing_page_url":"https://doaj.org/article/e2c1a45466a1492392a06db627570a9b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 17, Iss 3, p e1008704 (2021)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7971886","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7971886","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:repositorium.sdum.uminho.pt:1822/61767","is_oa":true,"landing_page_url":"http://hdl.handle.net/1822/61767","pdf_url":null,"source":{"id":"https://openalex.org/S4306401240","display_name":"Reposit\u00f3riUM (Universidade do Minho)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I99682543","host_organization_name":"University of Minho","host_organization_lineage":["https://openalex.org/I99682543"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"conference poster"},{"id":"pmh:oai:repositorium.sdum.uminho.pt:1822/71048","is_oa":true,"landing_page_url":"http://hdl.handle.net/1822/71048","pdf_url":null,"source":{"id":"https://openalex.org/S4306400354","display_name":"Reposit\u00f3riUM (Universidade do Minho)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I99682543","host_organization_name":"University of Minho","host_organization_lineage":["https://openalex.org/I99682543"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},{"id":"pmh:oai:repositorium.sdum.uminho.pt:1822/79954","is_oa":true,"landing_page_url":"https://hdl.handle.net/1822/79954","pdf_url":null,"source":{"id":"https://openalex.org/S4306400354","display_name":"Reposit\u00f3riUM (Universidade do Minho)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I99682543","host_organization_name":"University of Minho","host_organization_lineage":["https://openalex.org/I99682543"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"master thesis"},{"id":"pmh:oai:repositorium.uminho.pt:1822/61767","is_oa":true,"landing_page_url":"https://hdl.handle.net/1822/61767","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"conference poster"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1008704","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008704","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6100000143051147,"display_name":"Industry, innovation and infrastructure","id":"https://metadata.un.org/sdg/9"}],"awards":[{"id":"https://openalex.org/G1203399442","display_name":"Centre of Biological Engineering of the University of Minho","funder_award_id":"UIDB/04469/2020","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G323769159","display_name":null,"funder_award_id":"PORTUGAL 2020","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G4403996651","display_name":null,"funder_award_id":"UIDB/04469/2020 unit","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G4850785371","display_name":null,"funder_award_id":"UIDB/04469/2020","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G6565430356","display_name":null,"funder_award_id":"UIDB/04469","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G7965203573","display_name":null,"funder_award_id":"01/SAICT/2016","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G7991599336","display_name":null,"funder_award_id":"01/SAICT/2016","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G8692966195","display_name":null,"funder_award_id":"22231/01/SAICT/2016","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"}],"funders":[{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W1152376270","https://openalex.org/W1480981925","https://openalex.org/W1486713232","https://openalex.org/W1506485944","https://openalex.org/W1517629656","https://openalex.org/W1543463078","https://openalex.org/W1557897326","https://openalex.org/W1562138142","https://openalex.org/W1584147780","https://openalex.org/W1604652729","https://openalex.org/W1605797683","https://openalex.org/W1607389303","https://openalex.org/W1803536756","https://openalex.org/W1822055815","https://openalex.org/W1950184471","https://openalex.org/W1969883879","https://openalex.org/W1972354492","https://openalex.org/W1976582766","https://openalex.org/W1985957672","https://openalex.org/W1991351347","https://openalex.org/W1993758378","https://openalex.org/W1998321859","https://openalex.org/W2000906001","https://openalex.org/W2013615057","https://openalex.org/W2025105469","https://openalex.org/W2032611046","https://openalex.org/W2034621068","https://openalex.org/W2041568433","https://openalex.org/W2047538168","https://openalex.org/W2047842052","https://openalex.org/W2050098324","https://openalex.org/W2053339983","https://openalex.org/W2053581347","https://openalex.org/W2074058008","https://openalex.org/W2076262841","https://openalex.org/W2084892458","https://openalex.org/W2094276685","https://openalex.org/W2102653059","https://openalex.org/W2109887423","https://openalex.org/W2111383241","https://openalex.org/W2115982735","https://openalex.org/W2116976883","https://openalex.org/W2131291038","https://openalex.org/W2140949609","https://openalex.org/W2140993741","https://openalex.org/W2145456961","https://openalex.org/W2156407455","https://openalex.org/W2156903017","https://openalex.org/W2219433241","https://openalex.org/W2236773221","https://openalex.org/W2291481849","https://openalex.org/W2296520771","https://openalex.org/W2304068652","https://openalex.org/W2528667662","https://openalex.org/W2574514708","https://openalex.org/W2586192494","https://openalex.org/W2764202526","https://openalex.org/W2766958291","https://openalex.org/W2767088268","https://openalex.org/W2767901981","https://openalex.org/W2897805491","https://openalex.org/W2899903294","https://openalex.org/W2914029604","https://openalex.org/W3014526382","https://openalex.org/W6983824593"],"related_works":["https://openalex.org/W2117907462","https://openalex.org/W2161076420","https://openalex.org/W385704401","https://openalex.org/W1990088060","https://openalex.org/W2352726313","https://openalex.org/W3043436041","https://openalex.org/W2947043338","https://openalex.org/W3197240279","https://openalex.org/W2146372898","https://openalex.org/W2969524935"],"abstract_inverted_index":{"Acrylic":[0],"acid":[1],"is":[2,25],"a":[3,27,87,139],"value-added":[4],"chemical":[5],"used":[6],"in":[7,43,131,142,175],"industry":[8],"to":[9,20,34,49,75,79,102,110,152],"produce":[10],"diapers,":[11],"coatings,":[12],"paints,":[13],"and":[14,31,66,98,135,145,167],"adhesives,":[15],"among":[16],"many":[17],"others.":[18],"Due":[19],"its":[21],"economic":[22],"importance,":[23],"there":[24],"currently":[26],"need":[28],"for":[29,90],"new":[30],"sustainable":[32],"ways":[33],"synthesise":[35],"it.":[36],"Recently,":[37],"the":[38,44,51,69,83,104,111,114,122,132,143],"focus":[39],"has":[40,86],"been":[41],"laid":[42],"use":[45,76],"of":[46,71,82,124],"Escherichia":[47],"coli":[48],"express":[50],"full":[52],"bio-based":[53],"pathway":[54],"using":[55,126,136],"3-hydroxypropionate":[56],"as":[57,128,138],"an":[58],"intermediary":[59],"through":[60],"three":[61,84],"distinct":[62],"pathways":[63,85,106],"(glycerol,":[64],"malonyl-CoA,":[65],"\u03b2-alanine).":[67],"Hence,":[68],"goals":[70],"this":[72,118,149],"work":[73,119,150],"were":[74],"COPASI":[77],"software":[78],"assess":[80],"which":[81],"higher":[88,176],"potential":[89,100,155],"industrial-scale":[91],"production,":[92],"from":[93],"either":[94],"glucose":[95,137],"or":[96],"glycerol,":[97],"identify":[99,153],"targets":[101,157],"improve":[103],"biosynthetic":[105],"yields.":[107,178],"When":[108],"compared":[109],"available":[112],"literature,":[113],"models":[115],"developed":[116],"during":[117],"successfully":[120],"predict":[121],"production":[123],"3-hydroxypropionate,":[125],"glycerol":[127,133],"carbon":[129,140],"source":[130,141],"pathway,":[134],"malonyl-CoA":[144],"\u03b2-alanine":[146],"pathways.":[147],"Finally,":[148],"allowed":[151],"four":[154],"over-expression":[156],"(glycerol-3-phosphate":[158],"dehydrogenase":[159],"(G3pD),":[160],"acetyl-CoA":[161],"carboxylase":[162,169],"(AccC),":[163],"aspartate":[164,168],"aminotransferase":[165],"(AspAT),":[166],"(AspC))":[170],"that":[171],"should,":[172],"theoretically,":[173],"result":[174],"AA":[177]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2}],"updated_date":"2026-05-18T08:16:58.900851","created_date":"2025-10-10T00:00:00"}
