{"id":"https://openalex.org/W3147279858","doi":"https://doi.org/10.1371/journal.pcbi.1008690","title":"Mathematical modeling of the Candida albicans yeast to hyphal transition reveals novel control strategies","display_name":"Mathematical modeling of the Candida albicans yeast to hyphal transition reveals novel control strategies","publication_year":2021,"publication_date":"2021-03-29","ids":{"openalex":"https://openalex.org/W3147279858","doi":"https://doi.org/10.1371/journal.pcbi.1008690","mag":"3147279858","pmid":"https://pubmed.ncbi.nlm.nih.gov/33780439"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1008690","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008690","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008690&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008690&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012317174","display_name":"David J. Wooten","orcid":"https://orcid.org/0000-0002-0067-123X"},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David J. Wooten","raw_affiliation_strings":["Department of Physics, Pennsylvania State University, University Park, Pennsylvania, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-0067-123X","affiliations":[{"raw_affiliation_string":"Department of Physics, Pennsylvania State University, University Park, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042886213","display_name":"Jorge G\u00f3mez Tejeda Za\u00f1udo","orcid":"https://orcid.org/0000-0002-1092-0068"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jorge G\u00f3mez Tejeda Za\u00f1udo","raw_affiliation_strings":["Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America","Eli and Edythe L. Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-1092-0068","affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Eli and Edythe L. Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028197670","display_name":"David Murrugarra","orcid":"https://orcid.org/0000-0001-9710-5025"},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Murrugarra","raw_affiliation_strings":["Department of Mathematics, University of Kentucky, Lexington, Kentucky, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-9710-5025","affiliations":[{"raw_affiliation_string":"Department of Mathematics, University of Kentucky, Lexington, Kentucky, United States of America","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066485567","display_name":"Austin M. Perry","orcid":"https://orcid.org/0000-0002-0847-787X"},"institutions":[{"id":"https://openalex.org/I156087764","display_name":"University of California, Merced","ror":"https://ror.org/00d9ah105","country_code":"US","type":"education","lineage":["https://openalex.org/I156087764"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Austin M. Perry","raw_affiliation_strings":["Department of Molecular and Cell Biology, School of Natural Sciences, University of California Merced, Merced, California, United States of America","Quantitative and Systems Biology Graduate Program, University of California Merced, Merced, California, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-0847-787X","affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology, School of Natural Sciences, University of California Merced, Merced, California, United States of America","institution_ids":["https://openalex.org/I156087764"]},{"raw_affiliation_string":"Quantitative and Systems Biology Graduate Program, University of California Merced, Merced, California, United States of America","institution_ids":["https://openalex.org/I156087764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017105081","display_name":"Anna Dongari\u2010Bagtzoglou","orcid":null},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Dongari-Bagtzoglou","raw_affiliation_strings":["Department of Oral Health and Diagnostic Sciences, University of Connecticut Health Center, Farmington, Connecticut, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-7615-1417","affiliations":[{"raw_affiliation_string":"Department of Oral Health and Diagnostic Sciences, University of Connecticut Health Center, Farmington, Connecticut, United States of America","institution_ids":["https://openalex.org/I75929689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091010756","display_name":"Reinhard Laubenbacher","orcid":"https://orcid.org/0000-0002-9143-9451"},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reinhard Laubenbacher","raw_affiliation_strings":["Department of Medicine, University of Florida, Gainesville, Florida, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-9143-9451","affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Florida, Gainesville, Florida, United States of America","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024622354","display_name":"Clarissa J. Nobile","orcid":"https://orcid.org/0000-0003-0799-6499"},"institutions":[{"id":"https://openalex.org/I156087764","display_name":"University of California, Merced","ror":"https://ror.org/00d9ah105","country_code":"US","type":"education","lineage":["https://openalex.org/I156087764"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clarissa J. Nobile","raw_affiliation_strings":["Department of Molecular and Cell Biology, School of Natural Sciences, University of California Merced, Merced, California, United States of America","Health Sciences Research Institute, University of California Merced, Merced, California, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-0799-6499","affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology, School of Natural Sciences, University of California Merced, Merced, California, United States of America","institution_ids":["https://openalex.org/I156087764"]},{"raw_affiliation_string":"Health Sciences Research Institute, University of California Merced, Merced, California, United States of America","institution_ids":["https://openalex.org/I156087764"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012905268","display_name":"R\u00e9ka Albert","orcid":"https://orcid.org/0000-0002-9485-0828"},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"R\u00e9ka Albert","raw_affiliation_strings":["Department of Physics, Pennsylvania State University, University Park, Pennsylvania, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-9485-0828","affiliations":[{"raw_affiliation_string":"Department of Physics, Pennsylvania State University, University Park, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I130769515"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5012905268"],"corresponding_institution_ids":["https://openalex.org/I130769515"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.2387,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.82432415,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"17","issue":"3","first_page":"e1008690","last_page":"e1008690"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.991599977016449,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":0.9250110983848572},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6151533126831055},{"id":"https://openalex.org/keywords/corpus-albicans","display_name":"Corpus albicans","score":0.6026523113250732},{"id":"https://openalex.org/keywords/yeast","display_name":"Yeast","score":0.6024248003959656},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.5299789905548096},{"id":"https://openalex.org/keywords/transition","display_name":"Transition (genetics)","score":0.49133673310279846},{"id":"https://openalex.org/keywords/hypha","display_name":"Hypha","score":0.4712142050266266},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.44622841477394104},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.44080305099487305},{"id":"https://openalex.org/keywords/microbiology","display_name":"Microbiology","score":0.4337858557701111},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4152825176715851},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3817726969718933}],"concepts":[{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.9250110983848572},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6151533126831055},{"id":"https://openalex.org/C145081991","wikidata":"https://www.wikidata.org/wiki/Q2576388","display_name":"Corpus albicans","level":3,"score":0.6026523113250732},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.6024248003959656},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5299789905548096},{"id":"https://openalex.org/C194232998","wikidata":"https://www.wikidata.org/wiki/Q1606712","display_name":"Transition (genetics)","level":3,"score":0.49133673310279846},{"id":"https://openalex.org/C90080823","wikidata":"https://www.wikidata.org/wiki/Q193129","display_name":"Hypha","level":2,"score":0.4712142050266266},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.44622841477394104},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.44080305099487305},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4337858557701111},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4152825176715851},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3817726969718933}],"mesh":[{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025301","descriptor_name":"Hyphae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D025301","descriptor_name":"Hyphae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D025301","descriptor_name":"Hyphae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D025301","descriptor_name":"Hyphae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D025301","descriptor_name":"Hyphae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D025301","descriptor_name":"Hyphae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1008690","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008690","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008690&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:33780439","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33780439","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:uknowledge.uky.edu:math_facpub-1043","is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/math_facpub/43","pdf_url":null,"source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mathematics Faculty Publications","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:893d94a7b6f5436ba2029f38dfd2ca27","is_oa":true,"landing_page_url":"https://doaj.org/article/893d94a7b6f5436ba2029f38dfd2ca27","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 17, Iss 3, p e1008690 (2021)","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt7rh0779n","is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/7rh0779n","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS Computational Biology, vol 17, iss 3","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8031856","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8031856","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1008690","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008690","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008690&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","score":0.6100000143051147,"display_name":"Life in Land"}],"awards":[{"id":"https://openalex.org/G1695616903","display_name":null,"funder_award_id":"R35 GM124594","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1787214374","display_name":null,"funder_award_id":"MCB-1715826","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G1830790450","display_name":null,"funder_award_id":"R01GM127909","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2141835443","display_name":"III: Small: Collaborative Research: Network Analysis and Anomaly Detection via Global Curvatures","funder_award_id":"1814405","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G2484726549","display_name":null,"funder_award_id":"CBET-1750183","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G394010042","display_name":null,"funder_award_id":"R35GM124594","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4194238180","display_name":"EAGER: Modular design of multiscale models, with an application to the innate immune response to fungal respiratory pathogens","funder_award_id":"1750183","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4458388953","display_name":null,"funder_award_id":"PHY-1545832","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6232561529","display_name":null,"funder_award_id":"R01 AI135128","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6272716307","display_name":null,"funder_award_id":"IIS-1814405","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6439859455","display_name":"Systems Biology of Plant Heterotrimeric G-protein Signaling in Overlapping Pathways Regulating Stomatal Closure","funder_award_id":"1715826","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6843249995","display_name":null,"funder_award_id":"R01 GM127909","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7152055900","display_name":null,"funder_award_id":"R35GM124594","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7352963152","display_name":null,"funder_award_id":"R01DE013986","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7382407927","display_name":null,"funder_award_id":"PHY 1545832","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7384627175","display_name":null,"funder_award_id":"U01EB024501","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7498078381","display_name":null,"funder_award_id":"U01 EB024501","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G7995573518","display_name":"Collaborative Research: Rational Design of Anticancer Drug Combinations using Dynamic Multidimensional Theory","funder_award_id":"1545832","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8344502715","display_name":null,"funder_award_id":"R011AI135128","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G86168018","display_name":null,"funder_award_id":"R01 DE013986","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"},{"id":"https://openalex.org/F4320337390","display_name":"Division of Chemical, Bioengineering, Environmental, and Transport Systems","ror":"https://ror.org/0471zv972"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3147279858.pdf","grobid_xml":"https://content.openalex.org/works/W3147279858.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1907088627","https://openalex.org/W1967864456","https://openalex.org/W1969395447","https://openalex.org/W1980621208","https://openalex.org/W1982151856","https://openalex.org/W1989915587","https://openalex.org/W1993028695","https://openalex.org/W2002379595","https://openalex.org/W2021225422","https://openalex.org/W2030271109","https://openalex.org/W2035036685","https://openalex.org/W2046538693","https://openalex.org/W2048093614","https://openalex.org/W2053367939","https://openalex.org/W2057932064","https://openalex.org/W2058216045","https://openalex.org/W2058268415","https://openalex.org/W2089491891","https://openalex.org/W2100005543","https://openalex.org/W2109785145","https://openalex.org/W2110020198","https://openalex.org/W2122902176","https://openalex.org/W2128207311","https://openalex.org/W2130873227","https://openalex.org/W2131772276","https://openalex.org/W2133900033","https://openalex.org/W2135707527","https://openalex.org/W2139307267","https://openalex.org/W2140865595","https://openalex.org/W2146115175","https://openalex.org/W2156091616","https://openalex.org/W2157151790","https://openalex.org/W2165284694","https://openalex.org/W2166552420","https://openalex.org/W2168426277","https://openalex.org/W2170764510","https://openalex.org/W2171851308","https://openalex.org/W2176409730","https://openalex.org/W2213101934","https://openalex.org/W2302083974","https://openalex.org/W2399184178","https://openalex.org/W2751681639","https://openalex.org/W2772324587","https://openalex.org/W2900855241","https://openalex.org/W2902246075","https://openalex.org/W2963855685","https://openalex.org/W2987102467","https://openalex.org/W3080647147","https://openalex.org/W3086340189","https://openalex.org/W3099614534","https://openalex.org/W3102568738","https://openalex.org/W3105108438","https://openalex.org/W3139860299"],"related_works":["https://openalex.org/W2145314651","https://openalex.org/W3016029167","https://openalex.org/W2102861863","https://openalex.org/W2367173716","https://openalex.org/W2247003880","https://openalex.org/W4362508968","https://openalex.org/W3029732278","https://openalex.org/W2778267304","https://openalex.org/W1974262451","https://openalex.org/W2127077017"],"abstract_inverted_index":{"Candida":[0],"albicans,":[1],"an":[2],"opportunistic":[3],"fungal":[4],"pathogen,":[5],"is":[6,26,66],"a":[7,27,83,107,197,204],"significant":[8],"cause":[9,40],"of":[10,87,120,135,142,173,208],"human":[11],"infections,":[12],"particularly":[13],"in":[14,36,42,75,117,177],"immunocompromised":[15],"individuals.":[16],"Phenotypic":[17],"plasticity":[18],"between":[19],"two":[20,139,172],"morphological":[21],"phenotypes,":[22],"yeast":[23,91,154],"and":[24,39,49,57,81,99,186],"hyphae,":[25],"key":[28,50],"mechanism":[29],"by":[30,106,131],"which":[31,113,201],"C.":[32,71,89,178,209],"albicans":[33,72,90,179,210],"can":[34,164],"thrive":[35],"many":[37],"microenvironments":[38],"disease":[41],"the":[43,46,76,88,104,149,153,182,187],"host.":[44,77],"Understanding":[45],"decision":[47],"points":[48],"driver":[51],"genes":[52,60],"controlling":[53],"this":[54,136,167],"important":[55],"transition":[56,151],"how":[58,70],"these":[59,174],"respond":[61],"to":[62,68,92,110,115,155,202],"different":[63],"environmental":[64,97],"signals":[65],"critical":[67],"understanding":[69,207],"causes":[73],"infections":[74],"Here":[78],"we":[79],"build":[80],"analyze":[82],"Boolean":[84],"dynamical":[85],"model":[86,105,137,193],"hyphal":[93,156],"transition,":[94],"integrating":[95],"multiple":[96],"factors":[98],"regulatory":[100],"mechanisms.":[101],"We":[102,169],"validate":[103,171],"systematic":[108],"comparison":[109],"prior":[111],"experiments,":[112],"led":[114],"agreement":[116],"17":[118],"out":[119],"22":[121],"cases.":[122],"The":[123],"discrepancies":[124],"motivate":[125],"alternative":[126],"hypotheses":[127],"that":[128,144,163],"are":[129],"testable":[130],"follow-up":[132],"experiments.":[133],"Analysis":[134],"revealed":[138],"time-constrained":[140],"windows":[141],"opportunity":[143],"must":[145],"be":[146],"met":[147],"for":[148],"complete":[150],"from":[152,200],"phenotype,":[157],"as":[158,160,196],"well":[159],"control":[161,175],"strategies":[162],"robustly":[165],"prevent":[166],"transition.":[168],"experimentally":[170],"predictions":[176],"strains":[180],"lacking":[181],"transcription":[183],"factor":[184],"UME6":[185],"histone":[188],"deacetylase":[189],"HDA1,":[190],"respectively.":[191],"This":[192],"will":[194],"serve":[195],"strong":[198],"base":[199],"develop":[203],"systems":[205],"biology":[206],"morphogenesis.":[211]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":1}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}
