{"id":"https://openalex.org/W3125305379","doi":"https://doi.org/10.1371/journal.pcbi.1008584","title":"Voxelized simulation of cerebral oxygen perfusion elucidates hypoxia in aged mouse cortex","display_name":"Voxelized simulation of cerebral oxygen perfusion elucidates hypoxia in aged mouse cortex","publication_year":2021,"publication_date":"2021-01-28","ids":{"openalex":"https://openalex.org/W3125305379","doi":"https://doi.org/10.1371/journal.pcbi.1008584","mag":"3125305379","pmid":"https://pubmed.ncbi.nlm.nih.gov/33507970"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1008584","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008584","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008584&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008584&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029600958","display_name":"Grant Hartung","orcid":"https://orcid.org/0000-0002-7107-3050"},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grant Hartung","raw_affiliation_strings":["Department of Bioengineering, University of Illinois at Chicago, Chicago, Illinois, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-7107-3050","affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Illinois at Chicago, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003659815","display_name":"Shoale Badr","orcid":null},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shoale Badr","raw_affiliation_strings":["Department of Bioengineering, University of Illinois at Chicago, Chicago, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Illinois at Chicago, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063404475","display_name":"Mohammad Moeini","orcid":"https://orcid.org/0000-0001-7620-8404"},"institutions":[{"id":"https://openalex.org/I45683168","display_name":"Polytechnique Montr\u00e9al","ror":"https://ror.org/05f8d4e86","country_code":"CA","type":"education","lineage":["https://openalex.org/I45683168"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mohammad Moeini","raw_affiliation_strings":["Polytechnique Montr\u00e9al, Department of Electrical Engineering, Montreal, Canada"],"raw_orcid":"https://orcid.org/0000-0001-7620-8404","affiliations":[{"raw_affiliation_string":"Polytechnique Montr\u00e9al, Department of Electrical Engineering, Montreal, Canada","institution_ids":["https://openalex.org/I45683168"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075040052","display_name":"Fr\u00e9d\u00e9ric Lesage","orcid":"https://orcid.org/0000-0003-3699-1283"},"institutions":[{"id":"https://openalex.org/I45683168","display_name":"Polytechnique Montr\u00e9al","ror":"https://ror.org/05f8d4e86","country_code":"CA","type":"education","lineage":["https://openalex.org/I45683168"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Fr\u00e9d\u00e9ric Lesage","raw_affiliation_strings":["Polytechnique Montr\u00e9al, Department of Electrical Engineering, Montreal, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Polytechnique Montr\u00e9al, Department of Electrical Engineering, Montreal, Canada","institution_ids":["https://openalex.org/I45683168"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020283755","display_name":"David Kleinfeld","orcid":"https://orcid.org/0000-0001-9797-4722"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Kleinfeld","raw_affiliation_strings":["Department of Physics, University of California San Diego, San Diego, California, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-9797-4722","affiliations":[{"raw_affiliation_string":"Department of Physics, University of California San Diego, San Diego, California, United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035302435","display_name":"Ali Alaraj","orcid":"https://orcid.org/0000-0002-1491-4634"},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ali Alaraj","raw_affiliation_strings":["Department of Neurosurgery, University of Illinois at Chicago, Chicago, Illinois, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-1491-4634","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of Illinois at Chicago, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014429141","display_name":"Andreas A. Linninger","orcid":null},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andreas Linninger","raw_affiliation_strings":["Department of Bioengineering, University of Illinois at Chicago, Chicago, Illinois, United States of America","Department of Neurosurgery, University of Illinois at Chicago, Chicago, Illinois, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-2694-630X","affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Illinois at Chicago, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Department of Neurosurgery, University of Illinois at Chicago, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I39422238"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5014429141"],"corresponding_institution_ids":["https://openalex.org/I39422238"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":3.4415,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.92845618,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":100},"biblio":{"volume":"17","issue":"1","first_page":"e1008584","last_page":"e1008584"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cerebral-blood-flow","display_name":"Cerebral blood flow","score":0.5314040780067444},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.49834418296813965},{"id":"https://openalex.org/keywords/blood-flow","display_name":"Blood flow","score":0.47624659538269043},{"id":"https://openalex.org/keywords/discretization","display_name":"Discretization","score":0.47531968355178833},{"id":"https://openalex.org/keywords/hypoxia","display_name":"Hypoxia (environmental)","score":0.44783711433410645},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.42600440979003906},{"id":"https://openalex.org/keywords/perfusion","display_name":"Perfusion","score":0.41240790486335754},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.35773777961730957},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.2801997661590576},{"id":"https://openalex.org/keywords/oxygen","display_name":"Oxygen","score":0.21185550093650818},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1860254406929016},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1852787435054779},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.16707593202590942},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.1353723406791687}],"concepts":[{"id":"https://openalex.org/C157767197","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral blood flow","level":2,"score":0.5314040780067444},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.49834418296813965},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.47624659538269043},{"id":"https://openalex.org/C73000952","wikidata":"https://www.wikidata.org/wiki/Q17007827","display_name":"Discretization","level":2,"score":0.47531968355178833},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.44783711433410645},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.42600440979003906},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.41240790486335754},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.35773777961730957},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2801997661590576},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.21185550093650818},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1860254406929016},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1852787435054779},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16707593202590942},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.1353723406791687},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1008584","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008584","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008584&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:33507970","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33507970","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:publications.polymtl.ca:9357","is_oa":true,"landing_page_url":null,"pdf_url":"https://publications.polymtl.ca/9357/7/2021_Merks_Voxelized_simulation_cerebral_oxygen_perfusion_supp1.pdf","source":{"id":"https://openalex.org/S4306401013","display_name":"PolyPublie (\u00c9cole Polytechnique de Montr\u00e9al)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I45683168","host_organization_name":"Polytechnique Montr\u00e9al","host_organization_lineage":["https://openalex.org/I45683168"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"pmh:oai:doaj.org/article:69827a9936e44f759af980341d64f995","is_oa":true,"landing_page_url":"https://doaj.org/article/69827a9936e44f759af980341d64f995","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 17, Iss 1, p e1008584 (2021)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7842915","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7842915","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1008584","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008584","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008584&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1132728217","display_name":null,"funder_award_id":"CBET-1301198","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1480158796","display_name":null,"funder_award_id":"NINDS 1R21NS099896","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1562170384","display_name":null,"funder_award_id":"CBET\u20101301198","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G1769348452","display_name":null,"funder_award_id":"NIH NINDS 1R21NS099896","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2658815384","display_name":null,"funder_award_id":"CBET-1301198","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G3841932371","display_name":"EAGER: Computational investigation of the  distributed decentralized control of cerebral blood flow","funder_award_id":"1301198","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G3928545718","display_name":null,"funder_award_id":"NINDS 1R21NS099896","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4971006044","display_name":null,"funder_award_id":"1301198","funder_id":"https://openalex.org/F4320337390","funder_display_name":"Division of Chemical, Bioengineering, Environmental, and Transport Systems"},{"id":"https://openalex.org/G520149309","display_name":null,"funder_award_id":"1R21NS099896","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337390","display_name":"Division of Chemical, Bioengineering, Environmental, and Transport Systems","ror":"https://ror.org/0471zv972"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3125305379.pdf","grobid_xml":"https://content.openalex.org/works/W3125305379.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W259079545","https://openalex.org/W1424154121","https://openalex.org/W1483154502","https://openalex.org/W1506342804","https://openalex.org/W1573339040","https://openalex.org/W1591500609","https://openalex.org/W1604912786","https://openalex.org/W1969255018","https://openalex.org/W1972864132","https://openalex.org/W1977905390","https://openalex.org/W1990754232","https://openalex.org/W1993156049","https://openalex.org/W1997542937","https://openalex.org/W1999795673","https://openalex.org/W2003666876","https://openalex.org/W2004217814","https://openalex.org/W2005059170","https://openalex.org/W2027097550","https://openalex.org/W2028989647","https://openalex.org/W2034604818","https://openalex.org/W2035514833","https://openalex.org/W2037194090","https://openalex.org/W2040299291","https://openalex.org/W2043195557","https://openalex.org/W2044723851","https://openalex.org/W2046996556","https://openalex.org/W2049742542","https://openalex.org/W2050765432","https://openalex.org/W2056022329","https://openalex.org/W2056547814","https://openalex.org/W2069734928","https://openalex.org/W2073216552","https://openalex.org/W2073321867","https://openalex.org/W2078261317","https://openalex.org/W2092043212","https://openalex.org/W2095147064","https://openalex.org/W2099802623","https://openalex.org/W2102178368","https://openalex.org/W2106017906","https://openalex.org/W2112311198","https://openalex.org/W2124239142","https://openalex.org/W2126009509","https://openalex.org/W2141411849","https://openalex.org/W2154620313","https://openalex.org/W2161161776","https://openalex.org/W2169118010","https://openalex.org/W2290212599","https://openalex.org/W2409934176","https://openalex.org/W2416275548","https://openalex.org/W2508489690","https://openalex.org/W2531712355","https://openalex.org/W2581593515","https://openalex.org/W2589041191","https://openalex.org/W2747884879","https://openalex.org/W2764061390","https://openalex.org/W2766847177","https://openalex.org/W2776552926","https://openalex.org/W2783740858","https://openalex.org/W2794740751","https://openalex.org/W2807046484","https://openalex.org/W2898147652","https://openalex.org/W2898980015","https://openalex.org/W2901054298","https://openalex.org/W2901074353","https://openalex.org/W2945522003","https://openalex.org/W2953157390","https://openalex.org/W2963959363","https://openalex.org/W3005181186","https://openalex.org/W3023643795","https://openalex.org/W3207759029","https://openalex.org/W4206273021","https://openalex.org/W4236747641","https://openalex.org/W4242769917"],"related_works":["https://openalex.org/W2006251942","https://openalex.org/W2364741597","https://openalex.org/W1492103595","https://openalex.org/W1864774435","https://openalex.org/W946352265","https://openalex.org/W3020787026","https://openalex.org/W2334479858","https://openalex.org/W2799209613","https://openalex.org/W2026961173","https://openalex.org/W2139059299"],"abstract_inverted_index":{"Departures":[0],"of":[1,39,52,130,157,173,183,190,212,228,278,282],"normal":[2,40],"blood":[3,54,106,242],"flow":[4,55],"and":[5,26,41,56,86,107,128,142,210,218,230,244,266,297],"metabolite":[6],"distribution":[7],"from":[8,67,180],"the":[9,46,119,131,158,174,181,191,198,213,290],"cerebral":[10,53],"microvasculature":[11],"into":[12],"neuronal":[13],"tissue":[14],"have":[15],"been":[16],"implicated":[17],"with":[18,90,193,203,220,274],"age-related":[19,279],"neurodegeneration.":[20],"Mathematical":[21],"models":[22,51],"informed":[23],"by":[24,152],"spatially":[25],"temporally":[27],"distributed":[28],"neuroimage":[29],"data":[30,225],"are":[31,177],"becoming":[32],"instrumental":[33],"for":[34,105,292,295],"reconstructing":[35],"a":[36],"coherent":[37],"picture":[38],"pathological":[42,247],"oxygen":[43,57,108,133,223,234],"delivery":[44],"throughout":[45],"brain.":[47],"Unfortunately,":[48],"current":[49],"mathematical":[50],"exchange":[58,235],"become":[59,201],"excessively":[60],"large":[61,155],"in":[62,161,221,226,253,271,289],"size.":[63],"They":[64],"further":[65],"suffer":[66],"boundary":[68,146],"effects":[69,147],"due":[70,80],"to":[71,81,118,197,259],"incomplete":[72],"or":[73,273],"physiologically":[74],"inaccurate":[75],"computational":[76],"domains,":[77],"numerical":[78],"instabilities":[79],"enormous":[82],"length":[83],"scale":[84,200],"differences,":[85],"convergence":[87],"problems":[88],"associated":[89],"condition":[91],"number":[92],"deterioration":[93],"at":[94],"fine":[95],"mesh":[96,115],"resolutions.":[97],"Our":[98,233],"proposed":[99],"simple":[100],"finite":[101],"volume":[102],"discretization":[103],"scheme":[104],"microperfusion":[109],"simulations":[110,176,186,236],"does":[111],"not":[112],"require":[113],"expensive":[114],"generation":[116],"leading":[117],"critical":[120],"benefit":[121],"that":[122,171,249],"it":[123,286],"drastically":[124],"reduces":[125],"matrix":[126],"size":[127],"bandwidth":[129],"coupled":[132],"transfer":[134],"problem.":[135],"The":[136,208],"compact":[137],"problem":[138],"formulation":[139],"yields":[140],"rapid":[141],"stable":[143],"convergence.":[144],"Moreover,":[145],"can":[148],"effectively":[149],"be":[150],"suppressed":[151],"generating":[153],"very":[154],"replica":[156],"cortical":[159],"microcirculation":[160],"silico":[162],"using":[163],"an":[164],"image-based":[165],"cerebrovascular":[166],"network":[167],"synthesis":[168],"algorithm,":[169],"so":[170],"boundaries":[172],"perfusion":[175,224],"far":[178],"removed":[179],"regions":[182],"interest.":[184],"Massive":[185],"over":[187],"sizeable":[188],"portions":[189],"cortex":[192],"feature":[194],"resolution":[195],"down":[196],"micron":[199],"tractable":[202],"even":[204],"modest":[205],"computer":[206],"resources.":[207],"feasibility":[209],"accuracy":[211],"novel":[214],"method":[215],"is":[216,281],"demonstrated":[217],"validated":[219],"vivo":[222],"cohorts":[227],"young":[229],"aged":[231,254],"mice.":[232],"quantify":[237],"steep":[238],"gradients":[239],"near":[240],"penetrating":[241],"vessels":[243],"point":[245],"towards":[246],"changes":[248,280],"might":[250,269,287],"cause":[251],"neurodegeneration":[252],"brains.":[255],"This":[256],"research":[257],"aims":[258],"explain":[260],"mechanistic":[261],"interactions":[262],"between":[263],"anatomical":[264],"structures":[265],"how":[267],"they":[268],"change":[270],"diseases":[272],"age.":[275],"Rigorous":[276],"quantification":[277],"significant":[283],"interest":[284],"because":[285],"aide":[288],"search":[291],"imaging":[293],"biomarkers":[294],"dementia":[296],"Alzheimer's":[298],"disease.":[299]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}
