{"id":"https://openalex.org/W3135390224","doi":"https://doi.org/10.1371/journal.pcbi.1008496","title":"PIEZO1 and the mechanism of the long circulatory longevity of human red blood cells","display_name":"PIEZO1 and the mechanism of the long circulatory longevity of human red blood cells","publication_year":2021,"publication_date":"2021-03-10","ids":{"openalex":"https://openalex.org/W3135390224","doi":"https://doi.org/10.1371/journal.pcbi.1008496","mag":"3135390224","pmid":"https://pubmed.ncbi.nlm.nih.gov/33690597"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1008496","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008496","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008496&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008496&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060432668","display_name":"Simon Rogers","orcid":"https://orcid.org/0000-0003-3578-4477"},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Simon Rogers","raw_affiliation_strings":["School of Computing Science, University of Glasgow, Glasgow, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0003-3578-4477","affiliations":[{"raw_affiliation_string":"School of Computing Science, University of Glasgow, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049033882","display_name":"Virgilio L. Lew","orcid":"https://orcid.org/0000-0002-0554-2701"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Virgilio L. Lew","raw_affiliation_strings":["Physiological Laboratory, Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Site, Cambridge, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-0554-2701","affiliations":[{"raw_affiliation_string":"Physiological Laboratory, Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Site, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5049033882","https://openalex.org/A5060432668"],"corresponding_institution_ids":["https://openalex.org/I241749","https://openalex.org/I7882870"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":2.8529,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.91627002,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"17","issue":"3","first_page":"e1008496","last_page":"e1008496"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.9929999709129333,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":0.9757000207901001,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/piezo1","display_name":"PIEZO1","score":0.7055853605270386},{"id":"https://openalex.org/keywords/longevity","display_name":"Longevity","score":0.5640422105789185},{"id":"https://openalex.org/keywords/red-blood-cell","display_name":"Red blood cell","score":0.5219182968139648},{"id":"https://openalex.org/keywords/circulatory-system","display_name":"Circulatory system","score":0.5151513814926147},{"id":"https://openalex.org/keywords/homeostasis","display_name":"Homeostasis","score":0.5095803737640381},{"id":"https://openalex.org/keywords/vascular-permeability","display_name":"Vascular permeability","score":0.45316874980926514},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.40780109167099},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3925328254699707},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.39111045002937317},{"id":"https://openalex.org/keywords/andrology","display_name":"Andrology","score":0.3275092840194702},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.3196052312850952},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.23783272504806519},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.2172153890132904},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.2032909393310547},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.20091021060943604},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.14441433548927307}],"concepts":[{"id":"https://openalex.org/C2780785647","wikidata":"https://www.wikidata.org/wiki/Q18034667","display_name":"PIEZO1","level":5,"score":0.7055853605270386},{"id":"https://openalex.org/C2776759703","wikidata":"https://www.wikidata.org/wiki/Q1066907","display_name":"Longevity","level":2,"score":0.5640422105789185},{"id":"https://openalex.org/C2776557347","wikidata":"https://www.wikidata.org/wiki/Q37187","display_name":"Red blood cell","level":2,"score":0.5219182968139648},{"id":"https://openalex.org/C72859922","wikidata":"https://www.wikidata.org/wiki/Q11068","display_name":"Circulatory system","level":2,"score":0.5151513814926147},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.5095803737640381},{"id":"https://openalex.org/C113045295","wikidata":"https://www.wikidata.org/wiki/Q7916465","display_name":"Vascular permeability","level":2,"score":0.45316874980926514},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.40780109167099},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3925328254699707},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39111045002937317},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3275092840194702},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3196052312850952},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23783272504806519},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2172153890132904},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2032909393310547},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20091021060943604},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14441433548927307},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.0},{"id":"https://openalex.org/C4001165","wikidata":"https://www.wikidata.org/wiki/Q6804689","display_name":"Mechanosensitive channels","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D001775","descriptor_name":"Blood Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001775","descriptor_name":"Blood Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001775","descriptor_name":"Blood Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1008496","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008496","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008496&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:33690597","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33690597","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.gla.ac.uk:236483","is_oa":true,"landing_page_url":"https://eprints.gla.ac.uk/view/author/11628.html>","pdf_url":null,"source":{"id":"https://openalex.org/S4210235606","display_name":"ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)","issn_l":"2622-8912","issn":["2622-8912","2622-8920"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Articles"},{"id":"pmh:oai:pubmedcentral.nih.gov:7946313","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7946313","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:5c266acc07c74027b74ac60c1c4c6a4c","is_oa":true,"landing_page_url":"https://doaj.org/article/5c266acc07c74027b74ac60c1c4c6a4c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 17, Iss 3, p e1008496 (2021)","raw_type":"article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/318632","is_oa":true,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/318632","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"doi:10.17863/cam.65749","is_oa":true,"landing_page_url":"https://doi.org/10.17863/cam.65749","pdf_url":null,"source":{"id":"https://openalex.org/S7407050737","display_name":"Apollo","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1008496","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008496","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008496&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.47999998927116394,"id":"https://metadata.un.org/sdg/12","display_name":"Responsible consumption and production"}],"awards":[{"id":"https://openalex.org/G1573303648","display_name":null,"funder_award_id":"17358","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G1672827616","display_name":"The Ca2+ homeostasis of Plasmodium falciparum-infected red cells.","funder_award_id":"064124","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G1745610835","display_name":null,"funder_award_id":"BB/E008542/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G1924089881","display_name":"Systems analysis of guard cell oscillatory mechanics in stomatal dynamics","funder_award_id":"BB/F001673/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G3194662369","display_name":"Regulation of membrane fusion by a novel Sec1/Munc18-associated protein","funder_award_id":"BB/H024867/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G3429862064","display_name":null,"funder_award_id":"033876","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G4002466403","display_name":null,"funder_award_id":"13056","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4136257277","display_name":null,"funder_award_id":"061269","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G4451241524","display_name":null,"funder_award_id":"EP/E059384","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G4855329700","display_name":null,"funder_award_id":"BB/H024867/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G5255973409","display_name":null,"funder_award_id":"BB/F001630/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G5303890229","display_name":null,"funder_award_id":"030699","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G6833247968","display_name":"Analysis of membrane traffic in adaptive stress tolerance in plants","funder_award_id":"BB/F001630/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G6862896296","display_name":null,"funder_award_id":"059725","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G7074733513","display_name":null,"funder_award_id":"13056","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G7104788713","display_name":null,"funder_award_id":"BB/F001673/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G7427847625","display_name":null,"funder_award_id":"R01 HL028018","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7702772931","display_name":null,"funder_award_id":"15543","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G8079785110","display_name":"The homeostasis of malaria-infected red blood cells","funder_award_id":"BB/E008542/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3135390224.pdf","grobid_xml":"https://content.openalex.org/works/W3135390224.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W63436316","https://openalex.org/W186426134","https://openalex.org/W191400563","https://openalex.org/W317076985","https://openalex.org/W1499118957","https://openalex.org/W1500892859","https://openalex.org/W1668843629","https://openalex.org/W1964495154","https://openalex.org/W1964546777","https://openalex.org/W1969706463","https://openalex.org/W1978348222","https://openalex.org/W1988912399","https://openalex.org/W1997273070","https://openalex.org/W2001678279","https://openalex.org/W2007456227","https://openalex.org/W2009576459","https://openalex.org/W2010673044","https://openalex.org/W2011929082","https://openalex.org/W2012189255","https://openalex.org/W2015929262","https://openalex.org/W2022931319","https://openalex.org/W2023559972","https://openalex.org/W2024386343","https://openalex.org/W2035215843","https://openalex.org/W2035330601","https://openalex.org/W2036597250","https://openalex.org/W2037765002","https://openalex.org/W2040629618","https://openalex.org/W2041378888","https://openalex.org/W2051487824","https://openalex.org/W2056401840","https://openalex.org/W2057721882","https://openalex.org/W2067977670","https://openalex.org/W2071803108","https://openalex.org/W2074358602","https://openalex.org/W2083144727","https://openalex.org/W2093975354","https://openalex.org/W2095372525","https://openalex.org/W2109257012","https://openalex.org/W2114284618","https://openalex.org/W2118818502","https://openalex.org/W2123470161","https://openalex.org/W2134577432","https://openalex.org/W2139005555","https://openalex.org/W2143525427","https://openalex.org/W2154689939","https://openalex.org/W2154711050","https://openalex.org/W2167869727","https://openalex.org/W2170185329","https://openalex.org/W2197911242","https://openalex.org/W2286255985","https://openalex.org/W2303146437","https://openalex.org/W2400962796","https://openalex.org/W2401592718","https://openalex.org/W2407968877","https://openalex.org/W2605267194","https://openalex.org/W2735841375","https://openalex.org/W2774623822","https://openalex.org/W2775715295","https://openalex.org/W2897670153","https://openalex.org/W3037395564","https://openalex.org/W3134460998"],"related_works":["https://openalex.org/W4384263780","https://openalex.org/W4318591662","https://openalex.org/W4393317135","https://openalex.org/W3037395564","https://openalex.org/W2925062284","https://openalex.org/W4224325757","https://openalex.org/W4315797749","https://openalex.org/W3131883789","https://openalex.org/W2913974223","https://openalex.org/W3212985269"],"abstract_inverted_index":{"Human":[0],"red":[1],"blood":[2],"cells":[3],"(RBCs)":[4],"have":[5,48],"a":[6,127,190,235,251,335],"circulatory":[7,267,360,402],"lifespan":[8,129,268,306,353],"of":[9,21,25,58,77,100,108,131,141,151,201,221,234,238,243,250,258,265,284,323,337,362,375,379,384,392],"about":[10],"four":[11],"months.":[12],"Under":[13],"constant":[14],"oxidative":[15],"and":[16,23,86,156,193,224,246,296,372,406],"mechanical":[17],"stress,":[18],"but":[19],"devoid":[20],"organelles":[22],"deprived":[24],"biosynthetic":[26],"capacity":[27],"for":[28,61,122,196,303,370,373],"protein":[29],"renewal,":[30],"RBCs":[31,60,202,319],"undergo":[32],"substantial":[33],"homeostatic":[34],"changes,":[35],"progressive":[36,199],"densification":[37,200,223,261],"followed":[38,343],"by":[39,51,69,149,157,231,271,281,344],"late":[40,225,276,340],"density":[41,180,277,346],"reversal":[42,226,278],"among":[43],"others,":[44],"changes":[45,161,181,295,397],"assumed":[46],"to":[47,53,116,137,163,301,321],"been":[49],"harnessed":[50],"evolution":[52],"sustain":[54],"the":[55,59,75,109,113,118,139,170,197,209,218,232,241,244,255,266,282,304,331,355,358,366,376,385,393,396],"rheological":[56],"competence":[57],"as":[62,64,105,167],"long":[63],"possible.":[65],"The":[66,173,212,260],"unknown":[67],"mechanisms":[68,394],"which":[70],"this":[71,78],"is":[72],"achieved":[73],"are":[74],"subject":[76],"investigation.":[79],"Each":[80],"RBC":[81,101,222,399],"traverses":[82],"capillaries":[83],"between":[84],"1000":[85],"2000":[87],"times":[88],"per":[89,94],"day,":[90],"roughly":[91],"one":[92],"transit":[93],"minute.":[95],"A":[96,288,313],"dedicated":[97],"Lifespan":[98],"model":[99,143],"homeostasis":[102,400],"was":[103,177,216,269,279,291],"developed":[104],"an":[106,388],"extension":[107],"RCM":[110],"introduced":[111],"in":[112,169,240,330,398,404],"previous":[114,171],"paper":[115],"explore":[117],"cumulative":[119],"patterns":[120,220],"predicted":[121],"repetitive":[123],"capillary":[124,185],"transits":[125,146,186],"over":[126,263,350],"standardized":[128],"period":[130],"120":[132],"days,":[133],"using":[134],"experimental":[135],"data":[136],"constrain":[138],"range":[140],"acceptable":[142],"outcomes.":[144],"Capillary":[145],"were":[147,299],"simulated":[148],"periods":[150,354],"elevated":[152],"cell/medium":[153],"volume":[154],"ratios":[155],"transient":[158],"deformation-induced":[159],"permeability":[160],"attributed":[162],"PIEZO1":[164],"channel":[165],"mediation":[166],"outlined":[168],"paper.":[172],"first":[174],"unexpected":[175,214],"finding":[176,215,290,316],"that":[178,217,292,318],"quantal":[179,210,294],"generated":[182],"during":[183,401],"single":[184],"cease":[187],"accumulating":[188],"after":[189],"few":[191],"days":[192],"cannot":[194],"account":[195,302],"observed":[198],"on":[203,310],"their":[204,311],"own,":[205],"thus":[206],"ruling":[207],"out":[208],"hypothesis.":[211],"second":[213],"documented":[219,305],"could":[227,333],"only":[228],"be":[229],"emulated":[230],"implementation":[233],"strict":[236],"time-course":[237],"decay":[239,274],"activities":[242],"calcium":[245,272,325],"Na/K":[247,285],"pumps,":[248],"suggestive":[249],"selective":[252],"mechanism":[253],"enabling":[254],"extended":[256],"longevity":[257],"RBCs.":[259],"pattern":[262,283,336],"most":[264,374],"determined":[270],"pump":[273,286],"whereas":[275],"shaped":[280],"decay.":[287],"third":[289],"both":[293],"pump-decay":[297],"regimes":[298],"necessary":[300],"pattern,":[307],"neither":[308],"sufficient":[309],"own.":[312],"fourth":[314],"new":[315,390],"revealed":[317],"exposed":[320],"levels":[322],"PIEZO1-medited":[324],"permeation":[326],"above":[327],"certain":[328],"thresholds":[329],"circulation":[332],"develop":[334],"early":[338],"or":[339],"hyperdense":[341],"collapse":[342],"delayed":[345],"reversal.":[347],"When":[348],"tested":[349],"much":[351],"reduced":[352],"results":[356,386],"reproduced":[357],"known":[359],"fate":[361],"irreversible":[363],"sickle":[364,380],"cells,":[365],"cell":[367,381],"subpopulation":[368],"responsible":[369],"vaso-occlusion":[371],"clinical":[377],"manifestations":[378],"disease.":[382,407],"Analysis":[383],"provided":[387],"insightful":[389],"understanding":[391],"driving":[395],"aging":[403],"health":[405]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-10-10T00:00:00"}