{"id":"https://openalex.org/W3120878446","doi":"https://doi.org/10.1371/journal.pcbi.1008470","title":"The value of decreasing the duration of the infectious period of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection","display_name":"The value of decreasing the duration of the infectious period of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection","publication_year":2021,"publication_date":"2021-01-07","ids":{"openalex":"https://openalex.org/W3120878446","doi":"https://doi.org/10.1371/journal.pcbi.1008470","mag":"3120878446","pmid":"https://pubmed.ncbi.nlm.nih.gov/33411742"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1008470","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008470","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008470&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008470&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071968122","display_name":"Bruce Y. Lee","orcid":"https://orcid.org/0000-0003-2633-8651"},"institutions":[{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bruce Y. Lee","raw_affiliation_strings":["Public Health Informatics, Computational, and Operations Research (PHICOR), City University of New York Graduate School of Public Health and Health Policy, New York City, New York, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-2633-8651","affiliations":[{"raw_affiliation_string":"Public Health Informatics, Computational, and Operations Research (PHICOR), City University of New York Graduate School of Public Health and Health Policy, New York City, New York, United States of America","institution_ids":["https://openalex.org/I78577930","https://openalex.org/I174216632"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070063697","display_name":"Sarah M. Bartsch","orcid":"https://orcid.org/0000-0002-0523-4717"},"institutions":[{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah M. Bartsch","raw_affiliation_strings":["Public Health Informatics, Computational, and Operations Research (PHICOR), City University of New York Graduate School of Public Health and Health Policy, New York City, New York, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-0523-4717","affiliations":[{"raw_affiliation_string":"Public Health Informatics, Computational, and Operations Research (PHICOR), City University of New York Graduate School of Public Health and Health Policy, New York City, New York, United States of America","institution_ids":["https://openalex.org/I78577930","https://openalex.org/I174216632"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113773684","display_name":"Marie C. Ferguson","orcid":null},"institutions":[{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marie C. Ferguson","raw_affiliation_strings":["Public Health Informatics, Computational, and Operations Research (PHICOR), City University of New York Graduate School of Public Health and Health Policy, New York City, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Public Health Informatics, Computational, and Operations Research (PHICOR), City University of New York Graduate School of Public Health and Health Policy, New York City, New York, United States of America","institution_ids":["https://openalex.org/I78577930","https://openalex.org/I174216632"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081602798","display_name":"Patrick T. Wedlock","orcid":"https://orcid.org/0000-0001-7635-5949"},"institutions":[{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick T. Wedlock","raw_affiliation_strings":["Public Health Informatics, Computational, and Operations Research (PHICOR), City University of New York Graduate School of Public Health and Health Policy, New York City, New York, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-7635-5949","affiliations":[{"raw_affiliation_string":"Public Health Informatics, Computational, and Operations Research (PHICOR), City University of New York Graduate School of Public Health and Health Policy, New York City, New York, United States of America","institution_ids":["https://openalex.org/I78577930","https://openalex.org/I174216632"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011108100","display_name":"Kelly J. O\u2019Shea","orcid":"https://orcid.org/0000-0003-4957-5975"},"institutions":[{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly J. O\u2019Shea","raw_affiliation_strings":["Public Health Informatics, Computational, and Operations Research (PHICOR), City University of New York Graduate School of Public Health and Health Policy, New York City, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Public Health Informatics, Computational, and Operations Research (PHICOR), City University of New York Graduate School of Public Health and Health Policy, New York City, New York, United States of America","institution_ids":["https://openalex.org/I78577930","https://openalex.org/I174216632"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112737720","display_name":"Sheryl S. Siegmund","orcid":null},"institutions":[{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sheryl S. Siegmund","raw_affiliation_strings":["Public Health Informatics, Computational, and Operations Research (PHICOR), City University of New York Graduate School of Public Health and Health Policy, New York City, New York, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-2784-6279","affiliations":[{"raw_affiliation_string":"Public Health Informatics, Computational, and Operations Research (PHICOR), City University of New York Graduate School of Public Health and Health Policy, New York City, New York, United States of America","institution_ids":["https://openalex.org/I78577930","https://openalex.org/I174216632"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050499823","display_name":"Sarah N. Cox","orcid":"https://orcid.org/0000-0002-2447-0504"},"institutions":[{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah N. Cox","raw_affiliation_strings":["Public Health Informatics, Computational, and Operations Research (PHICOR), City University of New York Graduate School of Public Health and Health Policy, New York City, New York, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-2447-0504","affiliations":[{"raw_affiliation_string":"Public Health Informatics, Computational, and Operations Research (PHICOR), City University of New York Graduate School of Public Health and Health Policy, New York City, New York, United States of America","institution_ids":["https://openalex.org/I78577930","https://openalex.org/I174216632"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052781570","display_name":"James A. McKinnell","orcid":null},"institutions":[{"id":"https://openalex.org/I1319677595","display_name":"Torrance Memorial Medical Center","ror":"https://ror.org/0480v3r94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1319677595"]},{"id":"https://openalex.org/I2801403999","display_name":"UCLA Medical Center","ror":"https://ror.org/04vq5kb54","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799798094","https://openalex.org/I2801403999"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James A. McKinnell","raw_affiliation_strings":["Infectious Disease Clinical Outcomes Research Unit (ID-CORE), Lundquist Institute, Harbor-UCLA Medical Center, Torrance, California, United States of America","Torrance Memorial Medical Center, Torrance, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease Clinical Outcomes Research Unit (ID-CORE), Lundquist Institute, Harbor-UCLA Medical Center, Torrance, California, United States of America","institution_ids":["https://openalex.org/I2801403999","https://openalex.org/I4210165985"]},{"raw_affiliation_string":"Torrance Memorial Medical Center, Torrance, California, United States of America","institution_ids":["https://openalex.org/I1319677595"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5071968122"],"corresponding_institution_ids":["https://openalex.org/I174216632","https://openalex.org/I78577930"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.6428,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.82971387,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"17","issue":"1","first_page":"e1008470","last_page":"e1008470"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10410","display_name":"COVID-19 epidemiological studies","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10410","display_name":"COVID-19 epidemiological studies","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11296","display_name":"COVID-19 and healthcare impacts","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11987","display_name":"COVID-19 Impact on Reproduction","score":0.9889000058174133,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.7246933579444885},{"id":"https://openalex.org/keywords/asymptomatic","display_name":"Asymptomatic","score":0.6686379313468933},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.6357738375663757},{"id":"https://openalex.org/keywords/severe-acute-respiratory-syndrome-coronavirus-2","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","score":0.5483300685882568},{"id":"https://openalex.org/keywords/coronavirus-disease-2019","display_name":"Coronavirus disease 2019 (COVID-19)","score":0.49912428855895996},{"id":"https://openalex.org/keywords/severe-acute-respiratory-syndrome","display_name":"Severe acute respiratory syndrome","score":0.44693267345428467},{"id":"https://openalex.org/keywords/pediatrics","display_name":"Pediatrics","score":0.4125070571899414},{"id":"https://openalex.org/keywords/infectious-disease","display_name":"Infectious disease (medical specialty)","score":0.3803068995475769},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.29917317628860474},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.19602146744728088},{"id":"https://openalex.org/keywords/environmental-health","display_name":"Environmental health","score":0.14094632863998413}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7246933579444885},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.6686379313468933},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.6357738375663757},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.5483300685882568},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.49912428855895996},{"id":"https://openalex.org/C2778859668","wikidata":"https://www.wikidata.org/wiki/Q103177","display_name":"Severe acute respiratory syndrome","level":5,"score":0.44693267345428467},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4125070571899414},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.3803068995475769},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29917317628860474},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.19602146744728088},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.14094632863998413}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000086663","descriptor_name":"COVID-19 Vaccines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000086663","descriptor_name":"COVID-19 Vaccines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000086663","descriptor_name":"COVID-19 Vaccines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000086663","descriptor_name":"COVID-19 Vaccines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D017201","descriptor_name":"Virus Shedding","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017201","descriptor_name":"Virus Shedding","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017201","descriptor_name":"Virus Shedding","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017201","descriptor_name":"Virus Shedding","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058873","descriptor_name":"Pandemics","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D058873","descriptor_name":"Pandemics","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D058873","descriptor_name":"Pandemics","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D058873","descriptor_name":"Pandemics","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D058873","descriptor_name":"Pandemics","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D058873","descriptor_name":"Pandemics","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D058873","descriptor_name":"Pandemics","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D058873","descriptor_name":"Pandemics","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1008470","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008470","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008470&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:33411742","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33411742","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:559472499ff547e1ba5bbbacd6202755","is_oa":true,"landing_page_url":"https://doaj.org/article/559472499ff547e1ba5bbbacd6202755","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 17, Iss 1, p e1008470 (2021)","raw_type":"article"},{"id":"pmh:oai:frl.publisso.de:frl:6428297","is_oa":true,"landing_page_url":"https://repository.publisso.de/resource/frl:6428297","pdf_url":null,"source":{"id":"https://openalex.org/S4377196269","display_name":"PUBLISSO (German National Library of Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210112663","host_organization_name":"ZB MED - Information Centre for Life Sciences","host_organization_lineage":["https://openalex.org/I4210112663"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, 17(1):e1008470","raw_type":"Zeitschriftenartikel"},{"id":"pmh:oai:pubmedcentral.nih.gov:7790237","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7790237","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1008470","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008470","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008470&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8299999833106995,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G166090523","display_name":null,"funder_award_id":"AID-OAA-A-15-00064","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2075599008","display_name":null,"funder_award_id":"R01HS023317","funder_id":"https://openalex.org/F4320306115","funder_display_name":"United States Agency for International Development"},{"id":"https://openalex.org/G2127494241","display_name":null,"funder_award_id":"U01HD086861","funder_id":"https://openalex.org/F4320337364","funder_display_name":"National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G2221344325","display_name":null,"funder_award_id":"R01HS023317","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G2851715955","display_name":null,"funder_award_id":"1 R01 GM127512-01A1","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G287966657","display_name":null,"funder_award_id":"R01HS023317","funder_id":"https://openalex.org/F4320332177","funder_display_name":"Agency for Healthcare Research and Quality"},{"id":"https://openalex.org/G2936877075","display_name":null,"funder_award_id":"AID-OAA-A-15-00064","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G3903803326","display_name":null,"funder_award_id":"U01HD086861 and 5R01HD086013-02","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G4211692377","display_name":null,"funder_award_id":"AID-OAA-A-15-00064","funder_id":"https://openalex.org/F4320332177","funder_display_name":"Agency for Healthcare Research and Quality"},{"id":"https://openalex.org/G5143405428","display_name":null,"funder_award_id":"R01HS023317","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5596939157","display_name":null,"funder_award_id":"R01 GM127512-01A1","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5656926381","display_name":null,"funder_award_id":"1 R01","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G6625236712","display_name":null,"funder_award_id":"R01 GM127512","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G726752762","display_name":null,"funder_award_id":"5R01HD086013-02","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G7312852459","display_name":null,"funder_award_id":"U01HD086861","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G8003787340","display_name":null,"funder_award_id":"AID-OAA-A-15-00064","funder_id":"https://openalex.org/F4320306115","funder_display_name":"United States Agency for International Development"},{"id":"https://openalex.org/G8181304577","display_name":null,"funder_award_id":"U01HD086861","funder_id":"https://openalex.org/F4320332177","funder_display_name":"Agency for Healthcare Research and Quality"}],"funders":[{"id":"https://openalex.org/F4320306115","display_name":"United States Agency for International Development","ror":"https://ror.org/01n6e6j62"},{"id":"https://openalex.org/F4320309102","display_name":"City University of New York","ror":"https://ror.org/00453a208"},{"id":"https://openalex.org/F4320332177","display_name":"Agency for Healthcare Research and Quality","ror":"https://ror.org/03jmfdf59"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337364","display_name":"National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3120878446.pdf","grobid_xml":"https://content.openalex.org/works/W3120878446.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W26131945","https://openalex.org/W2001187841","https://openalex.org/W2002406591","https://openalex.org/W2005349838","https://openalex.org/W2022781679","https://openalex.org/W2028350108","https://openalex.org/W2039737448","https://openalex.org/W2046335330","https://openalex.org/W2047838565","https://openalex.org/W2049774536","https://openalex.org/W2050496195","https://openalex.org/W2059059346","https://openalex.org/W2078615887","https://openalex.org/W2082414258","https://openalex.org/W2090410258","https://openalex.org/W2105167857","https://openalex.org/W2130878567","https://openalex.org/W2135476128","https://openalex.org/W2140057779","https://openalex.org/W2290821530","https://openalex.org/W2579174706","https://openalex.org/W2770143337","https://openalex.org/W2788805987","https://openalex.org/W2789826333","https://openalex.org/W2800114337","https://openalex.org/W2897642295","https://openalex.org/W2901806162","https://openalex.org/W3001118548","https://openalex.org/W3003668884","https://openalex.org/W3004239190","https://openalex.org/W3004397688","https://openalex.org/W3005079553","https://openalex.org/W3006177842","https://openalex.org/W3008028633","https://openalex.org/W3008827533","https://openalex.org/W3010235353","https://openalex.org/W3010781325","https://openalex.org/W3010930696","https://openalex.org/W3012413501","https://openalex.org/W3012610905","https://openalex.org/W3013893137","https://openalex.org/W3014199470","https://openalex.org/W3014948915","https://openalex.org/W3015571324","https://openalex.org/W3015632652","https://openalex.org/W3018023298","https://openalex.org/W3027630905","https://openalex.org/W3027829318","https://openalex.org/W3033285830","https://openalex.org/W3040751560","https://openalex.org/W3165656738","https://openalex.org/W4233976476","https://openalex.org/W6996256334"],"related_works":["https://openalex.org/W4206669628","https://openalex.org/W4205317059","https://openalex.org/W4224279380","https://openalex.org/W3176864053","https://openalex.org/W4206651655","https://openalex.org/W4206548596","https://openalex.org/W4292098121","https://openalex.org/W4210433452","https://openalex.org/W3036314732","https://openalex.org/W3084808338"],"abstract_inverted_index":{"Finding":[0],"medications":[1],"or":[2],"vaccines":[3],"that":[4,55],"may":[5],"decrease":[6],"the":[7,23,32,35,40,48,57,87,113,157,206,214,219],"infectious":[8,49,59,115,159,221],"period":[9,50,60,116,160,222],"of":[10,31,37,46,66,70,86,99,123,136,147,171,178,205,217],"severe":[11],"acute":[12],"respiratory":[13],"syndrome":[14],"coronavirus":[15],"2":[16],"(SARS-CoV-2)":[17],"could":[18,62],"potentially":[19],"reduce":[20],"transmission":[21],"in":[22],"broader":[24],"population.":[25],"We":[26],"developed":[27],"a":[28,64],"computational":[29],"model":[30],"U.S.":[33],"simulating":[34],"spread":[36],"SARS-CoV-2":[38,95,220],"and":[39,43,81,130,191,200],"potential":[41,215],"clinical":[42],"economic":[44],"impact":[45],"reducing":[47,56,73,103,112,156,218],"duration.":[51,223],"Simulation":[52],"experiments":[53],"found":[54],"average":[58,114,158],"duration":[61,117,161],"avert":[63],"median":[65],"442,852":[67],"[treating":[68],"25%":[69,122,146,170],"symptomatic":[71,124,137,148,172],"cases,":[72,102,181],"by":[74,104,118,162],"0.5":[75,119],"days,":[76,106],"reproductive":[77],"number":[78],"(R0)":[79],"3.5,":[80],"starting":[82,201],"treatment":[83,175,202],"when":[84],"15%":[85],"population":[88,207],"has":[89,208],"been":[90,209],"exposed]":[91],"to":[92,134,176],"44.4":[93],"million":[94,128,141,167,189,193],"cases":[96,125,129,138,149,168,190],"(treating":[97,169],"75%":[98,135,177],"all":[100,179],"infected":[101,180],"3.5":[105,163],"R0":[107,110],"2.0).":[108],"With":[109],"2.5,":[111],"days":[120,164],"for":[121],"averted":[126,139,165,187],"1.4":[127],"99,398":[131],"hospitalizations;":[132],"increasing":[133],"2.8":[140],"cases.":[142],"At":[143],"$500/person,":[144],"treating":[145],"saved":[150],"$209.5":[151],"billion":[152,197],"(societal":[153,198],"perspective).":[154],"Further":[155],"7.4":[166],"cases).":[173],"Expanding":[174],"including":[182],"asymptomatic":[183],"infections":[184],"(R0":[185],"2.5),":[186],"35.9":[188],"4":[192],"hospitalizations,":[194],"saving":[195],"$48.8":[196],"perspective":[199],"after":[203],"5%":[204],"exposed).":[210],"Our":[211],"study":[212],"quantifies":[213],"effects":[216]},"counts_by_year":[{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}