{"id":"https://openalex.org/W3112917873","doi":"https://doi.org/10.1371/journal.pcbi.1008463","title":"Bursting in cerebellar stellate cells induced by pharmacological agents: Non-sequential spike adding","display_name":"Bursting in cerebellar stellate cells induced by pharmacological agents: Non-sequential spike adding","publication_year":2020,"publication_date":"2020-12-14","ids":{"openalex":"https://openalex.org/W3112917873","doi":"https://doi.org/10.1371/journal.pcbi.1008463","mag":"3112917873","pmid":"https://pubmed.ncbi.nlm.nih.gov/33315892"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1008463","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008463","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008463&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008463&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039117603","display_name":"Saeed Farjami","orcid":null},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Saeed Farjami","raw_affiliation_strings":["Department of Physiology, McGill University, Montr\u00e9al, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, McGill University, Montr\u00e9al, QC, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075449812","display_name":"Ryan P.D. Alexander","orcid":null},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Ryan P. D. Alexander","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, McGill University, Montr\u00e9al, QC, Canada"],"raw_orcid":"https://orcid.org/0000-0002-6769-1489","affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, McGill University, Montr\u00e9al, QC, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008112491","display_name":"Derek Bowie","orcid":"https://orcid.org/0000-0001-9491-8768"},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Derek Bowie","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, McGill University, Montr\u00e9al, QC, Canada"],"raw_orcid":"https://orcid.org/0000-0001-9491-8768","affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, McGill University, Montr\u00e9al, QC, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083742913","display_name":"Anmar Khadra","orcid":"https://orcid.org/0000-0002-8228-9914"},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Anmar Khadra","raw_affiliation_strings":["Department of Physiology, McGill University, Montr\u00e9al, QC, Canada"],"raw_orcid":"https://orcid.org/0000-0002-8228-9914","affiliations":[{"raw_affiliation_string":"Department of Physiology, McGill University, Montr\u00e9al, QC, Canada","institution_ids":["https://openalex.org/I5023651"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5008112491","https://openalex.org/A5039117603","https://openalex.org/A5075449812","https://openalex.org/A5083742913"],"corresponding_institution_ids":["https://openalex.org/I5023651"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.066,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.76834987,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"16","issue":"12","first_page":"e1008463","last_page":"e1008463"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11513","display_name":"stochastic dynamics and bifurcation","score":0.9914000034332275,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11513","display_name":"stochastic dynamics and bifurcation","score":0.9914000034332275,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11187","display_name":"Nonlinear Dynamics and Pattern Formation","score":0.9843000173568726,"subfield":{"id":"https://openalex.org/subfields/1705","display_name":"Computer Networks and Communications"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9660000205039978,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spike","display_name":"Spike (software development)","score":0.8010109663009644},{"id":"https://openalex.org/keywords/bursting","display_name":"Bursting","score":0.7641153335571289},{"id":"https://openalex.org/keywords/hepatic-stellate-cell","display_name":"Hepatic stellate cell","score":0.6119537353515625},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.594910740852356},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.363762766122818},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.23233327269554138}],"concepts":[{"id":"https://openalex.org/C2781390188","wikidata":"https://www.wikidata.org/wiki/Q25203449","display_name":"Spike (software development)","level":2,"score":0.8010109663009644},{"id":"https://openalex.org/C195221683","wikidata":"https://www.wikidata.org/wiki/Q5000649","display_name":"Bursting","level":2,"score":0.7641153335571289},{"id":"https://openalex.org/C176891718","wikidata":"https://www.wikidata.org/wiki/Q1997459","display_name":"Hepatic stellate cell","level":2,"score":0.6119537353515625},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.594910740852356},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.363762766122818},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.23233327269554138},{"id":"https://openalex.org/C115903868","wikidata":"https://www.wikidata.org/wiki/Q80993","display_name":"Software engineering","level":1,"score":0.0},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002104","descriptor_name":"Cadmium","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002104","descriptor_name":"Cadmium","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002104","descriptor_name":"Cadmium","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002104","descriptor_name":"Cadmium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002104","descriptor_name":"Cadmium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002104","descriptor_name":"Cadmium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011689","descriptor_name":"Purkinje Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011689","descriptor_name":"Purkinje Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011689","descriptor_name":"Purkinje Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011689","descriptor_name":"Purkinje Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011689","descriptor_name":"Purkinje Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011689","descriptor_name":"Purkinje Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015761","descriptor_name":"4-Aminopyridine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015761","descriptor_name":"4-Aminopyridine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015761","descriptor_name":"4-Aminopyridine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015761","descriptor_name":"4-Aminopyridine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015761","descriptor_name":"4-Aminopyridine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015761","descriptor_name":"4-Aminopyridine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D026902","descriptor_name":"Potassium Channel Blockers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D026902","descriptor_name":"Potassium Channel Blockers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D026902","descriptor_name":"Potassium Channel Blockers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1008463","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008463","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008463&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:33315892","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33315892","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1008463","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008463","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:81be1e8618154ace93b05494cc0e168c","is_oa":true,"landing_page_url":"https://doaj.org/article/81be1e8618154ace93b05494cc0e168c","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 16, Iss 12, p e1008463 (2020)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:6701751","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7769625","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:7769625","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7769625","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1008463","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008463","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008463&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G7023943099","display_name":null,"funder_award_id":"142431","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"}],"funders":[{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3112917873.pdf","grobid_xml":"https://content.openalex.org/works/W3112917873.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W10447158","https://openalex.org/W61471679","https://openalex.org/W316919195","https://openalex.org/W1548039665","https://openalex.org/W1596321532","https://openalex.org/W1645484672","https://openalex.org/W1664326609","https://openalex.org/W1680669385","https://openalex.org/W1712664294","https://openalex.org/W1964294610","https://openalex.org/W1967520985","https://openalex.org/W1973937712","https://openalex.org/W1985940938","https://openalex.org/W1992223493","https://openalex.org/W1999170261","https://openalex.org/W2002317454","https://openalex.org/W2020787149","https://openalex.org/W2035835569","https://openalex.org/W2037044617","https://openalex.org/W2059278152","https://openalex.org/W2060450020","https://openalex.org/W2063191631","https://openalex.org/W2064108635","https://openalex.org/W2067290406","https://openalex.org/W2071848675","https://openalex.org/W2075474584","https://openalex.org/W2076427697","https://openalex.org/W2079061153","https://openalex.org/W2080018957","https://openalex.org/W2081026643","https://openalex.org/W2085968788","https://openalex.org/W2088017330","https://openalex.org/W2091481906","https://openalex.org/W2093174559","https://openalex.org/W2093685279","https://openalex.org/W2094410817","https://openalex.org/W2094658769","https://openalex.org/W2099925060","https://openalex.org/W2108333597","https://openalex.org/W2111563015","https://openalex.org/W2112015090","https://openalex.org/W2118985327","https://openalex.org/W2143590623","https://openalex.org/W2144296767","https://openalex.org/W2159864873","https://openalex.org/W2163621583","https://openalex.org/W2168013023","https://openalex.org/W2175333929","https://openalex.org/W2330064022","https://openalex.org/W2333322910","https://openalex.org/W2396196877","https://openalex.org/W2476844384","https://openalex.org/W2564295114","https://openalex.org/W2773488274","https://openalex.org/W2786906736","https://openalex.org/W2887076119","https://openalex.org/W2913708088","https://openalex.org/W2946185511","https://openalex.org/W2969555988","https://openalex.org/W2974464184","https://openalex.org/W2986312945","https://openalex.org/W2989276764","https://openalex.org/W3000211002","https://openalex.org/W3000938659","https://openalex.org/W3010077458","https://openalex.org/W3017509829","https://openalex.org/W3033017505","https://openalex.org/W3106534923","https://openalex.org/W4245552230","https://openalex.org/W4295526211","https://openalex.org/W6602494707"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2080788537","https://openalex.org/W3181055709","https://openalex.org/W2002830460","https://openalex.org/W2064213689","https://openalex.org/W2036451364","https://openalex.org/W3195397619","https://openalex.org/W4243975172","https://openalex.org/W2165689100","https://openalex.org/W2090649048"],"abstract_inverted_index":{"Cerebellar":[0],"stellate":[1],"cells":[2],"(CSCs)":[3],"are":[4,153,272],"spontaneously":[5],"active,":[6],"tonically":[7],"firing":[8],"(5-30":[9],"Hz),":[10],"inhibitory":[11],"interneurons":[12],"that":[13,63,105,164,190,229,290],"synapse":[14],"onto":[15],"Purkinje":[16],"cells.":[17],"We":[18],"previously":[19,133],"analyzed":[20],"the":[21,139,165,169,251,255,281,285,294],"excitability":[22,46,171],"properties":[23],"of":[24,86,124,141,173,222,258,284],"CSCs,":[25,174],"focusing":[26],"on":[27],"four":[28,170],"key":[29],"features:":[30],"type":[31,136],"I":[32],"excitability,":[33],"non-monotonic":[34],"first-spike":[35],"latency,":[36],"switching":[37],"in":[38,45,100,217,232],"responsiveness":[39],"and":[40,89,145,155,185,201,241,261,268,275,288],"runup":[41],"(i.e.,":[42],"temporal":[43],"increase":[44],"during":[47],"whole-cell":[48,59],"configuration).":[49],"In":[50],"this":[51,55],"study,":[52],"we":[53,148,162,227],"extend":[54],"analysis":[56],"by":[57,183],"using":[58],"configuration":[60],"to":[61],"show":[62,228],"these":[64,151],"neurons":[65],"can":[66,263],"also":[67],"burst":[68],"when":[69,111,215,237,266],"treated":[70],"with":[71,80,119,219],"certain":[72],"pharmacological":[73],"agents":[74],"separately":[75],"or":[76,110],"jointly.":[77],"Indeed,":[78],"treatment":[79],"4-Aminopyridine":[81],"(4-AP),":[82],"a":[83,97,122,132],"partial":[84],"blocker":[85,123],"delayed":[87,245],"rectifier":[88],"A-type":[90],"K+":[91,143],"channels,":[92],"at":[93,107,115,198,204],"low":[94,116,199,220,274],"doses":[95,109,117,200,221],"induces":[96],"bursting":[98,180,197,203,214,262],"profile":[99],"CSCs":[101,291],"significantly":[102],"different":[103],"than":[104],"produced":[106],"high":[108,125,205],"it":[112],"is":[113,192,209,235,247],"applied":[114,216,287],"but":[118],"cadmium":[120],"(Cd2+),":[121],"voltage-activated":[126],"(HVA)":[127],"Ca2+":[128],"channels.":[129],"By":[130],"expanding":[131],"revised":[134],"Hodgkin-Huxley":[135],"model,":[137],"through":[138],"inclusion":[140],"Ca2+-activated":[142],"(K(Ca))":[144],"HVA":[146,240,267],"currents,":[147],"explain":[149],"how":[150],"bursts":[152,234],"generated":[154],"what":[156],"their":[157,179],"underlying":[158],"dynamics":[159],"are.":[160],"Specifically,":[161],"demonstrate":[163],"expanded":[166],"model":[167],"preserves":[168],"features":[172],"as":[175,177],"well":[176],"captures":[178],"patterns":[181],"induced":[182],"4-AP":[184,191],"Cd2+.":[186],"Model":[187],"investigation":[188],"reveals":[189],"potentiating":[193,210],"HVA,":[194],"inducing":[195,212],"square-wave":[196,233],"pseudo-plateau":[202,213,259],"doses,":[206],"whereas":[207],"Cd2+":[208],"K(Ca),":[211],"combination":[218],"4-AP.":[223],"Using":[224],"bifurcation":[225],"analysis,":[226],"spike":[230],"adding":[231],"non-sequential":[236],"gradually":[238],"changing":[239],"K(Ca)":[242,269],"maximum":[243,270],"conductances,":[244],"Hopf":[246],"responsible":[248],"for":[249,297],"generating":[250],"plateau":[252],"segment":[253],"within":[254],"active":[256],"phase":[257],"bursts,":[260],"become":[264],"\"chaotic\"":[265],"conductances":[271],"made":[273],"high,":[276],"respectively.":[277],"These":[278],"results":[279],"highlight":[280],"secondary":[282],"effects":[283],"drugs":[286],"suggest":[289],"have":[292],"all":[293],"ingredients":[295],"needed":[296],"bursting.":[298]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2}],"updated_date":"2026-02-25T06:17:34.324206","created_date":"2025-10-10T00:00:00"}
