{"id":"https://openalex.org/W3109319026","doi":"https://doi.org/10.1371/journal.pcbi.1008454","title":"Inference of mutability landscapes of tumors from single cell sequencing data","display_name":"Inference of mutability landscapes of tumors from single cell sequencing data","publication_year":2020,"publication_date":"2020-11-30","ids":{"openalex":"https://openalex.org/W3109319026","doi":"https://doi.org/10.1371/journal.pcbi.1008454","mag":"3109319026","pmid":"https://pubmed.ncbi.nlm.nih.gov/33253159"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1008454","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008454","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008454&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008454&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041661925","display_name":"Viachaslau Tsyvina","orcid":"https://orcid.org/0000-0002-7230-4009"},"institutions":[{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Viachaslau Tsyvina","raw_affiliation_strings":["Department of Computer Science, Georgia State University, Atlanta, Georgia, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Georgia State University, Atlanta, Georgia, United States of America","institution_ids":["https://openalex.org/I181565077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072751459","display_name":"Alex Zelikovsky","orcid":"https://orcid.org/0000-0003-4424-4691"},"institutions":[{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex Zelikovsky","raw_affiliation_strings":["Department of Computer Science, Georgia State University, Atlanta, Georgia, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Georgia State University, Atlanta, Georgia, United States of America","institution_ids":["https://openalex.org/I181565077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063493591","display_name":"Sagi Snir","orcid":"https://orcid.org/0000-0001-5833-7659"},"institutions":[{"id":"https://openalex.org/I91203450","display_name":"University of Haifa","ror":"https://ror.org/02f009v59","country_code":"IL","type":"education","lineage":["https://openalex.org/I91203450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Sagi Snir","raw_affiliation_strings":["Department of Evolutionary and Environmental Biology, University of Haifa, Haifa, Israel"],"affiliations":[{"raw_affiliation_string":"Department of Evolutionary and Environmental Biology, University of Haifa, Haifa, Israel","institution_ids":["https://openalex.org/I91203450"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052456631","display_name":"Pavel Skums","orcid":"https://orcid.org/0000-0003-4007-5624"},"institutions":[{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Pavel Skums","raw_affiliation_strings":["Department of Computer Science, Georgia State University, Atlanta, Georgia, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Georgia State University, Atlanta, Georgia, United States of America","institution_ids":["https://openalex.org/I181565077"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5052456631"],"corresponding_institution_ids":["https://openalex.org/I181565077"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.3193,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.51518374,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"16","issue":"11","first_page":"e1008454","last_page":"e1008454"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.7307336926460266},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6572887897491455},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.6542475819587708},{"id":"https://openalex.org/keywords/mutation-rate","display_name":"Mutation rate","score":0.6389040946960449},{"id":"https://openalex.org/keywords/epistasis","display_name":"Epistasis","score":0.5718072056770325},{"id":"https://openalex.org/keywords/genome-instability","display_name":"Genome instability","score":0.5531840324401855},{"id":"https://openalex.org/keywords/clone","display_name":"clone (Java method)","score":0.5441339015960693},{"id":"https://openalex.org/keywords/somatic-evolution-in-cancer","display_name":"Somatic evolution in cancer","score":0.5400660037994385},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.49068915843963623},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4301969110965729},{"id":"https://openalex.org/keywords/dna-sequencing","display_name":"DNA sequencing","score":0.4137665033340454},{"id":"https://openalex.org/keywords/fitness-landscape","display_name":"Fitness landscape","score":0.4118586778640747},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.396356999874115},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.38916245102882385},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3741290271282196},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.19184938073158264},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.14069971442222595},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.09156477451324463},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.08924564719200134}],"concepts":[{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.7307336926460266},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6572887897491455},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.6542475819587708},{"id":"https://openalex.org/C98638677","wikidata":"https://www.wikidata.org/wiki/Q2067051","display_name":"Mutation rate","level":3,"score":0.6389040946960449},{"id":"https://openalex.org/C61727976","wikidata":"https://www.wikidata.org/wiki/Q751748","display_name":"Epistasis","level":3,"score":0.5718072056770325},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.5531840324401855},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.5441339015960693},{"id":"https://openalex.org/C113968399","wikidata":"https://www.wikidata.org/wiki/Q7559241","display_name":"Somatic evolution in cancer","level":3,"score":0.5400660037994385},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.49068915843963623},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4301969110965729},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.4137665033340454},{"id":"https://openalex.org/C91852762","wikidata":"https://www.wikidata.org/wiki/Q3307742","display_name":"Fitness landscape","level":3,"score":0.4118586778640747},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.396356999874115},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.38916245102882385},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3741290271282196},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.19184938073158264},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.14069971442222595},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.09156477451324463},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.08924564719200134},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D042822","descriptor_name":"Genomic Instability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042822","descriptor_name":"Genomic Instability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042822","descriptor_name":"Genomic Instability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042822","descriptor_name":"Genomic Instability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042822","descriptor_name":"Genomic Instability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1008454","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008454","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008454&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:33253159","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33253159","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:24ce93a7dac94d01863e380a49978175","is_oa":true,"landing_page_url":"https://doaj.org/article/24ce93a7dac94d01863e380a49978175","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 16, Iss 11, p e1008454 (2020)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7728263","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7728263","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1008454","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008454","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008454&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6600000262260437,"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land"}],"awards":[{"id":"https://openalex.org/G4420866426","display_name":null,"funder_award_id":"1R01EB025022","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7726618816","display_name":null,"funder_award_id":"R01EB025022","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320310607","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3109319026.pdf","grobid_xml":"https://content.openalex.org/works/W3109319026.grobid-xml"},"referenced_works_count":85,"referenced_works":["https://openalex.org/W1964575260","https://openalex.org/W1988481255","https://openalex.org/W1996973085","https://openalex.org/W1997493715","https://openalex.org/W2002295829","https://openalex.org/W2004232113","https://openalex.org/W2004875842","https://openalex.org/W2023560061","https://openalex.org/W2033666853","https://openalex.org/W2034629821","https://openalex.org/W2045391589","https://openalex.org/W2050086663","https://openalex.org/W2051296828","https://openalex.org/W2055035445","https://openalex.org/W2062220010","https://openalex.org/W2065423665","https://openalex.org/W2074572936","https://openalex.org/W2077813812","https://openalex.org/W2084697344","https://openalex.org/W2088580309","https://openalex.org/W2094939159","https://openalex.org/W2112794045","https://openalex.org/W2115674146","https://openalex.org/W2117847813","https://openalex.org/W2122392334","https://openalex.org/W2128923603","https://openalex.org/W2129081404","https://openalex.org/W2142635246","https://openalex.org/W2144847592","https://openalex.org/W2161455936","https://openalex.org/W2161566038","https://openalex.org/W2163859522","https://openalex.org/W2164432702","https://openalex.org/W2168175751","https://openalex.org/W2168432681","https://openalex.org/W2205700110","https://openalex.org/W2260951263","https://openalex.org/W2292919485","https://openalex.org/W2296319761","https://openalex.org/W2311424835","https://openalex.org/W2331240949","https://openalex.org/W2340974016","https://openalex.org/W2346273585","https://openalex.org/W2552325035","https://openalex.org/W2564445904","https://openalex.org/W2586389371","https://openalex.org/W2612847024","https://openalex.org/W2618389271","https://openalex.org/W2704159227","https://openalex.org/W2754025713","https://openalex.org/W2762185802","https://openalex.org/W2794424827","https://openalex.org/W2794829817","https://openalex.org/W2795499463","https://openalex.org/W2800632101","https://openalex.org/W2802415313","https://openalex.org/W2890035501","https://openalex.org/W2947209894","https://openalex.org/W2949688529","https://openalex.org/W2949793499","https://openalex.org/W2951391875","https://openalex.org/W2952522477","https://openalex.org/W2954321455","https://openalex.org/W2957221979","https://openalex.org/W2961229668","https://openalex.org/W2963037532","https://openalex.org/W2966657105","https://openalex.org/W2980515223","https://openalex.org/W2982154804","https://openalex.org/W2990492099","https://openalex.org/W3004973969","https://openalex.org/W3012079654","https://openalex.org/W3017999335","https://openalex.org/W3042807857","https://openalex.org/W3075371075","https://openalex.org/W3104815945","https://openalex.org/W4211177544","https://openalex.org/W4230482292","https://openalex.org/W4250589301","https://openalex.org/W4251042002","https://openalex.org/W4252314705","https://openalex.org/W4256183008","https://openalex.org/W4379510236","https://openalex.org/W6677719745","https://openalex.org/W6767034622"],"related_works":["https://openalex.org/W4225153397","https://openalex.org/W4295749382","https://openalex.org/W2952742538","https://openalex.org/W4301429967","https://openalex.org/W4302338605","https://openalex.org/W4304195508","https://openalex.org/W2337872996","https://openalex.org/W1968336705","https://openalex.org/W2950940317","https://openalex.org/W4226215149"],"abstract_inverted_index":{"One":[0],"of":[1,4,14,19,27,38,58,61,77,96,100,106,117,126,140],"the":[2,7,35,71,75,104,115,124,138],"hallmarks":[3],"cancer":[5,63,82],"is":[6,152],"extremely":[8],"high":[9,25],"mutability":[10,43,94],"and":[11,85,93,120,129,143],"genetic":[12,141],"instability":[13,29,36,142],"tumor":[15,145],"cells.":[16],"Inherent":[17],"heterogeneity":[18],"intra-tumor":[20],"populations":[21,40],"manifests":[22],"itself":[23],"in":[24],"variability":[26],"clone":[28],"rates.":[30],"Analogously":[31],"to":[32,113,136],"fitness":[33],"landscapes,":[34],"rates":[37,60,102],"clonal":[39],"form":[41],"their":[42],"landscapes.":[44],"Here,":[45],"we":[46],"present":[47],"MULAN":[48,151],"(MUtability":[49],"LANdscape":[50],"inference),":[51],"a":[52,97],"maximum-likelihood":[53],"computational":[54],"framework":[55],"for":[56],"inference":[57],"mutation":[59,78,83,101],"individual":[62,110],"subclones":[64,107],"using":[65],"single-cell":[66],"sequencing":[67],"data.":[68,150],"It":[69],"utilizes":[70],"partial":[72],"information":[73],"about":[74],"orders":[76],"events":[79],"provided":[80],"by":[81,88],"trees":[84],"extends":[86],"it":[87,132],"inferring":[89],"full":[90],"evolutionary":[91,146],"history":[92,147],"landscape":[95],"tumor.":[98],"Evaluation":[99],"on":[103],"level":[105],"rather":[108],"than":[109],"genes":[111],"allows":[112],"capture":[114],"effects":[116],"genomic":[118],"interactions":[119],"epistasis.":[121],"We":[122],"estimate":[123],"accuracy":[125],"our":[127],"approach":[128],"demonstrate":[130],"that":[131],"can":[133],"be":[134],"used":[135],"study":[137],"evolution":[139],"infer":[144],"from":[148],"experimental":[149],"available":[153],"at":[154],"https://github.com/compbel/MULAN.":[155]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}