{"id":"https://openalex.org/W3109491463","doi":"https://doi.org/10.1371/journal.pcbi.1008434","title":"Pre-existing resistance in the latent reservoir can compromise VRC01 therapy during chronic HIV-1 infection","display_name":"Pre-existing resistance in the latent reservoir can compromise VRC01 therapy during chronic HIV-1 infection","publication_year":2020,"publication_date":"2020-11-30","ids":{"openalex":"https://openalex.org/W3109491463","doi":"https://doi.org/10.1371/journal.pcbi.1008434","mag":"3109491463","pmid":"https://pubmed.ncbi.nlm.nih.gov/33253162"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1008434","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008434","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008434&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008434&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048425525","display_name":"Ananya Saha","orcid":"https://orcid.org/0009-0002-8205-0716"},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ananya Saha","raw_affiliation_strings":["Department of Chemical Engineering, Indian Institute of Science, Bengaluru, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Indian Institute of Science, Bengaluru, India","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009087944","display_name":"Narendra M. Dixit","orcid":"https://orcid.org/0000-0002-2145-9828"},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Narendra M. Dixit","raw_affiliation_strings":["Centre for Biosystems Science and Engineering, Indian Institute of Science, Bengaluru, India","Department of Chemical Engineering, Indian Institute of Science, Bengaluru, India"],"raw_orcid":"https://orcid.org/0000-0002-2145-9828","affiliations":[{"raw_affiliation_string":"Centre for Biosystems Science and Engineering, Indian Institute of Science, Bengaluru, India","institution_ids":["https://openalex.org/I59270414"]},{"raw_affiliation_string":"Department of Chemical Engineering, Indian Institute of Science, Bengaluru, India","institution_ids":["https://openalex.org/I59270414"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5009087944"],"corresponding_institution_ids":["https://openalex.org/I59270414"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.5061,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.82648204,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"16","issue":"11","first_page":"e1008434","last_page":"e1008434"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/viremia","display_name":"Viremia","score":0.7635089159011841},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5861444473266602},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.5830378532409668},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.5504945516586304},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"Antiretroviral therapy","score":0.5481465458869934},{"id":"https://openalex.org/keywords/clinical-trial","display_name":"Clinical trial","score":0.4963863492012024},{"id":"https://openalex.org/keywords/human-immunodeficiency-virus","display_name":"Human immunodeficiency virus (HIV)","score":0.44836705923080444},{"id":"https://openalex.org/keywords/antibody","display_name":"Antibody","score":0.4444889426231384},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.39358508586883545},{"id":"https://openalex.org/keywords/viral-load","display_name":"Viral load","score":0.30587467551231384},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.13946157693862915}],"concepts":[{"id":"https://openalex.org/C2776185481","wikidata":"https://www.wikidata.org/wiki/Q1425304","display_name":"Viremia","level":3,"score":0.7635089159011841},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5861444473266602},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5830378532409668},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5504945516586304},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.5481465458869934},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4963863492012024},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.44836705923080444},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4444889426231384},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.39358508586883545},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.30587467551231384},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13946157693862915},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000080908","descriptor_name":"Broadly Neutralizing Antibodies","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000080908","descriptor_name":"Broadly Neutralizing Antibodies","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000080908","descriptor_name":"Broadly Neutralizing Antibodies","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004197","descriptor_name":"Disease Reservoirs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004197","descriptor_name":"Disease Reservoirs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004197","descriptor_name":"Disease Reservoirs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015483","descriptor_name":"HIV Antibodies","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015483","descriptor_name":"HIV Antibodies","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015483","descriptor_name":"HIV Antibodies","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D017735","descriptor_name":"Virus Latency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017735","descriptor_name":"Virus Latency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017735","descriptor_name":"Virus Latency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1008434","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008434","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008434&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:33253162","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33253162","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai::78996","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4377196309","display_name":"NOT FOUND REPOSITORY (Indian Institute of Science Bangalore)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I59270414","host_organization_name":"Indian Institute of Science Bangalore","host_organization_lineage":["https://openalex.org/I59270414"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:4542bb6ecfe64c76a89344b7e8add5ce","is_oa":true,"landing_page_url":"https://doaj.org/article/4542bb6ecfe64c76a89344b7e8add5ce","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 16, Iss 11, p e1008434 (2020)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7728175","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7728175","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1008434","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008434","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008434&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8500000238418579,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G5897988762","display_name":null,"funder_award_id":"Senior Fellowship IA/S/14/1/501307","funder_id":"https://openalex.org/F4320325580","funder_display_name":"The Wellcome Trust DBT India Alliance"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320717","display_name":"Department of Biotechnology, Ministry of Science and Technology, India","ror":"https://ror.org/03tjsyq23"},{"id":"https://openalex.org/F4320325580","display_name":"The Wellcome Trust DBT India Alliance","ror":"https://ror.org/04reqzt68"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3109491463.pdf","grobid_xml":"https://content.openalex.org/works/W3109491463.grobid-xml"},"referenced_works_count":106,"referenced_works":["https://openalex.org/W829574961","https://openalex.org/W978228178","https://openalex.org/W1485557578","https://openalex.org/W1495576644","https://openalex.org/W1497870368","https://openalex.org/W1802153259","https://openalex.org/W1817014772","https://openalex.org/W1964972892","https://openalex.org/W1966066354","https://openalex.org/W1968223042","https://openalex.org/W1978430573","https://openalex.org/W1980223851","https://openalex.org/W1980811933","https://openalex.org/W1989762371","https://openalex.org/W1992566288","https://openalex.org/W1995278079","https://openalex.org/W2002574877","https://openalex.org/W2007441249","https://openalex.org/W2019559865","https://openalex.org/W2026814484","https://openalex.org/W2030856851","https://openalex.org/W2030987189","https://openalex.org/W2038110764","https://openalex.org/W2045550107","https://openalex.org/W2051063688","https://openalex.org/W2051205639","https://openalex.org/W2051453551","https://openalex.org/W2058501504","https://openalex.org/W2060701294","https://openalex.org/W2066218700","https://openalex.org/W2075032293","https://openalex.org/W2078723335","https://openalex.org/W2081550246","https://openalex.org/W2081772552","https://openalex.org/W2083826108","https://openalex.org/W2095985058","https://openalex.org/W2098605123","https://openalex.org/W2103731776","https://openalex.org/W2108422942","https://openalex.org/W2112391961","https://openalex.org/W2115280360","https://openalex.org/W2115580899","https://openalex.org/W2117367044","https://openalex.org/W2118274231","https://openalex.org/W2120612096","https://openalex.org/W2126515754","https://openalex.org/W2129186628","https://openalex.org/W2133139512","https://openalex.org/W2135151522","https://openalex.org/W2155418451","https://openalex.org/W2168736565","https://openalex.org/W2171228793","https://openalex.org/W2200798239","https://openalex.org/W2240032856","https://openalex.org/W2264411206","https://openalex.org/W2294780401","https://openalex.org/W2314791685","https://openalex.org/W2346116821","https://openalex.org/W2413278262","https://openalex.org/W2466398959","https://openalex.org/W2557191642","https://openalex.org/W2564237271","https://openalex.org/W2597074085","https://openalex.org/W2598871150","https://openalex.org/W2610780794","https://openalex.org/W2618943818","https://openalex.org/W2622379346","https://openalex.org/W2734230971","https://openalex.org/W2756263269","https://openalex.org/W2762486448","https://openalex.org/W2766842037","https://openalex.org/W2768170182","https://openalex.org/W2768623425","https://openalex.org/W2774292278","https://openalex.org/W2785308733","https://openalex.org/W2786918104","https://openalex.org/W2800948940","https://openalex.org/W2801742197","https://openalex.org/W2805610138","https://openalex.org/W2808216890","https://openalex.org/W2808681599","https://openalex.org/W2888247319","https://openalex.org/W2895775323","https://openalex.org/W2899319571","https://openalex.org/W2899779910","https://openalex.org/W2900064231","https://openalex.org/W2900567433","https://openalex.org/W2911228036","https://openalex.org/W2912648593","https://openalex.org/W2916757324","https://openalex.org/W2930343531","https://openalex.org/W2936127489","https://openalex.org/W2936745461","https://openalex.org/W2961620228","https://openalex.org/W2962878859","https://openalex.org/W2967649901","https://openalex.org/W2982401945","https://openalex.org/W2995826607","https://openalex.org/W3003399029","https://openalex.org/W3006954854","https://openalex.org/W3030327683","https://openalex.org/W3081081198","https://openalex.org/W4235232179","https://openalex.org/W4238063882","https://openalex.org/W4249843085","https://openalex.org/W6674847467"],"related_works":["https://openalex.org/W2183070931","https://openalex.org/W34945428","https://openalex.org/W2320118331","https://openalex.org/W2002753371","https://openalex.org/W2086616853","https://openalex.org/W4236946429","https://openalex.org/W1992302788","https://openalex.org/W4249966514","https://openalex.org/W2006097873","https://openalex.org/W4230957370"],"abstract_inverted_index":{"Passive":[0],"immunization":[1],"with":[2,21,30,177,193,226],"broadly":[3],"neutralizing":[4],"antibodies":[5],"(bNAbs)":[6],"of":[7,24,60,73,99,109,232],"HIV-1":[8,16,47,185,295],"appears":[9],"a":[10,167,215,281],"promising":[11],"strategy":[12],"for":[13,65,283],"eliciting":[14],"long-term":[15],"remission.":[17,40,296],"When":[18],"administered":[19],"concomitantly":[20],"the":[22,49,58,77,96,107,172,210,242,253,270],"cessation":[23],"antiretroviral":[25],"therapy":[26,35],"(ART)":[27],"to":[28,38,53,116,248],"patients":[29,84],"established":[31],"viremic":[32],"control,":[33],"bNAb":[34,50],"is":[36,63],"expected":[37],"prolong":[39,54],"Surprisingly,":[41],"in":[42,82,89,145,209,252,269],"clinical":[43,179,236],"trials":[44],"on":[45,171],"chronic":[46],"patients,":[48],"VRC01":[51,87,93,128,153,195,233,246,261],"failed":[52],"remission":[55],"substantially.":[56],"Identifying":[57],"cause":[59,98],"this":[61,162,227],"failure":[62,234,247,292],"important":[64],"improving":[66],"VRC01-based":[67],"therapies":[68],"and":[69,149,174,190,293],"unraveling":[70],"potential":[71],"vulnerabilities":[72],"other":[74,276],"bNAbs.":[75,277],"In":[76],"trials,":[78,237],"viremia":[79],"resurged":[80],"rapidly":[81],"most":[83],"despite":[85],"suppressive":[86],"concentrations":[88],"circulation,":[90],"suggesting":[91],"that":[92,133,200,219,288],"resistance":[94,110,114],"was":[95,262],"likely":[97],"failure.":[100,157],"ART":[101,141,144],"swiftly":[102],"halts":[103],"viral":[104,191,257],"replication,":[105],"precluding":[106],"development":[108],"during":[111,152],"ART.":[112],"If":[113],"were":[115],"emerge":[117],"post":[118],"ART,":[119],"virological":[120],"breakthrough":[121],"would":[122,207,289],"have":[123,137],"taken":[124],"longer":[125],"than":[126],"without":[127],"therapy.":[129],"We":[130,165,213,244],"hypothesized":[131],"therefore":[132],"VRC01-resistant":[134,205,250],"strains":[135],"must":[136],"been":[138,150],"formed":[139],"before":[140],"initiation,":[142],"survived":[143],"latently":[146],"infected":[147],"cells,":[148],"activated":[151],"therapy,":[154],"causing":[155],"treatment":[156],"Current":[158],"assays":[159],"preclude":[160],"testing":[161],"hypothesis":[163,173],"experimentally.":[164],"developed":[166],"mathematical":[168],"model":[169,182,198],"based":[170],"challenged":[175],"it":[176],"available":[178],"data.":[180],"The":[181,197],"integrated":[183],"within-host":[184],"evolution,":[186],"stochastic":[187],"latency":[188],"reactivation,":[189],"dynamics":[192],"multiple-dose":[194],"pharmacokinetics.":[196],"predicted":[199],"single":[201],"but":[202],"not":[203],"higher":[204],"mutants":[206],"pre-exist":[208],"latent":[211,254,271],"reservoir.":[212],"constructed":[214],"virtual":[216],"patient":[217],"population":[218,228],"parsimoniously":[220],"recapitulated":[221],"inter-patient":[222],"variations.":[223],"Model":[224],"predictions":[225],"quantitatively":[229],"captured":[230],"data":[231],"from":[235],"presenting":[238],"strong":[239],"evidence":[240],"supporting":[241],"hypothesis.":[243],"attributed":[245],"single-mutant":[249],"proviruses":[251,268],"reservoir":[255,272],"triggering":[256],"recrudescence,":[258],"particularly":[259],"when":[260],"at":[263],"trough":[264],"levels.":[265],"Pre-existing":[266],"resistant":[267],"may":[273],"similarly":[274],"compromise":[275],"Our":[278],"study":[279],"provides":[280],"framework":[282],"designing":[284],"bNAb-based":[285],"therapeutic":[286],"protocols":[287],"avert":[290],"such":[291],"maximize":[294]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2026-07-28T07:46:37.118299","created_date":"2025-10-10T00:00:00"}