{"id":"https://openalex.org/W3093947647","doi":"https://doi.org/10.1371/journal.pcbi.1008337","title":"CystAnalyser: A new software tool for the automatic detection and quantification of cysts in Polycystic Kidney and Liver Disease, and other cystic disorders","display_name":"CystAnalyser: A new software tool for the automatic detection and quantification of cysts in Polycystic Kidney and Liver Disease, and other cystic disorders","publication_year":2020,"publication_date":"2020-10-22","ids":{"openalex":"https://openalex.org/W3093947647","doi":"https://doi.org/10.1371/journal.pcbi.1008337","mag":"3093947647","pmid":"https://pubmed.ncbi.nlm.nih.gov/33090995"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1008337","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008337","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008337&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008337&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089660372","display_name":"Adri\u00e1n Cordido","orcid":"https://orcid.org/0000-0003-1095-2139"},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"funder","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210148771","display_name":"Instituto de Investigaci\u00f3n Sanitaria de Santiago","ror":"https://ror.org/05n7xcf53","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210148771"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Adri\u00e1n Cordido","raw_affiliation_strings":["Grupo de Medicina Xen\u00f3mica, Complexo Hospitalario de Santiago de Compostela (CHUS), Santiago de Compostela, Spain","Grupo de Xen\u00e9tica e Biolox\u00eda do Desenvolvemento das Enfermidades Renais, Laboratorio de Nefrolox\u00eda (No. 11), Instituto de Investigaci\u00f3n Sanitaria de Santiago (IDIS), Complexo Hospitalario de Santiago de Compostela (CHUS), Santiago de Compostela, Spain","RedInRen RETIC, ISCIII, Spain"],"raw_orcid":"https://orcid.org/0000-0003-1095-2139","affiliations":[{"raw_affiliation_string":"Grupo de Medicina Xen\u00f3mica, Complexo Hospitalario de Santiago de Compostela (CHUS), Santiago de Compostela, Spain","institution_ids":[]},{"raw_affiliation_string":"Grupo de Xen\u00e9tica e Biolox\u00eda do Desenvolvemento das Enfermidades Renais, Laboratorio de Nefrolox\u00eda (No. 11), Instituto de Investigaci\u00f3n Sanitaria de Santiago (IDIS), Complexo Hospitalario de Santiago de Compostela (CHUS), Santiago de Compostela, Spain","institution_ids":["https://openalex.org/I4210148771"]},{"raw_affiliation_string":"RedInRen RETIC, ISCIII, Spain","institution_ids":["https://openalex.org/I2801357902"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074509766","display_name":"Eva Cernadas","orcid":"https://orcid.org/0000-0002-1562-2553"},"institutions":[{"id":"https://openalex.org/I200284239","display_name":"Universidade de Santiago de Compostela","ror":"https://ror.org/030eybx10","country_code":"ES","type":"education","lineage":["https://openalex.org/I200284239"]},{"id":"https://openalex.org/I4210111807","display_name":"Center for Research in Molecular Medicine and Chronic Diseases","ror":"https://ror.org/0280bnq76","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210111807"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Eva Cernadas","raw_affiliation_strings":["Centro Singular de Investigaci\u00f3n en Tecnolox\u00edas Intelixentes da USC (CiTIUS) Universidade de Santiago de Compostela, R\u00faa Xenaro de la Fuente Dom\u00ednguez, Santiago de Compostela, Spain"],"raw_orcid":"https://orcid.org/0000-0002-1562-2553","affiliations":[{"raw_affiliation_string":"Centro Singular de Investigaci\u00f3n en Tecnolox\u00edas Intelixentes da USC (CiTIUS) Universidade de Santiago de Compostela, R\u00faa Xenaro de la Fuente Dom\u00ednguez, Santiago de Compostela, Spain","institution_ids":["https://openalex.org/I4210111807","https://openalex.org/I200284239"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086425124","display_name":"Manuel Fern\u00e1ndez-Delgado","orcid":"https://orcid.org/0000-0001-5483-9424"},"institutions":[{"id":"https://openalex.org/I200284239","display_name":"Universidade de Santiago de Compostela","ror":"https://ror.org/030eybx10","country_code":"ES","type":"education","lineage":["https://openalex.org/I200284239"]},{"id":"https://openalex.org/I4210111807","display_name":"Center for Research in Molecular Medicine and Chronic Diseases","ror":"https://ror.org/0280bnq76","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210111807"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Manuel Fern\u00e1ndez-Delgado","raw_affiliation_strings":["Centro Singular de Investigaci\u00f3n en Tecnolox\u00edas Intelixentes da USC (CiTIUS) Universidade de Santiago de Compostela, R\u00faa Xenaro de la Fuente Dom\u00ednguez, Santiago de Compostela, Spain"],"raw_orcid":"https://orcid.org/0000-0001-5483-9424","affiliations":[{"raw_affiliation_string":"Centro Singular de Investigaci\u00f3n en Tecnolox\u00edas Intelixentes da USC (CiTIUS) Universidade de Santiago de Compostela, R\u00faa Xenaro de la Fuente Dom\u00ednguez, Santiago de Compostela, Spain","institution_ids":["https://openalex.org/I4210111807","https://openalex.org/I200284239"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071943932","display_name":"Miguel A. Garc\u00eda-Gonz\u00e1lez","orcid":"https://orcid.org/0000-0002-4330-7200"},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"funder","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210123801","display_name":"Fundaci\u00f3n P\u00fablica Galega de Medicina Xen\u00f3mica","ror":"https://ror.org/025h0r574","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210123801"]},{"id":"https://openalex.org/I4210148771","display_name":"Instituto de Investigaci\u00f3n Sanitaria de Santiago","ror":"https://ror.org/05n7xcf53","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210148771"]},{"id":"https://openalex.org/I4210158352","display_name":"Servicio Gallego de Salud","ror":"https://ror.org/0591s4t67","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158352"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Miguel A. Garc\u00eda-Gonz\u00e1lez","raw_affiliation_strings":["Fundaci\u00f3n P\u00fablica Galega de Medicina Xen\u00f3mica-SERGAS, Complexo Hospitalario de Santiago de Compostela (CHUS), Santiago de Compostela, Spain","Grupo de Medicina Xen\u00f3mica, Complexo Hospitalario de Santiago de Compostela (CHUS), Santiago de Compostela, Spain","Grupo de Xen\u00e9tica e Biolox\u00eda do Desenvolvemento das Enfermidades Renais, Laboratorio de Nefrolox\u00eda (No. 11), Instituto de Investigaci\u00f3n Sanitaria de Santiago (IDIS), Complexo Hospitalario de Santiago de Compostela (CHUS), Santiago de Compostela, Spain","RedInRen RETIC, ISCIII, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fundaci\u00f3n P\u00fablica Galega de Medicina Xen\u00f3mica-SERGAS, Complexo Hospitalario de Santiago de Compostela (CHUS), Santiago de Compostela, Spain","institution_ids":["https://openalex.org/I4210123801","https://openalex.org/I4210158352"]},{"raw_affiliation_string":"Grupo de Medicina Xen\u00f3mica, Complexo Hospitalario de Santiago de Compostela (CHUS), Santiago de Compostela, Spain","institution_ids":[]},{"raw_affiliation_string":"Grupo de Xen\u00e9tica e Biolox\u00eda do Desenvolvemento das Enfermidades Renais, Laboratorio de Nefrolox\u00eda (No. 11), Instituto de Investigaci\u00f3n Sanitaria de Santiago (IDIS), Complexo Hospitalario de Santiago de Compostela (CHUS), Santiago de Compostela, Spain","institution_ids":["https://openalex.org/I4210148771"]},{"raw_affiliation_string":"RedInRen RETIC, ISCIII, Spain","institution_ids":["https://openalex.org/I2801357902"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5071943932","https://openalex.org/A5074509766"],"corresponding_institution_ids":["https://openalex.org/I200284239","https://openalex.org/I2801357902","https://openalex.org/I4210111807","https://openalex.org/I4210123801","https://openalex.org/I4210148771","https://openalex.org/I4210158352"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.6216,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.84577249,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"16","issue":"10","first_page":"e1008337","last_page":"e1008337"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.9793000221252441,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11174","display_name":"Pediatric Urology and Nephrology Studies","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyst","display_name":"Cyst","score":0.6533865928649902},{"id":"https://openalex.org/keywords/polycystic-kidney-disease","display_name":"Polycystic kidney disease","score":0.5889805555343628},{"id":"https://openalex.org/keywords/polycystic-liver-disease","display_name":"Polycystic liver disease","score":0.5058881640434265},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.491931676864624},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.47987642884254456},{"id":"https://openalex.org/keywords/cystic-kidney-disease","display_name":"Cystic kidney disease","score":0.4663960337638855},{"id":"https://openalex.org/keywords/thresholding","display_name":"Thresholding","score":0.45585498213768005},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.414531946182251},{"id":"https://openalex.org/keywords/liver-disease","display_name":"Liver disease","score":0.4132780432701111},{"id":"https://openalex.org/keywords/biomarker","display_name":"Biomarker","score":0.41174018383026123},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.367287814617157},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3312211334705353},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3032987713813782},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.25087517499923706},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.20836728811264038},{"id":"https://openalex.org/keywords/image","display_name":"Image (mathematics)","score":0.09548506140708923},{"id":"https://openalex.org/keywords/transplantation","display_name":"Transplantation","score":0.07848381996154785}],"concepts":[{"id":"https://openalex.org/C2780597408","wikidata":"https://www.wikidata.org/wiki/Q193211","display_name":"Cyst","level":2,"score":0.6533865928649902},{"id":"https://openalex.org/C2780145431","wikidata":"https://www.wikidata.org/wiki/Q15443105","display_name":"Polycystic kidney disease","level":3,"score":0.5889805555343628},{"id":"https://openalex.org/C2780021040","wikidata":"https://www.wikidata.org/wiki/Q246002","display_name":"Polycystic liver disease","level":4,"score":0.5058881640434265},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.491931676864624},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.47987642884254456},{"id":"https://openalex.org/C2780337666","wikidata":"https://www.wikidata.org/wiki/Q5201211","display_name":"Cystic kidney disease","level":3,"score":0.4663960337638855},{"id":"https://openalex.org/C191178318","wikidata":"https://www.wikidata.org/wiki/Q2256906","display_name":"Thresholding","level":3,"score":0.45585498213768005},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.414531946182251},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.4132780432701111},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.41174018383026123},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.367287814617157},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3312211334705353},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3032987713813782},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.25087517499923706},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20836728811264038},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.09548506140708923},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.07848381996154785},{"id":"https://openalex.org/C2779609443","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Liver transplantation","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003560","descriptor_name":"Cysts","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D003560","descriptor_name":"Cysts","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D003560","descriptor_name":"Cysts","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D003560","descriptor_name":"Cysts","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D003560","descriptor_name":"Cysts","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D003560","descriptor_name":"Cysts","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D003560","descriptor_name":"Cysts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003560","descriptor_name":"Cysts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003560","descriptor_name":"Cysts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006651","descriptor_name":"Histocytochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006651","descriptor_name":"Histocytochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006651","descriptor_name":"Histocytochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007690","descriptor_name":"Polycystic Kidney Diseases","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D007690","descriptor_name":"Polycystic Kidney Diseases","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D007690","descriptor_name":"Polycystic Kidney Diseases","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D007690","descriptor_name":"Polycystic Kidney Diseases","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D007690","descriptor_name":"Polycystic Kidney Diseases","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D007690","descriptor_name":"Polycystic Kidney Diseases","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D007690","descriptor_name":"Polycystic Kidney Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007690","descriptor_name":"Polycystic Kidney Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007690","descriptor_name":"Polycystic Kidney Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1008337","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008337","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008337&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:33090995","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33090995","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:d2df838b583e4c88821ec175d2a1444e","is_oa":true,"landing_page_url":"https://doaj.org/article/d2df838b583e4c88821ec175d2a1444e","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 16, Iss 10, p e1008337 (2020)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7608985","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7608985","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1008337","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008337","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008337&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4699999988079071,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G2082234138","display_name":null,"funder_award_id":"IN607B","funder_id":"https://openalex.org/F4320326655","funder_display_name":"Xunta de Galicia"},{"id":"https://openalex.org/G2312131674","display_name":null,"funder_award_id":"RD016/0009","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G2620658983","display_name":null,"funder_award_id":"PI11/","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G2693503634","display_name":null,"funder_award_id":"INB607-2019","funder_id":"https://openalex.org/F4320316148","funder_display_name":"Sociedad Espa\u00f1ola de Nefrolog\u00eda"},{"id":"https://openalex.org/G3383717794","display_name":null,"funder_award_id":"PI18/0037","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G3894869924","display_name":null,"funder_award_id":"N607B-2016/020","funder_id":"https://openalex.org/F4320316148","funder_display_name":"Sociedad Espa\u00f1ola de Nefrolog\u00eda"},{"id":"https://openalex.org/G3904215241","display_name":null,"funder_award_id":"PI11/00690","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G4074276006","display_name":null,"funder_award_id":"IN607B-2016/020","funder_id":"https://openalex.org/F4320326655","funder_display_name":"Xunta de Galicia"},{"id":"https://openalex.org/G4336889254","display_name":null,"funder_award_id":"DOG n\u00b0 122 de 2016/6/29 - Xunta de Galicia","funder_id":"https://openalex.org/F4320326633","funder_display_name":"Axencia Galega de Innovaci\u00f3n"},{"id":"https://openalex.org/G5221841855","display_name":null,"funder_award_id":"ccreditation 2019-2022 ED431G-2019/04","funder_id":"https://openalex.org/F4320326655","funder_display_name":"Xunta de Galicia"},{"id":"https://openalex.org/G970449324","display_name":null,"funder_award_id":"PI15/01467","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"}],"funders":[{"id":"https://openalex.org/F4320316148","display_name":"Sociedad Espa\u00f1ola de Nefrolog\u00eda","ror":null},{"id":"https://openalex.org/F4320326633","display_name":"Axencia Galega de Innovaci\u00f3n","ror":"https://ror.org/02vcxyt85"},{"id":"https://openalex.org/F4320326655","display_name":"Xunta de Galicia","ror":"https://ror.org/0181xnw06"},{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3093947647.pdf","grobid_xml":"https://content.openalex.org/works/W3093947647.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W172711948","https://openalex.org/W1411640090","https://openalex.org/W1676738208","https://openalex.org/W1977697731","https://openalex.org/W1981631546","https://openalex.org/W1989864848","https://openalex.org/W1994746887","https://openalex.org/W2000538799","https://openalex.org/W2010311664","https://openalex.org/W2020888723","https://openalex.org/W2065429801","https://openalex.org/W2085346322","https://openalex.org/W2089042234","https://openalex.org/W2090831751","https://openalex.org/W2106182995","https://openalex.org/W2106525823","https://openalex.org/W2110258634","https://openalex.org/W2110452525","https://openalex.org/W2127325275","https://openalex.org/W2132115473","https://openalex.org/W2135100794","https://openalex.org/W2143108257","https://openalex.org/W2153635508","https://openalex.org/W2163352848","https://openalex.org/W2169316465","https://openalex.org/W2190376035","https://openalex.org/W2212083730","https://openalex.org/W2223529392","https://openalex.org/W2252211299","https://openalex.org/W2312175723","https://openalex.org/W2393484866","https://openalex.org/W2467731011","https://openalex.org/W2528623852","https://openalex.org/W2586637063","https://openalex.org/W2588834240","https://openalex.org/W2771431842","https://openalex.org/W2889535805","https://openalex.org/W2890311099","https://openalex.org/W2945570232","https://openalex.org/W2998768810","https://openalex.org/W3093243321"],"related_works":["https://openalex.org/W2322739447","https://openalex.org/W3202932073","https://openalex.org/W2415309267","https://openalex.org/W2059301963","https://openalex.org/W2024067296","https://openalex.org/W2127737900","https://openalex.org/W2222288027","https://openalex.org/W2001137596","https://openalex.org/W2069442512","https://openalex.org/W2907334011"],"abstract_inverted_index":{"The":[0,44,265],"Polycystic":[1,17],"Kidney":[2],"Disease":[3,19],"(PKD)":[4],"is":[5,50,83,99,331],"characterized":[6],"by":[7,81,131,164,275,346],"progressive":[8],"renal":[9],"cyst":[10,215],"development":[11],"and":[12,39,55,60,75,170,192,214,227,267,285,291,296,298,316,335,365],"other":[13],"extrarenal":[14],"manifestation":[15],"including":[16,208],"Liver":[18],"(PLD).":[20],"Phenotypical":[21],"characterization":[22],"of":[23,47,53,72,77,88,109,117,136,145,212,269,272,283,314,321,344,350],"animal":[24],"models":[25],"mimicking":[26],"human":[27,59],"diseases":[28],"are":[29],"commonly":[30,103],"used,":[31],"in":[32,57,247,304],"order":[33,218],"to,":[34],"study":[35,328],"new":[36,41,159,308,333],"molecular":[37],"mechanisms":[38,90],"identify":[40],"therapeutic":[42],"approaches.":[43],"main":[45],"biomarker":[46],"disease":[48,345],"progression":[49],"total":[51],"volume":[52],"kidney":[54,295],"liver":[56,228],"both":[58],"mouse,":[61],"which":[62],"correlates":[63],"with":[64,181,288],"organ":[65,284],"function.":[66],"For":[67],"this":[68,95],"reason,":[69],"the":[70,73,78,86,92,107,110,114,128,133,195,221,255,270,276,281,294,301,312,322,342],"estimation":[71],"number":[74,211,271,313],"area":[76],"tissue":[79],"occupied":[80],"cysts,":[82],"critical":[84],"for":[85,254,293,300,310,340,353,367],"understanding":[87],"physiological":[89],"underlying":[91],"disease.":[93,111],"In":[94,217],"regard,":[96],"cystic":[97,129,134,206,209,225,240,261,286,323,351],"index":[98,130,241,324],"a":[100,123,158,182,205,307,317,332],"robust":[101,334],"parameter":[102],"used":[104],"to":[105,126,150,190,203,219,257],"quantify":[106],"severity":[108,343],"To":[112],"date,":[113],"vast":[115],"majority":[116],"biomedical":[118,355],"researchers":[119],"use":[120],"ImageJ":[121],"as":[122],"software":[124,338],"tool":[125,142,309,339],"estimate":[127],"quantifying":[132,347],"areas":[135],"histological":[137,229,348],"images":[138,230,349],"after":[139],"thresholding.":[140],"This":[141,327],"has":[143],"imitations":[144],"being":[146],"inaccurate,":[147],"largely":[148],"due":[149],"incorrectly":[151],"identifying":[152],"non-cystic":[153,263],"regions.":[154,264],"We":[155],"have":[156],"developed":[157],"software,":[160,223],"named":[161],"CystAnalyser":[162,200,222,234,330,357],"(register":[163],"Universidade":[165],"de":[166,168,174],"Santiago":[167],"Compostela-USC,":[169],"Fundaci\u00f3n":[171],"Investigaci\u00f3n":[172],"Sanitaria":[173],"Santiago-FIDIS),":[175],"that":[176,187],"combines":[177],"automatic":[178,277],"image":[179,196],"processing":[180,197],"graphical":[183],"user":[184,244,256],"friendly":[185],"interface":[186],"allows":[188],"investigators":[189],"oversee":[191],"easily":[193],"correct":[194],"before":[198],"quantification.":[199],"was":[201,252],"able":[202],"generate":[204],"profile":[207],"index,":[210],"cysts":[213,273,315],"size.":[216],"test":[220],"795":[224],"kidney,":[226],"were":[231,236],"analyzed.":[232],"Using":[233],"there":[235],"no":[237],"differences":[238],"calculating":[239],"automatically":[242],"versus":[243],"input,":[245],"except":[246],"specific":[248,319],"circumstances":[249],"where":[250],"it":[251],"necessary":[253],"distinguish":[258],"between":[259],"mildly":[260],"from":[262,361],"sensitivity":[266],"specificity":[268],"detected":[274],"quantification":[278],"depends":[279],"on":[280],"type":[282],"severity,":[287],"values":[289],"76.84-78.59%":[290],"76.96-89.66%":[292],"87.29-93.80%":[297],"63.42-86.07%":[299],"liver.":[302],"CystAnalyser,":[303],"addition,":[305],"provides":[306],"estimating":[311],"more":[318],"measure":[320],"than":[325],"ImageJ.":[326],"proposes":[329],"freely":[336],"downloadable":[337],"analyzing":[341],"organs":[352],"routine":[354],"research.":[356],"can":[358],"be":[359],"downloaded":[360],"https://citius.usc.es/transferencia/software/cystanalyser":[362],"(for":[363],"Windows":[364],"Linux)":[366],"research":[368],"purposes.":[369]},"counts_by_year":[{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}
