{"id":"https://openalex.org/W3091051496","doi":"https://doi.org/10.1371/journal.pcbi.1008296","title":"Mutation bias interacts with composition bias to influence adaptive evolution","display_name":"Mutation bias interacts with composition bias to influence adaptive evolution","publication_year":2020,"publication_date":"2020-09-28","ids":{"openalex":"https://openalex.org/W3091051496","doi":"https://doi.org/10.1371/journal.pcbi.1008296","mag":"3091051496","pmid":"https://pubmed.ncbi.nlm.nih.gov/32986712"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1008296","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008296","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1008296","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038273569","display_name":"Alejandro V. Cano","orcid":"https://orcid.org/0000-0003-4728-8489"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Alejandro V. Cano","raw_affiliation_strings":["Institute of Integrative Biology, ETH, Zurich, Switzerland","Swiss Institute of Bioinformatics, Lausanne, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-4728-8489","affiliations":[{"raw_affiliation_string":"Institute of Integrative Biology, ETH, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"Swiss Institute of Bioinformatics, Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074476792","display_name":"Joshua L. Payne","orcid":"https://orcid.org/0000-0002-2978-8423"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Joshua L. Payne","raw_affiliation_strings":["Institute of Integrative Biology, ETH, Zurich, Switzerland","Swiss Institute of Bioinformatics, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Integrative Biology, ETH, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"Swiss Institute of Bioinformatics, Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5074476792"],"corresponding_institution_ids":["https://openalex.org/I12708293","https://openalex.org/I35440088"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2230,"currency":"EUR","value_usd":2405},"fwci":3.9638,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.93949319,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"16","issue":"9","first_page":"e1008296","last_page":"e1008296"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9954000115394592,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.994700014591217,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/composition","display_name":"Composition (language)","score":0.5424313545227051},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.4615045189857483},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3819127082824707},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3316706418991089},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.15076914429664612}],"concepts":[{"id":"https://openalex.org/C40231798","wikidata":"https://www.wikidata.org/wiki/Q1333743","display_name":"Composition (language)","level":2,"score":0.5424313545227051},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4615045189857483},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3819127082824707},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3316706418991089},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15076914429664612},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1008296","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008296","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:32986712","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32986712","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:08246e0d6e2f498397142e53875a0a5b","is_oa":true,"landing_page_url":"https://doaj.org/article/08246e0d6e2f498397142e53875a0a5b","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 16, Iss 9, p e1008296 (2020)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7571706","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7571706","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1008296","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008296","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.49000000953674316,"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land"}],"awards":[{"id":"https://openalex.org/G1462378961","display_name":null,"funder_award_id":"PP00P3_17060","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G1893454185","display_name":null,"funder_award_id":"PP00P3_170604","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":72,"referenced_works":["https://openalex.org/W1857209124","https://openalex.org/W1952115120","https://openalex.org/W1964778231","https://openalex.org/W1969857637","https://openalex.org/W1982379208","https://openalex.org/W1983658594","https://openalex.org/W1989298969","https://openalex.org/W1992613346","https://openalex.org/W1994122295","https://openalex.org/W2002964220","https://openalex.org/W2003393395","https://openalex.org/W2008543278","https://openalex.org/W2012354488","https://openalex.org/W2033169664","https://openalex.org/W2034525444","https://openalex.org/W2035654977","https://openalex.org/W2042392223","https://openalex.org/W2045362835","https://openalex.org/W2047919241","https://openalex.org/W2054981017","https://openalex.org/W2078059415","https://openalex.org/W2088791835","https://openalex.org/W2089806726","https://openalex.org/W2105557836","https://openalex.org/W2105694586","https://openalex.org/W2115622704","https://openalex.org/W2123089649","https://openalex.org/W2126643167","https://openalex.org/W2138843850","https://openalex.org/W2146222452","https://openalex.org/W2148972293","https://openalex.org/W2150172942","https://openalex.org/W2151784676","https://openalex.org/W2152061559","https://openalex.org/W2153367920","https://openalex.org/W2153561273","https://openalex.org/W2161849959","https://openalex.org/W2167202109","https://openalex.org/W2168338628","https://openalex.org/W2178598518","https://openalex.org/W2270152626","https://openalex.org/W2308616703","https://openalex.org/W2336101408","https://openalex.org/W2357558255","https://openalex.org/W2379594833","https://openalex.org/W2398070776","https://openalex.org/W2508444502","https://openalex.org/W2572573235","https://openalex.org/W2616463610","https://openalex.org/W2622319469","https://openalex.org/W2684381243","https://openalex.org/W2766872892","https://openalex.org/W2791405408","https://openalex.org/W2796625107","https://openalex.org/W2797104734","https://openalex.org/W2800231751","https://openalex.org/W2806410943","https://openalex.org/W2890052694","https://openalex.org/W2890595259","https://openalex.org/W2898806520","https://openalex.org/W2902290256","https://openalex.org/W2905701416","https://openalex.org/W2922480775","https://openalex.org/W2944831967","https://openalex.org/W2946722611","https://openalex.org/W2950760001","https://openalex.org/W2951701224","https://openalex.org/W2967059818","https://openalex.org/W2981638144","https://openalex.org/W2991283314","https://openalex.org/W3101328213","https://openalex.org/W4251916321"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189","https://openalex.org/W2146849562","https://openalex.org/W2028961943"],"abstract_inverted_index":{"Mutation":[0],"is":[1,94,152],"a":[2,51,103,115,127,133,140],"biased":[3],"stochastic":[4],"process,":[5],"with":[6,171],"some":[7],"types":[8,108],"of":[9,40,46,58,64,100,109,132,136,154,189,201],"mutations":[10,110],"occurring":[11],"more":[12],"frequently":[13],"than":[14],"others.":[15],"Previous":[16],"work":[17],"has":[18],"used":[19],"synthetic":[20],"genotype-phenotype":[21,37,71],"landscapes":[22,124],"to":[23,50,54,75,118,139],"study":[24,55],"how":[25,183],"such":[26,184,192],"mutation":[27,59,137,159,175],"bias":[28,60,156,169],"affects":[29],"adaptive":[30,62,120,190],"evolution.":[31],"Here,":[32],"we":[33,73],"consider":[34],"746":[35],"empirical":[36,70],"landscapes,":[38,72],"each":[39,89],"which":[41,167],"describes":[42],"the":[43,56,85,98,107,158,164,174,199],"binding":[44,66],"affinity":[45],"target":[47],"DNA":[48,86],"sequences":[49,87,101],"transcription":[52],"factor,":[53],"influence":[57],"on":[61],"evolution":[63,200],"increased":[65],"affinity.":[67],"By":[68],"using":[69],"need":[74],"make":[76],"only":[77],"few":[78],"assumptions":[79],"about":[80,84],"landscape":[81,90,104,146],"topography":[82],"and":[83,182,204],"that":[88,102,111],"contains.":[91],"The":[92],"latter":[93],"particularly":[95],"important":[96],"because":[97],"set":[99],"contains":[105],"determines":[106],"can":[112,125],"occur":[113],"along":[114,148],"mutational":[116,150,205],"path":[117],"an":[119,144],"peak.":[121],"That":[122],"is,":[123],"exhibit":[126],"composition":[128,168],"bias-a":[129],"statistical":[130],"enrichment":[131],"particular":[134,149],"type":[135],"relative":[138],"null":[141],"expectation,":[142],"throughout":[143],"entire":[145],"or":[147],"paths-that":[151],"independent":[153],"any":[155],"in":[157,166,173],"process.":[160],"Our":[161],"results":[162],"reveal":[163],"way":[165],"interacts":[170],"biases":[172],"process":[176],"under":[177],"different":[178],"population":[179],"genetic":[180,202],"conditions,":[181],"interaction":[185],"impacts":[186],"fundamental":[187],"properties":[188],"evolution,":[191],"as":[193,196,198],"its":[194],"predictability,":[195],"well":[197],"diversity":[203],"robustness.":[206]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}