{"id":"https://openalex.org/W3085090957","doi":"https://doi.org/10.1371/journal.pcbi.1008202","title":"Kinetic modeling of H2O2 dynamics in the mitochondria of HeLa cells","display_name":"Kinetic modeling of H2O2 dynamics in the mitochondria of HeLa cells","publication_year":2020,"publication_date":"2020-09-14","ids":{"openalex":"https://openalex.org/W3085090957","doi":"https://doi.org/10.1371/journal.pcbi.1008202","mag":"3085090957","pmid":"https://pubmed.ncbi.nlm.nih.gov/32925922"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1008202","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008202","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1008202","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075900136","display_name":"Kassi T. Stein","orcid":null},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kassi T. Stein","raw_affiliation_strings":["Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-1033-2899","affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States of America","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051016783","display_name":"Sun Jin Moon","orcid":"https://orcid.org/0000-0003-0714-5125"},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sun Jin Moon","raw_affiliation_strings":["Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-0714-5125","affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States of America","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075183999","display_name":"Athena N. Nguyen","orcid":"https://orcid.org/0000-0001-6779-1159"},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Athena N. Nguyen","raw_affiliation_strings":["Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-6779-1159","affiliations":[{"raw_affiliation_string":"Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States of America","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049698973","display_name":"Hadley D. Sikes","orcid":null},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hadley D. Sikes","raw_affiliation_strings":["Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-7096-138X","affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States of America","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5049698973"],"corresponding_institution_ids":["https://openalex.org/I63966007"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.4212,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.81515192,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"16","issue":"9","first_page":"e1008202","last_page":"e1008202"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hela","display_name":"HeLa","score":0.7798791527748108},{"id":"https://openalex.org/keywords/mitochondrion","display_name":"Mitochondrion","score":0.5445407629013062},{"id":"https://openalex.org/keywords/dynamics","display_name":"Dynamics (music)","score":0.5418965816497803},{"id":"https://openalex.org/keywords/kinetic-energy","display_name":"Kinetic energy","score":0.5142276287078857},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.46822401881217957},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.46443256735801697},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.38823315501213074},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.38052332401275635},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.356319785118103},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.31695061922073364},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.24411216378211975},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.20228847861289978},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.1657564342021942}],"concepts":[{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.7798791527748108},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5445407629013062},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.5418965816497803},{"id":"https://openalex.org/C135889238","wikidata":"https://www.wikidata.org/wiki/Q46276","display_name":"Kinetic energy","level":2,"score":0.5142276287078857},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.46822401881217957},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46443256735801697},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38823315501213074},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38052332401275635},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.356319785118103},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31695061922073364},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24411216378211975},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.20228847861289978},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.1657564342021942},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1008202","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008202","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:32925922","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32925922","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:e94eb91d5e5a445ba66241a27cefa7dd","is_oa":true,"landing_page_url":"https://doaj.org/article/e94eb91d5e5a445ba66241a27cefa7dd","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 16, Iss 9, p e1008202 (2020)","raw_type":"article"},{"id":"pmh:oai:dspace.mit.edu:1721.1/135222","is_oa":true,"landing_page_url":"https://hdl.handle.net/1721.1/135222","pdf_url":null,"source":{"id":"https://openalex.org/S4306400425","display_name":"DSpace@MIT (Massachusetts Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I63966007","host_organization_name":"Massachusetts Institute of Technology","host_organization_lineage":["https://openalex.org/I63966007"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS","raw_type":"http://purl.org/eprint/type/JournalArticle"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1008202","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008202","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":81,"referenced_works":["https://openalex.org/W122110278","https://openalex.org/W769987918","https://openalex.org/W1504571050","https://openalex.org/W1582734710","https://openalex.org/W1609496572","https://openalex.org/W1872295493","https://openalex.org/W1957064683","https://openalex.org/W1963558489","https://openalex.org/W1968095645","https://openalex.org/W1970818338","https://openalex.org/W1971585037","https://openalex.org/W1974838099","https://openalex.org/W1984387620","https://openalex.org/W1985448020","https://openalex.org/W1991482163","https://openalex.org/W1991952977","https://openalex.org/W1993058298","https://openalex.org/W1994025158","https://openalex.org/W1996061215","https://openalex.org/W1998655683","https://openalex.org/W2001735644","https://openalex.org/W2001830362","https://openalex.org/W2002449018","https://openalex.org/W2002490399","https://openalex.org/W2006925676","https://openalex.org/W2009304280","https://openalex.org/W2011399604","https://openalex.org/W2019560775","https://openalex.org/W2026225426","https://openalex.org/W2027107445","https://openalex.org/W2029996404","https://openalex.org/W2037083980","https://openalex.org/W2040856926","https://openalex.org/W2047869666","https://openalex.org/W2049599781","https://openalex.org/W2051902906","https://openalex.org/W2056813366","https://openalex.org/W2060308976","https://openalex.org/W2065693787","https://openalex.org/W2081519457","https://openalex.org/W2085869920","https://openalex.org/W2086196945","https://openalex.org/W2087598382","https://openalex.org/W2088066082","https://openalex.org/W2088161908","https://openalex.org/W2091857499","https://openalex.org/W2092163817","https://openalex.org/W2094510532","https://openalex.org/W2101032933","https://openalex.org/W2103665725","https://openalex.org/W2103828946","https://openalex.org/W2108834847","https://openalex.org/W2110997472","https://openalex.org/W2112268703","https://openalex.org/W2132878122","https://openalex.org/W2133966054","https://openalex.org/W2135418090","https://openalex.org/W2138145411","https://openalex.org/W2140578136","https://openalex.org/W2147080431","https://openalex.org/W2170347547","https://openalex.org/W2180760460","https://openalex.org/W2203317814","https://openalex.org/W2266089591","https://openalex.org/W2281109239","https://openalex.org/W2319499784","https://openalex.org/W2418148234","https://openalex.org/W2419532700","https://openalex.org/W2461148724","https://openalex.org/W2499479787","https://openalex.org/W2568510753","https://openalex.org/W2613209849","https://openalex.org/W2624338235","https://openalex.org/W2747696521","https://openalex.org/W2768089081","https://openalex.org/W2790401034","https://openalex.org/W2811404035","https://openalex.org/W2888340233","https://openalex.org/W2894601652","https://openalex.org/W2923317642","https://openalex.org/W3028885196"],"related_works":["https://openalex.org/W2319590788","https://openalex.org/W2373307992","https://openalex.org/W2357943637","https://openalex.org/W2372231441","https://openalex.org/W2375824005","https://openalex.org/W2350526420","https://openalex.org/W2381761676","https://openalex.org/W2350373849","https://openalex.org/W2361676330","https://openalex.org/W2350990105"],"abstract_inverted_index":{"Hydrogen":[0],"peroxide":[1],"(H2O2)":[2],"promotes":[3],"a":[4,40,59,90,233],"range":[5,156,234],"of":[6,32,43,79,93,124,168,173,209,216,235,246,279,287],"phenotypes":[7],"depending":[8],"on":[9,164],"its":[10,127],"intracellular":[11,44],"concentration":[12],"and":[13,29,76,96,102,113,121,126,159,218,260],"dosing":[14],"kinetics,":[15],"including":[16],"cell":[17,61],"death.":[18],"While":[19],"this":[20,94],"qualitative":[21],"relationship":[22],"has":[23],"been":[24,48],"well":[25,187],"established,":[26],"the":[27,80,108,153,165,176,178,200,249,252,292],"quantitative":[28,111],"mechanistic":[30,77],"aspects":[31],"H2O2":[33,56,82,125,149,174,190,238,247,280],"signaling":[34],"are":[35],"still":[36],"being":[37],"elucidated.":[38],"Mitochondria,":[39],"putative":[41],"source":[42],"H2O2,":[45],"have":[46],"recently":[47],"demonstrated":[49,222],"to":[50,54,66,72,99,117,138,175,184,189,206,251,276],"be":[51,151,161,204],"particularly":[52],"vulnerable":[53],"localized":[55],"perturbations,":[57],"eliciting":[58],"dramatic":[60],"death":[62],"response":[63],"in":[64,85,152],"comparison":[65],"similar":[67],"cytosolic":[68],"perturbations.":[69],"We":[70,143],"sought":[71],"improve":[73],"our":[74],"dynamic":[75],"understanding":[78],"mitochondrial":[81,148,179],"reaction":[83,119,128,180],"network":[84,181],"HeLa":[86],"cells":[87],"by":[88,256],"creating":[89],"kinetic":[91,114],"model":[92,106,268,285],"system":[95,202],"using":[97,269],"it":[98],"explore":[100,277],"basal":[101],"perturbed":[103,237],"conditions.":[104],"The":[105],"uses":[107],"most":[109],"current":[110],"proteomic":[112],"data":[115],"available":[116],"predict":[118,144],"rates":[120,192,278],"steady-state":[122,147],"concentrations":[123],"partners":[129],"within":[130],"individual":[131],"mitochondria.":[132],"Time":[133],"scales":[134],"ranging":[135],"from":[136,248],"milliseconds":[137],"one":[139],"hour":[140],"were":[141],"simulated.":[142],"that":[145,282],"basal,":[146],"will":[150,160],"low":[154],"nM":[155],"(2-4":[157],"nM)":[158],"inversely":[162],"dependent":[163],"total":[166],"pool":[167],"peroxiredoxin-3":[169],"(Prx3).":[170],"Neglecting":[171],"efflux":[172,245,281],"cytosol,":[177],"is":[182],"expected":[183,205],"control":[185],"perturbations":[186],"up":[188],"generation":[191,239],"~50":[193],"\u03bcM/s":[194],"(0.25":[195],"nmol/mg-protein/s),":[196],"above":[197],"which":[198],"point":[199],"Prx3":[201,217,261,288],"would":[203],"collapse.":[207],"Comparison":[208],"these":[210],"results":[211],"with":[212,291],"redox":[213],"Western":[214],"blots":[215],"Prx2":[219],"oxidation":[220,289],"states":[221,290],"reasonable":[223],"trend":[224],"agreement":[225],"at":[226],"short":[227],"times":[228],"(\u2264":[229],"15":[230],"min)":[231],"for":[232],"experimentally":[236],"rates.":[240],"At":[241],"longer":[242],"times,":[243],"substantial":[244],"mitochondria":[250],"cytosol":[253],"was":[254,263,274],"evidenced":[255],"peroxiredoxin-2":[257],"(Prx2)":[258],"oxidation,":[259],"collapse":[262],"not":[264],"observed.":[265],"A":[266],"refined":[267],"Monte":[270],"Carlo":[271],"parameter":[272],"sampling":[273],"used":[275],"could":[283],"reconcile":[284],"predictions":[286],"experimental":[293],"observations.":[294]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}