{"id":"https://openalex.org/W3084995528","doi":"https://doi.org/10.1371/journal.pcbi.1008193","title":"NuSeT: A deep learning tool for reliably separating and analyzing crowded cells","display_name":"NuSeT: A deep learning tool for reliably separating and analyzing crowded cells","publication_year":2020,"publication_date":"2020-09-14","ids":{"openalex":"https://openalex.org/W3084995528","doi":"https://doi.org/10.1371/journal.pcbi.1008193","mag":"3084995528","pmid":"https://pubmed.ncbi.nlm.nih.gov/32925919"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1008193","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008193","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008193&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008193&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115603725","display_name":"Linfeng Yang","orcid":"https://orcid.org/0000-0002-4373-8983"},"institutions":[{"id":"https://openalex.org/I4390039303","display_name":"Stanford Cancer Institute","ror":"https://ror.org/014qe3j22","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4390039303","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linfeng Yang","raw_affiliation_strings":["BioX Institute, Stanford University, Stanford, CA, United States of America","Bioengineering, Stanford University, Stanford, CA, United States of America","Cell Biology Division, Stanford Cancer Institute, Stanford, CA, United States of America","ChEM-H, Stanford University, Stanford, CA, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioX Institute, Stanford University, Stanford, CA, United States of America","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Bioengineering, Stanford University, Stanford, CA, United States of America","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Cell Biology Division, Stanford Cancer Institute, Stanford, CA, United States of America","institution_ids":["https://openalex.org/I4390039303"]},{"raw_affiliation_string":"ChEM-H, Stanford University, Stanford, CA, United States of America","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055261141","display_name":"Rajarshi P. Ghosh","orcid":"https://orcid.org/0000-0002-0020-6194"},"institutions":[{"id":"https://openalex.org/I4390039303","display_name":"Stanford Cancer Institute","ror":"https://ror.org/014qe3j22","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4390039303","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rajarshi P. Ghosh","raw_affiliation_strings":["BioX Institute, Stanford University, Stanford, CA, United States of America","Bioengineering, Stanford University, Stanford, CA, United States of America","Cell Biology Division, Stanford Cancer Institute, Stanford, CA, United States of America","ChEM-H, Stanford University, Stanford, CA, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-0020-6194","affiliations":[{"raw_affiliation_string":"BioX Institute, Stanford University, Stanford, CA, United States of America","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Bioengineering, Stanford University, Stanford, CA, United States of America","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Cell Biology Division, Stanford Cancer Institute, Stanford, CA, United States of America","institution_ids":["https://openalex.org/I4390039303"]},{"raw_affiliation_string":"ChEM-H, Stanford University, Stanford, CA, United States of America","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049775493","display_name":"James Franklin","orcid":"https://orcid.org/0000-0002-0316-3177"},"institutions":[{"id":"https://openalex.org/I4390039303","display_name":"Stanford Cancer Institute","ror":"https://ror.org/014qe3j22","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4390039303","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Matthew Franklin","raw_affiliation_strings":["BioX Institute, Stanford University, Stanford, CA, United States of America","Bioengineering, Stanford University, Stanford, CA, United States of America","Cell Biology Division, Stanford Cancer Institute, Stanford, CA, United States of America","ChEM-H, Stanford University, Stanford, CA, United States of America","Chemical Engineering, Stanford University, Stanford, CA, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioX Institute, Stanford University, Stanford, CA, United States of America","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Bioengineering, Stanford University, Stanford, CA, United States of America","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Cell Biology Division, Stanford Cancer Institute, Stanford, CA, United States of America","institution_ids":["https://openalex.org/I4390039303"]},{"raw_affiliation_string":"ChEM-H, Stanford University, Stanford, CA, United States of America","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Chemical Engineering, Stanford University, Stanford, CA, United States of America","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101680106","display_name":"Simon Chen","orcid":"https://orcid.org/0000-0003-0409-5978"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simon Chen","raw_affiliation_strings":["Department of Pathology, Stanford University School of Medicine, Stanford, CA, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-0409-5978","affiliations":[{"raw_affiliation_string":"Department of Pathology, Stanford University School of Medicine, Stanford, CA, United States of America","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076320750","display_name":"Chenyu You","orcid":"https://orcid.org/0000-0001-8365-7822"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chenyu You","raw_affiliation_strings":["Electrical Engineering, Stanford University, Stanford, CA, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-8365-7822","affiliations":[{"raw_affiliation_string":"Electrical Engineering, Stanford University, Stanford, CA, United States of America","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056521594","display_name":"Raja R. Narayan","orcid":"https://orcid.org/0000-0001-7938-4702"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raja R. Narayan","raw_affiliation_strings":["Department of Surgery, Stanford University School of Medicine, Stanford, CA, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-7938-4702","affiliations":[{"raw_affiliation_string":"Department of Surgery, Stanford University School of Medicine, Stanford, CA, United States of America","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083189199","display_name":"Marc L. Melcher","orcid":"https://orcid.org/0000-0002-7185-4383"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc L. Melcher","raw_affiliation_strings":["Department of Surgery, Stanford University School of Medicine, Stanford, CA, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-7185-4383","affiliations":[{"raw_affiliation_string":"Department of Surgery, Stanford University School of Medicine, Stanford, CA, United States of America","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006142941","display_name":"Jan Liphardt","orcid":"https://orcid.org/0000-0003-2835-5025"},"institutions":[{"id":"https://openalex.org/I4390039303","display_name":"Stanford Cancer Institute","ror":"https://ror.org/014qe3j22","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4390039303","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jan T. Liphardt","raw_affiliation_strings":["BioX Institute, Stanford University, Stanford, CA, United States of America","Bioengineering, Stanford University, Stanford, CA, United States of America","Cell Biology Division, Stanford Cancer Institute, Stanford, CA, United States of America","ChEM-H, Stanford University, Stanford, CA, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-2835-5025","affiliations":[{"raw_affiliation_string":"BioX Institute, Stanford University, Stanford, CA, United States of America","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Bioengineering, Stanford University, Stanford, CA, United States of America","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Cell Biology Division, Stanford Cancer Institute, Stanford, CA, United States of America","institution_ids":["https://openalex.org/I4390039303"]},{"raw_affiliation_string":"ChEM-H, Stanford University, Stanford, CA, United States of America","institution_ids":["https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5006142941","https://openalex.org/A5055261141"],"corresponding_institution_ids":["https://openalex.org/I4390039303","https://openalex.org/I97018004"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":17.4226,"has_fulltext":true,"cited_by_count":100,"citation_normalized_percentile":{"value":0.99344832,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"16","issue":"9","first_page":"e1008193","last_page":"e1008193"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.9876000285148621,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.987500011920929,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.8075900077819824},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.7710766196250916},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7236118316650391},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.6963074803352356},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.652818500995636},{"id":"https://openalex.org/keywords/false-positive-paradox","display_name":"False positive paradox","score":0.560754656791687},{"id":"https://openalex.org/keywords/market-segmentation","display_name":"Market segmentation","score":0.547265350818634},{"id":"https://openalex.org/keywords/normalization","display_name":"Normalization (sociology)","score":0.5093644857406616},{"id":"https://openalex.org/keywords/bottleneck","display_name":"Bottleneck","score":0.4792449474334717},{"id":"https://openalex.org/keywords/sample","display_name":"Sample (material)","score":0.4419345259666443},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.37040573358535767},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.07016047835350037}],"concepts":[{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.8075900077819824},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.7710766196250916},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7236118316650391},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.6963074803352356},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.652818500995636},{"id":"https://openalex.org/C64869954","wikidata":"https://www.wikidata.org/wiki/Q1859747","display_name":"False positive paradox","level":2,"score":0.560754656791687},{"id":"https://openalex.org/C125308379","wikidata":"https://www.wikidata.org/wiki/Q363057","display_name":"Market segmentation","level":2,"score":0.547265350818634},{"id":"https://openalex.org/C136886441","wikidata":"https://www.wikidata.org/wiki/Q926129","display_name":"Normalization (sociology)","level":2,"score":0.5093644857406616},{"id":"https://openalex.org/C2780513914","wikidata":"https://www.wikidata.org/wiki/Q18210350","display_name":"Bottleneck","level":2,"score":0.4792449474334717},{"id":"https://openalex.org/C198531522","wikidata":"https://www.wikidata.org/wiki/Q485146","display_name":"Sample (material)","level":2,"score":0.4419345259666443},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.37040573358535767},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07016047835350037},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.0},{"id":"https://openalex.org/C162853370","wikidata":"https://www.wikidata.org/wiki/Q39809","display_name":"Marketing","level":1,"score":0.0},{"id":"https://openalex.org/C149635348","wikidata":"https://www.wikidata.org/wiki/Q193040","display_name":"Embedded system","level":1,"score":0.0},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016477","descriptor_name":"Artifacts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016477","descriptor_name":"Artifacts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016477","descriptor_name":"Artifacts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016477","descriptor_name":"Artifacts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1008193","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008193","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008193&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:32925919","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32925919","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1008193","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008193","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:b1465e3dfd0347d695e217e01e9ead8e","is_oa":true,"landing_page_url":"https://doaj.org/article/b1465e3dfd0347d695e217e01e9ead8e","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 16, Iss 9, p e1008193 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1008193","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008193","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008193&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land","score":0.47999998927116394}],"awards":[{"id":"https://openalex.org/G1057202028","display_name":null,"funder_award_id":"U54CA143836","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2044843925","display_name":null,"funder_award_id":"GM77856","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G2600302832","display_name":null,"funder_award_id":"U54CA143836","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3755311418","display_name":null,"funder_award_id":"1U01EB021237","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"}],"funders":[{"id":"https://openalex.org/F4320306080","display_name":"Foundation for the National Institutes of Health","ror":"https://ror.org/00k86s890"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3084995528.pdf","grobid_xml":"https://content.openalex.org/works/W3084995528.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W151895561","https://openalex.org/W639708223","https://openalex.org/W1536680647","https://openalex.org/W1686810756","https://openalex.org/W1896854564","https://openalex.org/W1901129140","https://openalex.org/W1903029394","https://openalex.org/W2030019694","https://openalex.org/W2054821087","https://openalex.org/W2071042551","https://openalex.org/W2089150737","https://openalex.org/W2105057212","https://openalex.org/W2122394460","https://openalex.org/W2133059825","https://openalex.org/W2144023435","https://openalex.org/W2163605009","https://openalex.org/W2167244112","https://openalex.org/W2254714379","https://openalex.org/W2294138058","https://openalex.org/W2395611524","https://openalex.org/W2548342201","https://openalex.org/W2557889580","https://openalex.org/W2565639579","https://openalex.org/W2566079294","https://openalex.org/W2586661295","https://openalex.org/W2590998239","https://openalex.org/W2613718673","https://openalex.org/W2628702118","https://openalex.org/W2744103196","https://openalex.org/W2799093543","https://openalex.org/W2806811242","https://openalex.org/W2884436604","https://openalex.org/W2895303488","https://openalex.org/W2900936384","https://openalex.org/W2905338897","https://openalex.org/W2909948317","https://openalex.org/W2913333192","https://openalex.org/W2922204263","https://openalex.org/W2946901414","https://openalex.org/W2949379258","https://openalex.org/W2952632681","https://openalex.org/W2961912654","https://openalex.org/W2963150697","https://openalex.org/W2963351448","https://openalex.org/W2964293073","https://openalex.org/W2980113692","https://openalex.org/W2980998394","https://openalex.org/W3003623648","https://openalex.org/W3085672394","https://openalex.org/W3087561277","https://openalex.org/W3106139043","https://openalex.org/W3106250896","https://openalex.org/W3111521801","https://openalex.org/W4308909683","https://openalex.org/W6675729508","https://openalex.org/W6680096826","https://openalex.org/W6762443710","https://openalex.org/W6785652829","https://openalex.org/W7063556251","https://openalex.org/W7075602742"],"related_works":["https://openalex.org/W2595172197","https://openalex.org/W2084856301","https://openalex.org/W2127970246","https://openalex.org/W2885125400","https://openalex.org/W1989889224","https://openalex.org/W4382618745","https://openalex.org/W1973775000","https://openalex.org/W2748922771","https://openalex.org/W1987128138","https://openalex.org/W2743976221"],"abstract_inverted_index":{"Segmenting":[0],"cell":[1],"nuclei":[2,49],"within":[3],"microscopy":[4],"images":[5,89,102],"is":[6,26],"a":[7,27,37,58,71],"ubiquitous":[8],"task":[9],"in":[10,30,79,85,118,124,146],"biological":[11],"research":[12],"and":[13,64,81,87,97,110,127,133,151],"clinical":[14],"applications.":[15],"Unfortunately,":[16],"segmenting":[17],"low-contrast":[18],"overlapping":[19],"objects":[20],"that":[21,46],"may":[22],"be":[23],"tightly":[24],"packed":[25],"major":[28],"bottleneck":[29],"standard":[31],"deep":[32,44],"learning-based":[33],"models.":[34],"We":[35],"report":[36],"Nuclear":[38],"Segmentation":[39],"Tool":[40],"(NuSeT)":[41],"based":[42],"on":[43,100],"learning":[45],"accurately":[47],"segments":[48],"across":[50],"multiple":[51],"types":[52],"of":[53,62,90],"fluorescence":[54],"imaging":[55],"data.":[56],"Using":[57],"hybrid":[59],"network":[60],"consisting":[61],"U-Net":[63],"Region":[65],"Proposal":[66],"Networks":[67],"(RPN),":[68],"followed":[69],"by":[70],"watershed":[72],"step,":[73],"we":[74],"have":[75],"achieved":[76],"superior":[77],"performance":[78],"detecting":[80],"delineating":[82],"nuclear":[83,108,119,125],"boundaries":[84,153],"2D":[86],"3D":[88],"varying":[91],"complexities.":[92],"By":[93],"using":[94],"foreground":[95],"normalization":[96],"additional":[98],"training":[99,130],"synthetic":[101],"containing":[103],"non-cellular":[104],"artifacts,":[105],"NuSeT":[106,114,142],"improves":[107],"detection":[109],"reduces":[111],"false":[112],"positives.":[113],"addresses":[115],"common":[116],"challenges":[117],"segmentation":[120,140,149],"such":[121],"as":[122],"variability":[123],"signal":[126],"shape,":[128],"limited":[129],"sample":[131,134],"size,":[132],"preparation":[135],"artifacts.":[136],"Compared":[137],"to":[138],"other":[139],"models,":[141],"consistently":[143],"fares":[144],"better":[145],"generating":[147],"accurate":[148],"masks":[150],"assigning":[152],"for":[154],"touching":[155],"nuclei.":[156]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":26},{"year":2022,"cited_by_count":28},{"year":2021,"cited_by_count":20},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}