{"id":"https://openalex.org/W3087945846","doi":"https://doi.org/10.1371/journal.pcbi.1008191","title":"Classification of estrogenic compounds by coupling high content analysis and machine learning algorithms","display_name":"Classification of estrogenic compounds by coupling high content analysis and machine learning algorithms","publication_year":2020,"publication_date":"2020-09-24","ids":{"openalex":"https://openalex.org/W3087945846","doi":"https://doi.org/10.1371/journal.pcbi.1008191","mag":"3087945846","pmid":"https://pubmed.ncbi.nlm.nih.gov/32970665"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1008191","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008191","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008191&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008191&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069201232","display_name":"Rajib Mukherjee","orcid":"https://orcid.org/0000-0002-4938-6210"},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajib Mukherjee","raw_affiliation_strings":["Texas A&M Energy Institute, Texas A&M University, College Station, TX, United States of America"],"affiliations":[{"raw_affiliation_string":"Texas A&M Energy Institute, Texas A&M University, College Station, TX, United States of America","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086217579","display_name":"Burcu Beykal","orcid":"https://orcid.org/0000-0002-6967-6661"},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Burcu Beykal","raw_affiliation_strings":["Artie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX, United States of America","Texas A&M Energy Institute, Texas A&M University, College Station, TX, United States of America"],"affiliations":[{"raw_affiliation_string":"Artie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX, United States of America","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Texas A&M Energy Institute, Texas A&M University, College Station, TX, United States of America","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067467801","display_name":"Adam T. Szafran","orcid":"https://orcid.org/0000-0002-3033-2378"},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam T. Szafran","raw_affiliation_strings":["Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, United States of America"],"affiliations":[{"raw_affiliation_string":"Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, United States of America","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035668530","display_name":"Melis Onel","orcid":null},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melis Onel","raw_affiliation_strings":["Artie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX, United States of America","Texas A&M Energy Institute, Texas A&M University, College Station, TX, United States of America"],"affiliations":[{"raw_affiliation_string":"Artie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX, United States of America","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Texas A&M Energy Institute, Texas A&M University, College Station, TX, United States of America","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026736259","display_name":"Fabio Stossi","orcid":"https://orcid.org/0000-0001-6029-5478"},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210145671","display_name":"Advanced Imaging Research (United States)","ror":"https://ror.org/047c3xe48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210145671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fabio Stossi","raw_affiliation_strings":["GCC Center for Advanced Microscopy and Image Informatics, Houston, TX, United States of America","Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, United States of America"],"affiliations":[{"raw_affiliation_string":"GCC Center for Advanced Microscopy and Image Informatics, Houston, TX, United States of America","institution_ids":["https://openalex.org/I4210145671"]},{"raw_affiliation_string":"Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, United States of America","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015613726","display_name":"Maureen G. Mancini","orcid":"https://orcid.org/0000-0003-4537-5343"},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210145671","display_name":"Advanced Imaging Research (United States)","ror":"https://ror.org/047c3xe48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210145671"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maureen G. Mancini","raw_affiliation_strings":["GCC Center for Advanced Microscopy and Image Informatics, Houston, TX, United States of America","Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, United States of America","Pharmacology and Chemical Genomics, Baylor College of Medicine, Houston, TX, United States of America","Texas A&M University Institute for Bioscience and Technology, Houston, TX, United States of America"],"affiliations":[{"raw_affiliation_string":"GCC Center for Advanced Microscopy and Image Informatics, Houston, TX, United States of America","institution_ids":["https://openalex.org/I4210145671"]},{"raw_affiliation_string":"Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, United States of America","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Pharmacology and Chemical Genomics, Baylor College of Medicine, Houston, TX, United States of America","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Texas A&M University Institute for Bioscience and Technology, Houston, TX, United States of America","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080819886","display_name":"Dillon Lloyd","orcid":null},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dillon Lloyd","raw_affiliation_strings":["Bioinformatics Research Center, Center for Human Health and the Environment, Department of Statistics, North Carolina State University, Raleigh, NC, United States of America"],"affiliations":[{"raw_affiliation_string":"Bioinformatics Research Center, Center for Human Health and the Environment, Department of Statistics, North Carolina State University, Raleigh, NC, United States of America","institution_ids":["https://openalex.org/I137902535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016238665","display_name":"Fred A. Wright","orcid":"https://orcid.org/0000-0002-8238-6626"},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fred A. Wright","raw_affiliation_strings":["Bioinformatics Research Center, Center for Human Health and the Environment, Department of Statistics, North Carolina State University, Raleigh, NC, United States of America"],"affiliations":[{"raw_affiliation_string":"Bioinformatics Research Center, Center for Human Health and the Environment, Department of Statistics, North Carolina State University, Raleigh, NC, United States of America","institution_ids":["https://openalex.org/I137902535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103201041","display_name":"Lan Zhou","orcid":"https://orcid.org/0000-0001-7469-3274"},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lan Zhou","raw_affiliation_strings":["Department of Statistics, Texas A&M University, College Station, TX, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Statistics, Texas A&M University, College Station, TX, United States of America","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103147933","display_name":"Michael A. Mancini","orcid":"https://orcid.org/0000-0002-4862-1944"},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210145671","display_name":"Advanced Imaging Research (United States)","ror":"https://ror.org/047c3xe48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210145671"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. Mancini","raw_affiliation_strings":["GCC Center for Advanced Microscopy and Image Informatics, Houston, TX, United States of America","Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, United States of America","Pharmacology and Chemical Genomics, Baylor College of Medicine, Houston, TX, United States of America","Texas A&M University Institute for Bioscience and Technology, Houston, TX, United States of America"],"affiliations":[{"raw_affiliation_string":"GCC Center for Advanced Microscopy and Image Informatics, Houston, TX, United States of America","institution_ids":["https://openalex.org/I4210145671"]},{"raw_affiliation_string":"Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, United States of America","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Pharmacology and Chemical Genomics, Baylor College of Medicine, Houston, TX, United States of America","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Texas A&M University Institute for Bioscience and Technology, Houston, TX, United States of America","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5115598076","display_name":"Efstratios N. Pistikopoulos","orcid":"https://orcid.org/0000-0001-6581-509X"},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Efstratios N. Pistikopoulos","raw_affiliation_strings":["Artie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX, United States of America","Texas A&M Energy Institute, Texas A&M University, College Station, TX, United States of America"],"affiliations":[{"raw_affiliation_string":"Artie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX, United States of America","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Texas A&M Energy Institute, Texas A&M University, College Station, TX, United States of America","institution_ids":["https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5115598076"],"corresponding_institution_ids":["https://openalex.org/I91045830"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.5878,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.87309645,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"16","issue":"9","first_page":"e1008191","last_page":"e1008191"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9884999990463257,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/random-forest","display_name":"Random forest","score":0.5432199239730835},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5118862390518188},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5100255608558655},{"id":"https://openalex.org/keywords/feature-selection","display_name":"Feature selection","score":0.4940979778766632},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"Estrogen receptor","score":0.43184131383895874},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.42241740226745605},{"id":"https://openalex.org/keywords/support-vector-machine","display_name":"Support vector machine","score":0.42236247658729553},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.35692569613456726},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2555450201034546},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"Breast cancer","score":0.10697722434997559},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.09992283582687378}],"concepts":[{"id":"https://openalex.org/C169258074","wikidata":"https://www.wikidata.org/wiki/Q245748","display_name":"Random forest","level":2,"score":0.5432199239730835},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5118862390518188},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5100255608558655},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.4940979778766632},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.43184131383895874},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.42241740226745605},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.42236247658729553},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35692569613456726},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2555450201034546},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.10697722434997559},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.09992283582687378},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1008191","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008191","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008191&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:32970665","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32970665","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1008191","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008191","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:9440bb450b124d04b846c5c42ede4b7a","is_oa":true,"landing_page_url":"https://doaj.org/article/9440bb450b124d04b846c5c42ede4b7a","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 16, Iss 9, p e1008191 (2020)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7538107","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7538107","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1008191","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008191","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008191&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5199999809265137,"display_name":"Peace, Justice and strong institutions","id":"https://metadata.un.org/sdg/16"}],"awards":[{"id":"https://openalex.org/G1539914497","display_name":null,"funder_award_id":"P30 CA125123","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2428140889","display_name":null,"funder_award_id":"CPRIT","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G274084553","display_name":null,"funder_award_id":"DK56338","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"},{"id":"https://openalex.org/G3497591915","display_name":null,"funder_award_id":"(NIH)","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4539825073","display_name":null,"funder_award_id":"CA1251","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4812121144","display_name":null,"funder_award_id":"RP150578","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"},{"id":"https://openalex.org/G4819929959","display_name":null,"funder_award_id":"RP170719","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5060956145","display_name":null,"funder_award_id":"CA125123","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6536806236","display_name":null,"funder_award_id":"DK56338","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6639498476","display_name":null,"funder_award_id":"P30 DK","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6821129334","display_name":null,"funder_award_id":"P30 CA125123","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"},{"id":"https://openalex.org/G7227650960","display_name":null,"funder_award_id":"RP170719","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"},{"id":"https://openalex.org/G7837447426","display_name":null,"funder_award_id":"CA125123","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"},{"id":"https://openalex.org/G8413015676","display_name":null,"funder_award_id":"RP150578","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8959465280","display_name":null,"funder_award_id":"P30 DK56338","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320308129","display_name":"Cancer Prevention and Research Institute of Texas","ror":"https://ror.org/0003xa228"},{"id":"https://openalex.org/F4320317728","display_name":"John S. Dunn Gulf Coast Consortium for Chemical Genomics","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3087945846.pdf","grobid_xml":"https://content.openalex.org/works/W3087945846.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1536061269","https://openalex.org/W1610612296","https://openalex.org/W1835137027","https://openalex.org/W1978694033","https://openalex.org/W2045583911","https://openalex.org/W2051656824","https://openalex.org/W2052988569","https://openalex.org/W2055631399","https://openalex.org/W2067980525","https://openalex.org/W2088832076","https://openalex.org/W2093676604","https://openalex.org/W2095649738","https://openalex.org/W2097936772","https://openalex.org/W2117625122","https://openalex.org/W2122025333","https://openalex.org/W2137219016","https://openalex.org/W2171903133","https://openalex.org/W2216094174","https://openalex.org/W2315587854","https://openalex.org/W2337122496","https://openalex.org/W2429101022","https://openalex.org/W2555601680","https://openalex.org/W2731835369","https://openalex.org/W2734980640","https://openalex.org/W2791043733","https://openalex.org/W2794268050","https://openalex.org/W2795114469","https://openalex.org/W2810116539","https://openalex.org/W2904171273","https://openalex.org/W2909578119","https://openalex.org/W2910248242","https://openalex.org/W2911964244","https://openalex.org/W2980226541","https://openalex.org/W4234650083"],"related_works":["https://openalex.org/W4200112873","https://openalex.org/W2955796858","https://openalex.org/W4224941037","https://openalex.org/W2004826645","https://openalex.org/W4394984040","https://openalex.org/W4388745254","https://openalex.org/W2980082554","https://openalex.org/W1517228774","https://openalex.org/W2767419625","https://openalex.org/W2389704471"],"abstract_inverted_index":{"Environmental":[0],"toxicants":[1],"affect":[2],"human":[3],"health":[4,51],"in":[5,14,50,63,92],"various":[6,72],"ways.":[7],"Of":[8],"the":[9,15,22,42,82,168,196,202,227,242,249,295],"thousands":[10],"of":[11,38,56,77,134,144,167,171,198,230,251,256,272,279,294,298],"chemicals":[12,30,173],"present":[13,156],"environment,":[16],"those":[17],"with":[18,268],"adverse":[19],"effects":[20],"on":[21,35,175,201],"endocrine":[23],"system":[24],"are":[25,96],"referred":[26],"to":[27,188,193],"as":[28,205,287],"endocrine-disrupting":[29,169],"(EDCs).":[31],"Here,":[32],"we":[33,100,155],"focused":[34],"a":[36,46,103,114,119,128,157,190,269,288],"subclass":[37],"EDCs":[39],"that":[40,70,95,110,147,261],"impacts":[41],"estrogen":[43],"receptor":[44],"(ER),":[45],"pivotal":[47],"transcriptional":[48],"regulator":[49],"and":[52,79,126,164,216,223,239,264],"disease.":[53],"Estrogenic":[54],"activity":[55,229],"compounds":[57,200],"can":[58,274],"be":[59,275],"measured":[60],"by":[61,98],"many":[62,299],"vitro":[64],"or":[65,207],"cell-based":[66],"high":[67,105,179],"throughput":[68],"assays":[69],"record":[71],"endpoints":[73,91],"from":[74,178],"large":[75],"pools":[76],"cells,":[78],"increasingly":[80],"at":[81],"single-cell":[83],"level.":[84],"To":[85,209],"simultaneously":[86],"capture":[87],"multiple":[88],"mechanistic":[89,150],"ER":[90,122,252],"individual":[93],"cells":[94],"affected":[97],"EDCs,":[99],"previously":[101],"developed":[102],"sensitive":[104,165],"throughput/high":[106],"content":[107,137,180],"imaging":[108,184],"assay":[109],"is":[111],"based":[112,174],"upon":[113],"stable":[115],"cell":[116],"line":[117],"harboring":[118],"visible":[120],"multicopy":[121],"responsive":[123],"transcription":[124],"unit":[125],"expressing":[127],"green":[129],"fluorescent":[130],"protein":[131],"(GFP)":[132],"fusion":[133],"ER.":[135],"High":[136],"analysis":[138],"generates":[139],"voluminous":[140],"multiplex":[141],"data":[142,176,185,237],"comprised":[143],"minable":[145],"features":[146,245,273],"describe":[148],"numerous":[149],"endpoints.":[151],"In":[152],"this":[153,210,257],"study,":[154],"machine":[158,283],"learning":[159,284],"pipeline":[160],"for":[161,225,248,290],"rapid,":[162],"accurate,":[163],"assessment":[166],"potential":[170,297],"benchmark":[172],"generated":[177],"analysis.":[181],"The":[182,254],"multidimensional":[183],"was":[186],"used":[187],"train":[189],"classification":[191,250,266],"model":[192,240],"ultimately":[194],"predict":[195],"impact":[197],"unknown":[199,231],"ER,":[203],"either":[204],"agonists":[206],"antagonists.":[208],"end,":[211],"both":[212],"linear":[213],"logistic":[214],"regression":[215],"nonlinear":[217],"Random":[218],"Forest":[219],"classifiers":[220],"were":[221,246],"benchmarked":[222],"evaluated":[224],"predicting":[226],"estrogenic":[228,296],"compounds.":[232],"Furthermore,":[233],"through":[234],"feature":[235],"selection,":[236],"visualization,":[238],"discrimination,":[241],"most":[243],"informative":[244],"identified":[247],"agonists/antagonists.":[253],"results":[255],"data-driven":[258],"study":[259],"showed":[260],"highly":[262],"accurate":[263],"generalized":[265],"models":[267,285],"minimum":[270],"number":[271],"constructed":[276],"without":[277],"loss":[278],"generality,":[280],"where":[281],"these":[282],"serve":[286],"means":[289],"rapid":[291],"mechanistic/phenotypic":[292],"evaluation":[293],"chemicals.":[300]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}
