{"id":"https://openalex.org/W3092476265","doi":"https://doi.org/10.1371/journal.pcbi.1008183","title":"Inferring tumor progression in large datasets","display_name":"Inferring tumor progression in large datasets","publication_year":2020,"publication_date":"2020-10-09","ids":{"openalex":"https://openalex.org/W3092476265","doi":"https://doi.org/10.1371/journal.pcbi.1008183","mag":"3092476265","pmid":"https://pubmed.ncbi.nlm.nih.gov/33035204"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1008183","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008183","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008183&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008183&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050305292","display_name":"Mohammadreza Mohaghegh Neyshabouri","orcid":"https://orcid.org/0000-0002-0782-8308"},"institutions":[{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]},{"id":"https://openalex.org/I86987016","display_name":"KTH Royal Institute of Technology","ror":"https://ror.org/026vcq606","country_code":"SE","type":"education","lineage":["https://openalex.org/I86987016"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Mohammadreza Mohaghegh Neyshabouri","raw_affiliation_strings":["Department of Electrical Engineering and Computer Science, KTH Royal Institute of Technology, Stockholm, Sweden","Science for Life Laboratory, Stockholm, Sweden"],"raw_orcid":"https://orcid.org/0000-0002-0782-8308","affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, KTH Royal Institute of Technology, Stockholm, Sweden","institution_ids":["https://openalex.org/I86987016"]},{"raw_affiliation_string":"Science for Life Laboratory, Stockholm, Sweden","institution_ids":["https://openalex.org/I2800139495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042178537","display_name":"Seong-Hwan Jun","orcid":"https://orcid.org/0000-0001-8924-0075"},"institutions":[{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]},{"id":"https://openalex.org/I86987016","display_name":"KTH Royal Institute of Technology","ror":"https://ror.org/026vcq606","country_code":"SE","type":"education","lineage":["https://openalex.org/I86987016"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Seong-Hwan Jun","raw_affiliation_strings":["Department of Electrical Engineering and Computer Science, KTH Royal Institute of Technology, Stockholm, Sweden","Science for Life Laboratory, Stockholm, Sweden"],"raw_orcid":"https://orcid.org/0000-0001-8924-0075","affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, KTH Royal Institute of Technology, Stockholm, Sweden","institution_ids":["https://openalex.org/I86987016"]},{"raw_affiliation_string":"Science for Life Laboratory, Stockholm, Sweden","institution_ids":["https://openalex.org/I2800139495"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064553103","display_name":"Jens Lagergren","orcid":"https://orcid.org/0000-0002-4552-0240"},"institutions":[{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]},{"id":"https://openalex.org/I86987016","display_name":"KTH Royal Institute of Technology","ror":"https://ror.org/026vcq606","country_code":"SE","type":"education","lineage":["https://openalex.org/I86987016"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Jens Lagergren","raw_affiliation_strings":["Department of Electrical Engineering and Computer Science, KTH Royal Institute of Technology, Stockholm, Sweden","Science for Life Laboratory, Stockholm, Sweden"],"raw_orcid":"https://orcid.org/0000-0002-4552-0240","affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, KTH Royal Institute of Technology, Stockholm, Sweden","institution_ids":["https://openalex.org/I86987016"]},{"raw_affiliation_string":"Science for Life Laboratory, Stockholm, Sweden","institution_ids":["https://openalex.org/I2800139495"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5064553103"],"corresponding_institution_ids":["https://openalex.org/I2800139495","https://openalex.org/I86987016"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2112,"currency":"EUR","value_usd":2277},"fwci":0.6688,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.68033148,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"16","issue":"10","first_page":"e1008183","last_page":"e1008183"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/probabilistic-logic","display_name":"Probabilistic logic","score":0.727658748626709},{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.688262403011322},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6871240139007568},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.6829831600189209},{"id":"https://openalex.org/keywords/scalability","display_name":"Scalability","score":0.6644108295440674},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.5307512283325195},{"id":"https://openalex.org/keywords/selection","display_name":"Selection (genetic algorithm)","score":0.49968624114990234},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.47465211153030396},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4320374131202698},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.38846805691719055},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3870681822299957},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.18760550022125244},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.11413177847862244}],"concepts":[{"id":"https://openalex.org/C49937458","wikidata":"https://www.wikidata.org/wiki/Q2599292","display_name":"Probabilistic logic","level":2,"score":0.727658748626709},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.688262403011322},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6871240139007568},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6829831600189209},{"id":"https://openalex.org/C48044578","wikidata":"https://www.wikidata.org/wiki/Q727490","display_name":"Scalability","level":2,"score":0.6644108295440674},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.5307512283325195},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.49968624114990234},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.47465211153030396},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4320374131202698},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.38846805691719055},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3870681822299957},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18760550022125244},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11413177847862244},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052138","descriptor_name":"Genes, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D052138","descriptor_name":"Genes, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D052138","descriptor_name":"Genes, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1008183","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008183","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008183&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:33035204","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33035204","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1008183","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008183","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:b816009df4e44b9985704170eff3ae26","is_oa":true,"landing_page_url":"https://doaj.org/article/b816009df4e44b9985704170eff3ae26","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 16, Iss 10, p e1008183 (2020)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7577444","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7577444","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1008183","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008183","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008183&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G5289289304","display_name":null,"funder_award_id":"BD15-0043","funder_id":"https://openalex.org/F4320320940","funder_display_name":"Stiftelsen f\u00f6r\u00a0Strategisk Forskning"},{"id":"https://openalex.org/G7956736171","display_name":"Computational ONcology TRaining Alliance","funder_award_id":"766030","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320940","display_name":"Stiftelsen f\u00f6r\u00a0Strategisk Forskning","ror":"https://ror.org/044wr7g58"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3092476265.pdf","grobid_xml":"https://content.openalex.org/works/W3092476265.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W14234604","https://openalex.org/W1598410563","https://openalex.org/W1662357506","https://openalex.org/W2039577063","https://openalex.org/W2042536531","https://openalex.org/W2061285646","https://openalex.org/W2094122486","https://openalex.org/W2100901335","https://openalex.org/W2121443461","https://openalex.org/W2123576600","https://openalex.org/W2135973421","https://openalex.org/W2150871663","https://openalex.org/W2153069574","https://openalex.org/W2154444902","https://openalex.org/W2167278498","https://openalex.org/W2270380494","https://openalex.org/W2562809264","https://openalex.org/W2597230258","https://openalex.org/W2605230952","https://openalex.org/W2611492308","https://openalex.org/W2613290483","https://openalex.org/W2618992230","https://openalex.org/W2883136814","https://openalex.org/W2887641167","https://openalex.org/W2887689358","https://openalex.org/W2890896123","https://openalex.org/W2903112818","https://openalex.org/W2924105651","https://openalex.org/W2938027661","https://openalex.org/W2955648521","https://openalex.org/W2965390994","https://openalex.org/W4292403327"],"related_works":["https://openalex.org/W2389214306","https://openalex.org/W4235240664","https://openalex.org/W2965083567","https://openalex.org/W1838576100","https://openalex.org/W2095886385","https://openalex.org/W2889616422","https://openalex.org/W2089704382","https://openalex.org/W1983399550","https://openalex.org/W97075385","https://openalex.org/W2163814182"],"abstract_inverted_index":{"Identification":[0],"of":[1,3,34,52,91,120,141],"mutations":[2],"the":[4,68,89,132,150,159],"genes":[5,36,70,92,157,169],"that":[6,84,148],"give":[7],"cancer":[8,176],"a":[9,26,42,50,60,97,103,117],"selective":[10],"advantage":[11],"is":[12],"an":[13,80],"important":[14],"step":[15],"towards":[16],"research":[17],"and":[18,37,93,113,143,170],"clinical":[19],"objectives.":[20],"As":[21],"such,":[22],"there":[23],"has":[24],"been":[25],"growing":[27],"interest":[28],"in":[29,66,158],"developing":[30],"methods":[31],"for":[32,63,175],"identification":[33],"driver":[35,69,76,160,168],"their":[38],"temporal":[39],"order":[40],"within":[41],"single":[43],"patient":[44],"(intra-tumor)":[45],"as":[46,48],"well":[47],"across":[49],"cohort":[51],"patients":[53],"(inter-tumor).":[54],"In":[55],"this":[56],"paper,":[57],"we":[58,125],"develop":[59,79],"probabilistic":[61,104],"model":[62,111],"tumor":[64],"progression,":[65],"which":[67],"are":[71],"clustered":[72],"into":[73],"several":[74],"ordered":[75],"pathways.":[77],"We":[78,135,146],"efficient":[81],"inference":[82],"algorithm":[83,163],"exhibits":[85],"favorable":[86],"scalability":[87],"to":[88,96,110,131],"number":[90],"samples":[94],"compared":[95,130],"previously":[98],"introduced":[99],"ILP-based":[100,133,151],"method.":[101,134],"Adopting":[102],"approach":[105],"also":[106,136],"allows":[107],"principled":[108],"approaches":[109],"selection":[112],"uncertainty":[114],"quantification.":[115],"Using":[116],"large":[118],"set":[119],"experiments":[121],"on":[122,166],"synthetic":[123],"datasets,":[124],"demonstrate":[126],"our":[127,162],"superior":[128],"performance":[129],"analyze":[137],"two":[138],"biological":[139],"datasets":[140],"colorectal":[142],"glioblastoma":[144],"cancers.":[145],"emphasize":[147],"while":[149],"method":[152],"puts":[153],"many":[154],"seemingly":[155],"passenger":[156],"pathways,":[161],"keeps":[164],"focused":[165],"truly":[167],"outputs":[171],"more":[172],"accurate":[173],"models":[174],"progression.":[177]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3}],"updated_date":"2026-04-25T08:17:42.794288","created_date":"2020-10-15T00:00:00"}
