{"id":"https://openalex.org/W3090770047","doi":"https://doi.org/10.1371/journal.pcbi.1008139","title":"Modeling the activation of the alternative complement pathway and its effects on hemolysis in health and disease","display_name":"Modeling the activation of the alternative complement pathway and its effects on hemolysis in health and disease","publication_year":2020,"publication_date":"2020-10-02","ids":{"openalex":"https://openalex.org/W3090770047","doi":"https://doi.org/10.1371/journal.pcbi.1008139","mag":"3090770047","pmid":"https://pubmed.ncbi.nlm.nih.gov/33006965"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1008139","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008139","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008139&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008139&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020813281","display_name":"Antonello Caruso","orcid":"https://orcid.org/0000-0001-5832-3636"},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"Roche (Switzerland)","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Antonello Caruso","raw_affiliation_strings":["Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-5832-3636","affiliations":[{"raw_affiliation_string":"Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035104537","display_name":"Jannik Vollmer","orcid":"https://orcid.org/0000-0001-8341-7730"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jannik Vollmer","raw_affiliation_strings":["LYO-X GmbH, Allschwil, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-8341-7730","affiliations":[{"raw_affiliation_string":"LYO-X GmbH, Allschwil, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049417070","display_name":"Matthias Mach\u00e1\u010dek","orcid":"https://orcid.org/0000-0003-0541-2365"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Matthias Machacek","raw_affiliation_strings":["LYO-X GmbH, Allschwil, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-0541-2365","affiliations":[{"raw_affiliation_string":"LYO-X GmbH, Allschwil, Switzerland","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039922196","display_name":"El\u00f6d K\u00f6rtvely","orcid":"https://orcid.org/0000-0003-1599-3116"},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"Roche (Switzerland)","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Elod Kortvely","raw_affiliation_strings":["Roche Pharma Research and Early Development, Immunology, Infectious Diseases and Ophthalmology (I2O) Discovery and Translational Area, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-1599-3116","affiliations":[{"raw_affiliation_string":"Roche Pharma Research and Early Development, Immunology, Infectious Diseases and Ophthalmology (I2O) Discovery and Translational Area, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland","institution_ids":["https://openalex.org/I118019719"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5020813281","https://openalex.org/A5035104537","https://openalex.org/A5039922196","https://openalex.org/A5049417070"],"corresponding_institution_ids":["https://openalex.org/I118019719"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.3252,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.57046283,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"16","issue":"10","first_page":"e1008139","last_page":"e1008139"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9922999739646912,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.989799976348877,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/complement-system","display_name":"Complement system","score":0.8310354351997375},{"id":"https://openalex.org/keywords/paroxysmal-nocturnal-hemoglobinuria","display_name":"Paroxysmal nocturnal hemoglobinuria","score":0.7929292321205139},{"id":"https://openalex.org/keywords/eculizumab","display_name":"Eculizumab","score":0.7823674082756042},{"id":"https://openalex.org/keywords/alternative-complement-pathway","display_name":"Alternative complement pathway","score":0.6669824719429016},{"id":"https://openalex.org/keywords/hemolysis","display_name":"Hemolysis","score":0.636124849319458},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.5433670878410339},{"id":"https://openalex.org/keywords/complement-membrane-attack-complex","display_name":"Complement membrane attack complex","score":0.5203239917755127},{"id":"https://openalex.org/keywords/innate-immune-system","display_name":"Innate immune system","score":0.5058600306510925},{"id":"https://openalex.org/keywords/complement","display_name":"Complement (music)","score":0.5029312968254089},{"id":"https://openalex.org/keywords/classical-complement-pathway","display_name":"Classical complement pathway","score":0.48254483938217163},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.4660782516002655},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.4528034031391144},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.45100605487823486},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.40476199984550476},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.32761329412460327},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.12572592496871948},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.10922038555145264},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.08270913362503052}],"concepts":[{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.8310354351997375},{"id":"https://openalex.org/C2777346216","wikidata":"https://www.wikidata.org/wiki/Q1479494","display_name":"Paroxysmal nocturnal hemoglobinuria","level":2,"score":0.7929292321205139},{"id":"https://openalex.org/C2777991916","wikidata":"https://www.wikidata.org/wiki/Q421617","display_name":"Eculizumab","level":4,"score":0.7823674082756042},{"id":"https://openalex.org/C189446657","wikidata":"https://www.wikidata.org/wiki/Q4736500","display_name":"Alternative complement pathway","level":4,"score":0.6669824719429016},{"id":"https://openalex.org/C2779902561","wikidata":"https://www.wikidata.org/wiki/Q471706","display_name":"Hemolysis","level":2,"score":0.636124849319458},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5433670878410339},{"id":"https://openalex.org/C79196540","wikidata":"https://www.wikidata.org/wiki/Q14905298","display_name":"Complement membrane attack complex","level":4,"score":0.5203239917755127},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.5058600306510925},{"id":"https://openalex.org/C112313634","wikidata":"https://www.wikidata.org/wiki/Q7886648","display_name":"Complement (music)","level":5,"score":0.5029312968254089},{"id":"https://openalex.org/C171279029","wikidata":"https://www.wikidata.org/wiki/Q5128320","display_name":"Classical complement pathway","level":4,"score":0.48254483938217163},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4660782516002655},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4528034031391144},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.45100605487823486},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40476199984550476},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32761329412460327},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12572592496871948},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.10922038555145264},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08270913362503052},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C188082640","wikidata":"https://www.wikidata.org/wiki/Q1780899","display_name":"Complementation","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D003167","descriptor_name":"Complement Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003167","descriptor_name":"Complement Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003167","descriptor_name":"Complement Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003167","descriptor_name":"Complement Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003167","descriptor_name":"Complement Activation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003167","descriptor_name":"Complement Activation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003167","descriptor_name":"Complement Activation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003167","descriptor_name":"Complement Activation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003170","descriptor_name":"Complement Pathway, Alternative","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003170","descriptor_name":"Complement Pathway, Alternative","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003170","descriptor_name":"Complement Pathway, Alternative","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003170","descriptor_name":"Complement Pathway, Alternative","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003170","descriptor_name":"Complement Pathway, Alternative","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003170","descriptor_name":"Complement Pathway, Alternative","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003170","descriptor_name":"Complement Pathway, Alternative","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003170","descriptor_name":"Complement Pathway, Alternative","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006457","descriptor_name":"Hemoglobinuria, Paroxysmal","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006457","descriptor_name":"Hemoglobinuria, Paroxysmal","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006457","descriptor_name":"Hemoglobinuria, Paroxysmal","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006457","descriptor_name":"Hemoglobinuria, Paroxysmal","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006457","descriptor_name":"Hemoglobinuria, Paroxysmal","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006457","descriptor_name":"Hemoglobinuria, Paroxysmal","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006457","descriptor_name":"Hemoglobinuria, Paroxysmal","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006457","descriptor_name":"Hemoglobinuria, Paroxysmal","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051056","descriptor_name":"Complement Inactivating Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051056","descriptor_name":"Complement Inactivating Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051056","descriptor_name":"Complement Inactivating Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051056","descriptor_name":"Complement Inactivating Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051056","descriptor_name":"Complement Inactivating Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D051056","descriptor_name":"Complement Inactivating Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D051056","descriptor_name":"Complement Inactivating Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D051056","descriptor_name":"Complement Inactivating Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1008139","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008139","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008139&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:33006965","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33006965","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:b7dd1bdece4f4d07a8661257628d9c8e","is_oa":true,"landing_page_url":"https://doaj.org/article/b7dd1bdece4f4d07a8661257628d9c8e","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 16, Iss 10, p e1008139 (2020)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:e52604fdad974a898ba411b5b2acef65","is_oa":true,"landing_page_url":"https://doaj.org/article/e52604fdad974a898ba411b5b2acef65","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 16, Iss 10 (2020)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7531836","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7531836","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1008139","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008139","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008139&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3090770047.pdf","grobid_xml":"https://content.openalex.org/works/W3090770047.grobid-xml"},"referenced_works_count":84,"referenced_works":["https://openalex.org/W24165733","https://openalex.org/W121889566","https://openalex.org/W189181064","https://openalex.org/W343272032","https://openalex.org/W1247518833","https://openalex.org/W1486365785","https://openalex.org/W1499593166","https://openalex.org/W1506059273","https://openalex.org/W1565126658","https://openalex.org/W1608773321","https://openalex.org/W1776878000","https://openalex.org/W1808460297","https://openalex.org/W1966578514","https://openalex.org/W1969762078","https://openalex.org/W1970718615","https://openalex.org/W1975460168","https://openalex.org/W1980493655","https://openalex.org/W1980533899","https://openalex.org/W1990057691","https://openalex.org/W1997288094","https://openalex.org/W2002727243","https://openalex.org/W2004073242","https://openalex.org/W2004265876","https://openalex.org/W2010189440","https://openalex.org/W2011277199","https://openalex.org/W2025189810","https://openalex.org/W2025678142","https://openalex.org/W2035310463","https://openalex.org/W2037318246","https://openalex.org/W2046901232","https://openalex.org/W2049544798","https://openalex.org/W2050448052","https://openalex.org/W2054898584","https://openalex.org/W2055655976","https://openalex.org/W2061729543","https://openalex.org/W2066290080","https://openalex.org/W2070576387","https://openalex.org/W2072926018","https://openalex.org/W2077094554","https://openalex.org/W2083031926","https://openalex.org/W2088046332","https://openalex.org/W2092148373","https://openalex.org/W2097222143","https://openalex.org/W2100119864","https://openalex.org/W2103722562","https://openalex.org/W2105479207","https://openalex.org/W2106044600","https://openalex.org/W2113784410","https://openalex.org/W2117386992","https://openalex.org/W2123156974","https://openalex.org/W2125236492","https://openalex.org/W2127290864","https://openalex.org/W2131218739","https://openalex.org/W2131852221","https://openalex.org/W2134558721","https://openalex.org/W2134914390","https://openalex.org/W2148310177","https://openalex.org/W2150466621","https://openalex.org/W2159057750","https://openalex.org/W2163295341","https://openalex.org/W2163568537","https://openalex.org/W2164858718","https://openalex.org/W2171537430","https://openalex.org/W2233221674","https://openalex.org/W2264055547","https://openalex.org/W2319567704","https://openalex.org/W2407829446","https://openalex.org/W2415123795","https://openalex.org/W2513429022","https://openalex.org/W2564107867","https://openalex.org/W2624111641","https://openalex.org/W2625957644","https://openalex.org/W2752956711","https://openalex.org/W2760674400","https://openalex.org/W2771846104","https://openalex.org/W2775288206","https://openalex.org/W2789834118","https://openalex.org/W2885871278","https://openalex.org/W2949468153","https://openalex.org/W2972927281","https://openalex.org/W3005556849","https://openalex.org/W3145351529","https://openalex.org/W4255000880","https://openalex.org/W4313311134"],"related_works":["https://openalex.org/W2978041444","https://openalex.org/W2045407001","https://openalex.org/W4238019217","https://openalex.org/W4211127375","https://openalex.org/W2395123849","https://openalex.org/W2035494890","https://openalex.org/W2808717877","https://openalex.org/W1419933820","https://openalex.org/W1968817172","https://openalex.org/W2462315822"],"abstract_inverted_index":{"The":[0,104,144],"complement":[1,95,137,147,200,226,240],"system":[2,108],"is":[3,18,64],"a":[4,92,110,131],"powerful":[5],"mechanism":[6],"of":[7,22,32,73,94,106,115,121,134,153,162,178,188,192,195,214,217,239,259],"innate":[8],"immunity":[9],"poised":[10],"to":[11,29,35,41,99,149],"eliminate":[12],"foreign":[13],"cells":[14],"and":[15,45,101,118,169,174,242,255],"pathogens.":[16],"It":[17],"an":[19,159,193],"intricate":[20],"network":[21],">35":[23],"proteins,":[24],"which,":[25],"once":[26],"activated,":[27],"leads":[28,98],"the":[30,33,68,74,107,113,119,135,150,154,179,184,190,215,225,233,237,257],"tagging":[31],"surface":[34],"be":[36,56],"eliminated,":[37],"produces":[38],"potent":[39],"chemoattractants":[40],"recruit":[42],"immune":[43],"cells,":[44],"inserts":[46],"cytotoxic":[47],"pores":[48],"into":[49],"nearby":[50],"lipid":[51],"surfaces.":[52],"Although":[53],"it":[54],"can":[55,235],"triggered":[57],"via":[58],"different":[59],"pathways,":[60],"its":[61,204,243],"net":[62],"output":[63],"largely":[65],"based":[66],"on":[67,140],"direct":[69],"or":[70,79],"indirect":[71],"activation":[72,148],"alternative":[75,136,156],"pathway.":[76],"Complement":[77],"dysregulation":[78],"deficiencies":[80],"may":[81],"cause":[82],"severe":[83],"pathologies,":[84],"such":[85],"as":[86,165],"paroxysmal":[87],"nocturnal":[88],"hemoglobinuria":[89],"(PNH),":[90],"where":[91],"lack":[93],"control":[96],"proteins":[97],"hemolysis":[100],"life-threatening":[102],"anemia.":[103],"complexity":[105],"poses":[109],"challenge":[111],"for":[112,252],"interpretation":[114],"experimental":[116,182],"data":[117],"design":[120],"effective":[122],"pharmacological":[123,253,261],"therapies.":[124],"To":[125,202],"address":[126],"this":[127],"issue,":[128],"we":[129,207],"developed":[130],"mathematical":[132],"model":[133,145,185,209,234],"pathway":[138,163],"building":[139],"previous":[141],"modelling":[142],"efforts.":[143],"links":[146],"hemolytic":[151],"activity":[152,164],"terminal":[155],"pathway,":[157],"providing":[158],"accurate":[160],"description":[161],"observed":[166],"in":[167,170,172,199,220,245],"vitro":[168],"vivo,":[171],"health":[173],"disease.":[175],"Through":[176],"adjustment":[177],"parameters":[180],"describing":[181],"conditions,":[183],"was":[186],"capable":[187],"reproducing":[189],"results":[191],"array":[194],"standard":[196],"assays":[197],"used":[198],"research.":[201],"demonstrate":[203],"clinical":[205,212],"applicability,":[206],"compared":[208],"predictions":[210],"with":[211,224],"observations":[213],"recovery":[216],"hematological":[218],"biomarkers":[219],"PNH":[221],"patients":[222],"treated":[223],"inhibiting":[227],"anti-C5":[228],"antibody":[229],"eculizumab.":[230],"In":[231],"conclusion,":[232],"enhance":[236],"understanding":[238],"biology":[241],"role":[244],"disease":[246],"pathogenesis,":[247],"help":[248],"identifying":[249],"promising":[250],"targets":[251],"intervention,":[254],"predict":[256],"outcome":[258],"complement-targeting":[260],"interventions.":[262]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}