{"id":"https://openalex.org/W3081855866","doi":"https://doi.org/10.1371/journal.pcbi.1008132","title":"Microtubule instability driven by longitudinal and lateral strain propagation","display_name":"Microtubule instability driven by longitudinal and lateral strain propagation","publication_year":2020,"publication_date":"2020-09-02","ids":{"openalex":"https://openalex.org/W3081855866","doi":"https://doi.org/10.1371/journal.pcbi.1008132","mag":"3081855866","pmid":"https://pubmed.ncbi.nlm.nih.gov/32877399"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1008132","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008132","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1008132","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034429136","display_name":"Maxim Igaev","orcid":"https://orcid.org/0000-0001-8781-1604"},"institutions":[{"id":"https://openalex.org/I4210131661","display_name":"Max Planck Institute for Biophysical Chemistry","ror":"https://ror.org/03e76ya46","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210131661"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Maxim Igaev","raw_affiliation_strings":["Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, D-37077 G\u00f6ttingen, Germany"],"raw_orcid":"https://orcid.org/0000-0001-8781-1604","affiliations":[{"raw_affiliation_string":"Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, D-37077 G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210131661"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045212144","display_name":"Helmut Grubm\u00fcller","orcid":"https://orcid.org/0000-0002-3270-3144"},"institutions":[{"id":"https://openalex.org/I4210131661","display_name":"Max Planck Institute for Biophysical Chemistry","ror":"https://ror.org/03e76ya46","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210131661"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Helmut Grubm\u00fcller","raw_affiliation_strings":["Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, D-37077 G\u00f6ttingen, Germany"],"raw_orcid":"https://orcid.org/0000-0002-3270-3144","affiliations":[{"raw_affiliation_string":"Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, D-37077 G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210131661"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5034429136","https://openalex.org/A5045212144"],"corresponding_institution_ids":["https://openalex.org/I4210131661"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.1108,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.86640116,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"16","issue":"9","first_page":"e1008132","last_page":"e1008132"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9860000014305115,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11247","display_name":"Plant nutrient uptake and metabolism","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microtubule","display_name":"Microtubule","score":0.8570433855056763},{"id":"https://openalex.org/keywords/dimer","display_name":"Dimer","score":0.7806534767150879},{"id":"https://openalex.org/keywords/metastability","display_name":"Metastability","score":0.6940329670906067},{"id":"https://openalex.org/keywords/tubulin","display_name":"Tubulin","score":0.6879996061325073},{"id":"https://openalex.org/keywords/lattice","display_name":"Lattice (music)","score":0.6219269037246704},{"id":"https://openalex.org/keywords/instability","display_name":"Instability","score":0.5685501098632812},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.5403485894203186},{"id":"https://openalex.org/keywords/gtpase","display_name":"GTPase","score":0.5119792222976685},{"id":"https://openalex.org/keywords/crystallography","display_name":"Crystallography","score":0.4841223657131195},{"id":"https://openalex.org/keywords/molecular-dynamics","display_name":"Molecular dynamics","score":0.47255346179008484},{"id":"https://openalex.org/keywords/strain-energy","display_name":"Strain energy","score":0.4407828450202942},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.42357468605041504},{"id":"https://openalex.org/keywords/chemical-physics","display_name":"Chemical physics","score":0.4048440456390381},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.35203230381011963},{"id":"https://openalex.org/keywords/mechanics","display_name":"Mechanics","score":0.20834875106811523},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.17716947197914124},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"Computational chemistry","score":0.1678520143032074},{"id":"https://openalex.org/keywords/nuclear-magnetic-resonance","display_name":"Nuclear magnetic resonance","score":0.11366114020347595},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.10923200845718384},{"id":"https://openalex.org/keywords/thermodynamics","display_name":"Thermodynamics","score":0.10855579376220703},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.09309384226799011}],"concepts":[{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.8570433855056763},{"id":"https://openalex.org/C2779546866","wikidata":"https://www.wikidata.org/wiki/Q531306","display_name":"Dimer","level":2,"score":0.7806534767150879},{"id":"https://openalex.org/C89464430","wikidata":"https://www.wikidata.org/wiki/Q849516","display_name":"Metastability","level":2,"score":0.6940329670906067},{"id":"https://openalex.org/C84425145","wikidata":"https://www.wikidata.org/wiki/Q422492","display_name":"Tubulin","level":3,"score":0.6879996061325073},{"id":"https://openalex.org/C2781204021","wikidata":"https://www.wikidata.org/wiki/Q6497091","display_name":"Lattice (music)","level":2,"score":0.6219269037246704},{"id":"https://openalex.org/C207821765","wikidata":"https://www.wikidata.org/wiki/Q405372","display_name":"Instability","level":2,"score":0.5685501098632812},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5403485894203186},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.5119792222976685},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.4841223657131195},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.47255346179008484},{"id":"https://openalex.org/C199201527","wikidata":"https://www.wikidata.org/wiki/Q496309","display_name":"Strain energy","level":3,"score":0.4407828450202942},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42357468605041504},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.4048440456390381},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.35203230381011963},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.20834875106811523},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17716947197914124},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.1678520143032074},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.11366114020347595},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10923200845718384},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.10855579376220703},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.09309384226799011},{"id":"https://openalex.org/C135628077","wikidata":"https://www.wikidata.org/wiki/Q220184","display_name":"Finite element method","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1008132","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008132","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:32877399","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32877399","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:discovery.dundee.ac.uk:publications/f06a6697-e426-4fdb-8226-8da364ad0116","is_oa":true,"landing_page_url":"https://discovery.dundee.ac.uk/en/publications/f06a6697-e426-4fdb-8226-8da364ad0116","pdf_url":"https://discovery.dundee.ac.uk/ws/files/140026772/file_1_.pdf","source":{"id":"https://openalex.org/S4306400523","display_name":"Discovery Research Portal (University of Dundee)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I177639307","host_organization_name":"University of Dundee","host_organization_lineage":["https://openalex.org/I177639307"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Igaev, M & Grubm\u00fcller, H 2020, 'Microtubule instability driven by longitudinal and lateral strain propagation', PLoS Computational Biology, vol. 16, no. 9, 1008132. https://doi.org/10.1371/journal.pcbi.1008132","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:RePEc:plo:pcbi00:1008132","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008132","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:848b40c7a85549d7b395b5a91992f65f","is_oa":true,"landing_page_url":"https://doaj.org/article/848b40c7a85549d7b395b5a91992f65f","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 16, Iss 9, p e1008132 (2020)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7467311","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7467311","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1008132","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008132","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Decent work and economic growth","id":"https://metadata.un.org/sdg/8","score":0.5600000023841858}],"awards":[{"id":"https://openalex.org/G3806508645","display_name":null,"funder_award_id":"IG 109/1-1","funder_id":"https://openalex.org/F4320322434","funder_display_name":"Max-Planck-Gesellschaft"},{"id":"https://openalex.org/G552962413","display_name":null,"funder_award_id":"IG 109/1-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G7723553117","display_name":null,"funder_award_id":"IG109/1-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320309650","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320322434","display_name":"Max-Planck-Gesellschaft","ror":"https://ror.org/01hhn8329"},{"id":"https://openalex.org/F4320332622","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54"},{"id":"https://openalex.org/F4320334763","display_name":"Leibniz-Gemeinschaft","ror":"https://ror.org/01n6r0e97"},{"id":"https://openalex.org/F4320336863","display_name":"Leibniz-Rechenzentrum","ror":"https://ror.org/05558nw16"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W1031578623","https://openalex.org/W1785817244","https://openalex.org/W1848121837","https://openalex.org/W1922219250","https://openalex.org/W1965404941","https://openalex.org/W1966078827","https://openalex.org/W1969245469","https://openalex.org/W1972338313","https://openalex.org/W1980374511","https://openalex.org/W1994345832","https://openalex.org/W2006441079","https://openalex.org/W2015580322","https://openalex.org/W2022958779","https://openalex.org/W2024965319","https://openalex.org/W2027408247","https://openalex.org/W2029667189","https://openalex.org/W2035266068","https://openalex.org/W2035687084","https://openalex.org/W2039098353","https://openalex.org/W2048468841","https://openalex.org/W2050333027","https://openalex.org/W2054341244","https://openalex.org/W2057477511","https://openalex.org/W2060757799","https://openalex.org/W2067149753","https://openalex.org/W2068099098","https://openalex.org/W2071217596","https://openalex.org/W2078268673","https://openalex.org/W2081531192","https://openalex.org/W2081693079","https://openalex.org/W2085680503","https://openalex.org/W2086187114","https://openalex.org/W2086701235","https://openalex.org/W2087130779","https://openalex.org/W2100343024","https://openalex.org/W2104266030","https://openalex.org/W2114225171","https://openalex.org/W2114771311","https://openalex.org/W2117931147","https://openalex.org/W2121903259","https://openalex.org/W2128824543","https://openalex.org/W2132629607","https://openalex.org/W2140274087","https://openalex.org/W2141273392","https://openalex.org/W2145992318","https://openalex.org/W2157420503","https://openalex.org/W2159335259","https://openalex.org/W2162785195","https://openalex.org/W2167096693","https://openalex.org/W2192105401","https://openalex.org/W2575108092","https://openalex.org/W2591669685","https://openalex.org/W2606253816","https://openalex.org/W2627078469","https://openalex.org/W2673913370","https://openalex.org/W2790617822","https://openalex.org/W2797907849","https://openalex.org/W2799809717","https://openalex.org/W2804594934","https://openalex.org/W2805514623","https://openalex.org/W2808368555","https://openalex.org/W2809170986","https://openalex.org/W2809813558","https://openalex.org/W2895310363","https://openalex.org/W2909456234","https://openalex.org/W2915131983","https://openalex.org/W2918297620","https://openalex.org/W2922207623","https://openalex.org/W2927838102","https://openalex.org/W2968250638","https://openalex.org/W2970877352","https://openalex.org/W3005618718","https://openalex.org/W3006609370","https://openalex.org/W3021731511","https://openalex.org/W4214894679","https://openalex.org/W4299357884"],"related_works":["https://openalex.org/W2020008420","https://openalex.org/W2415662583","https://openalex.org/W2528453622","https://openalex.org/W1901412126","https://openalex.org/W3163690654","https://openalex.org/W2024145976","https://openalex.org/W2405887049","https://openalex.org/W4313640443","https://openalex.org/W2079310684","https://openalex.org/W2069851853"],"abstract_inverted_index":{"Tubulin":[0],"dimers":[1],"associate":[2],"longitudinally":[3],"and":[4,42,63,106],"laterally":[5],"to":[6,49],"form":[7,86],"metastable":[8],"microtubules":[9],"(MTs).":[10],"MT":[11,29,115],"disassembly":[12],"is":[13,34,79],"preceded":[14],"by":[15,22],"subtle":[16],"structural":[17],"changes":[18,26],"in":[19,81,84,102],"tubulin":[20,57],"fueled":[21],"GTP":[23,54],"hydrolysis.":[24],"These":[25],"render":[27],"the":[28,51,76,82,85,97,114],"lattice":[30,40,58,83],"unstable,":[31],"but":[32],"it":[33],"unclear":[35],"exactly":[36],"how":[37],"they":[38],"affect":[39],"energetics":[41],"strain.":[43,89],"We":[44],"performed":[45],"long-time":[46],"atomistic":[47],"simulations":[48,71],"interrogate":[50],"impacts":[52],"of":[53,67,75,87,109],"hydrolysis":[55,77],"on":[56],"conformation,":[59],"lateral":[60,65,94],"inter-dimer":[61],"interactions,":[62],"(non-)local":[64],"coordination":[66],"dimer":[68],"motions.":[69],"The":[70],"suggest":[72],"that":[73],"most":[74],"energy":[78,100],"stored":[80,98],"longitudinal":[88],"While":[90],"not":[91],"significantly":[92],"affecting":[93],"bond":[95],"stability,":[96],"elastic":[99],"results":[101],"more":[103],"strongly":[104],"confined":[105],"correlated":[107],"dynamics":[108],"GDP-tubulins,":[110],"thereby":[111],"entropically":[112],"destabilizing":[113],"lattice.":[116]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":5}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}