{"id":"https://openalex.org/W3080269749","doi":"https://doi.org/10.1371/journal.pcbi.1008126","title":"Ten simple rules to power drug discovery with data science","display_name":"Ten simple rules to power drug discovery with data science","publication_year":2020,"publication_date":"2020-08-27","ids":{"openalex":"https://openalex.org/W3080269749","doi":"https://doi.org/10.1371/journal.pcbi.1008126","mag":"3080269749","pmid":"https://pubmed.ncbi.nlm.nih.gov/32853229"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1008126","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008126","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008126&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008126&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018254174","display_name":"Enrico Ferrero","orcid":"https://orcid.org/0000-0002-8362-100X"},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]},{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":null,"type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Enrico Ferrero","raw_affiliation_strings":["Computational Sciences Council, Novartis Institutes for BioMedical Research, Basel, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-8362-100X","affiliations":[{"raw_affiliation_string":"Computational Sciences Council, Novartis Institutes for BioMedical Research, Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021884298","display_name":"Sophie Brachat","orcid":"https://orcid.org/0000-0002-3398-8225"},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]},{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":null,"type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Sophie Brachat","raw_affiliation_strings":["Computational Sciences Council, Novartis Institutes for BioMedical Research, Basel, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-3398-8225","affiliations":[{"raw_affiliation_string":"Computational Sciences Council, Novartis Institutes for BioMedical Research, Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009211876","display_name":"Jeremy L. Jenkins","orcid":"https://orcid.org/0000-0001-9795-0771"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeremy L. Jenkins","raw_affiliation_strings":["Computational Sciences Council, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-9795-0771","affiliations":[{"raw_affiliation_string":"Computational Sciences Council, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012222427","display_name":"Philippe Marc","orcid":"https://orcid.org/0000-0002-0064-0572"},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]},{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":null,"type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Philippe Marc","raw_affiliation_strings":["Computational Sciences Council, Novartis Institutes for BioMedical Research, Basel, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-0064-0572","affiliations":[{"raw_affiliation_string":"Computational Sciences Council, Novartis Institutes for BioMedical Research, Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023943507","display_name":"Peter Skewes-Cox","orcid":"https://orcid.org/0000-0003-1633-5190"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Skewes-Cox","raw_affiliation_strings":["Computational Sciences Council, Novartis Institutes for BioMedical Research, Emeryville, California, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-1633-5190","affiliations":[{"raw_affiliation_string":"Computational Sciences Council, Novartis Institutes for BioMedical Research, Emeryville, California, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006535005","display_name":"Robert C. Altshuler","orcid":"https://orcid.org/0000-0001-5096-1932"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert C. Altshuler","raw_affiliation_strings":["Computational Sciences Council, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-5096-1932","affiliations":[{"raw_affiliation_string":"Computational Sciences Council, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026318125","display_name":"Caroline Gubser Keller","orcid":"https://orcid.org/0000-0001-9459-6076"},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]},{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":null,"type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Caroline Gubser Keller","raw_affiliation_strings":["Computational Sciences Council, Novartis Institutes for BioMedical Research, Basel, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-9459-6076","affiliations":[{"raw_affiliation_string":"Computational Sciences Council, Novartis Institutes for BioMedical Research, Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114045802","display_name":"Audrey Kauffmann","orcid":"https://orcid.org/0000-0002-5560-4210"},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]},{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":null,"type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Audrey Kauffmann","raw_affiliation_strings":["Computational Sciences Council, Novartis Institutes for BioMedical Research, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Sciences Council, Novartis Institutes for BioMedical Research, Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019137915","display_name":"Erik K. Sassaman","orcid":"https://orcid.org/0000-0001-5521-7635"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erik K. Sassaman","raw_affiliation_strings":["Computational Sciences Council, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-5521-7635","affiliations":[{"raw_affiliation_string":"Computational Sciences Council, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007667789","display_name":"Jason M. Laramie","orcid":"https://orcid.org/0000-0002-1473-7105"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jason M. Laramie","raw_affiliation_strings":["Computational Sciences Council, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Sciences Council, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087864188","display_name":"Birgit Schoeberl","orcid":"https://orcid.org/0000-0002-1990-5315"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Birgit Schoeberl","raw_affiliation_strings":["Computational Sciences Council, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-1990-5315","affiliations":[{"raw_affiliation_string":"Computational Sciences Council, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001741248","display_name":"Mark L. Borowsky","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark L. Borowsky","raw_affiliation_strings":["Computational Sciences Council, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Sciences Council, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057292715","display_name":"Nikolaus Stiefl","orcid":"https://orcid.org/0000-0003-2562-7080"},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]},{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":null,"type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Nikolaus Stiefl","raw_affiliation_strings":["Computational Sciences Council, Novartis Institutes for BioMedical Research, Basel, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-2562-7080","affiliations":[{"raw_affiliation_string":"Computational Sciences Council, Novartis Institutes for BioMedical Research, Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5018254174"],"corresponding_institution_ids":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.0032,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.75037137,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"16","issue":"8","first_page":"e1008126","last_page":"e1008126"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13937","display_name":"Genetics, Bioinformatics, and Biomedical Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13937","display_name":"Genetics, Bioinformatics, and Biomedical Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11986","display_name":"Scientific Computing and Data Management","score":0.9904999732971191,"subfield":{"id":"https://openalex.org/subfields/1802","display_name":"Information Systems and Management"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11937","display_name":"Research Data Management Practices","score":0.9886000156402588,"subfield":{"id":"https://openalex.org/subfields/1710","display_name":"Information Systems"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.7208753228187561},{"id":"https://openalex.org/keywords/simple","display_name":"Simple (philosophy)","score":0.6253853440284729},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5002806186676025},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.4061204195022583},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.38730329275131226},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.26173338294029236},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.21663817763328552}],"concepts":[{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.7208753228187561},{"id":"https://openalex.org/C2780586882","wikidata":"https://www.wikidata.org/wiki/Q7520643","display_name":"Simple (philosophy)","level":2,"score":0.6253853440284729},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5002806186676025},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.4061204195022583},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38730329275131226},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.26173338294029236},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21663817763328552},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000077488","descriptor_name":"Data Science","qualifier_ui":"Q000458","qualifier_name":"organization & administration","is_major_topic":true},{"descriptor_ui":"D000077488","descriptor_name":"Data Science","qualifier_ui":"Q000458","qualifier_name":"organization & administration","is_major_topic":true},{"descriptor_ui":"D000077488","descriptor_name":"Data Science","qualifier_ui":"Q000458","qualifier_name":"organization & administration","is_major_topic":true},{"descriptor_ui":"D000077488","descriptor_name":"Data Science","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D000077488","descriptor_name":"Data Science","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D000077488","descriptor_name":"Data Science","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D006040","descriptor_name":"Goals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006040","descriptor_name":"Goals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006040","descriptor_name":"Goals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007857","descriptor_name":"Leadership","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007857","descriptor_name":"Leadership","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007857","descriptor_name":"Leadership","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000458","qualifier_name":"organization & administration","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000458","qualifier_name":"organization & administration","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000458","qualifier_name":"organization & administration","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1008126","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008126","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008126&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:32853229","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32853229","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:f082e4cb53aa47739dce312fd02efbf6","is_oa":true,"landing_page_url":"https://doaj.org/article/f082e4cb53aa47739dce312fd02efbf6","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 16, Iss 8, p e1008126 (2020)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7451597","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7451597","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1008126","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008126","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008126&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320333796","display_name":"Novartis Institutes for BioMedical Research","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3080269749.pdf","grobid_xml":"https://content.openalex.org/works/W3080269749.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W1530446948","https://openalex.org/W1731081199","https://openalex.org/W1756240476","https://openalex.org/W1973094248","https://openalex.org/W2008985174","https://openalex.org/W2011301426","https://openalex.org/W2101234009","https://openalex.org/W2138350815","https://openalex.org/W2242464395","https://openalex.org/W2302501749","https://openalex.org/W2342249984","https://openalex.org/W2394812591","https://openalex.org/W2582743722","https://openalex.org/W2752535314","https://openalex.org/W2773787581","https://openalex.org/W2923101443","https://openalex.org/W2989807288","https://openalex.org/W2990427812","https://openalex.org/W2996717911","https://openalex.org/W3015214847","https://openalex.org/W3124215585","https://openalex.org/W3209575515","https://openalex.org/W6675354045","https://openalex.org/W6728933153"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W1585007175","https://openalex.org/W2382521049","https://openalex.org/W2390279801","https://openalex.org/W2144385241","https://openalex.org/W2013003323","https://openalex.org/W1981076832","https://openalex.org/W2024773645","https://openalex.org/W2001717001","https://openalex.org/W2043147644"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}