{"id":"https://openalex.org/W3048535101","doi":"https://doi.org/10.1371/journal.pcbi.1008125","title":"In silico co-factor balance estimation using constraint-based modelling informs metabolic engineering in Escherichia coli","display_name":"In silico co-factor balance estimation using constraint-based modelling informs metabolic engineering in Escherichia coli","publication_year":2020,"publication_date":"2020-08-10","ids":{"openalex":"https://openalex.org/W3048535101","doi":"https://doi.org/10.1371/journal.pcbi.1008125","mag":"3048535101","pmid":"https://pubmed.ncbi.nlm.nih.gov/32776925"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1008125","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008125","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008125&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008125&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054150862","display_name":"Laura de Arroyo Garcia","orcid":null},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Laura de Arroyo Garcia","raw_affiliation_strings":["Department of Life Sciences, Imperial College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Sciences, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081995040","display_name":"Patrik R. Jones","orcid":"https://orcid.org/0000-0001-7618-8204"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Patrik R. Jones","raw_affiliation_strings":["Department of Life Sciences, Imperial College London, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0001-7618-8204","affiliations":[{"raw_affiliation_string":"Department of Life Sciences, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5081995040"],"corresponding_institution_ids":["https://openalex.org/I47508984"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.6688,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.67674094,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"16","issue":"8","first_page":"e1008125","last_page":"e1008125"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10171","display_name":"Biofuel production and bioconversion","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11053","display_name":"Process Optimization and Integration","score":0.9927999973297119,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.7862621545791626},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.6800958514213562},{"id":"https://openalex.org/keywords/constraint","display_name":"Constraint (computer-aided design)","score":0.5846195220947266},{"id":"https://openalex.org/keywords/metabolic-engineering","display_name":"Metabolic engineering","score":0.5020534992218018},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.48101454973220825},{"id":"https://openalex.org/keywords/balance","display_name":"Balance (ability)","score":0.4595758616924286},{"id":"https://openalex.org/keywords/estimation","display_name":"Estimation","score":0.442125529050827},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3799367845058441},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3543122112751007},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.34951451420783997},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.18540948629379272},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1502719521522522},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.13105860352516174},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.08762967586517334}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.7862621545791626},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.6800958514213562},{"id":"https://openalex.org/C2776036281","wikidata":"https://www.wikidata.org/wiki/Q48769818","display_name":"Constraint (computer-aided design)","level":2,"score":0.5846195220947266},{"id":"https://openalex.org/C6350086","wikidata":"https://www.wikidata.org/wiki/Q6822347","display_name":"Metabolic engineering","level":3,"score":0.5020534992218018},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.48101454973220825},{"id":"https://openalex.org/C168031717","wikidata":"https://www.wikidata.org/wiki/Q1530280","display_name":"Balance (ability)","level":2,"score":0.4595758616924286},{"id":"https://openalex.org/C96250715","wikidata":"https://www.wikidata.org/wiki/Q965330","display_name":"Estimation","level":2,"score":0.442125529050827},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3799367845058441},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3543122112751007},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.34951451420783997},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18540948629379272},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1502719521522522},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.13105860352516174},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08762967586517334},{"id":"https://openalex.org/C201995342","wikidata":"https://www.wikidata.org/wiki/Q682496","display_name":"Systems engineering","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000440","descriptor_name":"Butanols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000440","descriptor_name":"Butanols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000440","descriptor_name":"Butanols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018533","descriptor_name":"Biomass","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018533","descriptor_name":"Biomass","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018533","descriptor_name":"Biomass","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060847","descriptor_name":"Metabolic Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D060847","descriptor_name":"Metabolic Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D060847","descriptor_name":"Metabolic Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D064688","descriptor_name":"Metabolic Flux Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064688","descriptor_name":"Metabolic Flux Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064688","descriptor_name":"Metabolic Flux Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1008125","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008125","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008125&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:32776925","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32776925","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:d3566dccfbde47d597e6f6696f6dfa74","is_oa":true,"landing_page_url":"https://doaj.org/article/d3566dccfbde47d597e6f6696f6dfa74","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 16, Iss 8, p e1008125 (2020)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7440669","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7440669","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1008125","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008125","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008125&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Affordable and clean energy","score":0.5400000214576721,"id":"https://metadata.un.org/sdg/7"}],"awards":[{"id":"https://openalex.org/G1492254208","display_name":"Multidisciplinary training for the Biosciences","funder_award_id":"BB/M011178/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G3829974171","display_name":null,"funder_award_id":"J014575/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G6412221817","display_name":"BB/J014575/1","funder_award_id":"BB/J014575/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3048535101.pdf","grobid_xml":"https://content.openalex.org/works/W3048535101.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1519685185","https://openalex.org/W1560272301","https://openalex.org/W1908199509","https://openalex.org/W1911715606","https://openalex.org/W1968467027","https://openalex.org/W1972990890","https://openalex.org/W1975356393","https://openalex.org/W1980802438","https://openalex.org/W1996724441","https://openalex.org/W1999912067","https://openalex.org/W2007767932","https://openalex.org/W2022374283","https://openalex.org/W2026089579","https://openalex.org/W2041715023","https://openalex.org/W2044223893","https://openalex.org/W2048465561","https://openalex.org/W2060036779","https://openalex.org/W2060985838","https://openalex.org/W2068481735","https://openalex.org/W2070851723","https://openalex.org/W2075684560","https://openalex.org/W2076262841","https://openalex.org/W2078355959","https://openalex.org/W2094397891","https://openalex.org/W2099456413","https://openalex.org/W2102062916","https://openalex.org/W2102164505","https://openalex.org/W2112515372","https://openalex.org/W2117474489","https://openalex.org/W2119907594","https://openalex.org/W2140593338","https://openalex.org/W2140944258","https://openalex.org/W2142072523","https://openalex.org/W2143861551","https://openalex.org/W2156528225","https://openalex.org/W2160541874","https://openalex.org/W2165612309","https://openalex.org/W2170427655","https://openalex.org/W2171493278","https://openalex.org/W2298762068","https://openalex.org/W2302221113","https://openalex.org/W2580403151","https://openalex.org/W2903668992","https://openalex.org/W2927966156","https://openalex.org/W2966850388","https://openalex.org/W4235405440","https://openalex.org/W4245225949","https://openalex.org/W7073876683"],"related_works":["https://openalex.org/W2912862995","https://openalex.org/W3129816939","https://openalex.org/W2101501829","https://openalex.org/W2985427592","https://openalex.org/W2003194288","https://openalex.org/W2060263731","https://openalex.org/W391093122","https://openalex.org/W1521239975","https://openalex.org/W4361305867","https://openalex.org/W2113159581"],"abstract_inverted_index":{"In":[0],"the":[1,22,25,31,41,50,98,114,123,163,173,198,212,220,230,256,263,281,302,326,341],"growing":[2],"field":[3],"of":[4,24,33,43,52,85,126,165,200,214,258,296,328,343],"metabolic":[5,360],"engineering,":[6],"where":[7],"cells":[8],"are":[9,160,225],"treated":[10],"as":[11,36,61,332],"'factories'":[12],"that":[13,222,290,310],"synthesize":[14],"industrial":[15],"compounds,":[16],"it":[17],"is":[18],"essential":[19],"to":[20,29,68,76,121,151,172,283],"consider":[21],"ability":[23],"cells'":[26],"native":[27],"metabolism":[28],"accommodate":[30],"demands":[32],"synthetic":[34],"pathways,":[35],"these":[37],"pathways":[38,132,292],"will":[39,92],"alter":[40],"homeostasis":[42],"cellular":[44,78],"energy":[45,135,247],"and":[46,56,63,71,83,101,111,113,128,136,153,157,211,248,288,312,334,350],"electron":[47,137],"metabolism.":[48],"From":[49],"breakdown":[51],"substrate,":[53],"microorganisms":[54],"activate":[55],"reduce":[57],"key":[58],"co-factors":[59,330],"such":[60,86,331],"ATP":[62,156,311],"NAD(P)H,":[64],"which":[65],"subsequently":[66],"need":[67,282],"be":[69,316],"hydrolysed":[70],"oxidized,":[72],"respectively,":[73],"in":[74,134,162,197,228,236,318],"order":[75],"restore":[77],"balance.":[79],"A":[80],"balanced":[81],"supply":[82],"consumption":[84],"co-factors,":[87],"here":[88],"termed":[89],"co-factor":[90,144,217,276,286,344],"balance,":[91],"influence":[93],"biotechnological":[94],"performance.":[95],"To":[96],"aid":[97],"strain":[99],"selection":[100,352],"design":[102],"process,":[103],"we":[104],"used":[105],"stoichiometric":[106,119],"modelling":[107],"(FBA,":[108],"pFBA,":[109],"FVA":[110],"MOMA)":[112],"Escherichia":[115],"coli":[116],"(E.coli)":[117],"core":[118],"model":[120],"investigate":[122],"network-wide":[124],"effect":[125],"butanol":[127,129],"precursor":[130],"production":[131],"differing":[133],"demand":[138],"on":[139],"product":[140],"yield.":[141,305],"An":[142],"FBA-based":[143],"balance":[145,174,327],"assessment":[146],"(CBA)":[147],"algorithm":[148],"was":[149,170],"developed":[150],"track":[152],"categorise":[154],"how":[155],"NAD(P)H":[158,313],"pools":[159],"affected":[161],"presence":[164],"a":[166,237],"new":[167,355],"pathway.":[168],"CBA":[169,346],"compared":[171],"calculations":[175],"proposed":[176],"by":[177,190,206,359],"Dugar":[178],"et":[179],"al.":[180],"(Nature":[181],"Biotechnol.":[182],"29":[183],"(12),":[184],"1074-1078).":[185],"Predicted":[186],"solutions":[187],"were":[188,233,269],"compromised":[189],"excessively":[191],"underdetermined":[192],"systems,":[193],"displaying":[194],"greater":[195],"flexibility":[196],"range":[199],"reaction":[201],"fluxes":[202],"than":[203],"experimentally":[204],"measured":[205,266],"13C-metabolic":[207],"flux":[208,267],"analysis":[209,307],"(MFA)":[210],"appearance":[213],"unrealistic":[215],"futile":[216,223,243,275],"cycles.":[218,277],"With":[219],"assumption":[221],"cycles":[224],"tightly":[226],"regulated":[227],"reality,":[229],"FBA":[231,260],"models":[232,264],"manually":[234],"constrained":[235],"step-wise":[238],"manner.":[239],"Solutions":[240],"with":[241,265,293],"minimal":[242,294],"cycling":[244],"diverted":[245],"surplus":[246,297],"electrons":[249],"towards":[250,298],"biomass":[251,299],"formation.":[252],"As":[253],"an":[254],"alternative,":[255],"use":[257],"loopless":[259],"or":[261,323],"constraining":[262],"ranges":[268],"tried":[270],"but":[271],"did":[272],"not":[273],"prevent":[274],"The":[278,306],"results":[279],"highlight":[280],"account":[284],"for":[285,357],"imbalance":[287,345],"confirm":[289],"better-balanced":[291],"diversion":[295],"formation":[300],"present":[301],"highest":[303],"theoretical":[304],"also":[308],"suggests":[309],"balancing":[314],"cannot":[315],"assessed":[317],"isolation":[319],"from":[320,325],"each":[321],"other,":[322],"even":[324],"additional":[329],"AMP":[333],"ADP.":[335],"We":[336],"conclude":[337],"that,":[338],"through":[339],"revealing":[340],"source":[342],"can":[347],"facilitate":[348],"pathway":[349],"host":[351],"when":[353],"designing":[354],"biocatalysts":[356],"implementation":[358],"engineering.":[361]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}
