{"id":"https://openalex.org/W3058283092","doi":"https://doi.org/10.1371/journal.pcbi.1008120","title":"Deconvolving the contributions of cell-type heterogeneity on cortical gene expression","display_name":"Deconvolving the contributions of cell-type heterogeneity on cortical gene expression","publication_year":2020,"publication_date":"2020-08-17","ids":{"openalex":"https://openalex.org/W3058283092","doi":"https://doi.org/10.1371/journal.pcbi.1008120","mag":"3058283092","pmid":"https://pubmed.ncbi.nlm.nih.gov/32804935"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1008120","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008120","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008120&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008120&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042620584","display_name":"Ellis Patrick","orcid":"https://orcid.org/0000-0002-5253-4747"},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I4210145422","display_name":"Westmead Institute for Medical Research","ror":"https://ror.org/04zj3ra44","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210145422"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Ellis Patrick","raw_affiliation_strings":["School of Mathematics and Statistics, The University of Sydney, Sydney, New South Wales, Australia","The Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia"],"raw_orcid":"https://orcid.org/0000-0002-5253-4747","affiliations":[{"raw_affiliation_string":"School of Mathematics and Statistics, The University of Sydney, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I129604602"]},{"raw_affiliation_string":"The Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I4210145422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032710063","display_name":"Mariko Taga","orcid":"https://orcid.org/0000-0003-3780-7054"},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mariko Taga","raw_affiliation_strings":["Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York City, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York City, New York, United States of America","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073539325","display_name":"Ayla Erg\u00fcn","orcid":"https://orcid.org/0000-0002-7934-1259"},"institutions":[{"id":"https://openalex.org/I1297540436","display_name":"Biogen (United States)","ror":"https://ror.org/02jqkb192","country_code":"US","type":"company","lineage":["https://openalex.org/I1297540436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ayla Ergun","raw_affiliation_strings":["Research and Development, Biogen, Cambridge, Massachusetts, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-7934-1259","affiliations":[{"raw_affiliation_string":"Research and Development, Biogen, Cambridge, Massachusetts, United States of America","institution_ids":["https://openalex.org/I1297540436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060855218","display_name":"Bernard Ng","orcid":"https://orcid.org/0000-0002-8688-3873"},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4210114564","display_name":"Pacific Centre for Reproductive Medicine","ror":"https://ror.org/027se6721","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210114564"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Bernard Ng","raw_affiliation_strings":["Centre for Molecular Medicine and Therapeutics, Vancouver, British Columbia, Canada","Departments of Statistics and Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada"],"raw_orcid":"https://orcid.org/0000-0002-8688-3873","affiliations":[{"raw_affiliation_string":"Centre for Molecular Medicine and Therapeutics, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I4210114564"]},{"raw_affiliation_string":"Departments of Statistics and Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081696760","display_name":"William Casazza","orcid":"https://orcid.org/0000-0002-4636-4710"},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4210114564","display_name":"Pacific Centre for Reproductive Medicine","ror":"https://ror.org/027se6721","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210114564"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"William Casazza","raw_affiliation_strings":["Centre for Molecular Medicine and Therapeutics, Vancouver, British Columbia, Canada","Departments of Statistics and Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada","The Bioinformatics Training Program, University of British Columbia, Vancouver, Canada"],"raw_orcid":"https://orcid.org/0000-0002-4636-4710","affiliations":[{"raw_affiliation_string":"Centre for Molecular Medicine and Therapeutics, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I4210114564"]},{"raw_affiliation_string":"Departments of Statistics and Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"The Bioinformatics Training Program, University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010817079","display_name":"Maria Cimpean","orcid":"https://orcid.org/0000-0003-3735-2643"},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Cimpean","raw_affiliation_strings":["Department of Pediatrics, Division of Rheumatology, Washington University School of Medicine, St. Louis, Missouri, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-3735-2643","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Division of Rheumatology, Washington University School of Medicine, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046766491","display_name":"Christina Yung","orcid":null},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina Yung","raw_affiliation_strings":["Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York City, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York City, New York, United States of America","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022605809","display_name":"Julie A. Schneider","orcid":"https://orcid.org/0000-0002-9482-1752"},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie A. Schneider","raw_affiliation_strings":["Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014075642","display_name":"David A. Bennett","orcid":"https://orcid.org/0000-0003-3689-554X"},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Bennett","raw_affiliation_strings":["Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072516895","display_name":"Chris Gaiteri","orcid":"https://orcid.org/0000-0001-7838-8664"},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chris Gaiteri","raw_affiliation_strings":["Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049324919","display_name":"Philip L. De Jager","orcid":"https://orcid.org/0000-0002-8057-2505"},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip L. De Jager","raw_affiliation_strings":["Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York City, New York, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-8057-2505","affiliations":[{"raw_affiliation_string":"Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York City, New York, United States of America","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034752878","display_name":"Elizabeth M. Bradshaw","orcid":"https://orcid.org/0000-0002-6766-4325"},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth M. Bradshaw","raw_affiliation_strings":["Department of Neurology, Columbia University Medical Center, New York City, New York, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-6766-4325","affiliations":[{"raw_affiliation_string":"Department of Neurology, Columbia University Medical Center, New York City, New York, United States of America","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065367298","display_name":"Sara Mostafavi","orcid":"https://orcid.org/0000-0003-4698-1177"},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4210114564","display_name":"Pacific Centre for Reproductive Medicine","ror":"https://ror.org/027se6721","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210114564"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Sara Mostafavi","raw_affiliation_strings":["Centre for Molecular Medicine and Therapeutics, Vancouver, British Columbia, Canada","Departments of Statistics and Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada"],"raw_orcid":"https://orcid.org/0000-0003-4698-1177","affiliations":[{"raw_affiliation_string":"Centre for Molecular Medicine and Therapeutics, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I4210114564"]},{"raw_affiliation_string":"Departments of Statistics and Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5065367298"],"corresponding_institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4210114564"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":5.5026,"has_fulltext":true,"cited_by_count":125,"citation_normalized_percentile":{"value":0.97223203,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"16","issue":"8","first_page":"e1008120","last_page":"e1008120"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9861000180244446,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/deconvolution","display_name":"Deconvolution","score":0.7308115363121033},{"id":"https://openalex.org/keywords/cell-type","display_name":"Cell type","score":0.7004601359367371},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5477092862129211},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.5375940203666687},{"id":"https://openalex.org/keywords/expression-quantitative-trait-loci","display_name":"Expression quantitative trait loci","score":0.5076223611831665},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4869595468044281},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4580773711204529},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.4300971031188965},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.3873558044433594},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.28570953011512756},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.27186763286590576},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.20278647541999817},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.08855116367340088}],"concepts":[{"id":"https://openalex.org/C174576160","wikidata":"https://www.wikidata.org/wiki/Q1183700","display_name":"Deconvolution","level":2,"score":0.7308115363121033},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.7004601359367371},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5477092862129211},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5375940203666687},{"id":"https://openalex.org/C168393362","wikidata":"https://www.wikidata.org/wiki/Q5421706","display_name":"Expression quantitative trait loci","level":5,"score":0.5076223611831665},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4869595468044281},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4580773711204529},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4300971031188965},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3873558044433594},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.28570953011512756},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.27186763286590576},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20278647541999817},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.08855116367340088},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1008120","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008120","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008120&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:32804935","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32804935","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:digitalcommons.wustl.edu:open_access_pubs-10473","is_oa":true,"landing_page_url":"https://digitalcommons.wustl.edu/open_access_pubs/9476","pdf_url":"https://digitalcommons.wustl.edu/cgi/viewcontent.cgi?article=10473&context=open_access_pubs","source":{"id":"https://openalex.org/S4306400764","display_name":"Digital Commons@Becker (Washington University School of Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I204465549","host_organization_name":"Washington University in St. Louis","host_organization_lineage":["https://openalex.org/I204465549"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Publications","raw_type":"text"},{"id":"pmh:oai:pubmedcentral.nih.gov:7451979","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7451979","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1008120","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008120","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:1295a6be968d4bca9402b6f0eb7ffac0","is_oa":true,"landing_page_url":"https://doaj.org/article/1295a6be968d4bca9402b6f0eb7ffac0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 16, Iss 8, p e1008120 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1008120","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008120","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008120&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1129744104","display_name":"Epidemiologic Study of Neural Reserve and Neurobiology of Aging","funder_award_id":"5r01ag017917-20","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2463493669","display_name":null,"funder_award_id":"R01 AG043617","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G266544023","display_name":null,"funder_award_id":"U01AG061356","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2702831338","display_name":"Identifying the origins of resilience through human single cell molecular networks, then testing them in diverse, resilient, human IPS lines","funder_award_id":"5r01ag061798-06","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3407010745","display_name":null,"funder_award_id":"R01AG057911","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3687192981","display_name":null,"funder_award_id":"R01AG061798","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3743240706","display_name":null,"funder_award_id":"R01 AG017917","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3841309259","display_name":null,"funder_award_id":"RF1 AG058852","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3997613085","display_name":"Identifying the molecular systems, networks, and key molecules that underlie cognitive resilience","funder_award_id":"7r01ag057911-06","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4132033372","display_name":null,"funder_award_id":"U01AG61356","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G4875156105","display_name":"Risk Factors, Pathology, and Clinical Expressions of AD","funder_award_id":"5r01ag015819-21","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5157209424","display_name":"Influence of genotype on microglia phenotype and function in PD","funder_award_id":"5r01ns089674-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5280164801","display_name":null,"funder_award_id":"R01 AG17917","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G5284255256","display_name":null,"funder_award_id":"R01 NS089674","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6063135672","display_name":"Multi-omic network-directed proteoform discovery, dissection and functional validation to prioritize novel AD therapeutic targets","funder_award_id":"5u01ag061356-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G643260330","display_name":"Altered monocyte function in relation to the CD33 Alzheimers disease locus","funder_award_id":"5r01ag043617-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G828200374","display_name":null,"funder_award_id":"P30AG010161","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8565308653","display_name":null,"funder_award_id":"R01AG15819","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G983864884","display_name":null,"funder_award_id":"R01-AG015819","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320315885","display_name":"Australian Government","ror":"https://ror.org/0314h5y94"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3058283092.pdf","grobid_xml":"https://content.openalex.org/works/W3058283092.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1546833668","https://openalex.org/W1552434751","https://openalex.org/W1967937330","https://openalex.org/W1971695370","https://openalex.org/W1985987855","https://openalex.org/W2028426093","https://openalex.org/W2055655674","https://openalex.org/W2090384073","https://openalex.org/W2097360283","https://openalex.org/W2104457974","https://openalex.org/W2113611401","https://openalex.org/W2130523009","https://openalex.org/W2137526110","https://openalex.org/W2164765928","https://openalex.org/W2165123547","https://openalex.org/W2191292005","https://openalex.org/W2266524792","https://openalex.org/W2523620612","https://openalex.org/W2747841296","https://openalex.org/W2761275051","https://openalex.org/W2770477678","https://openalex.org/W2794476560","https://openalex.org/W2804633924","https://openalex.org/W2806989085","https://openalex.org/W2942678593","https://openalex.org/W2949785910","https://openalex.org/W2950843563","https://openalex.org/W2952240309","https://openalex.org/W2954825129","https://openalex.org/W2973075426","https://openalex.org/W2977195112","https://openalex.org/W3023126733","https://openalex.org/W3104212943","https://openalex.org/W4294541781","https://openalex.org/W6749793787"],"related_works":["https://openalex.org/W2164780420","https://openalex.org/W2995716764","https://openalex.org/W2995369528","https://openalex.org/W2161056048","https://openalex.org/W3090782779","https://openalex.org/W4251527294","https://openalex.org/W3205474347","https://openalex.org/W2008960745","https://openalex.org/W3118849221","https://openalex.org/W1599494094"],"abstract_inverted_index":{"Complexity":[0],"of":[1,11,35,64,87,125],"cell-type":[2,29,127,148,183],"composition":[3],"has":[4],"created":[5],"much":[6],"skepticism":[7],"surrounding":[8],"the":[9,76,80,147],"interpretation":[10],"bulk":[12,36,70,138],"tissue":[13,46,63,100,140],"transcriptomic":[14],"studies.":[15],"Recent":[16],"studies":[17],"have":[18,51,69],"shown":[19],"that":[20,117,145,170],"deconvolution":[21,88,96],"algorithms":[22,89,97,119],"can":[23,120,133,176],"be":[24,135],"applied":[25,43],"to":[26,44,98],"computationally":[27],"estimate":[28],"proportions":[30],"from":[31,61,106,137],"gene":[32,72,165],"expression":[33,73,185],"data":[34,78],"blood":[37],"samples,":[38],"but":[39],"their":[40],"performance":[41],"when":[42],"brain":[45,62,91,99,108,139],"is":[47,154],"unclear.":[48],"Here,":[49],"we":[50,143,168],"generated":[52],"an":[53],"immunohistochemistry":[54],"(IHC)":[55],"dataset":[56],"for":[57,90,156],"five":[58],"major":[59],"cell-types":[60],"70":[65],"individuals,":[66],"who":[67],"also":[68,134],"cortical":[71],"data.":[74,114],"With":[75],"IHC":[77],"as":[79,151],"benchmark,":[81],"this":[82],"resource":[83],"enables":[84],"quantitative":[85,186],"assessment":[86],"tissue.":[92],"We":[93,115],"apply":[94],"existing":[95],"by":[101],"using":[102,171],"marker":[103,174],"sets":[104,175],"derived":[105],"human":[107],"single":[109],"cell":[110],"and":[111,164],"cell-sorted":[112],"RNA-seq":[113],"show":[116,144],"these":[118],"indeed":[121],"produce":[122],"informative":[123],"estimates":[124,150],"constituent":[126],"proportions.":[128],"In":[129],"fact,":[130],"neuronal":[131],"subpopulations":[132],"estimated":[136],"samples.":[141],"Further,":[142],"including":[146],"proportion":[149],"confounding":[152],"factors":[153],"important":[155],"reducing":[157],"false":[158],"associations":[159],"between":[160],"Alzheimer's":[161],"disease":[162],"phenotypes":[163],"expression.":[166],"Lastly,":[167],"demonstrate":[169],"more":[172],"accurate":[173],"substantially":[177],"improve":[178],"statistical":[179],"power":[180],"in":[181],"detecting":[182],"specific":[184],"trait":[187],"loci":[188],"(eQTLs).":[189]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":38},{"year":2023,"cited_by_count":30},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":20},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":3}],"updated_date":"2026-08-14T07:06:38.338062","created_date":"2025-10-10T00:00:00"}
