{"id":"https://openalex.org/W3044522460","doi":"https://doi.org/10.1371/journal.pcbi.1008099","title":"A practical application of generative adversarial networks for RNA-seq analysis to predict the molecular progress of Alzheimer's disease","display_name":"A practical application of generative adversarial networks for RNA-seq analysis to predict the molecular progress of Alzheimer's disease","publication_year":2020,"publication_date":"2020-07-24","ids":{"openalex":"https://openalex.org/W3044522460","doi":"https://doi.org/10.1371/journal.pcbi.1008099","mag":"3044522460","pmid":"https://pubmed.ncbi.nlm.nih.gov/32706788"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1008099","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008099","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008099&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008099&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100681218","display_name":"Jinhee Park","orcid":"https://orcid.org/0000-0002-3612-203X"},"institutions":[{"id":"https://openalex.org/I31419693","display_name":"Kyungpook National University","ror":"https://ror.org/040c17130","country_code":"KR","type":"education","lineage":["https://openalex.org/I31419693"]},{"id":"https://openalex.org/I4210155455","display_name":"Korea Brain Research Institute","ror":"https://ror.org/055zd7d59","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210155455"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jinhee Park","raw_affiliation_strings":["Dementia Research Group, Korea Brain Research Institute (KBRI), Daegu, Korea","School of Electronics Engineering, Kyungpook National University, Daegu, Korea"],"raw_orcid":"https://orcid.org/0000-0002-3612-203X","affiliations":[{"raw_affiliation_string":"Dementia Research Group, Korea Brain Research Institute (KBRI), Daegu, Korea","institution_ids":["https://openalex.org/I4210155455"]},{"raw_affiliation_string":"School of Electronics Engineering, Kyungpook National University, Daegu, Korea","institution_ids":["https://openalex.org/I31419693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024958867","display_name":"Hye\u2010Rin Kim","orcid":"https://orcid.org/0000-0003-4962-8272"},"institutions":[{"id":"https://openalex.org/I4210155455","display_name":"Korea Brain Research Institute","ror":"https://ror.org/055zd7d59","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210155455"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyerin Kim","raw_affiliation_strings":["Dementia Research Group, Korea Brain Research Institute (KBRI), Daegu, Korea"],"raw_orcid":"https://orcid.org/0000-0003-4962-8272","affiliations":[{"raw_affiliation_string":"Dementia Research Group, Korea Brain Research Institute (KBRI), Daegu, Korea","institution_ids":["https://openalex.org/I4210155455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100652684","display_name":"Jaekwang Kim","orcid":"https://orcid.org/0000-0002-7312-4077"},"institutions":[{"id":"https://openalex.org/I4210155455","display_name":"Korea Brain Research Institute","ror":"https://ror.org/055zd7d59","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210155455"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jaekwang Kim","raw_affiliation_strings":["Dementia Research Group, Korea Brain Research Institute (KBRI), Daegu, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dementia Research Group, Korea Brain Research Institute (KBRI), Daegu, Korea","institution_ids":["https://openalex.org/I4210155455"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045004906","display_name":"Mookyung Cheon","orcid":"https://orcid.org/0000-0001-6777-6725"},"institutions":[{"id":"https://openalex.org/I4210155455","display_name":"Korea Brain Research Institute","ror":"https://ror.org/055zd7d59","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210155455"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Mookyung Cheon","raw_affiliation_strings":["Dementia Research Group, Korea Brain Research Institute (KBRI), Daegu, Korea"],"raw_orcid":"https://orcid.org/0000-0001-6777-6725","affiliations":[{"raw_affiliation_string":"Dementia Research Group, Korea Brain Research Institute (KBRI), Daegu, Korea","institution_ids":["https://openalex.org/I4210155455"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5045004906"],"corresponding_institution_ids":["https://openalex.org/I4210155455"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.3342,"has_fulltext":true,"cited_by_count":55,"citation_normalized_percentile":{"value":0.89307925,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"16","issue":"7","first_page":"e1008099","last_page":"e1008099"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9948999881744385,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6208088397979736},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5806286334991455},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.561333417892456},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.43796810507774353},{"id":"https://openalex.org/keywords/alzheimers-disease","display_name":"Alzheimer's disease","score":0.4244893491268158},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.400126576423645},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.38978832960128784},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3495503067970276},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.31923019886016846},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.18431314826011658},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.15835464000701904}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6208088397979736},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5806286334991455},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.561333417892456},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.43796810507774353},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4244893491268158},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.400126576423645},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.38978832960128784},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3495503067970276},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.31923019886016846},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18431314826011658},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15835464000701904}],"mesh":[{"descriptor_ui":"D000073359","descriptor_name":"Exome Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000073359","descriptor_name":"Exome Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000073359","descriptor_name":"Exome Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013702","descriptor_name":"Temporal Lobe","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013702","descriptor_name":"Temporal Lobe","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013702","descriptor_name":"Temporal Lobe","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1008099","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008099","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008099&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:32706788","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32706788","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1008099","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008099","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:9263745926474e06bc2adb9ec7b2f729","is_oa":true,"landing_page_url":"https://doaj.org/article/9263745926474e06bc2adb9ec7b2f729","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 16, Iss 7, p e1008099 (2020)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7406107","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7406107","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1008099","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008099","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008099&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G5043016601","display_name":null,"funder_award_id":"H I14C1135","funder_id":"https://openalex.org/F4320322034","funder_display_name":"Ministry of Health and Welfare"},{"id":"https://openalex.org/G6934394395","display_name":null,"funder_award_id":"H I14C1135","funder_id":"https://openalex.org/F4320322107","funder_display_name":"Korea Health Industry Development Institute"},{"id":"https://openalex.org/G7179424102","display_name":null,"funder_award_id":"20-BR-02-10","funder_id":"https://openalex.org/F4320328359","funder_display_name":"Ministry of Science and ICT, South Korea"}],"funders":[{"id":"https://openalex.org/F4320318413","display_name":"Korea Brain Research Institute","ror":"https://ror.org/055zd7d59"},{"id":"https://openalex.org/F4320322034","display_name":"Ministry of Health and Welfare","ror":"https://ror.org/00vxgjw72"},{"id":"https://openalex.org/F4320322107","display_name":"Korea Health Industry Development Institute","ror":"https://ror.org/00fdzyk40"},{"id":"https://openalex.org/F4320328359","display_name":"Ministry of Science and ICT, South Korea","ror":"https://ror.org/01wpjm123"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3044522460.pdf","grobid_xml":"https://content.openalex.org/works/W3044522460.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W888909304","https://openalex.org/W1543871129","https://openalex.org/W1966485745","https://openalex.org/W1989058981","https://openalex.org/W1990008286","https://openalex.org/W2004750343","https://openalex.org/W2006161539","https://openalex.org/W2009230396","https://openalex.org/W2012862746","https://openalex.org/W2033105784","https://openalex.org/W2036433301","https://openalex.org/W2037122545","https://openalex.org/W2054275187","https://openalex.org/W2055488264","https://openalex.org/W2081124007","https://openalex.org/W2095949378","https://openalex.org/W2099471712","https://openalex.org/W2102278945","https://openalex.org/W2131271579","https://openalex.org/W2134526812","https://openalex.org/W2135351049","https://openalex.org/W2142467924","https://openalex.org/W2148918646","https://openalex.org/W2173520492","https://openalex.org/W2179438025","https://openalex.org/W2187089797","https://openalex.org/W2260642650","https://openalex.org/W2411855022","https://openalex.org/W2766527293","https://openalex.org/W2790963596","https://openalex.org/W2790983771","https://openalex.org/W2804691345","https://openalex.org/W2804990321","https://openalex.org/W2901677030","https://openalex.org/W2902382430","https://openalex.org/W2911484089","https://openalex.org/W2913015596","https://openalex.org/W2914222102","https://openalex.org/W2924067995","https://openalex.org/W2935703330","https://openalex.org/W2936572536","https://openalex.org/W2936873828","https://openalex.org/W2937828061","https://openalex.org/W2946173685","https://openalex.org/W2949272108","https://openalex.org/W2951381561","https://openalex.org/W2953405766","https://openalex.org/W2962760235","https://openalex.org/W2962770929","https://openalex.org/W2962879692","https://openalex.org/W2963684088","https://openalex.org/W3003301247","https://openalex.org/W3024013192","https://openalex.org/W3037567775","https://openalex.org/W3039072393","https://openalex.org/W3100015175","https://openalex.org/W4211186501","https://openalex.org/W4226348722","https://openalex.org/W4294643831","https://openalex.org/W4295521014","https://openalex.org/W6681283096","https://openalex.org/W6735913928","https://openalex.org/W6779669310"],"related_works":["https://openalex.org/W4375867731","https://openalex.org/W2611989081","https://openalex.org/W2731899572","https://openalex.org/W4230611425","https://openalex.org/W4294635752","https://openalex.org/W4304166257","https://openalex.org/W4383066092","https://openalex.org/W3215138031","https://openalex.org/W2804383999","https://openalex.org/W2802049774"],"abstract_inverted_index":{"Next-generation":[0],"sequencing":[1],"(NGS)":[2],"technology":[3],"has":[4],"become":[5],"a":[6,17,34,72,99,212,242],"powerful":[7],"tool":[8,244],"for":[9],"dissecting":[10],"the":[11,23,62,83,116,121,135,149,169,197,222,227,251],"molecular":[12,84],"and":[13,41,59,129,185],"pathological":[14,44,156,176,255],"signatures":[15],"of":[16,19,26,64,86,103,110,152,199,207,216,230,233,253],"variety":[18],"human":[20],"diseases.":[21],"However,":[22],"limited":[24],"availability":[25],"biological":[27,65,130],"samples":[28],"from":[29,98,158],"different":[30],"disease":[31,39,88,141,247],"stages":[32],"is":[33,123,221],"major":[35,107],"hurdle":[36],"in":[37,115,196],"studying":[38],"progressions":[40],"identifying":[42],"early":[43,214,254],"changes.":[45],"Deep":[46],"learning":[47,74],"techniques":[48],"have":[49,126,189],"recently":[50],"begun":[51],"to":[52,55,81,94,125,147,160,193,225,245,250],"be":[53,194],"applied":[54,71,92],"analyze":[56,95],"NGS":[57],"data":[58,97],"thereby":[60],"predict":[61,82],"progression":[63],"processes.":[66],"In":[67],"this":[68],"study,":[69],"we":[70,138,173,237],"deep":[73],"technique":[75],"called":[76],"generative":[77],"adversarial":[78],"networks":[79],"(GANs)":[80],"progress":[85,142],"Alzheimer's":[87],"(AD).":[89],"We":[90,118],"successfully":[91],"GANs":[93,240],"RNA-seq":[96],"5xFAD":[100],"mouse":[101],"model":[102],"AD,":[104,217],"which":[105,188],"recapitulates":[106],"AD":[108,161,231],"features":[109],"massive":[111],"amyloid-\u03b2":[112],"(A\u03b2)":[113],"accumulation":[114],"brain.":[117],"examined":[119],"how":[120],"generator":[122],"featured":[124],"specific-sample":[127],"generation":[128],"gene":[131],"association.":[132],"Based":[133],"on":[134,168],"above":[136],"observations,":[137],"suggested":[139],"virtual":[140],"by":[143],"latent":[144],"space":[145],"interpolation":[146],"yield":[148],"transition":[150,170],"curves":[151],"various":[153],"genes":[154],"with":[155,178],"changes":[157],"normal":[159],"state.":[162],"By":[163],"performing":[164],"pathway":[165],"analysis":[166,203],"based":[167],"curve":[171],"patterns,":[172],"identified":[174],"several":[175],"processes":[177],"progressive":[179],"changes,":[180],"such":[181],"as":[182],"inflammatory":[183],"systems":[184],"synapse":[186],"functions,":[187],"previously":[190],"been":[191],"demonstrated":[192],"involved":[195],"pathogenesis":[198],"AD.":[200],"Interestingly,":[201],"our":[202],"indicates":[204],"that":[205,219,239],"alteration":[206],"cholesterol":[208,228],"biosynthesis":[209],"begins":[210],"at":[211],"very":[213],"stage":[215],"suggesting":[218],"it":[220],"first":[223],"effect":[224],"mediate":[226],"metabolism":[229],"downstream":[232],"A\u03b2":[234],"accumulation.":[235],"Here,":[236],"suggest":[238],"are":[241],"useful":[243],"study":[246],"progression,":[248],"leading":[249],"identification":[252],"signatures.":[256]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":1}],"updated_date":"2026-06-12T08:23:45.883708","created_date":"2025-10-10T00:00:00"}
