{"id":"https://openalex.org/W3049133966","doi":"https://doi.org/10.1371/journal.pcbi.1008082","title":"Genotype networks of 80 quantitative Arabidopsis thaliana phenotypes reveal phenotypic evolvability despite pervasive epistasis","display_name":"Genotype networks of 80 quantitative Arabidopsis thaliana phenotypes reveal phenotypic evolvability despite pervasive epistasis","publication_year":2020,"publication_date":"2020-08-13","ids":{"openalex":"https://openalex.org/W3049133966","doi":"https://doi.org/10.1371/journal.pcbi.1008082","mag":"3049133966","pmid":"https://pubmed.ncbi.nlm.nih.gov/32790763"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1008082","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008082","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008082&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008082&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001360174","display_name":"Gabriel Schweizer","orcid":"https://orcid.org/0000-0002-8679-4598"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Gabriel Schweizer","raw_affiliation_strings":["Swiss Institute of Bioinformatics, Lausanne, Switzerland","University of Z\u00fcrich, Department of Evolutionary Biology and Environmental Studies, Z\u00fcrich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-8679-4598","affiliations":[{"raw_affiliation_string":"Swiss Institute of Bioinformatics, Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293"]},{"raw_affiliation_string":"University of Z\u00fcrich, Department of Evolutionary Biology and Environmental Studies, Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079730045","display_name":"Andreas Wagner","orcid":"https://orcid.org/0000-0003-4299-3840"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1308548392","display_name":"Santa Fe Institute","ror":"https://ror.org/01arysc35","country_code":"US","type":"funder","lineage":["https://openalex.org/I1308548392"]},{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH","US"],"is_corresponding":true,"raw_author_name":"Andreas Wagner","raw_affiliation_strings":["Santa Fe Institute, Santa Fe, New Mexico, United States of America","Swiss Institute of Bioinformatics, Lausanne, Switzerland","University of Z\u00fcrich, Department of Evolutionary Biology and Environmental Studies, Z\u00fcrich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Santa Fe Institute, Santa Fe, New Mexico, United States of America","institution_ids":["https://openalex.org/I1308548392"]},{"raw_affiliation_string":"Swiss Institute of Bioinformatics, Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293"]},{"raw_affiliation_string":"University of Z\u00fcrich, Department of Evolutionary Biology and Environmental Studies, Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5079730045"],"corresponding_institution_ids":["https://openalex.org/I12708293","https://openalex.org/I1308548392","https://openalex.org/I202697423"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.081,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.79357557,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"16","issue":"8","first_page":"e1008082","last_page":"e1008082"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epistasis","display_name":"Epistasis","score":0.9162994623184204},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7751548290252686},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.7369783520698547},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.6731985807418823},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.5480672121047974},{"id":"https://openalex.org/keywords/phenotypic-trait","display_name":"Phenotypic trait","score":0.43303200602531433},{"id":"https://openalex.org/keywords/arabidopsis-thaliana","display_name":"Arabidopsis thaliana","score":0.4113408625125885},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.37604451179504395},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.28102007508277893},{"id":"https://openalex.org/keywords/mutant","display_name":"Mutant","score":0.22141462564468384}],"concepts":[{"id":"https://openalex.org/C61727976","wikidata":"https://www.wikidata.org/wiki/Q751748","display_name":"Epistasis","level":3,"score":0.9162994623184204},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7751548290252686},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.7369783520698547},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6731985807418823},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5480672121047974},{"id":"https://openalex.org/C130073038","wikidata":"https://www.wikidata.org/wiki/Q1211967","display_name":"Phenotypic trait","level":4,"score":0.43303200602531433},{"id":"https://openalex.org/C2775988993","wikidata":"https://www.wikidata.org/wiki/Q158695","display_name":"Arabidopsis thaliana","level":4,"score":0.4113408625125885},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.37604451179504395},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28102007508277893},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.22141462564468384}],"mesh":[{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017343","descriptor_name":"Genes, Plant","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017343","descriptor_name":"Genes, Plant","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017343","descriptor_name":"Genes, Plant","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1008082","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008082","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008082&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:32790763","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32790763","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:www.zora.uzh.ch:198012","is_oa":true,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Schweizer, Gabriel; Wagner, Andreas  (2020). Genotype networks of 80 quantitative Arabidopsis thaliana phenotypes reveal phenotypic evolvability despite pervasive epistasis.  PLoS Computational Biology, 16(8):e1008082.","raw_type":"info:eu-repo/semantics/acceptedVersion"},{"id":"pmh:oai:doaj.org/article:590b3b7433e449c082ea0221e9d5d917","is_oa":true,"landing_page_url":"https://doaj.org/article/590b3b7433e449c082ea0221e9d5d917","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 16, Iss 8, p e1008082 (2020)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7447023","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7447023","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"doi:10.5167/uzh-198012","is_oa":true,"landing_page_url":"https://doi.org/10.5167/uzh-198012","pdf_url":null,"source":{"id":"https://openalex.org/S7407051291","display_name":"Universit\u00e4t Z\u00fcrich, ZORA","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1008082","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008082","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008082&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land","score":0.44999998807907104}],"awards":[{"id":"https://openalex.org/G1835917608","display_name":null,"funder_award_id":"739874","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G2394732050","display_name":null,"funder_award_id":"739874","funder_id":"https://openalex.org/F4320338335","funder_display_name":"H2020 European Research Council"},{"id":"https://openalex.org/G3215241047","display_name":null,"funder_award_id":"31003A_172887","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5516143098","display_name":null,"funder_award_id":"31003A_172887","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320323874","display_name":"Universit\u00e4t Z\u00fcrich","ror":"https://ror.org/02crff812"},{"id":"https://openalex.org/F4320338335","display_name":"H2020 European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3049133966.pdf","grobid_xml":"https://content.openalex.org/works/W3049133966.grobid-xml"},"referenced_works_count":97,"referenced_works":["https://openalex.org/W229097380","https://openalex.org/W1780698104","https://openalex.org/W1866477831","https://openalex.org/W1965857389","https://openalex.org/W1968763100","https://openalex.org/W1973413549","https://openalex.org/W1977708739","https://openalex.org/W1977940795","https://openalex.org/W1978150238","https://openalex.org/W1981542950","https://openalex.org/W1982583288","https://openalex.org/W1982639980","https://openalex.org/W1983658594","https://openalex.org/W1992613346","https://openalex.org/W2011759634","https://openalex.org/W2015243851","https://openalex.org/W2016666153","https://openalex.org/W2021085327","https://openalex.org/W2022161986","https://openalex.org/W2024152270","https://openalex.org/W2025079535","https://openalex.org/W2032457672","https://openalex.org/W2035422475","https://openalex.org/W2039959586","https://openalex.org/W2047919241","https://openalex.org/W2057659038","https://openalex.org/W2064690758","https://openalex.org/W2064950342","https://openalex.org/W2066669827","https://openalex.org/W2069504710","https://openalex.org/W2072000717","https://openalex.org/W2073171022","https://openalex.org/W2075741092","https://openalex.org/W2077723503","https://openalex.org/W2078440622","https://openalex.org/W2078935977","https://openalex.org/W2081531630","https://openalex.org/W2084314118","https://openalex.org/W2084482326","https://openalex.org/W2084516445","https://openalex.org/W2084616473","https://openalex.org/W2094189284","https://openalex.org/W2096059337","https://openalex.org/W2105329815","https://openalex.org/W2105557836","https://openalex.org/W2108350807","https://openalex.org/W2125910575","https://openalex.org/W2126606094","https://openalex.org/W2126643167","https://openalex.org/W2128292906","https://openalex.org/W2129240922","https://openalex.org/W2131681506","https://openalex.org/W2133757548","https://openalex.org/W2137797806","https://openalex.org/W2139359390","https://openalex.org/W2142150916","https://openalex.org/W2142464651","https://openalex.org/W2143691084","https://openalex.org/W2144893575","https://openalex.org/W2149687548","https://openalex.org/W2151936673","https://openalex.org/W2156469654","https://openalex.org/W2158729340","https://openalex.org/W2165327448","https://openalex.org/W2210383493","https://openalex.org/W2338807579","https://openalex.org/W2339766289","https://openalex.org/W2379594833","https://openalex.org/W2419574648","https://openalex.org/W2462342490","https://openalex.org/W2471654536","https://openalex.org/W2483469645","https://openalex.org/W2534895556","https://openalex.org/W2572573235","https://openalex.org/W2588507788","https://openalex.org/W2593447578","https://openalex.org/W2599595699","https://openalex.org/W2615678788","https://openalex.org/W2622164463","https://openalex.org/W2756289581","https://openalex.org/W2766784689","https://openalex.org/W2800231751","https://openalex.org/W2804099821","https://openalex.org/W2884631095","https://openalex.org/W2889897651","https://openalex.org/W2898806520","https://openalex.org/W2902394141","https://openalex.org/W2928861204","https://openalex.org/W2946722611","https://openalex.org/W2951905689","https://openalex.org/W2952287548","https://openalex.org/W2963313115","https://openalex.org/W2981780393","https://openalex.org/W3099768174","https://openalex.org/W4246887724","https://openalex.org/W4248776151","https://openalex.org/W4256140420"],"related_works":["https://openalex.org/W4231501520","https://openalex.org/W1787347804","https://openalex.org/W2140140747","https://openalex.org/W2583262180","https://openalex.org/W3014691397","https://openalex.org/W2052001298","https://openalex.org/W2342312410","https://openalex.org/W4245102296","https://openalex.org/W4400060393","https://openalex.org/W2143131037"],"abstract_inverted_index":{"We":[0,94,126],"study":[1],"the":[2,10,17,57,99,115,149,164,170,210],"genotype-phenotype":[3],"maps":[4],"of":[5,79,101,111,117,151,166,177,213],"80":[6,66],"quantitative":[7],"phenotypes":[8,136,180],"in":[9,61,130,134,148,216],"model":[11],"plant":[12],"Arabidopsis":[13],"thaliana,":[14],"by":[15,53],"representing":[16],"genotypes":[18,59],"affecting":[19],"each":[20,30],"phenotype":[21],"as":[22],"a":[23,28,46,108],"genotype":[24,38,67,199],"network.":[25],"In":[26],"such":[27],"network,":[29],"vertex":[31],"or":[32,122],"node":[33],"corresponds":[34],"to":[35,155,208],"an":[36,54],"individual's":[37],"at":[39],"all":[40],"those":[41],"genomic":[42],"loci":[43],"that":[44,184],"affect":[45],"given":[47],"phenotype.":[48],"Two":[49],"vertices":[50],"are":[51,71,181],"connected":[52,86],"edge":[55],"if":[56],"associated":[58],"differ":[60],"exactly":[62],"one":[63],"nucleotide.":[64],"The":[65,198],"networks":[68],"we":[69,144,202],"analyze":[70],"based":[72],"on":[73,98],"data":[74],"from":[75],"genome-wide":[76],"association":[77],"studies":[78],"199":[80],"A.":[81],"thaliana":[82],"accessions.":[83],"They":[84],"form":[85],"graphs":[87],"whose":[88],"topography":[89],"differs":[90],"substantially":[91],"among":[92,105],"phenotypes.":[93],"focus":[95],"our":[96,178],"analysis":[97],"incidence":[100,110],"epistasis":[102,112,162,195],"(non-additive":[103],"interactions":[104,129],"mutations)":[106],"because":[107],"high":[109,121],"can":[113,204],"reduce":[114],"accessibility":[116,165],"evolutionary":[118,186],"paths":[119,154,187],"towards":[120],"low":[123],"phenotypic":[124,157,168,175],"values.":[125,158],"find":[127,145],"epistatic":[128],"67":[131],"phenotypes,":[132,192],"and":[133,174],"51":[135],"every":[137],"pairwise":[138],"mutant":[139],"interaction":[140],"is":[141,196],"epistatic.":[142],"Moreover,":[143],"phenotype-specific":[146],"differences":[147],"fraction":[150],"accessible":[152,189],"mutational":[153],"maximum":[156,167],"However,":[159],"even":[160,193],"though":[161],"affects":[163],"values,":[169],"relationships":[171],"between":[172],"genotypic":[173],"change":[176],"analyzed":[179],"sufficiently":[182],"smooth":[183],"some":[185],"remain":[188],"for":[190],"most":[191],"where":[194],"pervasive.":[197],"network":[200],"representation":[201],"use":[203],"complement":[205],"existing":[206],"approaches":[207],"understand":[209],"genetic":[211],"architecture":[212],"polygenic":[214],"traits":[215],"many":[217],"different":[218],"organisms.":[219]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}
